GREMLIN Database
YHCJ - Uncharacterized lipoprotein YhcJ
UniProt: P54594 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (256)
Sequences: 3632 (2519)
Seq/√Len: 157.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_T166_D3.6051.00
243_D247_A3.3221.00
30_K58_I3.1821.00
126_V174_K3.1041.00
96_N225_A3.0841.00
128_S185_A3.0461.00
224_R227_D2.9451.00
32_G75_I2.9341.00
125_A186_D2.9181.00
247_A251_K2.8591.00
83_I87_Q2.8151.00
47_K244_D2.7891.00
123_R170_H2.5461.00
88_S92_K2.5401.00
28_S54_D2.5051.00
113_K183_S2.4571.00
126_V172_K2.3941.00
51_A235_T2.3581.00
115_Y122_S2.3531.00
101_G237_L2.3031.00
100_L233_L2.2901.00
49_E54_D2.1721.00
28_S56_Q2.1691.00
227_D230_R2.1561.00
116_E120_D2.1191.00
43_Y245_T2.0811.00
129_V136_F2.0641.00
30_K56_Q2.0571.00
122_S125_A2.0541.00
130_P139_A2.0341.00
98_A225_A2.0341.00
161_V175_A2.0221.00
127_V187_V2.0121.00
71_A96_N2.0081.00
89_F95_L2.0081.00
51_A238_E1.9351.00
141_T144_Q1.9271.00
90_T95_L1.8891.00
97_L222_V1.7861.00
127_V171_L1.7841.00
201_N204_K1.7771.00
110_I187_V1.7701.00
247_A250_E1.7661.00
77_A223_V1.7421.00
121_I187_V1.6801.00
148_L171_L1.6631.00
42_N45_A1.6241.00
231_E235_T1.6211.00
102_T218_M1.5941.00
68_I72_N1.5871.00
73_K224_R1.5841.00
145_E211_G1.5771.00
243_D246_A1.5741.00
115_Y186_D1.5471.00
225_A228_Q1.5191.00
53_L235_T1.5091.00
77_A236_I1.5061.00
83_I99_P1.5021.00
206_T209_S1.4691.00
129_V173_L1.4341.00
234_Q238_E1.4151.00
146_A208_K1.4141.00
150_T165_K1.4101.00
43_Y47_K1.4091.00
27_E232_A1.4021.00
39_A252_E1.3941.00
43_Y46_Q1.3881.00
152_K165_K1.3871.00
109_G206_T1.3781.00
47_K50_E1.3671.00
164_I173_L1.3491.00
237_L241_Q1.3351.00
121_I125_A1.3301.00
98_A228_Q1.3301.00
155_F159_G1.3101.00
64_A85_Y1.3101.00
152_K163_M1.3071.00
68_I89_F1.3041.00
123_R169_R1.2991.00
221_I237_L1.2911.00
29_I232_A1.2851.00
109_G209_S1.2801.00
248_F252_E1.2701.00
47_K245_T1.2621.00
71_A95_L1.2541.00
117_R120_D1.2451.00
229_D234_Q1.2351.00
83_I220_L1.2291.00
47_K239_L1.2291.00
230_R233_L1.2261.00
132_K135_D1.2131.00
128_S181_A1.1981.00
68_I93_Y1.1881.00
53_L232_A1.1821.00
100_L237_L1.1711.00
43_Y248_F1.1641.00
38_G59_P1.1621.00
16_S19_A1.1531.00
70_L75_I1.1471.00
185_A188_F1.1391.00
42_N57_L1.1241.00
114_R186_D1.1231.00
115_Y125_A1.1091.00
32_G70_L1.1071.00
151_L165_K1.1031.00
90_T225_A1.0870.99
39_A253_Y1.0830.99
99_P220_L1.0810.99
200_L205_H1.0760.99
223_V227_D1.0650.99
110_I189_V1.0630.99
29_I53_L1.0620.99
83_I102_T1.0570.99
90_T96_N1.0520.99
176_V181_A1.0490.99
73_K226_E1.0450.99
32_G60_F1.0420.99
137_G159_G1.0350.99
33_I41_W1.0340.99
17_F20_C1.0270.99
87_Q91_E1.0270.99
144_Q150_T1.0230.99
118_I121_I1.0210.99
43_Y244_D1.0100.99
90_T97_L1.0080.99
67_D81_Q1.0020.99
77_A233_L1.0020.99
205_H209_S0.9990.99
70_L224_R0.9980.99
