YHCH - BACSU - GREMLIN Contacts

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YHCH - Uncharacterized ABC transporter ATP-binding protein YhcH

UniProt:	P54592	Sequences: MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKTTTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFARMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPTNGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVKDENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIRIYEVKVITKSLEDRFLEMTGETKEEVQHA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	305 (237)
Sequences:	100178 (58139)
Seq/√Len:	3776.5

ECOLI - YADG PROV METN FBPC YDCT CYSA MALK POTG YCJV POTA UGPC MACB YEHX DPPF RBSA MODC SAPD OPPD DPPD DDPD OPPF ARAG DDPF YHES PHNC GSIA FEPC MLAF TAUB UUP SAPF HISP ZNUC SSUB YECC LSRA FHUC FECE YTFR NIKE MDLB MDLA GLNQ XYLG YHDZ LPTB GLTL MSBA YPHE CYDC LIVG PHNK LIVF YOJI SUFC CYDD ARTP ALSA MODF MGLA PSTB FTSE ETTA NIKD BTUD THIQ LOLD FETA YBBA CCMA YBHF PHNL YDDA YEJF YNJD YBIT YHIH
BACSU - YHCH YCBN YDBJ YFIL YVRA OPUCA OPUAA OPUBA YVFR YXLF YHAQ METN YURJ MSMX DPPD TAGH APPD YKFD OPPD YTRB APPF OPPF YKPA YFMM RBSA YUSV YXDL FHUC YFMF YFMR ECFA1 TCYN YDIF YCLP YLMA ECSA SUNT SSUB SUFC YHEH YXEO NATA YFIC ECFA2 BCEA CYDD SKFE YTLC BMRA GLNQ YTHP YFIB YKNV TCYC ARTM YKNU YGAD YVCR YWJA YKOD YJKB YHEI ALBC FTSE PSTB1 MNTB CYDC PSTB2 YUFO YVRO YHCG YYBJ EXPZ YKNY ZNUC YCLH YYDI YTRE
HALSA - Q9HRJ6 Q9HMU8 BTUDA Q9HMX3 Q9HHQ5 Q9HR06 Q9HMW0 Q9HNZ9 Q9HMT3 Q9HMX2 Q9HRH8 Q9HMG1 Q9HMG6 PSTB2 PHNC Q9HHM2 Q9HSQ7 Q9HNY3 Y1631 Q9HRZ9 Y2317 Q9HRV7 PSTB1 Q9HHR7 Q9HS04 Q9HR96 Q9HQA8 Q9HT03 Q9HR21 Q9HMC1 Q9HMW1
SULSO - Q7LX64 Q97YY4 Q97UF2 Q97VH6 Q97UY8 Q97YK2 Q97ZC0 Q97X18 Q97VC1 Q97VF5 Q97VK8 Q97YQ7 Q97UH3 Q97YP3 Q97VK9 Q97YP8 Q97YP7 Q97UD4 Q97VF4 Q97U54 Q97UJ9 Q97Z03 Q980W0 Y2030 Q97UH4 Q7LY07 Q97V00 Y1893 Q97W42 PSTB Q97V01 Q97VM2 Q7LXM4 Q97VY4 Q7LX80 Q97Z56 Q97UG5 Q97UC2 Q97Z96 Q97YP4 Q97ZU0 Q980K5 Q980E6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
31_E	202_R	3.483	1.00
78_H	152_K	3.050	1.00
18_T	21_D	3.048	1.00
6_E	26_T	3.020	1.00
33_F	204_A	2.948	1.00
34_G	200_C	2.932	1.00
9_N	22_D	2.911	1.00
8_K	60_D	2.839	1.00
125_R	128_D	2.838	1.00
60_D	67_S	2.632	1.00
13_N	18_T	2.590	1.00
202_R	214_I	2.566	1.00
6_E	62_L	2.515	1.00
215_Q	219_D	2.462	1.00
28_R	31_E	2.436	1.00
216_N	219_D	2.352	1.00
12_K	49_M	2.315	1.00
11_T	18_T	2.273	1.00
21_D	210_K	2.255	1.00
11_T	58_K	2.203	1.00
8_K	62_L	2.132	1.00
64_C	152_K	2.113	1.00
204_A	211_L	2.105	1.00
11_T	22_D	2.090	1.00
112_K	150_D	2.070	1.00
204_A	214_I	2.006	1.00
114_D	126_I	1.966	1.00
7_L	10_V	1.957	1.00
