GREMLIN Database
YHCK - Uncharacterized protein YhcK
UniProt: P54595 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 359 (315)
Sequences: 12734 (11828)
Seq/√Len: 666.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_R266_D4.2451.00
234_H349_R3.9531.00
190_F194_F3.7861.00
228_I292_A3.5391.00
228_I318_L3.4751.00
210_T330_P3.3921.00
344_A353_C3.3541.00
201_Y205_K3.2861.00
226_A322_H3.2481.00
206_F277_A2.9871.00
200_V255_G2.7231.00
300_S350_N2.7091.00
181_A185_F2.5621.00
232_I254_L2.5361.00
226_A288_A2.5111.00
293_E296_R2.4971.00
271_I277_A2.4871.00
206_F269_A2.4571.00
200_V268_A2.4301.00
317_S344_A2.4131.00
249_Q252_K2.3321.00
347_T353_C2.2831.00
245_H335_I2.2481.00
213_L216_Q2.1901.00
284_S287_K2.1731.00
185_F188_Y2.1681.00
205_K209_T2.1191.00
258_L268_A2.1151.00
296_R352_V1.9901.00
198_T251_L1.9881.00
233_D317_S1.9761.00
238_I250_V1.9621.00
250_V314_V1.9471.00
230_M318_L1.9421.00
335_I339_Q1.9271.00
329_Q332_S1.9221.00
343_K347_T1.9031.00
315_T350_N1.8971.00
347_T351_R1.8901.00
262_I268_A1.8841.00
209_T212_A1.8331.00
230_M316_I1.8181.00
296_R300_S1.7951.00
299_V316_I1.7891.00
280_L291_I1.7841.00
189_K193_H1.7801.00
229_Y341_L1.7221.00
324_P327_T1.7221.00
343_K353_C1.7011.00
327_T336_L1.6941.00
225_F333_L1.6811.00
344_A351_R1.6811.00
228_I280_L1.6601.00
246_E249_Q1.6391.00
254_L299_V1.6341.00
193_H208_E1.6291.00
229_Y271_I1.6281.00
343_K346_E1.5961.00
253_E256_L1.5901.00
201_Y267_P1.5851.00
177_H181_A1.5741.00
256_L259_K1.5651.00
209_T269_A1.5531.00
271_I334_P1.5521.00
203_R248_D1.5521.00
225_F323_Y1.5461.00
232_I316_I1.5381.00
253_E257_R1.5371.00
323_Y333_L1.5251.00
328_E336_L1.5221.00
253_E304_I1.5211.00
174_I177_H1.5041.00
209_T213_L1.4861.00
209_T267_P1.4851.00
229_Y334_P1.4811.00
181_A184_L1.4721.00
293_E297_S1.4661.00
261_T294_R1.4661.00
291_I294_R1.4441.00
262_I266_D1.4401.00
205_K267_P1.4241.00
262_I278_V1.4181.00
236_K240_D1.4151.00
246_E306_L1.4151.00
338_D342_Y1.4111.00
235_F251_L1.4041.00
261_T298_T1.4001.00
257_R303_P1.3931.00
321_A333_L1.3851.00
234_H274_E1.3791.00
255_G268_A1.3771.00
254_L258_L1.3751.00
196_F204_R1.3641.00
236_K342_Y1.3551.00
249_Q253_E1.3541.00
237_T241_Q1.3441.00
240_D342_Y1.3351.00
184_L187_Q1.3291.00
193_H205_K1.3271.00
203_R207_E1.3121.00
207_E331_G1.3081.00
178_E181_A1.3051.00
296_R318_L1.3001.00
191_Q204_R1.2891.00
230_M258_L1.2721.00
274_E315_T1.2721.00
336_L340_M1.2581.00
234_H237_T1.2481.00
174_I178_E1.2481.00
244_H338_D1.2341.00
320_A352_V1.2321.00
239_N247_G1.2251.00
288_A320_A1.2241.00
182_H185_F1.2221.00
