GREMLIN Database
YHCB - Uncharacterized protein YhcB
UniProt: P54586 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 176 (171)
Sequences: 2595 (1456)
Seq/√Len: 111.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_R167_Q3.0891.00
27_E163_R2.9511.00
53_I165_V2.8451.00
89_A161_L2.8161.00
8_D64_S2.6181.00
17_L158_G2.5761.00
103_M106_H2.4041.00
22_A26_R2.3841.00
23_E159_R2.2261.00
15_K19_E2.1371.00
53_I89_A2.0981.00
87_V172_L2.0791.00
25_A33_V2.0711.00
74_L115_Q1.9751.00
152_E156_Q1.9401.00
162_G166_S1.9371.00
89_A165_V1.9311.00
77_L82_E1.8581.00
24_G162_G1.8041.00
27_E159_R1.8001.00
88_G112_M1.7991.00
56_C64_S1.7731.00
92_C139_G1.7581.00
3_I51_A1.7491.00
84_I125_N1.7481.00
4_Y49_M1.7351.00
122_L157_L1.7281.00
2_K32_E1.7131.00
20_A159_R1.7011.00
134_S139_G1.6861.00
120_V168_V1.6821.00
47_K77_L1.6661.00
47_K82_E1.6541.00
68_K111_P1.6411.00
90_V108_L1.6221.00
138_A161_L1.6041.00
34_F45_K1.5711.00
38_V67_L1.5321.00
44_R47_K1.5171.00
113_F121_G1.4711.00
20_A155_I1.4551.00
20_A23_E1.4501.00
85_N164_R1.4341.00
55_G91_F1.4111.00
68_K72_D1.4011.00
109_I113_F1.3711.00
21_I91_F1.3701.00
54_W108_L1.3571.00
17_L138_A1.3491.00
16_V19_E1.3481.00
56_C108_L1.3401.00
16_V155_I1.3351.00
81_G84_I1.3161.00
34_F49_M1.3100.99
87_V165_V1.3070.99
88_G117_M1.3050.99
94_T101_L1.2980.99
167_Q171_N1.2190.99
4_Y36_D1.1990.99
7_Y15_K1.1980.99
89_A138_A1.1940.99
92_C105_M1.1910.99
169_T173_T1.1870.99
93_T142_C1.1790.99
126_V157_L1.1640.99
62_T107_N1.1640.99
85_N167_Q1.1600.99
5_V22_A1.1600.99
52_I117_M1.1480.99
150_M155_I1.1370.99
168_V172_L1.1290.98
113_F119_V1.0890.98
25_A166_S1.0850.98
155_I159_R1.0830.98
44_R48_D1.0720.98
36_D45_K1.0710.98
24_G166_S1.0660.98
77_L83_L1.0660.98
95_A144_V1.0650.98
158_G162_G1.0550.98
26_R33_V1.0370.97
63_I108_L1.0370.97
23_E26_R1.0340.97
42_D45_K1.0330.97
131_L153_E1.0260.97
58_G104_T1.0190.97
41_A45_K1.0100.97
28_N166_S1.0070.97
46_L74_L1.0030.97
87_V169_T1.0010.97
5_V25_A0.9970.97
65_S69_T0.9940.97
94_T141_T0.9930.97
29_D170_G0.9870.96
21_I24_G0.9850.96
45_K48_D0.9800.96
51_A165_V0.9790.96
131_L151_S0.9710.96
3_I25_A0.9670.96
143_P146_S0.9660.96
90_V109_I0.9590.96
3_I166_S0.9590.96
43_I73_R0.9580.96
63_I68_K0.9560.96
66_G72_D0.9550.96
71_I111_P0.9480.95
17_L140_V0.9390.95
23_E27_E0.9340.95
151_S154_G0.9330.95
26_R32_E0.9330.95
19_E26_R0.9320.95
62_T111_P0.9270.95
152_E155_I0.9200.95
62_T68_K0.9180.95
90_V105_M0.9180.95
67_L71_I0.9170.95
28_N170_G0.9110.94
50_D173_T0.9000.94
106_H136_Y0.8960.94
21_I162_G0.8950.94
28_N167_Q0.8900.94
90_V119_V0.8800.93
47_K80_E0.8740.93
161_L165_V0.8720.93
140_V150_M0.8680.93
69_T73_R0.8670.93
90_V112_M0.8600.93
103_M107_N0.8600.93
18_A91_F0.8570.92
63_I111_P0.8540.92
118_I168_V0.8460.92
160_A164_R0.8430.92
15_K37_H0.8360.91
30_A166_S0.8350.91
63_I107_N0.8310.91
