YHCO - BACSU - GREMLIN Contacts

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YHCO - Uncharacterized protein YhcO

UniProt:	P54599	Sequences: MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASGITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDIIFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEYSHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQEARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQFEKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	322 (253)
Sequences:	322 (280)
Seq/√Len:	17.6

BACSU - YHCO

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
59_F	78_K	5.325	1.00
58_S	99_P	4.507	1.00
59_F	82_E	4.428	1.00
158_H	162_H	4.072	1.00
159_E	162_H	3.994	1.00
162_H	229_Y	3.661	1.00
158_H	229_Y	3.492	1.00
162_H	185_E	3.322	0.99
61_Q	82_E	3.301	0.99
185_E	229_Y	3.235	0.99
158_H	185_E	3.229	0.99
159_E	229_Y	3.154	0.99
62_A	82_E	2.812	0.98
239_L	269_T	2.786	0.98
59_F	62_A	2.741	0.98
62_A	85_V	2.611	0.97
159_E	185_E	2.604	0.97
59_F	64_I	2.565	0.97
242_K	279_D	2.562	0.97
61_Q	85_V	2.321	0.94
272_S	275_Q	2.298	0.94
234_Y	280_F	2.285	0.93
158_H	188_S	2.275	0.93
189_E	192_A	2.267	0.93
57_E	74_L	2.150	0.91
235_M	276_F	2.121	0.90
240_T	248_I	2.033	0.88
237_D	241_D	2.017	0.88
81_L	102_I	1.991	0.87
49_Q	113_A	1.919	0.85
159_E	211_L	1.901	0.85
155_L	159_E	1.878	0.84
232_S	236_I	1.833	0.83
251_M	265_F	1.811	0.82
124_Y	163_H	1.796	0.81
159_E	188_S	1.794	0.81
190_W	241_D	1.786	0.81
265_F	273_L	1.767	0.80
162_H	188_S	1.752	0.79
59_F	167_Q	1.712	0.78
71_K	75_P	1.685	0.77
88_N	131_I	1.660	0.76
153_Q	168_K	1.645	0.75
154_R	192_A	1.641	0.75
26_S	31_S	1.604	0.73
54_M	115_S	1.587	0.72
271_E	279_D	1.570	0.71
251_M	269_T	1.532	0.69
26_S	30_S	1.503	0.68
66_Y	74_L	1.472	0.66
37_S	64_I	1.463	0.66
183_F	265_F	1.456	0.65
243_Y	271_E	1.436	0.64
27_A	31_S	1.428	0.64
157_I	163_H	1.424	0.64
155_L	165_F	1.415	0.63
204_S	208_F	1.402	0.62
190_W	238_E	1.375	0.61
29_V	32_A	1.368	0.60
82_E	99_P	1.366	0.60
34_Y	37_S	1.366	0.60
183_F	261_F	1.365	0.60
82_E	85_V	1.355	0.60
210_R	241_D	1.349	0.59
62_A	99_P	1.345	0.59
78_K	133_L	1.331	0.58
286_K	290_A	1.319	0.57
26_S	34_Y	1.285	0.55
85_V	160_Y	1.285	0.55
211_L	229_Y	1.283	0.55
28_I	33_M	1.277	0.55
102_I	110_Q	1.265	0.54
64_I	78_K	1.239	0.53
74_L	77_T	1.228	0.52
93_G	110_Q	1.207	0.51
64_I	74_L	1.200	0.50
290_A	294_I	1.181	0.49
95_S	107_N	1.177	0.49
189_E	229_Y	1.173	0.49
26_S	29_V	1.158	0.48
54_M	74_L	1.157	0.48