177_K	181_E	1.925	1.00
119_L	182_R	1.923	1.00
29_E	152_K	1.850	1.00
94_G	133_Y	1.709	1.00
112_K	115_E	1.696	1.00
110_K	114_D	1.693	1.00
95_Y	126_I	1.686	1.00
95_Y	99_Q	1.656	1.00
118_E	123_T	1.649	1.00
95_Y	127_H	1.642	1.00
47_I	189_S	1.638	1.00
115_E	119_L	1.621	1.00
14_I	45_T	1.610	1.00
190_S	196_M	1.601	1.00
14_I	19_I	1.584	1.00
176_K	198_L	1.579	1.00
197_E	218_K	1.572	1.00
128_D	132_T	1.561	1.00
47_I	155_I	1.553	1.00
12_K	57_S	1.542	1.00
9_N	24_S	1.538	1.00
150_D	184_M	1.525	1.00
117_V	126_I	1.512	1.00
12_K	54_M	1.512	1.00
99_Q	109_T	1.480	1.00
119_L	181_E	1.438	1.00
33_F	214_I	1.433	1.00
215_Q	220_E	1.429	1.00
11_T	21_D	1.416	1.00
99_Q	113_I	1.413	1.00
25_F	204_A	1.403	1.00
212_I	226_D	1.383	1.00
64_C	78_H	1.382	1.00
95_Y	110_K	1.381	1.00
31_E	201_D	1.380	1.00
119_L	177_K	1.359	1.00
116_V	148_L	1.355	1.00
67_S	70_K	1.349	1.00
10_V	56_L	1.341	1.00
7_L	25_F	1.333	1.00
23_L	46_T	1.329	1.00
13_N	57_S	1.311	1.00
226_D	229_F	1.304	1.00
62_L	67_S	1.298	1.00
156_L	186_V	1.297	1.00
207_Q	212_I	1.280	1.00
28_R	202_R	1.265	1.00
111_E	115_E	1.260	1.00
27_I	33_F	1.255	1.00
98_L	117_V	1.248	1.00
150_D	182_R	1.246	1.00
219_D	223_D	1.231	1.00
114_D	118_E	1.229	1.00
34_G	196_M	1.229	1.00
4_V	64_C	1.222	1.00
93_S	96_K	1.219	1.00
99_Q	110_K	1.210	1.00
32_V	179_T	1.208	1.00
7_L	50_M	1.204	1.00
95_Y	114_D	1.187	1.00
49_M	56_L	1.182	1.00
20_I	49_M	1.177	1.00
108_V	111_E	1.162	1.00
52_G	55_K	1.161	1.00
33_F	202_R	1.157	1.00
116_V	120_V	1.141	1.00
8_K	26_T	1.139	1.00
95_Y	113_I	1.132	1.00
103_R	109_T	1.128	1.00
25_F	46_T	1.111	1.00
125_R	133_Y	1.110	1.00
92_L	96_K	1.104	1.00
227_T	231_Q	1.092	1.00
66_Q	71_E	1.084	1.00
218_K	222_I	1.073	1.00
8_K	24_S	1.071	1.00
97_N	145_Q	1.068	1.00
29_E	64_C	1.063	1.00
35_F	46_T	1.055	1.00
227_T	230_F	1.051	1.00
51_V	81_A	1.051	1.00
179_T	186_V	1.032	1.00
121_G	170_E	1.031	1.00
98_L	148_L	1.029	1.00
48_R	54_M	1.028	1.00
172_R	195_E	1.025	1.00
7_L	46_T	1.023	1.00
112_K	116_V	1.013	1.00
35_F	187_I	1.009	1.00
107_G	111_E	1.009	1.00
93_S	127_H	1.002	1.00
32_V	186_V	0.992	1.00
93_S	129_K	0.988	1.00
84_E	135_L	0.983	1.00
116_V	144_A	0.981	1.00
96_K	99_Q	0.979	1.00
176_K	179_T	0.976	1.00
50_M	187_I	0.975	1.00
174_H	177_K	0.973	1.00
115_E	118_E	0.967	1.00
106_K	109_T	0.961	1.00
46_T	206_L	0.952	1.00
217_V	228_Y	0.950	1.00
82_I	156_L	0.947	1.00
5_L	153_V	0.946	1.00
163_L	171_I	0.941	1.00
179_T	201_D	0.939	1.00
9_N	58_K	0.938	1.00
32_V	200_C	0.937	1.00
133_Y	141_L	0.933	1.00
109_T	113_I	0.932	1.00
120_V	144_A	0.929	1.00
168_I	195_E	0.927	1.00
105_V	149_H	0.922	1.00
80_G	151_P	0.921	1.00
154_L	184_M	0.916	1.00
203_I	217_V	0.913	1.00