223_F282_N1.2161.00
306_L310_D1.2141.00
213_L281_P1.2131.00
321_A337_A1.1971.00
289_A293_E1.1961.00
207_E211_K1.1941.00
205_K269_A1.1871.00
187_Q191_Q1.1841.00
277_A334_P1.1801.00
210_T279_L1.1711.00
344_A348_G1.1621.00
254_L316_I1.1521.00
205_K208_E1.1461.00
201_Y269_A1.1341.00
194_F201_Y1.1201.00
297_S301_D1.1091.00
250_V274_E1.1011.00
330_P334_P1.0891.00
292_A318_L1.0871.00
296_R350_N1.0861.00
193_H201_Y1.0801.00
320_A354_F1.0711.00
228_I278_V1.0641.00
211_K330_P1.0611.00
273_G342_Y1.0591.00
269_A277_A1.0581.00
206_F279_L1.0571.00
185_F189_K1.0551.00
272_G275_E1.0491.00
252_K255_G1.0481.00
262_I295_I1.0451.00
298_T301_D1.0371.00
230_M278_V1.0291.00
244_H342_Y1.0291.00
231_D345_K1.0171.00
177_H182_H1.0171.00
252_K256_L1.0121.00
321_A336_L1.0071.00
256_L260_Q1.0021.00
211_K215_Q0.9991.00
180_N183_L0.9891.00
187_Q190_F0.9861.00
289_A354_F0.9851.00
227_L334_P0.9841.00
226_A320_A0.9721.00
175_I179_T0.9701.00
257_R298_T0.9691.00
206_F210_T0.9631.00
315_T348_G0.9541.00
292_A352_V0.9521.00
288_A292_A0.9511.00
266_D294_R0.9451.00
238_I312_L0.9421.00
236_K338_D0.9411.00
285_L322_H0.9391.00
332_S335_I0.9381.00
292_A320_A0.9371.00
321_A340_M0.9351.00
45_G48_G0.9301.00
272_G338_D0.9271.00
233_D349_R0.9271.00
254_L314_V0.9261.00
238_I306_L0.9251.00
289_A352_V0.9251.00
240_D338_D0.9221.00
260_Q298_T0.9181.00
210_T214_Y0.9161.00
263_R291_I0.9141.00
257_R304_I0.9141.00
272_G342_Y0.9131.00
178_E182_H0.9071.00
228_I320_A0.9051.00
175_I178_E0.9041.00
217_A323_Y0.9031.00
268_A278_V0.9001.00
186_K189_K0.8971.00
232_I315_T0.8971.00
227_L333_L0.8951.00
250_V304_I0.8951.00
253_E303_P0.8911.00
231_D244_H0.8881.00
44_C48_G0.8861.00
213_L225_F0.8831.00
297_S300_S0.8811.00
105_S108_I0.8801.00
208_E212_A0.8771.00
232_I251_L0.8761.00
179_T182_H0.8721.00
263_R294_R0.8721.00
280_L288_A0.8681.00
192_A202_N0.8621.00
238_I246_E0.8581.00
231_D342_Y0.8421.00
275_E338_D0.8371.00
233_D348_G0.8301.00
224_Q325_N0.8281.00
237_T274_E0.8271.00
283_C287_K0.8251.00
258_L278_V0.8231.00
245_H331_G0.8191.00
239_N273_G0.8181.00
236_K239_N0.8171.00
340_M344_A0.8161.00
240_D275_E0.8141.00
263_R283_C0.8121.00
246_E312_L0.8121.00
236_K244_H0.8091.00
341_L349_R0.8061.00
196_F207_E0.8051.00
214_Y323_Y0.8041.00
235_F250_V0.8031.00
305_V311_E0.7991.00
214_Y330_P0.7981.00
244_H275_E0.7911.00
275_E342_Y0.7901.00
101_S105_S0.7901.00
239_N345_K0.7881.00
262_I291_I0.7871.00
287_K290_R0.7831.00
285_L289_A0.7801.00
231_D274_E0.7771.00
245_H249_Q0.7741.00
266_D280_L0.7731.00
197_L251_L0.7721.00
292_A316_I0.7711.00
328_E332_S0.7671.00
