GREMLIN Database
TCYP - L-cystine uptake protein TcyP
UniProt: P54596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 463 (395)
Sequences: 6272 (3786)
Seq/√Len: 190.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_L181_G4.7701.00
213_E217_K3.6851.00
210_E213_E3.2151.00
129_L371_I3.1371.00
170_L192_I3.0851.00
127_S270_A3.0551.00
108_L443_T3.0081.00
86_F194_A2.9041.00
67_N71_G2.7851.00
90_L219_V2.7371.00
318_K321_R2.7311.00
44_F242_L2.6661.00
313_L334_G2.6411.00
72_G171_L2.5841.00
214_T221_A2.5821.00
326_P445_E2.5141.00
132_D135_A2.5131.00
367_D370_F2.5051.00
86_F90_L2.5001.00
69_A243_A2.4741.00
321_R327_E2.4641.00
228_R231_T2.4461.00
87_I222_V2.4411.00
441_K448_Q2.4211.00
48_L242_L2.3321.00
37_A235_R2.3081.00
268_Y423_G2.2421.00
197_L225_I2.2411.00
326_P440_S2.2361.00
300_L430_S2.2221.00
47_A51_I2.1961.00
112_I435_S2.1281.00
205_K212_A2.1011.00
116_T281_L2.0781.00
265_I269_A2.0601.00
108_L442_V2.0091.00
211_Q224_A2.0091.00
34_V49_Q2.0051.00
165_Q169_E2.0051.00
299_V319_T2.0011.00
33_R36_T1.9911.00
173_G177_L1.9731.00
215_F218_L1.9471.00
364_N367_D1.9401.00
34_V37_A1.8871.00
131_F266_A1.8731.00
127_S272_I1.8731.00
357_I409_L1.8691.00
37_A49_Q1.8631.00
80_V233_I1.8471.00
214_T217_K1.8461.00
126_A130_S1.8451.00
122_A126_A1.8351.00
87_I226_V1.8291.00
271_L423_G1.8221.00
325_V437_L1.8211.00
133_L359_P1.7891.00
95_K220_D1.7741.00
128_A355_M1.7731.00
107_G111_G1.7561.00
318_K322_S1.7561.00
215_F221_A1.7511.00
186_S189_A1.7471.00
417_E424_R1.7231.00
282_L434_T1.7061.00
203_G228_R1.6991.00
39_G43_V1.6951.00
333_A436_G1.6881.00
34_V38_L1.6741.00
175_P193_F1.6641.00
215_F225_I1.6591.00
131_F269_A1.6411.00
201_F225_I1.6391.00
176_F180_T1.6311.00
104_K443_T1.6101.00
258_L262_M1.6061.00
181_G186_S1.6011.00
325_V440_S1.5861.00
316_N433_M1.5821.00
176_F179_F1.5761.00
296_A433_M1.5741.00
295_K323_M1.5731.00
127_S266_A1.5671.00
41_G45_G1.5601.00
128_A352_M1.5551.00
364_N369_V1.5501.00
285_S441_K1.5461.00
86_F179_F1.5311.00
41_G242_L1.5281.00
33_R37_A1.5201.00
32_K36_T1.5151.00
38_L49_Q1.4811.00
72_G168_V1.4771.00
421_D425_T1.4741.00
291_I294_K1.4741.00
271_L427_L1.4701.00
94_T216_K1.4631.00
361_V409_L1.4561.00
357_I405_M1.4441.00
78_Q173_G1.4391.00
270_A348_I1.4351.00
295_K322_S1.4281.00
200_A229_V1.4271.00
300_L426_A1.4181.00
218_L221_A1.4041.00
71_G75_K1.3931.00
203_G232_L1.3881.00
317_I330_A1.3811.00
48_L52_Y1.3741.00
310_A387_G1.3671.00
261_G265_I1.3571.00
79_M193_F1.3421.00
85_V187_T1.3401.00
290_V294_K1.3381.00
36_T40_L1.3361.00
