YHCI - BACSU - GREMLIN Contacts

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YHCI - Uncharacterized protein YhcI

UniProt:	P54593	Sequences: MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGESNSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTDSANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLLLILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVATMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGTPLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	313 (300)
Sequences:	1239 (1144)
Seq/√Len:	66.0

BACSU - YHCI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
172_L	177_T	6.484	1.00
81_D	85_E	4.422	1.00
125_E	148_K	4.128	1.00
9_W	151_T	3.954	1.00
5_I	154_L	3.743	1.00
118_A	152_V	3.568	1.00
149_Y	219_T	2.946	1.00
224_L	228_F	2.872	1.00
11_K	148_K	2.818	1.00
122_V	145_L	2.816	1.00
137_R	140_S	2.736	1.00
17_G	120_G	2.691	1.00
11_K	125_E	2.547	1.00
204_A	208_L	2.543	1.00
152_V	222_F	2.532	1.00
156_G	218_A	2.494	1.00
53_Q	57_A	2.273	1.00
48_W	52_L	2.263	1.00
123_A	225_S	2.222	1.00
114_T	221_A	2.216	1.00
157_L	211_S	2.180	1.00
9_W	154_L	2.136	1.00
6_Y	10_L	2.128	1.00
152_V	218_A	2.112	1.00
47_H	50_Q	2.094	1.00
87_N	90_S	2.088	1.00
82_Y	86_H	2.080	1.00
145_L	302_A	2.078	1.00
8_E	11_K	2.076	1.00
165_I	296_I	2.021	1.00
59_L	62_E	1.995	1.00
4_L	147_S	1.979	1.00
57_A	60_K	1.978	1.00
52_L	56_N	1.977	1.00
121_I	152_V	1.970	1.00
160_L	211_S	1.961	1.00
139_L	143_Q	1.946	1.00
149_Y	222_F	1.902	1.00
160_L	210_E	1.898	1.00
52_L	55_Q	1.874	1.00
8_E	125_E	1.843	1.00
31_G	35_L	1.841	1.00
16_A	19_W	1.825	1.00
12_I	151_T	1.823	1.00
122_V	222_F	1.813	1.00
133_L	137_R	1.767	1.00
4_L	11_K	1.758	1.00
125_E	144_I	1.756	1.00
50_Q	53_Q	1.737	1.00
208_L	212_V	1.715	0.99
216_M	263_L	1.698	0.99
70_K	74_K	1.695	0.99
198_N	201_G	1.695	0.99
5_I	150_I	1.688	0.99
266_N	287_S	1.681	0.99
9_W	13_F	1.677	0.99
58_E	61_K	1.676	0.99
56_N	60_K	1.652	0.99
55_Q	59_L	1.640	0.99
300_L	304_G	1.606	0.99
291_L	294_Y	1.602	0.99
76_T	79_L	1.602	0.99
146_M	303_F	1.600	0.99
232_S	236_G	1.593	0.99
7_N	10_L	1.592	0.99
134_L	148_K	1.588	0.99
281_G	284_M	1.577	0.99
77_I	81_D	1.523	0.99
164_F	210_E	1.516	0.99
228_F	234_A	1.494	0.99
82_Y	87_N	1.462	0.98
20_V	283_T	1.451	0.98
26_G	239_I	1.451	0.98
3_N	6_Y	1.431	0.98
224_L	237_F	1.429	0.98
33_A	170_L	1.428	0.98
228_F	233_L	1.407	0.98
122_V	131_I	1.403	0.98
134_L	144_I	1.400	0.98
52_L	60_K	1.399	0.98
10_L	263_L	1.379	0.98
268_D	271_Q	1.348	0.97
151_T	154_L	1.341	0.97
60_K	81_D	1.338	0.97
56_N	59_L	1.333	0.97
8_E	148_K	1.329	0.97
224_L	234_A	1.325	0.97
15_R	18_T	1.325	0.97
13_F	19_W	1.323	0.97
116_I	170_L	1.318	0.97
129_G	132_K	1.292	0.96
4_L	8_E	1.271	0.96
121_I	222_F	1.263	0.96
7_N	263_L	1.242	0.96
290_M	293_I	1.226	0.95
52_L	80_N	1.222	0.95
78_T	81_D	1.221	0.95
158_L	209_S	1.221	0.95
107_T	210_E	1.203	0.95
