GREMLIN Database
YHCH - Uncharacterized ABC transporter ATP-binding protein YhcH
UniProt: P54592 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (237)
Sequences: 100178 (58139)
Seq/√Len: 3776.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_E202_R3.4831.00
78_H152_K3.0501.00
18_T21_D3.0481.00
6_E26_T3.0201.00
33_F204_A2.9481.00
34_G200_C2.9321.00
9_N22_D2.9111.00
8_K60_D2.8391.00
125_R128_D2.8381.00
60_D67_S2.6321.00
13_N18_T2.5901.00
202_R214_I2.5661.00
6_E62_L2.5151.00
215_Q219_D2.4621.00
28_R31_E2.4361.00
216_N219_D2.3521.00
12_K49_M2.3151.00
11_T18_T2.2731.00
21_D210_K2.2551.00
11_T58_K2.2031.00
8_K62_L2.1321.00
64_C152_K2.1131.00
204_A211_L2.1051.00
11_T22_D2.0901.00
112_K150_D2.0701.00
204_A214_I2.0061.00
114_D126_I1.9661.00
7_L10_V1.9571.00
177_K181_E1.9251.00
119_L182_R1.9231.00
29_E152_K1.8501.00
94_G133_Y1.7091.00
112_K115_E1.6961.00
110_K114_D1.6931.00
95_Y126_I1.6861.00
95_Y99_Q1.6561.00
118_E123_T1.6491.00
95_Y127_H1.6421.00
47_I189_S1.6381.00
115_E119_L1.6211.00
14_I45_T1.6101.00
190_S196_M1.6011.00
14_I19_I1.5841.00
176_K198_L1.5791.00
197_E218_K1.5721.00
128_D132_T1.5611.00
47_I155_I1.5531.00
12_K57_S1.5421.00
9_N24_S1.5381.00
150_D184_M1.5251.00
117_V126_I1.5121.00
12_K54_M1.5121.00
99_Q109_T1.4801.00
119_L181_E1.4381.00
33_F214_I1.4331.00
215_Q220_E1.4291.00
11_T21_D1.4161.00
99_Q113_I1.4131.00
25_F204_A1.4031.00
212_I226_D1.3831.00
64_C78_H1.3821.00
95_Y110_K1.3811.00
31_E201_D1.3801.00
119_L177_K1.3591.00
116_V148_L1.3551.00
67_S70_K1.3491.00
10_V56_L1.3411.00
7_L25_F1.3331.00
23_L46_T1.3291.00
13_N57_S1.3111.00
226_D229_F1.3041.00
62_L67_S1.2981.00
156_L186_V1.2971.00
207_Q212_I1.2801.00
28_R202_R1.2651.00
111_E115_E1.2601.00
27_I33_F1.2551.00
98_L117_V1.2481.00
150_D182_R1.2461.00
219_D223_D1.2311.00
114_D118_E1.2291.00
34_G196_M1.2291.00
4_V64_C1.2221.00
93_S96_K1.2191.00
99_Q110_K1.2101.00
32_V179_T1.2081.00
7_L50_M1.2041.00
95_Y114_D1.1871.00
49_M56_L1.1821.00
20_I49_M1.1771.00
108_V111_E1.1621.00
52_G55_K1.1611.00
33_F202_R1.1571.00
116_V120_V1.1411.00
8_K26_T1.1391.00
95_Y113_I1.1321.00
103_R109_T1.1281.00
25_F46_T1.1111.00
125_R133_Y1.1101.00
92_L96_K1.1041.00
227_T231_Q1.0921.00
66_Q71_E1.0841.00
218_K222_I1.0731.00
8_K24_S1.0711.00
97_N145_Q1.0681.00
29_E64_C1.0631.00
35_F46_T1.0551.00
227_T230_F1.0511.00
51_V81_A1.0511.00
179_T186_V1.0321.00
121_G170_E1.0311.00
98_L148_L1.0291.00
48_R54_M1.0281.00
172_R195_E1.0251.00
7_L46_T1.0231.00
112_K116_V1.0131.00
35_F187_I1.0091.00
107_G111_E1.0091.00
93_S127_H1.0021.00
32_V186_V0.9921.00
