GREMLIN Database
YHCI - Uncharacterized protein YhcI
UniProt: P54593 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (300)
Sequences: 1239 (1144)
Seq/√Len: 66.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_L177_T6.4841.00
81_D85_E4.4221.00
125_E148_K4.1281.00
9_W151_T3.9541.00
5_I154_L3.7431.00
118_A152_V3.5681.00
149_Y219_T2.9461.00
224_L228_F2.8721.00
11_K148_K2.8181.00
122_V145_L2.8161.00
137_R140_S2.7361.00
17_G120_G2.6911.00
11_K125_E2.5471.00
204_A208_L2.5431.00
152_V222_F2.5321.00
156_G218_A2.4941.00
53_Q57_A2.2731.00
48_W52_L2.2631.00
123_A225_S2.2221.00
114_T221_A2.2161.00
157_L211_S2.1801.00
9_W154_L2.1361.00
6_Y10_L2.1281.00
152_V218_A2.1121.00
47_H50_Q2.0941.00
87_N90_S2.0881.00
82_Y86_H2.0801.00
145_L302_A2.0781.00
8_E11_K2.0761.00
165_I296_I2.0211.00
59_L62_E1.9951.00
4_L147_S1.9791.00
57_A60_K1.9781.00
52_L56_N1.9771.00
121_I152_V1.9701.00
160_L211_S1.9611.00
139_L143_Q1.9461.00
149_Y222_F1.9021.00
160_L210_E1.8981.00
52_L55_Q1.8741.00
8_E125_E1.8431.00
31_G35_L1.8411.00
16_A19_W1.8251.00
12_I151_T1.8231.00
122_V222_F1.8131.00
133_L137_R1.7671.00
4_L11_K1.7581.00
125_E144_I1.7561.00
50_Q53_Q1.7371.00
208_L212_V1.7150.99
216_M263_L1.6980.99
70_K74_K1.6950.99
198_N201_G1.6950.99
5_I150_I1.6880.99
266_N287_S1.6810.99
9_W13_F1.6770.99
58_E61_K1.6760.99
56_N60_K1.6520.99
55_Q59_L1.6400.99
300_L304_G1.6060.99
291_L294_Y1.6020.99
76_T79_L1.6020.99
146_M303_F1.6000.99
232_S236_G1.5930.99
7_N10_L1.5920.99
134_L148_K1.5880.99
281_G284_M1.5770.99
77_I81_D1.5230.99
164_F210_E1.5160.99
228_F234_A1.4940.99
82_Y87_N1.4620.98
20_V283_T1.4510.98
26_G239_I1.4510.98
3_N6_Y1.4310.98
224_L237_F1.4290.98
33_A170_L1.4280.98
228_F233_L1.4070.98
122_V131_I1.4030.98
134_L144_I1.4000.98
52_L60_K1.3990.98
10_L263_L1.3790.98
268_D271_Q1.3480.97
151_T154_L1.3410.97
60_K81_D1.3380.97
56_N59_L1.3330.97
8_E148_K1.3290.97
224_L234_A1.3250.97
15_R18_T1.3250.97
13_F19_W1.3230.97
116_I170_L1.3180.97
129_G132_K1.2920.96
4_L8_E1.2710.96
121_I222_F1.2630.96
7_N263_L1.2420.96
290_M293_I1.2260.95
52_L80_N1.2220.95
78_T81_D1.2210.95
158_L209_S1.2210.95
107_T210_E1.2030.95
126_F229_R1.1970.95
4_L144_I1.1940.94
279_I300_L1.1830.94
151_T160_L1.1820.94
119_A234_A1.1810.94
114_T118_A1.1790.94
7_N232_S1.1770.94
130_T134_L1.1650.94
97_W203_L1.1570.93
279_I284_M1.1560.93
181_T198_N1.1550.93
236_G240_F1.1530.93
7_N11_K1.1450.93