220_D224_A1.3301.00
326_P329_I1.3251.00
125_I371_I1.3071.00
281_L438_I1.3061.00
169_E186_S1.3061.00
109_I333_A1.2981.00
139_D362_G1.2971.00
93_F195_A1.2891.00
204_V212_A1.2801.00
91_G219_V1.2601.00
329_I440_S1.2591.00
201_F215_F1.2541.00
283_T286_G1.2541.00
368_P372_I1.2531.00
282_L287_L1.2521.00
75_K173_G1.2511.00
171_L192_I1.2471.00
32_K40_L1.2381.00
272_I276_I1.2351.00
339_S342_Q1.2251.00
214_T218_L1.2231.00
296_A430_S1.2211.00
197_L222_V1.2191.00
288_N291_I1.2181.00
440_S446_I1.2181.00
37_A41_G1.2081.00
316_N334_G1.1971.00
274_M427_L1.1921.00
364_N370_F1.1901.00
35_F49_Q1.1891.00
266_A352_M1.1881.00
440_S444_K1.1751.00
258_L261_G1.1711.00
82_M190_V1.1711.00
196_F229_V1.1691.00
175_P180_T1.1671.00
80_V230_V1.1671.00
264_V416_I1.1661.00
200_A232_L1.1591.00
231_T318_K1.1581.00
162_T165_Q1.1541.00
273_T277_I1.1541.00
232_L236_L1.1531.00
35_F38_L1.1491.00
101_N328_G1.1411.00
280_L283_T1.1391.00
247_K251_T1.1361.00
393_T414_I1.1361.00
111_G115_A1.1341.00
262_M265_I1.1321.00
259_K262_M1.1291.00
374_V403_L1.1221.00
303_A425_T1.1201.00
122_A375_I1.1121.00
276_I280_L1.1111.00
44_F48_L1.1111.00
349_Y417_E1.0991.00
226_V230_V1.0981.00
205_K213_E1.0951.00
354_A374_V1.0941.00
343_N382_S1.0941.00
313_L338_L1.0921.00
292_Y296_A1.0911.00
204_V221_A1.0901.00
67_N247_K1.0891.00
126_A129_L1.0831.00
43_V47_A1.0801.00
264_V419_L1.0741.00
312_A316_N1.0711.00
53_G250_A1.0701.00
174_N178_D1.0671.00
279_L293_L1.0651.00
113_L333_A1.0651.00
104_K108_L1.0571.00
195_A199_V1.0551.00
204_V225_I1.0491.00
217_K221_A1.0471.00
87_I91_G1.0471.00
69_A236_L1.0441.00
72_G76_L1.0431.00
215_F219_V1.0351.00
316_N429_V1.0351.00
134_Q359_P1.0341.00
440_S445_E1.0321.00
320_Q327_E1.0301.00
32_K37_A1.0251.00
298_P322_S1.0231.00
116_T343_N1.0221.00
122_A372_I1.0101.00
177_L180_T1.0101.00
372_I376_A1.0101.00
345_C392_A1.0031.00
287_L446_I1.0021.00
255_D258_L1.0011.00
286_G441_K0.9980.99
307_R418_P0.9980.99
349_Y424_R0.9940.99
320_Q330_A0.9940.99
115_A119_V0.9890.99
213_E216_K0.9890.99
441_K444_K0.9870.99
47_A50_L0.9850.99
276_I279_L0.9830.99
105_I329_I0.9760.99
236_L239_Y0.9720.99
217_K220_D0.9670.99
124_G351_A0.9640.99
52_Y55_T0.9550.99
127_S131_F0.9480.99
287_L291_I0.9440.99
325_V330_A0.9370.99
31_S37_A0.9290.99
49_Q53_G0.9260.99
294_K297_V0.9220.99
260_L263_F0.9210.99
267_S352_M0.9200.99
41_G49_Q0.9170.99
212_A221_A0.9150.99
70_G244_I0.9140.99
38_L42_I0.9100.99
228_R232_L0.9090.99
175_P178_D0.9090.99
164_P168_V0.9070.99
212_A216_K0.9060.99
368_P371_I0.9030.99
