YHCK - BACSU - GREMLIN Contacts

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YHCK - Uncharacterized protein YhcK

UniProt:	P54595	Sequences: MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLACGLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSALYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYFWIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAADTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEFAVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLPILADQMLYKAKETGRNRVCFSEKKE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	359 (315)
Sequences:	12734 (11828)
Seq/√Len:	666.4

ECOLI - YEAI YCDT YEGE ADRA YEDQ YNEF YFEA DOSC YDAM YEAJ DOSP YFGF YEAP YFIN GMR YLIF CSRD YHJK YLIE YDEH YLAB RTN YJCC
BACSU - YHCK YKOW YTRP YDAK

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
263_R	266_D	4.245	1.00
234_H	349_R	3.953	1.00
190_F	194_F	3.786	1.00
228_I	292_A	3.539	1.00
228_I	318_L	3.475	1.00
210_T	330_P	3.392	1.00
344_A	353_C	3.354	1.00
201_Y	205_K	3.286	1.00
226_A	322_H	3.248	1.00
206_F	277_A	2.987	1.00
200_V	255_G	2.723	1.00
300_S	350_N	2.709	1.00
181_A	185_F	2.562	1.00
232_I	254_L	2.536	1.00
226_A	288_A	2.511	1.00
293_E	296_R	2.497	1.00
271_I	277_A	2.487	1.00
206_F	269_A	2.457	1.00
200_V	268_A	2.430	1.00
317_S	344_A	2.413	1.00
249_Q	252_K	2.332	1.00
347_T	353_C	2.283	1.00
245_H	335_I	2.248	1.00
213_L	216_Q	2.190	1.00
284_S	287_K	2.173	1.00
185_F	188_Y	2.168	1.00
205_K	209_T	2.119	1.00
258_L	268_A	2.115	1.00
296_R	352_V	1.990	1.00
198_T	251_L	1.988	1.00
233_D	317_S	1.976	1.00
238_I	250_V	1.962	1.00
250_V	314_V	1.947	1.00
230_M	318_L	1.942	1.00
335_I	339_Q	1.927	1.00
329_Q	332_S	1.922	1.00
343_K	347_T	1.903	1.00
315_T	350_N	1.897	1.00
347_T	351_R	1.890	1.00
262_I	268_A	1.884	1.00
209_T	212_A	1.833	1.00
230_M	316_I	1.818	1.00
296_R	300_S	1.795	1.00
299_V	316_I	1.789	1.00
280_L	291_I	1.784	1.00
189_K	193_H	1.780	1.00
229_Y	341_L	1.722	1.00
324_P	327_T	1.722	1.00
343_K	353_C	1.701	1.00
327_T	336_L	1.694	1.00
225_F	333_L	1.681	1.00
344_A	351_R	1.681	1.00
228_I	280_L	1.660	1.00
246_E	249_Q	1.639	1.00
254_L	299_V	1.634	1.00
193_H	208_E	1.629	1.00
229_Y	271_I	1.628	1.00
343_K	346_E	1.596	1.00
253_E	256_L	1.590	1.00
201_Y	267_P	1.585	1.00
177_H	181_A	1.574	1.00
256_L	259_K	1.565	1.00
209_T	269_A	1.553	1.00
271_I	334_P	1.552	1.00
203_R	248_D	1.552	1.00
225_F	323_Y	1.546	1.00
232_I	316_I	1.538	1.00
253_E	257_R	1.537	1.00
323_Y	333_L	1.525	1.00