113_F161_L1.1290.93
223_M301_L1.1110.92
52_L58_E1.1100.92
5_I306_F1.1050.92
123_A234_A1.0990.92
97_W179_G1.0980.92
216_M295_F1.0800.91
233_L243_V1.0740.91
285_T289_V1.0670.90
4_L244_A1.0650.90
27_L173_I1.0650.90
124_N234_A1.0570.90
170_L174_F1.0560.90
39_F304_G1.0560.90
52_L59_L1.0530.90
256_F260_K1.0460.89
116_I216_M1.0400.89
77_I90_S1.0400.89
97_W101_T1.0390.89
196_E226_A1.0340.89
145_L222_F1.0340.89
89_P220_M1.0280.89
119_A225_S1.0260.89
167_S210_E1.0260.89
96_V101_T1.0150.88
221_A234_A1.0150.88
85_E237_F1.0070.88
77_I80_N1.0060.88
86_H89_P1.0010.87
225_S231_S0.9960.87
100_V219_T0.9930.87
26_G166_G0.9930.87
56_N80_N0.9900.87
73_Y80_N0.9900.87
172_L178_G0.9850.86
73_Y76_T0.9840.86
288_L292_A0.9810.86
113_F207_Y0.9810.86
56_N212_V0.9770.86
119_A231_S0.9770.86
109_L116_I0.9660.85
37_N41_A0.9640.85
302_A306_F0.9640.85
219_T222_F0.9630.85
89_P156_G0.9620.85
100_V168_T0.9550.85
170_L204_A0.9550.85
126_F131_I0.9510.84
294_Y298_F0.9450.84
130_T190_K0.9450.84
201_G205_T0.9440.84
147_S150_I0.9430.84
178_G181_T0.9420.84
83_R87_N0.9330.83
281_G285_T0.9290.83
74_K77_I0.9270.83
118_A218_A0.9270.83
34_F108_I0.9220.83
26_G162_I0.9180.82
60_K63_I0.9170.82
289_V293_I0.9130.82
22_I50_Q0.9090.82
129_G141_R0.9070.81
86_H116_I0.9060.81
298_F302_A0.9030.81
272_Y282_M0.9010.81
112_L235_V0.8970.81
28_T211_S0.8970.81
157_L233_L0.8950.81
145_L232_S0.8910.80
5_I147_S0.8900.80
147_S151_T0.8810.80
4_L88_I0.8810.80
300_L303_F0.8770.79
192_G229_R0.8700.79
53_Q56_N0.8690.79
148_K222_F0.8650.78
136_I141_R0.8640.78
111_G127_N0.8600.78
75_E80_N0.8580.78
105_N230_N0.8550.78
156_G231_S0.8510.77
20_V208_L0.8480.77
115_I221_A0.8450.77
281_G287_S0.8400.76
121_I225_S0.8370.76
282_M287_S0.8360.76
178_G182_A0.8350.76
216_M298_F0.8340.76
49_K54_A0.8240.75
38_H166_G0.8200.75
175_F261_Y0.8120.74
73_Y90_S0.8090.74
203_L274_D0.8080.73
51_E55_Q0.8040.73
11_K130_T0.8010.73
58_E65_E0.7990.73
158_L171_G0.7990.73
288_L296_I0.7960.72
184_N202_H0.7930.72
53_Q154_L0.7920.72
80_N84_I0.7910.72
245_G264_F0.7900.72
287_S291_L0.7900.72
116_I125_E0.7850.71
184_N190_K0.7840.71
141_R232_S0.7840.71
8_E266_N0.7810.71
79_L83_R0.7810.71
222_F225_S0.7810.71
235_V279_I0.7790.71
11_K137_R0.7770.70
92_T212_V0.7760.70
121_I151_T0.7640.69
33_A217_V0.7620.69
22_I162_I0.7620.69
12_I68_S0.7610.69
237_F241_L0.7600.69
50_Q61_K0.7600.69
157_L205_T0.7580.69
51_E63_I0.7560.68