183_F	248_I	1.154	0.47
58_S	97_Q	1.148	0.47
80_T	84_A	1.147	0.47
155_L	162_H	1.143	0.47
290_A	293_S	1.137	0.46
85_V	101_D	1.119	0.45
188_S	229_Y	1.101	0.44
77_T	218_Q	1.101	0.44
79_E	102_I	1.088	0.44
31_S	34_Y	1.079	0.43
190_W	236_I	1.078	0.43
92_I	226_T	1.071	0.43
84_A	157_I	1.071	0.43
73_L	86_S	1.070	0.42
183_F	252_I	1.068	0.42
134_L	161_S	1.064	0.42
42_A	45_I	1.061	0.42
29_V	34_Y	1.058	0.42
262_E	280_F	1.055	0.42
60_K	250_E	1.038	0.41
63_D	99_P	1.024	0.40
89_Q	96_N	1.023	0.40
205_V	210_R	1.017	0.39
185_E	188_S	1.017	0.39
275_Q	285_E	1.014	0.39
272_S	278_K	1.012	0.39
107_N	210_R	1.011	0.39
84_A	165_F	1.011	0.39
93_G	188_S	1.008	0.39
102_I	246_D	1.008	0.39
166_H	184_H	1.001	0.38
208_F	238_E	0.996	0.38
64_I	86_S	0.990	0.38
104_F	262_E	0.990	0.38
91_M	191_I	0.987	0.38
208_F	211_L	0.986	0.38
95_S	282_K	0.985	0.37
57_E	75_P	0.977	0.37
28_I	36_L	0.971	0.37
28_I	35_I	0.967	0.36
88_N	164_A	0.965	0.36
116_G	121_V	0.955	0.36
242_K	272_S	0.954	0.36
72_S	286_K	0.951	0.36
262_E	273_L	0.949	0.35
155_L	158_H	0.948	0.35
183_F	283_K	0.947	0.35
133_L	221_R	0.943	0.35
115_S	220_A	0.943	0.35
128_E	134_L	0.941	0.35
43_S	239_L	0.937	0.35
254_E	268_A	0.934	0.35
161_S	188_S	0.931	0.34
155_L	161_S	0.927	0.34
54_M	232_S	0.925	0.34
59_F	85_V	0.925	0.34
111_M	189_E	0.922	0.34
56_K	65_Y	0.921	0.34
265_F	268_A	0.912	0.33
274_D	279_D	0.910	0.33
104_F	166_H	0.898	0.33
288_S	291_L	0.888	0.32
240_T	245_K	0.888	0.32
62_A	78_K	0.883	0.32
95_S	100_I	0.883	0.32
248_I	251_M	0.881	0.32
88_N	211_L	0.877	0.32
26_S	33_M	0.871	0.31
70_E	106_P	0.870	0.31
271_E	291_L	0.866	0.31
222_A	279_D	0.865	0.31
99_P	287_N	0.863	0.31
162_H	211_L	0.855	0.30
92_I	103_I	0.855	0.30
278_K	282_K	0.854	0.30
111_M	123_F	0.852	0.30
271_E	287_N	0.851	0.30
96_N	163_H	0.847	0.30
62_A	238_E	0.846	0.30
196_L	201_I	0.838	0.30
168_K	187_L	0.837	0.30
81_L	104_F	0.833	0.29
271_E	276_F	0.829	0.29
155_L	185_E	0.828	0.29
65_Y	252_I	0.825	0.29
195_E	198_I	0.821	0.29
93_G	292_D	0.819	0.29
152_Y	248_I	0.816	0.28
178_E	279_D	0.816	0.28
66_Y	118_L	0.816	0.28
123_F	236_I	0.811	0.28
74_L	253_K	0.811	0.28
77_T	115_S	0.809	0.28
52_K	269_T	0.809	0.28
209_D	282_K	0.809	0.28
226_T	230_L	0.806	0.28
165_F	234_Y	0.804	0.28
42_A	46_T	0.800	0.28
124_Y	232_S	0.800	0.28
89_Q	100_I	0.798	0.28
239_L	273_L	0.798	0.28
97_Q	266_K	0.797	0.28
102_I	106_P	0.794	0.27
88_N	191_I	0.786	0.27
117_L	123_F	0.786	0.27
263_K	286_K	0.783	0.27
149_V	183_F	0.780	0.27