328_E	336_L	1.522	1.00
253_E	304_I	1.521	1.00
174_I	177_H	1.504	1.00
209_T	213_L	1.486	1.00
209_T	267_P	1.485	1.00
229_Y	334_P	1.481	1.00
181_A	184_L	1.472	1.00
293_E	297_S	1.466	1.00
261_T	294_R	1.466	1.00
291_I	294_R	1.444	1.00
262_I	266_D	1.440	1.00
205_K	267_P	1.424	1.00
262_I	278_V	1.418	1.00
236_K	240_D	1.415	1.00
246_E	306_L	1.415	1.00
338_D	342_Y	1.411	1.00
235_F	251_L	1.404	1.00
261_T	298_T	1.400	1.00
257_R	303_P	1.393	1.00
321_A	333_L	1.385	1.00
234_H	274_E	1.379	1.00
255_G	268_A	1.377	1.00
254_L	258_L	1.375	1.00
196_F	204_R	1.364	1.00
236_K	342_Y	1.355	1.00
249_Q	253_E	1.354	1.00
237_T	241_Q	1.344	1.00
240_D	342_Y	1.335	1.00
184_L	187_Q	1.329	1.00
193_H	205_K	1.327	1.00
203_R	207_E	1.312	1.00
207_E	331_G	1.308	1.00
178_E	181_A	1.305	1.00
296_R	318_L	1.300	1.00
191_Q	204_R	1.289	1.00
230_M	258_L	1.272	1.00
274_E	315_T	1.272	1.00
336_L	340_M	1.258	1.00
234_H	237_T	1.248	1.00
174_I	178_E	1.248	1.00
244_H	338_D	1.234	1.00
320_A	352_V	1.232	1.00
239_N	247_G	1.225	1.00
288_A	320_A	1.224	1.00
182_H	185_F	1.222	1.00
223_F	282_N	1.216	1.00
306_L	310_D	1.214	1.00
213_L	281_P	1.213	1.00
321_A	337_A	1.197	1.00
289_A	293_E	1.196	1.00
207_E	211_K	1.194	1.00
205_K	269_A	1.187	1.00
187_Q	191_Q	1.184	1.00
277_A	334_P	1.180	1.00
210_T	279_L	1.171	1.00
344_A	348_G	1.162	1.00
254_L	316_I	1.152	1.00
205_K	208_E	1.146	1.00
201_Y	269_A	1.134	1.00
194_F	201_Y	1.120	1.00
297_S	301_D	1.109	1.00
250_V	274_E	1.101	1.00
330_P	334_P	1.089	1.00
292_A	318_L	1.087	1.00
296_R	350_N	1.086	1.00
193_H	201_Y	1.080	1.00
320_A	354_F	1.071	1.00
228_I	278_V	1.064	1.00
211_K	330_P	1.061	1.00
273_G	342_Y	1.059	1.00
269_A	277_A	1.058	1.00
206_F	279_L	1.057	1.00
185_F	189_K	1.055	1.00
272_G	275_E	1.049	1.00
252_K	255_G	1.048	1.00
262_I	295_I	1.045	1.00
298_T	301_D	1.037	1.00
230_M	278_V	1.029	1.00
244_H	342_Y	1.029	1.00
231_D	345_K	1.017	1.00
177_H	182_H	1.017	1.00
252_K	256_L	1.012	1.00
321_A	336_L	1.007	1.00
256_L	260_Q	1.002	1.00
211_K	215_Q	0.999	1.00
180_N	183_L	0.989	1.00
187_Q	190_F	0.986	1.00
289_A	354_F	0.985	1.00
227_L	334_P	0.984	1.00
226_A	320_A	0.972	1.00
175_I	179_T	0.970	1.00
257_R	298_T	0.969	1.00
206_F	210_T	0.963	1.00
315_T	348_G	0.954	1.00
292_A	352_V	0.952	1.00
288_A	292_A	0.951	1.00
266_D	294_R	0.945	1.00
238_I	312_L	0.942	1.00
236_K	338_D	0.941	1.00
285_L	322_H	0.939	1.00
332_S	335_I	0.938	1.00
292_A	320_A	0.937	1.00
321_A	340_M	0.935	1.00
45_G	48_G	0.930	1.00
272_G	338_D	0.927	1.00
233_D	349_R	0.927	1.00