175_F182_A0.7520.68
86_H183_A0.7520.68
138_P185_I0.7520.68
138_P283_T0.7500.68
225_S229_R0.7480.68
159_L174_F0.7460.67
137_R287_S0.7450.67
181_T200_M0.7430.67
133_L136_I0.7400.67
14_S195_I0.7380.67
263_L267_V0.7320.66
71_D74_K0.7320.66
161_L239_I0.7320.66
130_T230_N0.7310.66
190_K194_V0.7270.65
76_T257_D0.7260.65
109_L297_I0.7250.65
235_V252_I0.7250.65
273_V277_P0.7240.65
284_M291_L0.7210.65
18_T230_N0.7200.65
36_A42_G0.7200.65
254_A260_K0.7170.64
29_M167_S0.7140.64
71_D76_T0.7140.64
165_I249_T0.7100.64
95_T103_S0.7070.63
54_A296_I0.7060.63
284_M288_L0.7040.63
150_I209_S0.7030.63
70_K88_I0.7020.63
238_S245_G0.7010.63
176_G179_G0.6980.62
41_A44_S0.6980.62
125_E146_M0.6960.62
161_L190_K0.6960.62
225_S245_G0.6940.62
65_E158_L0.6930.62
266_N272_Y0.6930.62
34_F38_H0.6910.61
221_A238_S0.6890.61
65_E88_I0.6880.61
99_Y103_S0.6870.61
257_D260_K0.6860.61
162_I279_I0.6850.61
76_T83_R0.6840.61
22_I51_E0.6840.61
280_K292_A0.6790.60
219_T299_L0.6790.60
168_T203_L0.6790.60
185_I196_E0.6770.60
21_M232_S0.6740.59
11_K133_L0.6710.59
47_H87_N0.6700.59
197_Q205_T0.6700.59
121_I215_L0.6650.58
103_S106_F0.6630.58
144_I235_V0.6620.58
226_A302_A0.6600.58
199_M242_L0.6600.58
38_H42_G0.6560.57
99_Y171_G0.6560.57
88_I250_A0.6550.57
53_Q77_I0.6550.57
228_F237_F0.6540.57
157_L301_L0.6520.57
223_M298_F0.6520.57
25_L113_F0.6510.57
29_M166_G0.6510.57
48_W59_L0.6480.57
130_T137_R0.6480.57
112_L302_A0.6480.57
29_M33_A0.6470.56
106_F159_L0.6460.56
212_V295_F0.6460.56
11_K114_T0.6450.56
64_K166_G0.6440.56
217_V242_L0.6420.56
190_K193_H0.6370.55
23_G57_A0.6360.55
25_L163_L0.6360.55
81_D91_D0.6360.55
49_K84_I0.6330.55
233_L237_F0.6320.55
281_G294_Y0.6310.55
56_N77_I0.6270.54
141_R225_S0.6260.54
155_F161_L0.6260.54
135_M147_S0.6260.54
47_H51_E0.6250.54
245_G259_A0.6240.54
45_N143_Q0.6220.53
119_A183_A0.6220.53
130_T272_Y0.6220.53
113_F236_G0.6180.53
135_M222_F0.6160.53
271_Q295_F0.6160.53
236_G242_L0.6150.53
118_A229_R0.6130.52
185_I193_H0.6110.52
134_L137_R0.6090.52
299_L303_F0.6090.52
140_S304_G0.6090.52
26_G33_A0.6080.52
67_P293_I0.6080.52
196_E215_L0.6070.52
28_T109_L0.6060.52
7_N132_K0.6050.51
154_L285_T0.6050.51
229_R297_I0.6050.51
275_G283_T0.6020.51
134_L154_L0.5990.51
40_S45_N0.5980.51
131_I144_I0.5970.51
165_I204_A0.5970.51
54_A153_L0.5970.51
125_E134_L0.5970.51
77_I140_S0.5960.50
262_I296_I0.5950.50
20_V169_L0.5940.50
40_S109_L0.5920.50