93_S129_K0.9881.00
84_E135_L0.9831.00
116_V144_A0.9811.00
96_K99_Q0.9791.00
176_K179_T0.9761.00
50_M187_I0.9751.00
174_H177_K0.9731.00
115_E118_E0.9671.00
106_K109_T0.9611.00
46_T206_L0.9521.00
217_V228_Y0.9501.00
82_I156_L0.9471.00
5_L153_V0.9461.00
163_L171_I0.9411.00
179_T201_D0.9391.00
9_N58_K0.9381.00
32_V200_C0.9371.00
133_Y141_L0.9331.00
109_T113_I0.9321.00
120_V144_A0.9291.00
168_I195_E0.9271.00
105_V149_H0.9221.00
80_G151_P0.9211.00
154_L184_M0.9161.00
203_I217_V0.9131.00
66_Q78_H0.9131.00
99_Q103_R0.9091.00
106_K110_K0.9031.00
108_V112_K0.9011.00
169_R173_D0.8981.00
102_A148_L0.8891.00
168_I192_L0.8851.00
219_D222_I0.8801.00
88_L138_R0.8791.00
7_L61_V0.8701.00
154_L186_V0.8531.00
71_E74_K0.8471.00
91_F96_K0.8461.00
110_K113_I0.8451.00
158_E191_H0.8441.00
156_L175_L0.8431.00
211_L214_I0.8381.00
130_V141_L0.8351.00
4_V29_E0.8331.00
80_G146_C0.8311.00
10_V49_M0.8311.00
29_E183_G0.8301.00
102_A109_T0.8231.00
94_G141_L0.8221.00
35_F204_A0.8191.00
229_F233_E0.8191.00
38_P207_Q0.8171.00
56_L69_T0.8161.00
129_K132_T0.8151.00
5_L50_M0.8151.00
103_R106_K0.8121.00
117_V122_L0.8101.00
82_I143_L0.8101.00
49_M61_V0.8091.00
230_F234_Q0.8051.00
54_M57_S0.8011.00
12_K45_T0.8011.00
123_T126_I0.8001.00
13_N21_D0.8001.00
51_V155_I0.7921.00
175_L186_V0.7901.00
109_T112_K0.7881.00
32_V188_V0.7851.00
125_R137_M0.7851.00
13_N19_I0.7851.00
121_G124_D0.7811.00
152_K184_M0.7801.00
116_V119_L0.7761.00
207_Q231_Q0.7761.00
114_D122_L0.7741.00
49_M54_M0.7711.00
32_V199_M0.7691.00
115_E150_D0.7691.00
110_K126_I0.7671.00
92_L97_N0.7611.00
28_R185_A0.7601.00
176_K199_M0.7571.00
173_D176_K0.7571.00
93_S97_N0.7541.00
32_V176_K0.7491.00
91_F131_K0.7441.00
133_Y137_M0.7441.00
20_I46_T0.7441.00
60_D69_T0.7441.00
13_N16_G0.7401.00
197_E217_V0.7401.00
22_D210_K0.7391.00
41_A206_L0.7381.00
23_L211_L0.7361.00
62_L65_G0.7351.00
173_D177_K0.7261.00
116_V147_L0.7241.00
22_D58_K0.7221.00
67_S71_E0.7191.00
20_I23_L0.7191.00
101_F145_Q0.7111.00
213_D223_D0.7111.00
13_N58_K0.7101.00
92_L100_Q0.7081.00
72_Y75_A0.7071.00
111_E114_D0.7061.00
172_R198_L0.7041.00
205_I220_E0.7031.00
82_I146_C0.7011.00
80_G149_H0.6971.00
9_N12_K0.6971.00
155_I187_I0.6961.00
217_V221_N0.6961.00
160_T171_I0.6921.00
4_V28_R0.6911.00
197_E221_N0.6881.00
170_E173_D0.6871.00
173_D198_L0.6871.00
98_L113_I0.6811.00
230_F233_E0.6751.00
238_A241_V0.6701.00
27_I185_A0.6701.00
33_F187_I0.6691.00
178_L184_M0.6691.00
101_F149_H0.6681.00
18_T22_D0.6671.00
188_V200_C0.6641.00
31_E214_I0.6631.00
36_L196_M0.6631.00
220_E229_F0.6621.00
27_I153_V0.6611.00