232_I235_F0.7661.00
184_L191_Q0.7651.00
336_L339_Q0.7641.00
299_V314_V0.7601.00
175_I181_A0.7571.00
274_E344_A0.7561.00
197_L203_R0.7561.00
67_N74_A0.7541.00
266_D291_I0.7531.00
209_T279_L0.7521.00
258_L262_I0.7511.00
177_H180_N0.7481.00
188_Y193_H0.7431.00
274_E345_K0.7361.00
194_F259_K0.7361.00
286_D289_A0.7361.00
259_K268_A0.7341.00
291_I295_I0.7331.00
219_D265_T0.7331.00
326_N354_F0.7301.00
267_P279_L0.7291.00
200_V269_A0.7261.00
225_F279_L0.7221.00
255_G258_L0.7201.00
239_N274_E0.7161.00
324_P336_L0.7131.00
306_L312_L0.7101.00
163_I167_G0.7101.00
203_R271_I0.7081.00
219_D263_R0.7071.00
207_E210_T0.7071.00
231_D239_N0.7061.00
285_L354_F0.7061.00
317_S348_G0.7011.00
178_E185_F0.7011.00
174_I181_A0.6991.00
227_L277_A0.6981.00
101_S104_Y0.6951.00
206_F271_I0.6941.00
258_L295_I0.6941.00
216_Q281_P0.6911.00
303_P311_E0.6911.00
318_L352_V0.6901.00
303_P313_S0.6891.00
217_A225_F0.6871.00
288_A322_H0.6831.00
229_Y277_A0.6821.00
274_E348_G0.6811.00
293_E352_V0.6791.00
242_Y312_L0.6771.00
236_K275_E0.6761.00
200_V258_L0.6761.00
174_I179_T0.6761.00
159_Y162_I0.6751.00
273_G338_D0.6721.00
246_E310_D0.6711.00
140_L144_S0.6701.00
164_S168_G0.6701.00
188_Y191_Q0.6671.00
214_Y225_F0.6631.00
81_S84_T0.6611.00
240_D244_H0.6571.00
194_F200_V0.6561.00
236_K273_G0.6561.00
199_G252_K0.6561.00
193_H204_R0.6561.00
216_Q219_D0.6551.00
157_H160_F0.6551.00
274_E350_N0.6541.00
235_F274_E0.6521.00
245_H271_I0.6521.00
182_H186_K0.6511.00
285_L288_A0.6501.00
83_A86_L0.6501.00
117_L120_S0.6491.00
40_K44_C0.6491.00
207_E269_A0.6481.00
193_H196_F0.6481.00
342_Y345_K0.6471.00
194_F205_K0.6461.00
210_T227_L0.6421.00
233_D341_L0.6421.00
170_L173_Y0.6421.00
160_F163_I0.6421.00
70_I74_A0.6411.00
166_A170_L0.6381.00
324_P328_E0.6371.00
177_H185_F0.6351.00
235_F344_A0.6301.00
231_D247_G0.6301.00
204_R207_E0.6301.00
41_G45_G0.6291.00
218_A323_Y0.6291.00
206_F334_P0.6281.00
85_A88_M0.6251.00
317_S342_Y0.6241.00
51_L55_G0.6231.00
76_Y79_W0.6191.00
244_H345_K0.6181.00
154_Y157_H0.6181.00
274_E342_Y0.6171.00
216_Q221_P0.6171.00
189_K208_E0.6161.00
144_S148_L0.6151.00
289_A320_A0.6141.00
332_S336_L0.6121.00
326_N336_L0.6121.00
249_Q308_N0.6101.00
64_D68_I0.6091.00
319_G337_A0.6091.00
278_V295_I0.6071.00
283_C288_A0.6051.00
290_R294_R0.6051.00
106_V109_I0.6031.00
210_T269_A0.6031.00
229_Y337_A0.6011.00
245_H334_P0.6001.00
250_V253_E0.6001.00
235_F239_N0.6001.00
162_I166_A0.6001.00
247_G274_E0.5981.00
52_M56_F0.5961.00
238_I242_Y0.5961.00
37_Q41_G0.5961.00
163_I170_L0.5931.00
163_I166_A0.5921.00
166_A173_Y0.5921.00