54_P64_D0.8980.99
89_I191_V0.8960.99
295_K319_T0.8960.99
98_L101_N0.8930.99
341_G432_S0.8920.99
196_F232_L0.8920.99
389_G421_D0.8900.99
158_M161_K0.8870.99
355_M371_I0.8840.99
319_T322_S0.8840.99
312_A315_L0.8800.99
55_T65_W0.8780.99
309_S428_N0.8760.99
381_S399_V0.8750.99
304_F422_M0.8720.99
350_P396_A0.8710.99
192_I196_F0.8700.99
295_K299_V0.8680.99
299_V312_A0.8670.99
199_V203_G0.8660.99
299_V316_N0.8650.99
267_S420_I0.8630.99
114_V118_A0.8590.98
205_K216_K0.8540.98
125_I129_L0.8520.98
80_V229_V0.8480.98
35_F42_I0.8470.98
178_D193_F0.8460.98
75_K78_Q0.8450.98
246_T250_A0.8440.98
273_T279_L0.8430.98
167_I171_L0.8420.98
90_L201_F0.8400.98
118_A122_A0.8370.98
349_Y420_I0.8360.98
242_L246_T0.8350.98
142_S145_L0.8340.98
52_Y66_F0.8340.98
161_K165_Q0.8320.98
91_G220_D0.8300.98
194_A198_G0.8280.98
262_M359_P0.8250.98
33_R38_L0.8240.98
297_V301_V0.8220.98
168_V171_L0.8200.98
66_F246_T0.8190.98
87_I219_V0.8170.98
342_Q432_S0.8160.98
201_F219_V0.8150.98
275_F279_L0.8140.98
264_V420_I0.8090.98
65_W68_I0.8050.98
179_F193_F0.8040.98
292_Y433_M0.8040.98
31_S36_T0.7990.98
165_Q168_V0.7970.98
218_L222_V0.7970.98
366_F370_F0.7940.97
397_L410_A0.7920.97
231_T235_R0.7900.97
141_G144_E0.7880.97
354_A399_V0.7870.97
278_H282_L0.7870.97
96_L105_I0.7870.97
353_L413_L0.7850.97
105_I439_T0.7830.97
302_F315_L0.7800.97
338_L432_S0.7780.97
302_F312_A0.7780.97
66_F243_A0.7770.97
269_A272_I0.7760.97
70_G240_G0.7710.97
197_L229_V0.7690.97
263_F413_L0.7690.97
63_A250_A0.7690.97
263_F271_L0.7680.97
223_Y227_M0.7670.97
65_W69_A0.7640.97
90_L194_A0.7640.97
163_L167_I0.7620.97
132_D359_P0.7620.97
393_T410_A0.7620.97
226_V233_I0.7600.97
99_T199_V0.7560.97
71_G168_V0.7530.97
73_Y237_T0.7510.96
329_I333_A0.7480.96
76_L171_L0.7470.96
237_T240_G0.7430.96
42_I245_M0.7410.96
266_A269_A0.7410.96
303_A429_V0.7400.96
161_K169_E0.7400.96
267_S271_L0.7390.96
171_L174_N0.7370.96
340_I383_F0.7370.96
88_S223_Y0.7360.96
350_P393_T0.7360.96
178_D181_G0.7360.96
100_K103_G0.7350.96
174_N193_F0.7350.96
33_R49_Q0.7340.96
369_V372_I0.7320.96
193_F197_L0.7310.96
101_N104_K0.7280.96
90_L197_L0.7240.96
307_R421_D0.7240.96
40_L44_F0.7220.96
361_V408_A0.7200.96
264_V268_Y0.7170.95
441_K446_I0.7160.95
291_I295_K0.7150.95
287_L295_K0.7150.95
94_T202_L0.7110.95
139_D142_S0.7110.95
127_S269_A0.7100.95
282_L285_S0.7090.95
48_L51_I0.7080.95
299_V315_L0.7040.95
440_S447_D0.7030.95
155_S158_M0.7000.95
49_Q52_Y0.6990.95
263_F420_I0.6980.95
73_Y236_L0.6960.95
262_M266_A0.6950.95
397_L401_S0.6940.95