126_F	229_R	1.197	0.95
4_L	144_I	1.194	0.94
279_I	300_L	1.183	0.94
151_T	160_L	1.182	0.94
119_A	234_A	1.181	0.94
114_T	118_A	1.179	0.94
7_N	232_S	1.177	0.94
130_T	134_L	1.165	0.94
97_W	203_L	1.157	0.93
279_I	284_M	1.156	0.93
181_T	198_N	1.155	0.93
236_G	240_F	1.153	0.93
7_N	11_K	1.145	0.93
113_F	161_L	1.129	0.93
223_M	301_L	1.111	0.92
52_L	58_E	1.110	0.92
5_I	306_F	1.105	0.92
123_A	234_A	1.099	0.92
97_W	179_G	1.098	0.92
216_M	295_F	1.080	0.91
233_L	243_V	1.074	0.91
285_T	289_V	1.067	0.90
4_L	244_A	1.065	0.90
27_L	173_I	1.065	0.90
124_N	234_A	1.057	0.90
170_L	174_F	1.056	0.90
39_F	304_G	1.056	0.90
52_L	59_L	1.053	0.90
256_F	260_K	1.046	0.89
116_I	216_M	1.040	0.89
77_I	90_S	1.040	0.89
97_W	101_T	1.039	0.89
196_E	226_A	1.034	0.89
145_L	222_F	1.034	0.89
89_P	220_M	1.028	0.89
119_A	225_S	1.026	0.89
167_S	210_E	1.026	0.89
96_V	101_T	1.015	0.88
221_A	234_A	1.015	0.88
85_E	237_F	1.007	0.88
77_I	80_N	1.006	0.88
86_H	89_P	1.001	0.87
225_S	231_S	0.996	0.87
100_V	219_T	0.993	0.87
26_G	166_G	0.993	0.87
56_N	80_N	0.990	0.87
73_Y	80_N	0.990	0.87
172_L	178_G	0.985	0.86
73_Y	76_T	0.984	0.86
288_L	292_A	0.981	0.86
113_F	207_Y	0.981	0.86
56_N	212_V	0.977	0.86
119_A	231_S	0.977	0.86
109_L	116_I	0.966	0.85
37_N	41_A	0.964	0.85
302_A	306_F	0.964	0.85
219_T	222_F	0.963	0.85
89_P	156_G	0.962	0.85
100_V	168_T	0.955	0.85
170_L	204_A	0.955	0.85
126_F	131_I	0.951	0.84
294_Y	298_F	0.945	0.84
130_T	190_K	0.945	0.84
201_G	205_T	0.944	0.84
147_S	150_I	0.943	0.84
178_G	181_T	0.942	0.84
83_R	87_N	0.933	0.83
281_G	285_T	0.929	0.83
74_K	77_I	0.927	0.83
118_A	218_A	0.927	0.83
34_F	108_I	0.922	0.83
26_G	162_I	0.918	0.82
60_K	63_I	0.917	0.82
289_V	293_I	0.913	0.82
22_I	50_Q	0.909	0.82
129_G	141_R	0.907	0.81
86_H	116_I	0.906	0.81
298_F	302_A	0.903	0.81
272_Y	282_M	0.901	0.81
112_L	235_V	0.897	0.81
28_T	211_S	0.897	0.81
157_L	233_L	0.895	0.81
145_L	232_S	0.891	0.80
5_I	147_S	0.890	0.80
147_S	151_T	0.881	0.80
4_L	88_I	0.881	0.80
300_L	303_F	0.877	0.79
192_G	229_R	0.870	0.79
53_Q	56_N	0.869	0.79
148_K	222_F	0.865	0.78
136_I	141_R	0.864	0.78
111_G	127_N	0.860	0.78
75_E	80_N	0.858	0.78
105_N	230_N	0.855	0.78
156_G	231_S	0.851	0.77
20_V	208_L	0.848	0.77
115_I	221_A	0.845	0.77
281_G	287_S	0.840	0.76
121_I	225_S	0.837	0.76
282_M	287_S	0.836	0.76
178_G	182_A	0.835	0.76
216_M	298_F	0.834	0.76
49_K	54_A	0.824	0.75
38_H	166_G	0.820	0.75
175_F	261_Y	0.812	0.74
73_Y	90_S	0.809	0.74
203_L	274_D	0.808	0.73
51_E	55_Q	0.804	0.73
11_K	130_T	0.801	0.73
58_E	65_E	0.799	0.73
158_L	171_G	0.799	0.73
288_L	296_I	0.796	0.72
184_N	202_H	0.793	0.72
53_Q	154_L	0.792	0.72
80_N	84_I	0.791	0.72
245_G	264_F	0.790	0.72
287_S	291_L	0.790	0.72
116_I	125_E	0.785	0.71
184_N	190_K	0.784	0.71
141_R	232_S	0.784	0.71
8_E	266_N	0.781	0.71
79_L	83_R	0.781	0.71
222_F	225_S	0.781	0.71
235_V	279_I	0.779	0.71