261_F	283_K	0.779	0.27
189_E	233_F	0.778	0.27
121_V	124_Y	0.776	0.27
221_R	239_L	0.769	0.26
49_Q	59_F	0.769	0.26
158_H	211_L	0.764	0.26
36_L	242_K	0.762	0.26
60_K	265_F	0.761	0.26
111_M	114_Y	0.760	0.26
63_D	160_Y	0.759	0.26
31_S	35_I	0.754	0.25
126_E	132_G	0.752	0.25
53_H	64_I	0.752	0.25
99_P	261_F	0.749	0.25
195_E	200_P	0.749	0.25
247_I	250_E	0.743	0.25
187_L	251_M	0.740	0.25
72_S	95_S	0.740	0.25
259_G	268_A	0.737	0.25
111_M	179_F	0.728	0.24
112_E	192_A	0.724	0.24
66_Y	92_I	0.720	0.24
54_M	114_Y	0.719	0.24
104_F	249_S	0.714	0.24
154_R	166_H	0.713	0.24
79_E	279_D	0.711	0.24
149_V	276_F	0.711	0.24
102_I	275_Q	0.709	0.23
95_S	187_L	0.708	0.23
247_I	269_T	0.707	0.23
111_M	233_F	0.706	0.23
92_I	160_Y	0.705	0.23
62_A	190_W	0.704	0.23
90_I	275_Q	0.700	0.23
74_L	102_I	0.694	0.23
116_G	135_P	0.694	0.23
101_D	164_A	0.694	0.23
156_L	280_F	0.694	0.23
120_V	124_Y	0.692	0.23
53_H	219_E	0.688	0.23
84_A	100_I	0.687	0.23
65_Y	245_K	0.685	0.22
70_E	256_A	0.682	0.22
70_E	236_I	0.681	0.22
156_L	180_P	0.679	0.22
186_G	190_W	0.679	0.22
237_D	248_I	0.679	0.22
120_V	135_P	0.678	0.22
44_G	253_K	0.677	0.22
282_K	287_N	0.674	0.22
26_S	32_A	0.674	0.22
78_K	261_F	0.669	0.22
275_Q	278_K	0.669	0.22
91_M	280_F	0.667	0.22
169_L	264_G	0.667	0.22
108_E	187_L	0.666	0.22
206_V	209_D	0.665	0.22
54_M	138_K	0.664	0.22
48_E	54_M	0.663	0.22
210_R	247_I	0.661	0.21
263_K	266_K	0.659	0.21
168_K	253_K	0.656	0.21
28_I	38_F	0.656	0.21
57_E	194_Y	0.656	0.21
83_Y	218_Q	0.653	0.21
57_E	267_S	0.652	0.21
88_N	198_I	0.652	0.21
33_M	38_F	0.648	0.21
291_L	295_Y	0.643	0.21
275_Q	279_D	0.642	0.21
58_S	260_D	0.641	0.21
271_E	280_F	0.641	0.21
96_N	100_I	0.639	0.21
250_E	274_D	0.638	0.21
104_F	109_K	0.635	0.20
63_D	121_V	0.632	0.20
190_W	240_T	0.626	0.20
92_I	211_L	0.625	0.20
125_S	161_S	0.624	0.20
56_K	113_A	0.623	0.20
164_A	192_A	0.621	0.20
207_P	210_R	0.620	0.20
237_D	287_N	0.618	0.20
39_P	60_K	0.617	0.20
133_L	247_I	0.614	0.20
187_L	244_G	0.614	0.20
93_G	164_A	0.613	0.20
54_M	62_A	0.609	0.19
283_K	289_A	0.608	0.19
63_D	254_E	0.607	0.19
263_K	267_S	0.604	0.19
72_S	282_K	0.603	0.19
122_G	234_Y	0.603	0.19
64_I	133_L	0.600	0.19
97_Q	286_K	0.599	0.19
133_L	153_Q	0.598	0.19
133_L	266_K	0.597	0.19
123_F	183_F	0.596	0.19
38_F	242_K	0.595	0.19
189_E	264_G	0.595	0.19
231_Q	277_E	0.595	0.19
109_K	272_S	0.595	0.19
43_S	62_A	0.591	0.19
95_S	156_L	0.588	0.19
159_E	186_G	0.587	0.19
110_Q	154_R	0.586	0.19
102_I	285_E	0.586	0.19
60_K	99_P	0.581	0.18