65_E68_I0.9960.99
223_V226_E0.9910.99
30_K76_D0.9910.99
44_I47_K0.9880.99
51_A239_L0.9860.99
235_T238_E0.9840.99
37_D104_Y0.9810.99
86_F90_T0.9800.99
79_A103_T0.9770.99
20_C23_S0.9740.99
13_L16_S0.9730.99
100_L223_V0.9540.99
201_N205_H0.9520.99
118_I208_K0.9420.98
45_A49_E0.9410.98
88_S91_E0.9410.98
48_A53_L0.9390.98
167_N171_L0.9360.98
152_K155_F0.9360.98
144_Q148_L0.9310.98
207_L210_G0.9300.98
86_F220_L0.9300.98
31_I41_W0.9260.98
33_I38_G0.9250.98
136_F161_V0.9220.98
101_G221_I0.9200.98
108_M189_V0.9200.98
78_N81_Q0.9140.98
29_I236_I0.9080.98
90_T98_A0.9080.98
60_F69_A0.9030.98
12_V15_V0.9030.98
110_I118_I0.9020.98
62_D65_E0.9010.98
86_F222_V0.8920.98
181_A184_G0.8710.97
48_A239_L0.8680.97
99_P102_T0.8610.97
46_Q49_E0.8550.97
47_K51_A0.8530.97
79_A240_Y0.8480.97
68_I71_A0.8460.97
39_A42_N0.8450.97
89_F93_Y0.8430.97
37_D106_T0.8430.97
106_T193_S0.8410.97
101_G241_Q0.8390.97
79_A104_Y0.8390.97
226_E230_R0.8370.97
246_A261_F0.8280.96
63_Y178_Q0.8270.96
211_G214_S0.8260.96
88_S134_F0.8240.96
27_E53_L0.8190.96
11_L15_V0.8180.96
60_F75_I0.8140.96
103_T240_Y0.8130.96
187_V207_L0.8120.96
235_T239_L0.8120.96
121_I148_L0.8110.96
67_D80_F0.8080.96
30_K70_L0.8020.96
45_A54_D0.7950.96
115_Y187_V0.7940.96
112_S115_Y0.7860.95
179_Q198_A0.7830.95
201_N254_Q0.7820.95
218_M260_A0.7810.95
12_V16_S0.7800.95
37_D79_A0.7800.95
161_V173_L0.7790.95
195_A200_L0.7630.94
67_D78_N0.7600.94
191_K219_N0.7580.94
47_K242_A0.7570.94
89_F97_L0.7570.94
200_L204_K0.7550.94
11_L14_L0.7540.94
206_T210_G0.7530.94
43_Y239_L0.7530.94
156_N159_G0.7530.94
202_P205_H0.7500.94
103_T237_L0.7470.94
246_A250_E0.7450.94
45_A57_L0.7430.94
182_V188_F0.7380.93
137_G141_T0.7360.93
99_P237_L0.7360.93
136_F175_A0.7340.93
99_P222_V0.7300.93
38_G42_N0.7290.93
41_W79_A0.7260.93
241_Q261_F0.7250.93
44_I239_L0.7240.93
80_F85_Y0.7200.93
70_L227_D0.7130.92
153_N156_N0.7090.92
103_T241_Q0.7090.92
201_N206_T0.7090.92
41_W55_I0.7050.92
139_A189_V0.7040.92
124_G170_H0.7040.92
10_V14_L0.7000.91
202_P209_S0.6990.91
202_P206_T0.6990.91
165_K168_P0.6980.91
63_Y66_S0.6980.91
14_L18_T0.6960.91
193_S197_K0.6870.91
37_D41_W0.6860.91
35_E59_P0.6800.90
79_A106_T0.6800.90
121_I186_D0.6790.90
221_I240_Y0.6730.90
167_N170_H0.6720.90
63_Y70_L0.6670.89
160_S163_M0.6650.89
106_T257_L0.6640.89
142_V146_A0.6630.89
6_I16_S0.6610.89
63_Y191_K0.6580.89
82_T134_F0.6560.89
141_T145_E0.6560.89
58_I70_L0.6530.88
68_I95_L0.6530.88
161_V165_K0.6520.88
22_P26_H0.6510.88
100_L222_V0.6460.88
84_S216_E0.6460.88
98_A223_V0.6420.88
115_Y121_I0.6370.87
17_F21_S0.6320.87
249_I259_P0.6290.86
205_H210_G0.6280.86
20_C25_E0.6270.86
132_K178_Q0.6270.86
243_D250_E0.6260.86
149_L173_L0.6250.86
180_D183_S0.6220.86
121_I127_V0.6200.86
91_E158_T0.6180.86