254_L	314_V	0.926	1.00
238_I	306_L	0.925	1.00
289_A	352_V	0.925	1.00
240_D	338_D	0.922	1.00
260_Q	298_T	0.918	1.00
210_T	214_Y	0.916	1.00
263_R	291_I	0.914	1.00
257_R	304_I	0.914	1.00
272_G	342_Y	0.913	1.00
178_E	182_H	0.907	1.00
228_I	320_A	0.905	1.00
175_I	178_E	0.904	1.00
217_A	323_Y	0.903	1.00
268_A	278_V	0.900	1.00
186_K	189_K	0.897	1.00
232_I	315_T	0.897	1.00
227_L	333_L	0.895	1.00
250_V	304_I	0.895	1.00
253_E	303_P	0.891	1.00
231_D	244_H	0.888	1.00
44_C	48_G	0.886	1.00
213_L	225_F	0.883	1.00
297_S	300_S	0.881	1.00
105_S	108_I	0.880	1.00
208_E	212_A	0.877	1.00
232_I	251_L	0.876	1.00
179_T	182_H	0.872	1.00
263_R	294_R	0.872	1.00
280_L	288_A	0.868	1.00
192_A	202_N	0.862	1.00
238_I	246_E	0.858	1.00
231_D	342_Y	0.842	1.00
275_E	338_D	0.837	1.00
233_D	348_G	0.830	1.00
224_Q	325_N	0.828	1.00
237_T	274_E	0.827	1.00
283_C	287_K	0.825	1.00
258_L	278_V	0.823	1.00
245_H	331_G	0.819	1.00
239_N	273_G	0.818	1.00
236_K	239_N	0.817	1.00
340_M	344_A	0.816	1.00
240_D	275_E	0.814	1.00
263_R	283_C	0.812	1.00
246_E	312_L	0.812	1.00
236_K	244_H	0.809	1.00
341_L	349_R	0.806	1.00
196_F	207_E	0.805	1.00
214_Y	323_Y	0.804	1.00
235_F	250_V	0.803	1.00
305_V	311_E	0.799	1.00
214_Y	330_P	0.798	1.00
244_H	275_E	0.791	1.00
275_E	342_Y	0.790	1.00
101_S	105_S	0.790	1.00
239_N	345_K	0.788	1.00
262_I	291_I	0.787	1.00
287_K	290_R	0.783	1.00
285_L	289_A	0.780	1.00
231_D	274_E	0.777	1.00
245_H	249_Q	0.774	1.00
266_D	280_L	0.773	1.00
197_L	251_L	0.772	1.00
292_A	316_I	0.771	1.00
328_E	332_S	0.767	1.00
232_I	235_F	0.766	1.00
184_L	191_Q	0.765	1.00
336_L	339_Q	0.764	1.00
299_V	314_V	0.760	1.00
175_I	181_A	0.757	1.00
274_E	344_A	0.756	1.00
197_L	203_R	0.756	1.00
67_N	74_A	0.754	1.00
266_D	291_I	0.753	1.00
209_T	279_L	0.752	1.00
258_L	262_I	0.751	1.00
177_H	180_N	0.748	1.00
188_Y	193_H	0.743	1.00
274_E	345_K	0.736	1.00
194_F	259_K	0.736	1.00
286_D	289_A	0.736	1.00
259_K	268_A	0.734	1.00
291_I	295_I	0.733	1.00
219_D	265_T	0.733	1.00
326_N	354_F	0.730	1.00
267_P	279_L	0.729	1.00
200_V	269_A	0.726	1.00
225_F	279_L	0.722	1.00
255_G	258_L	0.720	1.00
239_N	274_E	0.716	1.00
324_P	336_L	0.713	1.00
306_L	312_L	0.710	1.00
163_I	167_G	0.710	1.00
203_R	271_I	0.708	1.00
219_D	263_R	0.707	1.00
207_E	210_T	0.707	1.00
231_D	239_N	0.706	1.00
285_L	354_F	0.706	1.00
317_S	348_G	0.701	1.00
178_E	185_F	0.701	1.00
174_I	181_A	0.699	1.00
227_L	277_A	0.698	1.00
101_S	104_Y	0.695	1.00
206_F	271_I	0.694	1.00
258_L	295_I	0.694	1.00
