GREMLIN Database
YHCS - Uncharacterized protein YhcS
UniProt: P54603 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (187)
Sequences: 2875 (2273)
Seq/√Len: 166.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_L194_G3.7761.00
150_V195_K3.7351.00
126_R129_E3.6051.00
99_V116_L3.4101.00
114_I172_L2.9111.00
79_K134_D2.7501.00
76_E139_L2.7341.00
90_T103_K2.6641.00
113_Q173_I2.6571.00
99_V118_G2.5831.00
169_K195_K2.5131.00
73_G86_I2.5131.00
171_E193_Y2.4881.00
74_I83_E2.4731.00
148_E195_K2.3471.00
138_L172_L2.3361.00
120_R128_G2.2831.00
149_I192_I2.1491.00
135_Q146_T2.1071.00
135_Q148_E2.1051.00
153_K162_I2.0941.00
136_L194_G2.0901.00
156_D188_K2.0471.00
94_D100_G2.0251.00
136_L172_L2.0221.00
77_I80_I1.9761.00
87_V94_D1.9551.00
79_K130_L1.8301.00
76_E83_E1.8171.00
78_P137_R1.7721.00
88_E101_H1.7601.00
79_K131_E1.7581.00
127_T130_L1.7451.00
91_D94_D1.7241.00
111_N170_E1.6891.00
137_R146_T1.6481.00
153_K193_Y1.5911.00
124_F174_L1.5901.00
170_E196_R1.5861.00
151_K193_Y1.5781.00
25_I29_T1.5551.00
84_L99_V1.5421.00
101_H105_S1.5311.00
152_T190_Y1.5111.00
106_Y165_L1.5011.00
114_I138_L1.4881.00
150_V171_E1.4591.00
122_T126_R1.4501.00
166_Q171_E1.4401.00
130_L149_I1.4341.00
155_V175_T1.4291.00
57_Q61_K1.4191.00
175_T191_I1.4101.00
75_L136_L1.3821.00
166_Q169_K1.3631.00
127_T190_Y1.3271.00
127_T176_T1.3151.00
92_A96_E1.3121.00
145_F196_R1.3051.00
13_G17_A1.3031.00
154_I178_Y1.3001.00
6_P10_I1.2861.00
176_T190_Y1.2601.00
86_I138_L1.2351.00
150_V193_Y1.2261.00
80_I130_L1.2251.00
87_V98_G1.2111.00
89_G100_G1.2031.00
13_G16_I1.2001.00
119_H177_C1.1951.00
60_N64_F1.1821.00
155_V191_I1.1611.00
140_L143_G1.1491.00
26_D29_T1.1451.00
76_E137_R1.1381.00
75_L86_I1.1321.00
120_R125_R1.1291.00
72_S88_E1.1241.00
101_H114_I1.1111.00
120_R179_P1.0961.00
75_L116_L1.0821.00
90_T100_G1.0811.00
178_Y188_K1.0731.00
99_V124_F1.0721.00
115_V175_T1.0700.99
121_D180_F1.0590.99
77_I130_L1.0460.99
137_R144_E1.0450.99
95_L98_G1.0450.99
120_R180_F1.0310.99
86_I116_L1.0280.99
74_I139_L1.0130.99
124_F176_T0.9990.99
139_L144_E0.9930.99
54_S57_Q0.9920.99
156_D159_D0.9920.99
73_G138_L0.9750.99
178_Y186_A0.9490.99
116_L138_L0.9340.99
127_T192_I0.9250.99
13_G20_G0.9100.98
19_Y23_K0.9060.98
113_Q193_Y0.9040.98
111_N165_L0.9000.98
121_D186_A0.8990.98
173_I193_Y0.8950.98
162_I191_I0.8940.98
152_T192_I0.8860.98
7_L15_V0.8830.98
154_I188_K0.8710.98
31_T34_T0.8670.98
118_G123_V0.8620.98
27_T31_T0.8510.97
29_T33_Q0.8450.97
130_L134_D0.8410.97
53_N57_Q0.8400.97
84_L123_V0.8400.97
18_G22_F0.8390.97
85_P99_V0.8370.97
160_T163_I0.8370.97
72_S101_H0.8340.97
6_P9_I0.8320.97
124_F127_T0.8250.97
26_D30_K0.8180.97
77_I82_A0.8170.97
61_K65_K0.8120.97
29_T32_E0.8100.97
39_K43_K0.8090.97
98_G116_L0.8070.97
113_Q191_I0.7990.96
132_K135_Q0.7980.96
178_Y187_P0.7940.96
56_D59_K0.7930.96
121_D125_R0.7900.96
109_D112_G0.7870.96
87_V97_K0.7790.96
57_Q62_A0.7780.96
10_I13_G0.7760.96
173_I191_I0.7730.96
42_A46_Q0.7670.95
72_S107_Y0.7570.95
149_I152_T0.7510.95
180_F190_Y0.7470.95
27_T30_K0.7450.95
10_I14_L0.7410.94
109_D114_I0.7400.94
7_L11_A0.7400.94