11_K	137_R	0.777	0.70
92_T	212_V	0.776	0.70
121_I	151_T	0.764	0.69
33_A	217_V	0.762	0.69
22_I	162_I	0.762	0.69
12_I	68_S	0.761	0.69
237_F	241_L	0.760	0.69
50_Q	61_K	0.760	0.69
157_L	205_T	0.758	0.69
51_E	63_I	0.756	0.68
175_F	182_A	0.752	0.68
86_H	183_A	0.752	0.68
138_P	185_I	0.752	0.68
138_P	283_T	0.750	0.68
225_S	229_R	0.748	0.68
159_L	174_F	0.746	0.67
137_R	287_S	0.745	0.67
181_T	200_M	0.743	0.67
133_L	136_I	0.740	0.67
14_S	195_I	0.738	0.67
263_L	267_V	0.732	0.66
71_D	74_K	0.732	0.66
161_L	239_I	0.732	0.66
130_T	230_N	0.731	0.66
190_K	194_V	0.727	0.65
76_T	257_D	0.726	0.65
109_L	297_I	0.725	0.65
235_V	252_I	0.725	0.65
273_V	277_P	0.724	0.65
284_M	291_L	0.721	0.65
18_T	230_N	0.720	0.65
36_A	42_G	0.720	0.65
254_A	260_K	0.717	0.64
29_M	167_S	0.714	0.64
71_D	76_T	0.714	0.64
165_I	249_T	0.710	0.64
95_T	103_S	0.707	0.63
54_A	296_I	0.706	0.63
284_M	288_L	0.704	0.63
150_I	209_S	0.703	0.63
70_K	88_I	0.702	0.63
238_S	245_G	0.701	0.63
176_G	179_G	0.698	0.62
41_A	44_S	0.698	0.62
125_E	146_M	0.696	0.62
161_L	190_K	0.696	0.62
225_S	245_G	0.694	0.62
65_E	158_L	0.693	0.62
266_N	272_Y	0.693	0.62
34_F	38_H	0.691	0.61
221_A	238_S	0.689	0.61
65_E	88_I	0.688	0.61
99_Y	103_S	0.687	0.61
257_D	260_K	0.686	0.61
162_I	279_I	0.685	0.61
76_T	83_R	0.684	0.61
22_I	51_E	0.684	0.61
280_K	292_A	0.679	0.60
219_T	299_L	0.679	0.60
168_T	203_L	0.679	0.60
185_I	196_E	0.677	0.60
21_M	232_S	0.674	0.59
11_K	133_L	0.671	0.59
47_H	87_N	0.670	0.59
197_Q	205_T	0.670	0.59
121_I	215_L	0.665	0.58
103_S	106_F	0.663	0.58
144_I	235_V	0.662	0.58
226_A	302_A	0.660	0.58
199_M	242_L	0.660	0.58
38_H	42_G	0.656	0.57
99_Y	171_G	0.656	0.57
88_I	250_A	0.655	0.57
53_Q	77_I	0.655	0.57
228_F	237_F	0.654	0.57
157_L	301_L	0.652	0.57
223_M	298_F	0.652	0.57
25_L	113_F	0.651	0.57
29_M	166_G	0.651	0.57
48_W	59_L	0.648	0.57
130_T	137_R	0.648	0.57
112_L	302_A	0.648	0.57
29_M	33_A	0.647	0.56
106_F	159_L	0.646	0.56
212_V	295_F	0.646	0.56
11_K	114_T	0.645	0.56
64_K	166_G	0.644	0.56
217_V	242_L	0.642	0.56
190_K	193_H	0.637	0.55
23_G	57_A	0.636	0.55
25_L	163_L	0.636	0.55
81_D	91_D	0.636	0.55
49_K	84_I	0.633	0.55
233_L	237_F	0.632	0.55
281_G	294_Y	0.631	0.55
56_N	77_I	0.627	0.54
141_R	225_S	0.626	0.54
155_F	161_L	0.626	0.54
135_M	147_S	0.626	0.54
47_H	51_E	0.625	0.54
245_G	259_A	0.624	0.54
45_N	143_Q	0.622	0.53
119_A	183_A	0.622	0.53
130_T	272_Y	0.622	0.53
113_F	236_G	0.618	0.53
135_M	222_F	0.616	0.53
271_Q	295_F	0.616	0.53
236_G	242_L	0.615	0.53
118_A	229_R	0.613	0.52
185_I	193_H	0.611	0.52
134_L	137_R	0.609	0.52
299_L	303_F	0.609	0.52
140_S	304_G	0.609	0.52
26_G	33_A	0.608	0.52
67_P	293_I	0.608	0.52
196_E	215_L	0.607	0.52
28_T	109_L	0.606	0.52
7_N	132_K	0.605	0.51
154_L	285_T	0.605	0.51
229_R	297_I	0.605	0.51
275_G	283_T	0.602	0.51
134_L	154_L	0.599	0.51
40_S	45_N	0.598	0.51
131_I	144_I	0.597	0.51
165_I	204_A	0.597	0.51