56_C63_I0.8280.91
22_A35_I0.8110.90
87_V168_V0.8010.90
128_E153_E0.7980.89
87_V118_I0.7920.89
65_S72_D0.7920.89
112_M117_M0.7900.89
105_M108_L0.7880.89
107_N110_T0.7790.88
43_I47_K0.7750.88
102_E110_T0.7690.88
25_A30_A0.7670.87
51_A87_V0.7580.87
159_R163_R0.7580.87
22_A33_V0.7570.87
43_I77_L0.7560.87
19_E35_I0.7510.86
19_E22_A0.7490.86
6_V41_A0.7440.86
43_I74_L0.7420.86
24_G158_G0.7380.85
19_E23_E0.7360.85
20_A24_G0.7360.85
131_L139_G0.7280.85
123_P164_R0.7270.85
58_G94_T0.7230.84
125_N160_A0.7180.84
156_Q159_R0.7160.84
21_I161_L0.7140.83
113_F123_P0.7080.83
118_I171_N0.7000.82
54_W71_I0.6990.82
16_V149_L0.6960.82
126_V160_A0.6960.82
2_K48_D0.6900.81
120_V165_V0.6830.81
56_C62_T0.6770.80
3_I169_T0.6750.80
109_I119_V0.6740.80
21_I158_G0.6740.80
114_H136_Y0.6690.79
75_G79_A0.6650.79
34_F48_D0.6640.79
46_L83_L0.6640.79
38_V41_A0.6640.79
37_H40_Q0.6610.79
52_I88_G0.6610.79
14_T91_F0.6590.78
48_D152_E0.6540.78
21_I138_A0.6500.77
156_Q160_A0.6410.76
118_I121_G0.6410.76
70_W74_L0.6370.76
6_V36_D0.6270.75
54_W90_V0.6230.74
102_E136_Y0.6220.74
57_P104_T0.6200.74
14_T56_C0.6190.74
36_D49_M0.6170.74
98_H139_G0.6150.73
102_E106_H0.6140.73
26_R29_D0.6080.73
4_Y41_A0.6070.72
6_V49_M0.6030.72
14_T55_G0.6020.72
46_L52_I0.5960.71
148_E151_S0.5950.71
66_G69_T0.5940.71
8_D40_Q0.5930.71
27_E30_A0.5910.70
7_Y10_E0.5890.70
10_E40_Q0.5870.70
21_I53_I0.5860.70
122_L138_A0.5810.69
81_G116_G0.5770.69
126_V164_R0.5760.68
59_H94_T0.5740.68
36_D41_A0.5740.68
98_H102_E0.5730.68
9_S12_E0.5710.68
11_G40_Q0.5700.68
13_H140_V0.5690.68
43_I76_Y0.5650.67
46_L70_W0.5630.67
63_I67_L0.5620.67
8_D66_G0.5600.66
51_A169_T0.5590.66
70_W115_Q0.5580.66
142_C155_I0.5560.66
169_T172_L0.5550.66
106_H110_T0.5530.65
40_Q50_D0.5520.65
111_P115_Q0.5500.65
97_T141_T0.5490.65
76_Y80_E0.5480.65
129_N153_E0.5480.65
2_K34_F0.5470.65
168_V171_N0.5450.64
98_H131_L0.5450.64
56_C90_V0.5430.64
71_I107_N0.5430.64
164_R168_V0.5410.64
53_I87_V0.5410.64
40_Q66_G0.5410.64
30_A170_G0.5410.64
102_E134_S0.5370.63
114_H135_Y0.5360.63
161_L164_R0.5360.63
14_T53_I0.5320.62
21_I55_G0.5300.62
56_C92_C0.5280.62
74_L77_L0.5280.62
150_M154_G0.5160.60
101_L141_T0.5140.60
118_I172_L0.5120.59
44_R77_L0.5080.59
131_L141_T0.5050.58
56_C115_Q0.5040.58
106_H109_I0.5020.58
71_I74_L0.5010.58
41_A44_R0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d7nA 4 0.858 100 0.449 Contact Map
4lafA 4 0.9943 100 0.466 Contact Map
2a5lA 4 0.9489 100 0.471 Contact Map
3zhoA 4 0.9602 100 0.472 Contact Map
1ydgA 4 0.9773 100 0.479 Contact Map
2zkiA 7 0.9716 100 0.494 Contact Map
2arkA 4 0.9375 100 0.52 Contact Map
2q62A 4 0.9261 99.9 0.592 Contact Map
2fzvA 5 0.9261 99.9 0.6 Contact Map
3svlA 4 0.9034 99.9 0.614 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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