192_I236_L0.6940.95
204_V224_A0.6910.94
141_G145_L0.6900.94
124_G352_M0.6900.94
118_A379_A0.6890.94
270_A352_M0.6880.94
345_C385_V0.6870.94
393_T420_I0.6860.94
406_P409_L0.6830.94
179_F189_A0.6810.94
119_V277_I0.6810.94
371_I375_I0.6760.94
263_F349_Y0.6760.94
274_M279_L0.6750.94
210_E217_K0.6750.94
174_N177_L0.6740.94
64_D250_A0.6740.94
38_L44_F0.6730.94
345_C350_P0.6730.94
316_N432_S0.6720.94
90_L222_V0.6710.93
48_L66_F0.6710.93
34_V40_L0.6700.93
31_S34_V0.6700.93
224_A228_R0.6680.93
111_G114_V0.6680.93
327_E331_N0.6620.93
129_L368_P0.6610.93
292_Y437_L0.6600.93
302_F306_S0.6600.93
123_V277_I0.6580.93
38_L41_G0.6580.93
48_L53_G0.6580.93
42_I53_G0.6550.93
75_K169_E0.6550.93
354_A358_A0.6540.93
336_F340_I0.6540.93
42_I49_Q0.6520.93
168_V172_P0.6490.92
385_V395_A0.6480.92
181_G185_T0.6470.92
124_G348_I0.6420.92
350_P385_V0.6420.92
445_E448_Q0.6400.92
221_A225_I0.6400.92
373_T403_L0.6390.92
154_K157_D0.6390.92
48_L55_T0.6370.92
76_L196_F0.6370.92
46_F49_Q0.6360.92
97_K100_K0.6360.92
123_V272_I0.6360.92
98_L106_S0.6350.92
109_I439_T0.6350.92
338_L342_Q0.6350.92
275_F280_L0.6340.91
358_A363_Q0.6300.91
263_F352_M0.6300.91
320_Q331_N0.6270.91
282_L438_I0.6260.91
228_R235_R0.6250.91
230_V304_F0.6250.91
123_V270_A0.6240.91
213_E218_L0.6230.91
179_F190_V0.6230.91
241_V389_G0.6220.91
369_V373_T0.6200.91
197_L215_F0.6200.91
407_V410_A0.6180.90
375_I378_V0.6150.90
237_T306_S0.6140.90
211_Q217_K0.6130.90
354_A357_I0.6130.90
101_N445_E0.6130.90
34_V41_G0.6130.90
212_A225_I0.6110.90
48_L246_T0.6110.90
174_N180_T0.6100.90
383_F432_S0.6090.90
409_L412_L0.6080.90
120_A348_I0.6070.90
31_S49_Q0.6060.90
166_Q169_E0.6060.90
172_P178_D0.6060.90
131_F262_M0.6030.89
201_F216_K0.6030.89
113_L435_S0.6030.89
134_Q137_Q0.6020.89
378_V395_A0.6000.89
334_G436_G0.6000.89
366_F374_V0.5990.89
84_L191_V0.5990.89
287_L447_D0.5990.89
119_V123_V0.5990.89
91_G216_K0.5990.89
278_H431_G0.5960.89
240_G244_I0.5960.89
178_D185_T0.5950.89
220_D223_Y0.5950.89
172_P175_P0.5920.88
385_V392_A0.5910.88
35_F39_G0.5890.88
387_G390_G0.5880.88
114_V383_F0.5860.88
277_I280_L0.5840.88
156_E159_T0.5840.88
239_Y243_A0.5840.88
436_G440_S0.5830.88
274_M278_H0.5810.87
37_A42_I0.5800.87
361_V406_P0.5800.87
284_F438_I0.5800.87
324_G447_D0.5790.87
129_L355_M0.5790.87
221_A224_A0.5770.87
215_F222_V0.5760.87
326_P330_A0.5750.87
353_L417_E0.5750.87
119_V122_A0.5740.87
172_P176_F0.5740.87
40_L49_Q0.5730.87
116_T120_A0.5730.87
72_G192_I0.5720.87
54_P250_A0.5720.87
292_Y323_M0.5690.86