140_L149_L0.6130.85
128_S176_V0.6130.85
182_V200_L0.6110.85
112_S120_D0.6100.85
11_L16_S0.6100.85
171_L187_V0.6100.85
44_I245_T0.6080.85
148_L187_V0.6040.84
223_V230_R0.6040.84
248_F251_K0.6010.84
41_W240_Y0.6010.84
63_Y219_N0.5990.84
82_T86_F0.5990.84
136_F178_Q0.5980.84
32_G69_A0.5970.84
66_S70_L0.5970.84
182_V185_A0.5960.83
250_E259_P0.5950.83
192_P256_D0.5940.83
119_R146_A0.5930.83
27_E54_D0.5890.83
144_Q156_N0.5890.83
48_A55_I0.5890.83
203_K206_T0.5870.83
82_T132_K0.5860.82
82_T220_L0.5860.82
141_T159_G0.5800.82
6_I18_T0.5770.81
85_Y89_F0.5740.81
223_V228_Q0.5740.81
36_S253_Y0.5740.81
8_S11_L0.5740.81
182_V190_M0.5740.81
161_V172_K0.5720.81
135_D139_A0.5700.81
157_G161_V0.5650.80
106_T192_P0.5630.80
9_F13_L0.5610.80
144_Q154_G0.5600.79
71_A89_F0.5590.79
208_K211_G0.5570.79
130_P135_D0.5560.79
36_S39_A0.5550.79
140_L151_L0.5550.79
230_R234_Q0.5550.79
86_F97_L0.5540.79
87_Q90_T0.5500.78
42_N59_P0.5490.78
82_T135_D0.5480.78
107_P191_K0.5450.78
246_A259_P0.5450.78
63_Y132_K0.5440.78
91_E116_E0.5440.78
179_Q190_M0.5420.77
147_G150_T0.5400.77
137_G157_G0.5390.77
100_L228_Q0.5390.77
130_P189_V0.5380.77
103_T106_T0.5370.77
23_S26_H0.5360.76
110_I121_I0.5360.76
78_N85_Y0.5350.76
45_A56_Q0.5350.76
251_K254_Q0.5330.76
85_Y197_K0.5330.76
248_F253_Y0.5310.76
116_E150_T0.5290.76
115_Y118_I0.5280.75
40_I248_F0.5280.75
124_G172_K0.5260.75
231_E234_Q0.5250.75
42_N46_Q0.5250.75
62_D66_S0.5250.75
143_L189_V0.5240.75
31_I56_Q0.5240.75
41_W57_L0.5220.75
70_L97_L0.5220.75
106_T219_N0.5220.75
64_A68_I0.5220.75
132_K139_A0.5210.74
107_P216_E0.5210.74
108_M192_P0.5210.74
55_I236_I0.5200.74
22_P25_E0.5200.74
227_D233_L0.5180.74
193_S196_K0.5180.74
102_T241_Q0.5180.74
238_E241_Q0.5180.74
233_L236_I0.5160.74
29_I233_L0.5150.74
20_C24_A0.5150.74
115_Y171_L0.5130.73
69_A74_E0.5130.73
167_N173_L0.5130.73
192_P196_K0.5120.73
102_T220_L0.5110.73
46_Q244_D0.5110.73
37_D257_L0.5110.73
40_I249_I0.5100.73
13_L17_F0.5100.73
6_I13_L0.5100.73
223_V233_L0.5090.73
79_A221_I0.5090.73
116_E119_R0.5080.73
110_I208_K0.5070.72
50_E238_E0.5070.72
195_A205_H0.5040.72
144_Q157_G0.5020.72
27_E235_T0.5010.72
86_F224_R0.5010.72
227_D232_A0.5010.72
144_Q153_N0.5000.71
60_F63_Y0.5000.71
38_G41_W0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qhqA 1 0.8442 100 0.439 Contact Map
3ir1A 3 0.8623 100 0.494 Contact Map
4ntlA 1 0.8551 100 0.505 Contact Map
3up9A 1 0.8406 100 0.514 Contact Map
4oteA 4 0.8551 100 0.516 Contact Map
1xs5A 1 0.8514 100 0.535 Contact Map
4k3fA 1 0.8551 100 0.54 Contact Map
3tqwA 1 0.8333 100 0.541 Contact Map
3gxaA 3 0.8623 100 0.544 Contact Map
4q5tA 1 0.8696 100 0.557 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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