190_F199_G0.5921.00
84_T88_M0.5911.00
257_R261_T0.5901.00
226_A280_L0.5881.00
292_A296_R0.5881.00
184_L188_Y0.5881.00
244_H274_E0.5871.00
271_I274_E0.5861.00
234_H341_L0.5851.00
176_D179_T0.5841.00
185_F191_Q0.5841.00
186_K190_F0.5831.00
213_L279_L0.5801.00
191_Q196_F0.5791.00
305_V309_G0.5791.00
207_E330_P0.5791.00
90_T94_L0.5771.00
42_L49_V0.5771.00
197_L252_K0.5771.00
104_Y107_I0.5771.00
227_L337_A0.5761.00
42_L46_L0.5761.00
196_F271_I0.5761.00
41_G48_G0.5741.00
196_F202_N0.5741.00
242_Y246_E0.5731.00
188_Y192_A0.5711.00
213_L219_D0.5711.00
64_D74_A0.5701.00
221_P282_N0.5691.00
38_A41_G0.5691.00
206_F330_P0.5681.00
98_M105_S0.5681.00
300_S315_T0.5671.00
233_D345_K0.5661.00
55_G59_Q0.5631.00
145_F148_L0.5631.00
144_S147_F0.5621.00
304_I314_V0.5621.00
169_M173_Y0.5621.00
226_A292_A0.5611.00
180_N184_L0.5611.00
309_G312_L0.5601.00
102_A105_S0.5571.00
306_L309_G0.5551.00
274_E316_I0.5541.00
88_M92_G0.5521.00
296_R315_T0.5511.00
44_C55_G0.5511.00
280_L283_C0.5511.00
116_S120_S0.5491.00
236_K345_K0.5491.00
247_G345_K0.5491.00
323_Y327_T0.5491.00
233_D315_T0.5481.00
107_I111_I0.5471.00
339_Q343_K0.5461.00
331_G335_I0.5441.00
102_A115_P0.5431.00
230_M268_A0.5421.00
93_R97_T0.5421.00
39_V50_I0.5411.00
39_V42_L0.5391.00
94_L97_T0.5391.00
323_Y326_N0.5391.00
141_I144_S0.5391.00
304_I313_S0.5391.00
53_V57_T0.5381.00
249_Q256_L0.5381.00
133_L137_T0.5381.00
41_G44_C0.5361.00
333_L337_A0.5361.00
327_T332_S0.5331.00
207_E334_P0.5321.00
238_I241_Q0.5301.00
240_D273_G0.5291.00
162_I165_I0.5281.00
204_R208_E0.5281.00
85_A91_A0.5220.99
125_V128_K0.5210.99
300_S304_I0.5210.99
49_V53_V0.5200.99
65_L69_P0.5180.99
294_R298_T0.5180.99
200_V259_K0.5180.99
151_L154_Y0.5150.99
41_G51_L0.5140.99
181_A188_Y0.5120.99
118_I121_R0.5120.99
160_F170_L0.5100.99
244_H247_G0.5100.99
39_V43_A0.5100.99
179_T183_L0.5090.99
159_Y164_S0.5090.99
244_H273_G0.5080.99
341_L344_A0.5070.99
233_D244_H0.5070.99
236_K274_E0.5060.99
165_I170_L0.5060.99
111_I115_P0.5050.99
231_D236_K0.5040.99
348_G351_R0.5040.99
74_A78_G0.5030.99
37_Q44_C0.5020.99
52_M57_T0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w25A 2 0.6379 100 0.377 Contact Map
4j40A 2 0 100 0.377 Contact Map
3pjxA 1 0.493 100 0.396 Contact Map
4rnhA 2 0.4457 100 0.402 Contact Map
3ignA 1 0.4624 100 0.41 Contact Map
3mtkA 2 0.4457 100 0.42 Contact Map
3hvaA 1 0.4513 100 0.43 Contact Map
3ezuA 2 0.9081 100 0.43 Contact Map
3tvkA 1 0.4624 100 0.431 Contact Map
3i5cA 2 0.5404 100 0.433 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0109 seconds.