121_G177_K0.6601.00
48_R53_L0.6571.00
14_I54_M0.6561.00
193_L221_N0.6561.00
225_N229_F0.6561.00
113_I116_V0.6541.00
27_I187_I0.6541.00
50_M61_V0.6531.00
118_E124_D0.6491.00
12_K20_I0.6461.00
97_N130_V0.6451.00
200_C217_V0.6431.00
4_V63_I0.6421.00
102_A112_K0.6301.00
100_Q104_M0.6301.00
55_K69_T0.6291.00
49_M57_S0.6291.00
114_D123_T0.6271.00
64_C153_V0.6261.00
5_L63_I0.6241.00
19_I45_T0.6221.00
153_V185_A0.6211.00
36_L193_L0.6191.00
36_L205_I0.6171.00
86_P142_G0.6161.00
207_Q210_K0.6161.00
79_I153_V0.6121.00
66_Q75_A0.6051.00
26_T214_I0.6011.00
63_I78_H0.5991.00
195_E199_M0.5981.00
44_T48_R0.5971.00
213_D225_N0.5971.00
135_L140_R0.5941.00
111_E118_E0.5931.00
219_D225_N0.5921.00
231_Q234_Q0.5881.00
200_C203_I0.5881.00
134_S137_M0.5801.00
190_S195_E0.5791.00
114_D124_D0.5781.00
4_V153_V0.5761.00
30_G185_A0.5751.00
13_N17_R0.5741.00
6_E65_G0.5711.00
85_N138_R0.5711.00
171_I174_H0.5701.00
160_T195_E0.5681.00
35_F206_L0.5671.00
139_Q162_G0.5641.00
112_K119_L0.5591.00
89_Y92_L0.5581.00
75_A79_I0.5571.00
82_I142_G0.5561.00
12_K19_I0.5501.00
196_M203_I0.5501.00
72_Y76_I0.5501.00
100_Q103_R0.5461.00
60_D70_K0.5461.00
153_V187_I0.5461.00
110_K127_H0.5461.00
177_K182_R0.5441.00
52_G56_L0.5431.00
194_S198_L0.5431.00
207_Q226_D0.5431.00
175_L188_V0.5411.00
21_D208_K0.5401.00
213_D226_D0.5391.00
29_E185_A0.5381.00
179_T182_R0.5371.00
56_L61_V0.5361.00
89_Y97_N0.5351.00
39_N158_E0.5341.00
12_K15_R0.5331.00
228_Y231_Q0.5321.00
213_D220_E0.5321.00
71_E75_A0.5301.00
196_M200_C0.5291.00
235_P238_A0.5281.00
32_V201_D0.5261.00
156_L188_V0.5261.00
4_V185_A0.5261.00
188_V199_M0.5251.00
179_T184_M0.5231.00
167_G170_E0.5211.00
4_V26_T0.5201.00
10_V61_V0.5181.00
70_K73_A0.5161.00
202_R216_N0.5151.00
205_I224_E0.5141.00
207_Q228_Y0.5131.00
63_I153_V0.5121.00
7_L49_M0.5111.00
207_Q227_T0.5081.00
114_D117_V0.5081.00
122_L125_R0.5081.00
83_V86_P0.5071.00
229_F232_V0.5061.00
38_P228_Y0.5061.00
113_I126_I0.5051.00
208_K231_Q0.5051.00
147_L184_M0.5041.00
88_L130_V0.5021.00
95_Y98_L0.5011.00
127_H130_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.9115 100 0.133 Contact Map
3tuiC 2 0.9934 100 0.183 Contact Map
4u00A 1 0.7705 100 0.195 Contact Map
2oljA 2 0.7705 100 0.2 Contact Map
4rvcA 4 0.7672 100 0.206 Contact Map
2it1A 1 0.9803 100 0.206 Contact Map
2yyzA 1 0.9738 100 0.207 Contact Map
1v43A 2 0.9246 100 0.208 Contact Map
1g291 4 0.9082 100 0.208 Contact Map
3fvqA 2 0.9869 100 0.209 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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