216_Q	281_P	0.691	1.00
303_P	311_E	0.691	1.00
318_L	352_V	0.690	1.00
303_P	313_S	0.689	1.00
217_A	225_F	0.687	1.00
288_A	322_H	0.683	1.00
229_Y	277_A	0.682	1.00
274_E	348_G	0.681	1.00
293_E	352_V	0.679	1.00
242_Y	312_L	0.677	1.00
236_K	275_E	0.676	1.00
200_V	258_L	0.676	1.00
174_I	179_T	0.676	1.00
159_Y	162_I	0.675	1.00
273_G	338_D	0.672	1.00
246_E	310_D	0.671	1.00
140_L	144_S	0.670	1.00
164_S	168_G	0.670	1.00
188_Y	191_Q	0.667	1.00
214_Y	225_F	0.663	1.00
81_S	84_T	0.661	1.00
240_D	244_H	0.657	1.00
194_F	200_V	0.656	1.00
236_K	273_G	0.656	1.00
199_G	252_K	0.656	1.00
193_H	204_R	0.656	1.00
216_Q	219_D	0.655	1.00
157_H	160_F	0.655	1.00
274_E	350_N	0.654	1.00
235_F	274_E	0.652	1.00
245_H	271_I	0.652	1.00
182_H	186_K	0.651	1.00
285_L	288_A	0.650	1.00
83_A	86_L	0.650	1.00
117_L	120_S	0.649	1.00
40_K	44_C	0.649	1.00
207_E	269_A	0.648	1.00
193_H	196_F	0.648	1.00
342_Y	345_K	0.647	1.00
194_F	205_K	0.646	1.00
210_T	227_L	0.642	1.00
233_D	341_L	0.642	1.00
170_L	173_Y	0.642	1.00
160_F	163_I	0.642	1.00
70_I	74_A	0.641	1.00
166_A	170_L	0.638	1.00
324_P	328_E	0.637	1.00
177_H	185_F	0.635	1.00
235_F	344_A	0.630	1.00
231_D	247_G	0.630	1.00
204_R	207_E	0.630	1.00
41_G	45_G	0.629	1.00
218_A	323_Y	0.629	1.00
206_F	334_P	0.628	1.00
85_A	88_M	0.625	1.00
317_S	342_Y	0.624	1.00
51_L	55_G	0.623	1.00
76_Y	79_W	0.619	1.00
244_H	345_K	0.618	1.00
154_Y	157_H	0.618	1.00
274_E	342_Y	0.617	1.00
216_Q	221_P	0.617	1.00
189_K	208_E	0.616	1.00
144_S	148_L	0.615	1.00
289_A	320_A	0.614	1.00
332_S	336_L	0.612	1.00
326_N	336_L	0.612	1.00
249_Q	308_N	0.610	1.00
64_D	68_I	0.609	1.00
319_G	337_A	0.609	1.00
278_V	295_I	0.607	1.00
283_C	288_A	0.605	1.00
290_R	294_R	0.605	1.00
106_V	109_I	0.603	1.00
210_T	269_A	0.603	1.00
229_Y	337_A	0.601	1.00
245_H	334_P	0.600	1.00
250_V	253_E	0.600	1.00
235_F	239_N	0.600	1.00
162_I	166_A	0.600	1.00
247_G	274_E	0.598	1.00
52_M	56_F	0.596	1.00
238_I	242_Y	0.596	1.00
37_Q	41_G	0.596	1.00
163_I	170_L	0.593	1.00
163_I	166_A	0.592	1.00
166_A	173_Y	0.592	1.00
190_F	199_G	0.592	1.00
84_T	88_M	0.591	1.00
257_R	261_T	0.590	1.00
226_A	280_L	0.588	1.00
292_A	296_R	0.588	1.00
184_L	188_Y	0.588	1.00
244_H	274_E	0.587	1.00
271_I	274_E	0.586	1.00
234_H	341_L	0.585	1.00
176_D	179_T	0.584	1.00
185_F	191_Q	0.584	1.00
186_K	190_F	0.583	1.00
213_L	279_L	0.580	1.00
191_Q	196_F	0.579	1.00
305_V	309_G	0.579	1.00
207_E	330_P	0.579	1.00
90_T	94_L	0.577	1.00
42_L	49_V	0.577	1.00
197_L	252_K	0.577	1.00