29_M99_Y0.5910.50
11_K18_T0.5900.50
115_I262_I0.5900.50
35_L255_K0.5900.50
27_L78_T0.5880.49
122_V245_G0.5840.49
134_L155_F0.5840.49
23_G26_G0.5820.49
107_T235_V0.5790.48
51_E62_E0.5790.48
192_G209_S0.5780.48
153_L215_L0.5780.48
7_N131_I0.5780.48
84_I87_N0.5780.48
28_T100_V0.5750.48
122_V225_S0.5740.48
219_T295_F0.5720.48
14_S207_Y0.5720.48
149_Y279_I0.5710.47
165_I280_K0.5680.47
50_Q241_L0.5680.47
91_D184_N0.5660.47
213_S238_S0.5630.47
149_Y288_L0.5620.46
131_I196_E0.5620.46
233_L263_L0.5620.46
256_F261_Y0.5610.46
121_I203_L0.5610.46
114_T218_A0.5600.46
156_G166_G0.5580.46
114_T156_G0.5560.46
23_G166_G0.5560.46
239_I276_T0.5550.46
135_M225_S0.5540.45
83_R182_A0.5540.45
231_S243_V0.5510.45
25_L172_L0.5500.45
49_K52_L0.5500.45
110_T210_E0.5490.45
24_I76_T0.5480.45
234_A258_W0.5440.44
106_F167_S0.5440.44
27_L71_D0.5430.44
9_W181_T0.5410.44
100_V104_A0.5390.44
30_V202_H0.5380.44
284_M306_F0.5380.44
35_L43_E0.5380.44
109_L209_S0.5340.43
297_I301_L0.5320.43
91_D116_I0.5320.43
76_T85_E0.5320.43
8_E141_R0.5310.43
22_I26_G0.5300.43
108_I159_L0.5290.43
178_G266_N0.5290.43
19_W250_A0.5280.42
9_W279_I0.5270.42
7_N223_M0.5260.42
131_I263_L0.5230.42
34_F233_L0.5230.42
205_T273_V0.5220.42
157_L160_L0.5210.42
67_P71_D0.5200.42
64_K279_I0.5200.42
50_Q60_K0.5190.41
145_L245_G0.5180.41
154_L208_L0.5180.41
36_A39_F0.5180.41
102_D268_D0.5170.41
166_G203_L0.5170.41
118_A251_F0.5160.41
57_A86_H0.5160.41
245_G249_T0.5150.41
173_I207_Y0.5140.41
77_I84_I0.5140.41
7_N117_I0.5120.41
6_Y101_T0.5120.41
27_L303_F0.5110.41
142_F303_F0.5100.40
58_E296_I0.5080.40
68_S72_G0.5080.40
119_A123_A0.5060.40
100_V165_I0.5060.40
139_L146_M0.5050.40
96_V171_G0.5050.40
260_K263_L0.5050.40
141_R231_S0.5040.40
40_S305_I0.5030.40
203_L303_F0.5030.40
118_A221_A0.5030.40
281_G301_L0.5020.39
98_S161_L0.5010.39
206_T289_V0.5010.39
246_T291_L0.5000.39
42_G45_N0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rvyA 3 0.1182 25.4 0.94 Contact Map
4cbcA 3 0.1022 21.3 0.942 Contact Map
3wdoA 1 0.3291 17.3 0.944 Contact Map
2m20A 2 0.1086 15.8 0.946 Contact Map
4bgnA 3 0.1661 15.2 0.946 Contact Map
4pypA 1 0.1246 11.9 0.948 Contact Map
3tx3A 2 0.3482 10.7 0.95 Contact Map
4ltoA 3 0.2396 10 0.95 Contact Map
3hd7A 1 0.2907 9.9 0.95 Contact Map
4ea3A 2 0.7636 9.7 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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