66_Q	78_H	0.913	1.00
99_Q	103_R	0.909	1.00
106_K	110_K	0.903	1.00
108_V	112_K	0.901	1.00
169_R	173_D	0.898	1.00
102_A	148_L	0.889	1.00
168_I	192_L	0.885	1.00
219_D	222_I	0.880	1.00
88_L	138_R	0.879	1.00
7_L	61_V	0.870	1.00
154_L	186_V	0.853	1.00
71_E	74_K	0.847	1.00
91_F	96_K	0.846	1.00
110_K	113_I	0.845	1.00
158_E	191_H	0.844	1.00
156_L	175_L	0.843	1.00
211_L	214_I	0.838	1.00
130_V	141_L	0.835	1.00
4_V	29_E	0.833	1.00
80_G	146_C	0.831	1.00
10_V	49_M	0.831	1.00
29_E	183_G	0.830	1.00
102_A	109_T	0.823	1.00
94_G	141_L	0.822	1.00
35_F	204_A	0.819	1.00
229_F	233_E	0.819	1.00
38_P	207_Q	0.817	1.00
56_L	69_T	0.816	1.00
129_K	132_T	0.815	1.00
5_L	50_M	0.815	1.00
103_R	106_K	0.812	1.00
117_V	122_L	0.810	1.00
82_I	143_L	0.810	1.00
49_M	61_V	0.809	1.00
230_F	234_Q	0.805	1.00
54_M	57_S	0.801	1.00
12_K	45_T	0.801	1.00
123_T	126_I	0.800	1.00
13_N	21_D	0.800	1.00
51_V	155_I	0.792	1.00
175_L	186_V	0.790	1.00
109_T	112_K	0.788	1.00
32_V	188_V	0.785	1.00
125_R	137_M	0.785	1.00
13_N	19_I	0.785	1.00
121_G	124_D	0.781	1.00
152_K	184_M	0.780	1.00
116_V	119_L	0.776	1.00
207_Q	231_Q	0.776	1.00
114_D	122_L	0.774	1.00
49_M	54_M	0.771	1.00
32_V	199_M	0.769	1.00
115_E	150_D	0.769	1.00
110_K	126_I	0.767	1.00
92_L	97_N	0.761	1.00
28_R	185_A	0.760	1.00
176_K	199_M	0.757	1.00
173_D	176_K	0.757	1.00
93_S	97_N	0.754	1.00
32_V	176_K	0.749	1.00
91_F	131_K	0.744	1.00
133_Y	137_M	0.744	1.00
20_I	46_T	0.744	1.00
60_D	69_T	0.744	1.00
13_N	16_G	0.740	1.00
197_E	217_V	0.740	1.00
22_D	210_K	0.739	1.00
41_A	206_L	0.738	1.00
23_L	211_L	0.736	1.00
62_L	65_G	0.735	1.00
173_D	177_K	0.726	1.00
116_V	147_L	0.724	1.00
22_D	58_K	0.722	1.00
67_S	71_E	0.719	1.00
20_I	23_L	0.719	1.00
101_F	145_Q	0.711	1.00
213_D	223_D	0.711	1.00
13_N	58_K	0.710	1.00
92_L	100_Q	0.708	1.00
72_Y	75_A	0.707	1.00
111_E	114_D	0.706	1.00
172_R	198_L	0.704	1.00
205_I	220_E	0.703	1.00
82_I	146_C	0.701	1.00
80_G	149_H	0.697	1.00
9_N	12_K	0.697	1.00
155_I	187_I	0.696	1.00
217_V	221_N	0.696	1.00
160_T	171_I	0.692	1.00
4_V	28_R	0.691	1.00
197_E	221_N	0.688	1.00
170_E	173_D	0.687	1.00
173_D	198_L	0.687	1.00
98_L	113_I	0.681	1.00
230_F	233_E	0.675	1.00
238_A	241_V	0.670	1.00
27_I	185_A	0.670	1.00
33_F	187_I	0.669	1.00
178_L	184_M	0.669	1.00
101_F	149_H	0.668	1.00
18_T	22_D	0.667	1.00
188_V	200_C	0.664	1.00
31_E	214_I	0.663	1.00
36_L	196_M	0.663	1.00
220_E	229_F	0.662	1.00
27_I	153_V	0.661	1.00
121_G	177_K	0.660	1.00
48_R	53_L	0.657	1.00
14_I	54_M	0.656	1.00
193_L	221_N	0.656	1.00
225_N	229_F	0.656	1.00
113_I	116_V	0.654	1.00
27_I	187_I	0.654	1.00
50_M	61_V	0.653	1.00
118_E	124_D	0.649	1.00
12_K	20_I	0.646	1.00
97_N	130_V	0.645	1.00