104_Y	107_I	0.577	1.00
227_L	337_A	0.576	1.00
42_L	46_L	0.576	1.00
196_F	271_I	0.576	1.00
41_G	48_G	0.574	1.00
196_F	202_N	0.574	1.00
242_Y	246_E	0.573	1.00
188_Y	192_A	0.571	1.00
213_L	219_D	0.571	1.00
64_D	74_A	0.570	1.00
221_P	282_N	0.569	1.00
38_A	41_G	0.569	1.00
206_F	330_P	0.568	1.00
98_M	105_S	0.568	1.00
300_S	315_T	0.567	1.00
233_D	345_K	0.566	1.00
55_G	59_Q	0.563	1.00
145_F	148_L	0.563	1.00
144_S	147_F	0.562	1.00
304_I	314_V	0.562	1.00
169_M	173_Y	0.562	1.00
226_A	292_A	0.561	1.00
180_N	184_L	0.561	1.00
309_G	312_L	0.560	1.00
102_A	105_S	0.557	1.00
306_L	309_G	0.555	1.00
274_E	316_I	0.554	1.00
88_M	92_G	0.552	1.00
296_R	315_T	0.551	1.00
44_C	55_G	0.551	1.00
280_L	283_C	0.551	1.00
116_S	120_S	0.549	1.00
236_K	345_K	0.549	1.00
247_G	345_K	0.549	1.00
323_Y	327_T	0.549	1.00
233_D	315_T	0.548	1.00
107_I	111_I	0.547	1.00
339_Q	343_K	0.546	1.00
331_G	335_I	0.544	1.00
102_A	115_P	0.543	1.00
230_M	268_A	0.542	1.00
93_R	97_T	0.542	1.00
39_V	50_I	0.541	1.00
39_V	42_L	0.539	1.00
94_L	97_T	0.539	1.00
323_Y	326_N	0.539	1.00
141_I	144_S	0.539	1.00
304_I	313_S	0.539	1.00
53_V	57_T	0.538	1.00
249_Q	256_L	0.538	1.00
133_L	137_T	0.538	1.00
41_G	44_C	0.536	1.00
333_L	337_A	0.536	1.00
327_T	332_S	0.533	1.00
207_E	334_P	0.532	1.00
238_I	241_Q	0.530	1.00
240_D	273_G	0.529	1.00
162_I	165_I	0.528	1.00
204_R	208_E	0.528	1.00
85_A	91_A	0.522	0.99
125_V	128_K	0.521	0.99
300_S	304_I	0.521	0.99
49_V	53_V	0.520	0.99
65_L	69_P	0.518	0.99
294_R	298_T	0.518	0.99
200_V	259_K	0.518	0.99
151_L	154_Y	0.515	0.99
41_G	51_L	0.514	0.99
181_A	188_Y	0.512	0.99
118_I	121_R	0.512	0.99
160_F	170_L	0.510	0.99
244_H	247_G	0.510	0.99
39_V	43_A	0.510	0.99
179_T	183_L	0.509	0.99
159_Y	164_S	0.509	0.99
244_H	273_G	0.508	0.99
341_L	344_A	0.507	0.99
233_D	244_H	0.507	0.99
236_K	274_E	0.506	0.99
165_I	170_L	0.506	0.99
111_I	115_P	0.505	0.99
231_D	236_K	0.504	0.99
348_G	351_R	0.504	0.99
74_A	78_G	0.503	0.99
37_Q	44_C	0.502	0.99
52_M	57_T	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1w25A	2	0.6379	100	0.377	Contact Map
4j40A	2	0	100	0.377	Contact Map
3pjxA	1	0.493	100	0.396	Contact Map
4rnhA	2	0.4457	100	0.402	Contact Map
3ignA	1	0.4624	100	0.41	Contact Map
3mtkA	2	0.4457	100	0.42	Contact Map
3hvaA	1	0.4513	100	0.43	Contact Map
3ezuA	2	0.9081	100	0.43	Contact Map
3tvkA	1	0.4624	100	0.431	Contact Map
3i5cA	2	0.5404	100	0.433	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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