54_A	153_L	0.597	0.51
125_E	134_L	0.597	0.51
77_I	140_S	0.596	0.50
262_I	296_I	0.595	0.50
20_V	169_L	0.594	0.50
40_S	109_L	0.592	0.50
29_M	99_Y	0.591	0.50
11_K	18_T	0.590	0.50
115_I	262_I	0.590	0.50
35_L	255_K	0.590	0.50
27_L	78_T	0.588	0.49
122_V	245_G	0.584	0.49
134_L	155_F	0.584	0.49
23_G	26_G	0.582	0.49
107_T	235_V	0.579	0.48
51_E	62_E	0.579	0.48
192_G	209_S	0.578	0.48
153_L	215_L	0.578	0.48
7_N	131_I	0.578	0.48
84_I	87_N	0.578	0.48
28_T	100_V	0.575	0.48
122_V	225_S	0.574	0.48
219_T	295_F	0.572	0.48
14_S	207_Y	0.572	0.48
149_Y	279_I	0.571	0.47
165_I	280_K	0.568	0.47
50_Q	241_L	0.568	0.47
91_D	184_N	0.566	0.47
213_S	238_S	0.563	0.47
149_Y	288_L	0.562	0.46
131_I	196_E	0.562	0.46
233_L	263_L	0.562	0.46
256_F	261_Y	0.561	0.46
121_I	203_L	0.561	0.46
114_T	218_A	0.560	0.46
156_G	166_G	0.558	0.46
114_T	156_G	0.556	0.46
23_G	166_G	0.556	0.46
239_I	276_T	0.555	0.46
135_M	225_S	0.554	0.45
83_R	182_A	0.554	0.45
231_S	243_V	0.551	0.45
25_L	172_L	0.550	0.45
49_K	52_L	0.550	0.45
110_T	210_E	0.549	0.45
24_I	76_T	0.548	0.45
234_A	258_W	0.544	0.44
106_F	167_S	0.544	0.44
27_L	71_D	0.543	0.44
9_W	181_T	0.541	0.44
100_V	104_A	0.539	0.44
30_V	202_H	0.538	0.44
284_M	306_F	0.538	0.44
35_L	43_E	0.538	0.44
109_L	209_S	0.534	0.43
297_I	301_L	0.532	0.43
91_D	116_I	0.532	0.43
76_T	85_E	0.532	0.43
8_E	141_R	0.531	0.43
22_I	26_G	0.530	0.43
108_I	159_L	0.529	0.43
178_G	266_N	0.529	0.43
19_W	250_A	0.528	0.42
9_W	279_I	0.527	0.42
7_N	223_M	0.526	0.42
131_I	263_L	0.523	0.42
34_F	233_L	0.523	0.42
205_T	273_V	0.522	0.42
157_L	160_L	0.521	0.42
67_P	71_D	0.520	0.42
64_K	279_I	0.520	0.42
50_Q	60_K	0.519	0.41
145_L	245_G	0.518	0.41
154_L	208_L	0.518	0.41
36_A	39_F	0.518	0.41
102_D	268_D	0.517	0.41
166_G	203_L	0.517	0.41
118_A	251_F	0.516	0.41
57_A	86_H	0.516	0.41
245_G	249_T	0.515	0.41
173_I	207_Y	0.514	0.41
77_I	84_I	0.514	0.41
7_N	117_I	0.512	0.41
6_Y	101_T	0.512	0.41
27_L	303_F	0.511	0.41
142_F	303_F	0.510	0.40
58_E	296_I	0.508	0.40
68_S	72_G	0.508	0.40
119_A	123_A	0.506	0.40
100_V	165_I	0.506	0.40
139_L	146_M	0.505	0.40
96_V	171_G	0.505	0.40
260_K	263_L	0.505	0.40
141_R	231_S	0.504	0.40
40_S	305_I	0.503	0.40
203_L	303_F	0.503	0.40
118_A	221_A	0.503	0.40
281_G	301_L	0.502	0.39
98_S	161_L	0.501	0.39
206_T	289_V	0.501	0.39
246_T	291_L	0.500	0.39
42_G	45_N	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rvyA	3	0.1182	25.4	0.94	Contact Map
4cbcA	3	0.1022	21.3	0.942	Contact Map
3wdoA	1	0.3291	17.3	0.944	Contact Map
2m20A	2	0.1086	15.8	0.946	Contact Map
4bgnA	3	0.1661	15.2	0.946	Contact Map
4pypA	1	0.1246	11.9	0.948	Contact Map
3tx3A	2	0.3482	10.7	0.95	Contact Map
4ltoA	3	0.2396	10	0.95	Contact Map
3hd7A	1	0.2907	9.9	0.95	Contact Map
4ea3A	2	0.7636	9.7	0.95	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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