200_C	217_V	0.643	1.00
4_V	63_I	0.642	1.00
102_A	112_K	0.630	1.00
100_Q	104_M	0.630	1.00
55_K	69_T	0.629	1.00
49_M	57_S	0.629	1.00
114_D	123_T	0.627	1.00
64_C	153_V	0.626	1.00
5_L	63_I	0.624	1.00
19_I	45_T	0.622	1.00
153_V	185_A	0.621	1.00
36_L	193_L	0.619	1.00
36_L	205_I	0.617	1.00
86_P	142_G	0.616	1.00
207_Q	210_K	0.616	1.00
79_I	153_V	0.612	1.00
66_Q	75_A	0.605	1.00
26_T	214_I	0.601	1.00
63_I	78_H	0.599	1.00
195_E	199_M	0.598	1.00
44_T	48_R	0.597	1.00
213_D	225_N	0.597	1.00
135_L	140_R	0.594	1.00
111_E	118_E	0.593	1.00
219_D	225_N	0.592	1.00
231_Q	234_Q	0.588	1.00
200_C	203_I	0.588	1.00
134_S	137_M	0.580	1.00
190_S	195_E	0.579	1.00
114_D	124_D	0.578	1.00
4_V	153_V	0.576	1.00
30_G	185_A	0.575	1.00
13_N	17_R	0.574	1.00
6_E	65_G	0.571	1.00
85_N	138_R	0.571	1.00
171_I	174_H	0.570	1.00
160_T	195_E	0.568	1.00
35_F	206_L	0.567	1.00
139_Q	162_G	0.564	1.00
112_K	119_L	0.559	1.00
89_Y	92_L	0.558	1.00
75_A	79_I	0.557	1.00
82_I	142_G	0.556	1.00
12_K	19_I	0.550	1.00
196_M	203_I	0.550	1.00
72_Y	76_I	0.550	1.00
100_Q	103_R	0.546	1.00
60_D	70_K	0.546	1.00
153_V	187_I	0.546	1.00
110_K	127_H	0.546	1.00
177_K	182_R	0.544	1.00
52_G	56_L	0.543	1.00
194_S	198_L	0.543	1.00
207_Q	226_D	0.543	1.00
175_L	188_V	0.541	1.00
21_D	208_K	0.540	1.00
213_D	226_D	0.539	1.00
29_E	185_A	0.538	1.00
179_T	182_R	0.537	1.00
56_L	61_V	0.536	1.00
89_Y	97_N	0.535	1.00
39_N	158_E	0.534	1.00
12_K	15_R	0.533	1.00
228_Y	231_Q	0.532	1.00
213_D	220_E	0.532	1.00
71_E	75_A	0.530	1.00
196_M	200_C	0.529	1.00
235_P	238_A	0.528	1.00
32_V	201_D	0.526	1.00
156_L	188_V	0.526	1.00
4_V	185_A	0.526	1.00
188_V	199_M	0.525	1.00
179_T	184_M	0.523	1.00
167_G	170_E	0.521	1.00
4_V	26_T	0.520	1.00
10_V	61_V	0.518	1.00
70_K	73_A	0.516	1.00
202_R	216_N	0.515	1.00
205_I	224_E	0.514	1.00
207_Q	228_Y	0.513	1.00
63_I	153_V	0.512	1.00
7_L	49_M	0.511	1.00
207_Q	227_T	0.508	1.00
114_D	117_V	0.508	1.00
122_L	125_R	0.508	1.00
83_V	86_P	0.507	1.00
229_F	232_V	0.506	1.00
38_P	228_Y	0.506	1.00
113_I	126_I	0.505	1.00
208_K	231_Q	0.505	1.00
147_L	184_M	0.504	1.00
88_L	130_V	0.502	1.00
95_Y	98_L	0.501	1.00
127_H	130_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4yerA	2	0.9115	100	0.133	Contact Map
3tuiC	2	0.9934	100	0.183	Contact Map
4u00A	1	0.7705	100	0.195	Contact Map
2oljA	2	0.7705	100	0.2	Contact Map
4rvcA	4	0.7672	100	0.206	Contact Map
2it1A	1	0.9803	100	0.206	Contact Map
2yyzA	1	0.9738	100	0.207	Contact Map
1v43A	2	0.9246	100	0.208	Contact Map
1g291	4	0.9082	100	0.208	Contact Map
3fvqA	2	0.9869	100	0.209	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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