260_L264_V0.5680.86
101_N106_S0.5680.86
104_K107_G0.5670.86
91_G95_K0.5670.86
350_P354_A0.5660.86
124_G349_Y0.5650.86
216_K220_D0.5620.86
310_A338_L0.5620.86
79_M229_V0.5600.86
351_A378_V0.5600.86
296_A316_N0.5590.85
53_G63_A0.5580.85
191_V361_V0.5570.85
175_P179_F0.5570.85
204_V228_R0.5570.85
357_I395_A0.5560.85
364_N368_P0.5560.85
329_I445_E0.5560.85
81_V391_G0.5560.85
127_S265_I0.5550.85
123_V273_T0.5540.85
281_L284_F0.5540.85
113_L432_S0.5530.85
377_V402_S0.5530.85
345_C424_R0.5530.85
127_S130_S0.5520.85
205_K211_Q0.5510.85
45_G246_T0.5500.85
392_A399_V0.5480.84
315_L318_K0.5480.84
125_I375_I0.5470.84
263_F353_L0.5470.84
382_S394_F0.5460.84
173_G181_G0.5460.84
343_N431_G0.5440.84
76_L233_I0.5430.84
294_K298_P0.5410.84
117_T346_A0.5410.84
186_S190_V0.5410.84
323_M437_L0.5400.83
387_G391_G0.5400.83
139_D143_T0.5390.83
390_G394_F0.5390.83
39_G49_Q0.5380.83
312_A338_L0.5380.83
342_Q385_V0.5380.83
39_G42_I0.5360.83
430_S434_T0.5340.83
444_K449_G0.5340.83
258_L264_V0.5340.83
44_F49_Q0.5330.83
317_I334_G0.5330.83
307_R311_G0.5330.83
213_E221_A0.5320.83
167_I175_P0.5320.83
76_L236_L0.5310.82
31_S38_L0.5300.82
159_T162_T0.5270.82
34_V53_G0.5260.82
107_G110_I0.5260.82
38_L237_T0.5250.82
283_T288_N0.5240.82
52_Y246_T0.5230.81
37_A40_L0.5230.81
113_L273_T0.5230.81
312_A429_V0.5220.81
265_I268_Y0.5210.81
320_Q334_G0.5210.81
326_P444_K0.5200.81
320_Q433_M0.5200.81
48_L63_A0.5200.81
96_L436_G0.5180.81
51_I55_T0.5170.81
121_A379_A0.5170.81
321_R330_A0.5170.81
428_N432_S0.5170.81
72_G236_L0.5160.81
345_C421_D0.5160.81
235_R239_Y0.5150.80
397_L407_V0.5120.80
200_A204_V0.5120.80
303_A426_A0.5120.80
157_D160_A0.5110.80
392_A396_A0.5100.80
253_D257_I0.5100.80
325_V436_G0.5090.80
84_L226_V0.5070.79
444_K448_Q0.5070.79
42_I241_V0.5070.79
81_V412_L0.5060.79
375_I379_A0.5040.79
175_P185_T0.5040.79
116_T340_I0.5040.79
296_A300_L0.5030.79
337_G436_G0.5030.79
113_L337_G0.5030.79
77_L302_F0.5020.79
200_A225_I0.5020.79
292_Y434_T0.5010.79
173_G178_D0.5000.79
154_K158_M0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.8488 100 0.14 Contact Map
4bgnA 3 0.4233 10.7 0.974 Contact Map
3zuxA 1 0.378 6.9 0.976 Contact Map
2m8rA 1 0.1145 5.9 0.977 Contact Map
4n7wA 2 0.3866 5.6 0.977 Contact Map
3nd0A 2 0.8121 4.9 0.978 Contact Map
1ji6A 1 0.1922 4.1 0.979 Contact Map
2cfqA 1 0.3715 3.6 0.979 Contact Map
4cz8A 2 0.5767 3.2 0.98 Contact Map
4wl1A 3 0.0648 2.7 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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