43_K46_Q0.7390.94
101_H107_Y0.7370.94
76_E144_E0.7300.94
85_P157_K0.7280.94
23_K27_T0.7230.94
11_A15_V0.7160.93
80_I126_R0.7160.93
121_D187_P0.7130.93
90_T94_D0.7050.93
24_L28_N0.6990.92
180_F186_A0.6950.92
128_G190_Y0.6900.92
113_Q136_L0.6840.92
106_Y112_G0.6830.92
121_D178_Y0.6830.92
18_G21_G0.6830.92
102_Y175_T0.6810.91
155_V159_D0.6780.91
136_L174_L0.6750.91
156_D187_P0.6730.91
62_A65_K0.6710.91
111_N168_E0.6670.91
105_S115_V0.6670.91
59_K65_K0.6630.90
21_G24_L0.6620.90
35_L39_K0.6570.90
177_C189_R0.6560.90
30_K33_Q0.6510.90
88_E100_G0.6510.90
75_L99_V0.6470.89
109_D196_R0.6430.89
38_A140_L0.6410.89
54_S58_A0.6400.89
20_G24_L0.6370.89
116_L123_V0.6360.88
179_P190_Y0.6360.88
95_L118_G0.6350.88
106_Y115_V0.6330.88
121_D179_P0.6300.88
89_G95_L0.6250.88
151_K164_T0.6240.88
178_Y185_N0.6230.87
82_A124_F0.6210.87
123_V186_A0.6160.87
39_K83_E0.6160.87
112_G165_L0.6150.87
180_F187_P0.6150.87
151_K162_I0.6150.87
10_I17_A0.6130.87
91_D100_G0.6120.87
52_K58_A0.6100.86
135_Q144_E0.6090.86
133_G148_E0.6080.86
157_K160_T0.6080.86
57_Q65_K0.6060.86
61_K64_F0.6010.86
161_S164_T0.6010.86
21_G27_T0.5960.85
54_S61_K0.5950.85
8_F11_A0.5930.85
58_A62_A0.5930.85
155_V162_I0.5930.85
20_G23_K0.5910.85
109_D145_F0.5850.84
62_A66_P0.5840.84
147_Y170_E0.5780.83
54_S59_K0.5780.83
14_L18_G0.5760.83
115_V191_I0.5730.83
90_T102_Y0.5720.83
127_T149_I0.5720.83
22_F25_I0.5700.82
104_D107_Y0.5670.82
157_K187_P0.5660.82
20_G27_T0.5570.81
8_F12_A0.5570.81
125_R180_F0.5550.81
49_S52_K0.5540.81
44_K135_Q0.5520.80
95_L186_A0.5520.80
6_P13_G0.5510.80
159_D162_I0.5510.80
106_Y114_I0.5510.80
5_I9_I0.5500.80
44_K47_E0.5490.80
90_T95_L0.5490.80
106_Y109_D0.5490.80
47_E158_D0.5460.80
113_Q155_V0.5440.79
122_T178_Y0.5440.79
21_G146_T0.5420.79
77_I126_R0.5400.79
61_K66_P0.5400.79
102_Y117_S0.5340.78
40_L43_K0.5340.78
160_T164_T0.5330.78
47_E50_G0.5320.78
162_I175_T0.5320.78
11_A14_L0.5320.78
71_A87_V0.5310.78
12_A25_I0.5290.78
178_Y190_Y0.5290.78
57_Q60_N0.5270.77
157_K188_K0.5260.77
11_A19_Y0.5250.77
171_E195_K0.5250.77
76_E135_Q0.5250.77
154_I190_Y0.5200.76
45_P48_A0.5190.76
40_L48_A0.5190.76
119_H189_R0.5170.76
73_G98_G0.5170.76
122_T125_R0.5160.76
30_K36_K0.5130.75
117_S175_T0.5100.75
58_A61_K0.5100.75
98_G123_V0.5090.75
26_D33_Q0.5080.75
179_P186_A0.5080.75
180_F188_K0.5080.75
22_F27_T0.5070.75
106_Y170_E0.5070.75
110_E168_E0.5060.74
16_I20_G0.5060.74
112_G118_G0.5060.74
108_P114_I0.5050.74
157_K186_A0.5040.74
103_K175_T0.5040.74
99_V123_V0.5030.74
45_P49_S0.5020.74
128_G178_Y0.5010.74
95_L100_G0.5000.74
37_E40_L0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xwgA 1 0.7677 100 0.316 Contact Map
4d70A 1 0.7879 100 0.321 Contact Map
2ln7A 1 0.7121 100 0.343 Contact Map
3o0pA 1 0.8182 100 0.343 Contact Map
4g1jA 1 0.8939 100 0.345 Contact Map
4g1hA 1 0.8232 100 0.345 Contact Map
2w1jA 1 0.8283 100 0.346 Contact Map
3g66A 1 0.8838 100 0.349 Contact Map
3rccA 5 0.6414 100 0.357 Contact Map
4tqxA 1 0.8434 100 0.359 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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