165_F	187_L	0.580	0.18
91_M	164_A	0.580	0.18
78_K	153_Q	0.580	0.18
182_W	217_W	0.579	0.18
85_V	105_F	0.578	0.18
81_L	156_L	0.577	0.18
129_Q	163_H	0.576	0.18
83_Y	270_K	0.576	0.18
46_T	117_L	0.574	0.18
119_D	234_Y	0.573	0.18
111_M	240_T	0.571	0.18
261_F	268_A	0.569	0.18
125_S	134_L	0.569	0.18
285_E	289_A	0.566	0.18
125_S	189_E	0.565	0.18
138_K	286_K	0.565	0.18
193_N	199_D	0.565	0.18
60_K	79_E	0.564	0.18
46_T	114_Y	0.564	0.18
62_A	235_M	0.563	0.18
105_F	114_Y	0.563	0.18
204_S	207_P	0.562	0.18
63_D	108_E	0.561	0.18
273_L	286_K	0.560	0.18
26_S	240_T	0.560	0.18
75_P	267_S	0.558	0.18
60_K	208_F	0.558	0.18
84_A	200_P	0.558	0.18
122_G	131_I	0.557	0.17
57_E	78_K	0.557	0.17
30_S	34_Y	0.554	0.17
45_I	103_I	0.550	0.17
133_L	277_E	0.549	0.17
58_S	63_D	0.547	0.17
60_K	86_S	0.546	0.17
182_W	228_V	0.544	0.17
250_E	284_F	0.544	0.17
130_L	232_S	0.544	0.17
134_L	188_S	0.541	0.17
161_S	191_I	0.541	0.17
75_P	180_P	0.541	0.17
133_L	160_Y	0.535	0.17
115_S	232_S	0.534	0.17
51_T	268_A	0.533	0.17
213_T	273_L	0.531	0.17
64_I	295_Y	0.530	0.17
133_L	204_S	0.530	0.17
62_A	81_L	0.527	0.16
93_G	252_I	0.525	0.16
77_T	133_L	0.524	0.16
85_V	96_N	0.524	0.16
131_I	156_L	0.522	0.16
220_A	228_V	0.521	0.16
85_V	164_A	0.520	0.16
239_L	271_E	0.520	0.16
133_L	210_R	0.520	0.16
27_A	36_L	0.519	0.16
158_H	161_S	0.519	0.16
255_T	289_A	0.519	0.16
160_Y	163_H	0.518	0.16
27_A	33_M	0.518	0.16
284_F	288_S	0.517	0.16
154_R	189_E	0.516	0.16
125_S	192_A	0.516	0.16
211_L	269_T	0.515	0.16
102_I	263_K	0.515	0.16
35_I	38_F	0.515	0.16
103_I	235_M	0.512	0.16
99_P	278_K	0.511	0.16
76_L	150_Y	0.511	0.16
37_S	131_I	0.509	0.16
111_M	155_L	0.507	0.16
180_P	186_G	0.506	0.16
238_E	272_S	0.506	0.16
87_I	157_I	0.506	0.16
235_M	271_E	0.506	0.16
246_D	275_Q	0.504	0.16
203_F	265_F	0.504	0.16
275_Q	286_K	0.504	0.16
122_G	182_W	0.504	0.16
286_K	293_S	0.502	0.16
29_V	33_M	0.501	0.16
69_K	75_P	0.500	0.16
72_S	279_D	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ar9A	1	0.8385	100	0.636	Contact Map
4arfA	2	0.7981	99.9	0.66	Contact Map
4areA	1	0.9379	99.9	0.682	Contact Map
2y3uA	1	0.9099	99.9	0.687	Contact Map
4gaaA	2	0.882	98.9	0.842	Contact Map
2yd0A	1	0.9068	98.8	0.849	Contact Map
4kx7A	1	0.9161	98.8	0.85	Contact Map
4wz9A	2	0.9441	98.7	0.852	Contact Map
1z5hA	3	0.9006	98.7	0.854	Contact Map
4qhpA	1	0.9348	98.7	0.854	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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