GREMLIN Database
YHCA - Uncharacterized MFS-type transporter YhcA
UniProt: P54585 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 532 (427)
Sequences: 36135 (25975)
Seq/√Len: 1257.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_P104_T5.5841.00
90_T178_G4.4401.00
88_C115_G3.8891.00
97_G172_Y3.7341.00
95_V108_G3.3861.00
103_S107_I3.2351.00
211_G243_I3.0661.00
207_L249_Q3.0421.00
348_Q364_I2.9771.00
101_N104_T2.8591.00
387_L395_G2.8591.00
78_Q129_L2.7881.00
12_P135_S2.6091.00
57_G110_L2.5481.00
318_M370_F2.5171.00
261_R391_L2.5101.00
314_V366_S2.4421.00
210_V242_A2.4331.00
46_V102_F2.4101.00
300_T303_Q2.4051.00
218_G236_V2.3991.00
276_I406_S2.3701.00
61_V110_L2.3391.00
83_L186_F2.3301.00
165_Y169_I2.2761.00
203_L249_Q2.2761.00
215_L239_G2.2641.00
92_G115_G2.2361.00
96_C108_G2.1881.00
65_L114_V2.1761.00
280_V410_G2.1311.00
47_S50_T2.0871.00
345_T368_R2.0541.00
135_S138_K2.0331.00
83_L182_I2.0301.00
183_I187_F2.0241.00
92_G111_I2.0041.00
259_D391_L1.9841.00
388_P391_L1.9831.00
161_I169_I1.9621.00
233_L237_I1.9611.00
284_T414_I1.9441.00
104_T108_G1.9311.00
222_A227_W1.9291.00
244_V248_V1.9061.00
185_A189_F1.8851.00
201_D204_G1.8771.00
85_A118_I1.8651.00
20_M146_A1.8541.00
57_G106_L1.7821.00
50_T102_F1.7811.00
102_F106_L1.7651.00
92_G108_G1.7511.00
36_A162_I1.7501.00
96_C105_M1.7491.00
69_S118_I1.7451.00
94_L98_I1.7381.00
294_Q304_S1.7221.00
292_Y297_V1.7211.00
166_T169_I1.7121.00
16_L131_F1.7101.00
22_G82_F1.7071.00
131_F139_G1.7051.00
214_S235_T1.7041.00
163_E302_L1.6821.00
211_G239_G1.6801.00
99_A104_T1.6711.00
338_G374_L1.6491.00
324_I328_K1.6371.00
359_T363_L1.6351.00
74_T393_S1.6231.00
283_Y407_G1.6141.00
79_R83_L1.6111.00
253_H256_P1.5971.00
137_G327_D1.5881.00
94_L175_V1.5691.00
132_P135_S1.5681.00
24_F150_A1.5631.00
357_P360_H1.5501.00
99_A108_G1.5431.00
345_T371_G1.5271.00
345_T364_I1.5241.00
46_V50_T1.5201.00
341_V371_G1.5141.00
36_A170_M1.5091.00
169_I176_P1.5031.00
249_Q253_H1.5011.00
93_T174_L1.5001.00
73_I78_Q1.4931.00
72_L81_L1.4921.00
234_S238_I1.4771.00
39_H42_T1.4741.00
15_L130_I1.4731.00
54_L105_M1.4691.00
214_S242_A1.4671.00
83_L185_A1.4611.00
211_G242_A1.4611.00
269_S273_V1.4541.00
299_F307_L1.4521.00
314_V318_M1.4471.00
41_M51_I1.4381.00
199_K255_D1.4111.00
80_S191_N1.3991.00
202_T206_I1.3951.00
333_P336_I1.3901.00
343_V347_Y1.3891.00
64_V209_I1.3881.00
91_L95_V1.3781.00
128_L136_R1.3761.00
87_F182_I1.3711.00
303_Q306_L1.3611.00
299_F303_Q1.3541.00
214_S238_I1.3531.00
73_I122_L1.3501.00
251_L261_R1.3481.00
90_T182_I1.3471.00
29_N32_L1.3371.00
184_V188_I1.3361.00
95_V104_T1.3361.00
84_V88_C1.3341.00
323_G327_D1.3331.00
230_P234_S1.3301.00
221_E224_S1.3301.00
263_F269_S1.3261.00
58_Y116_G1.3201.00
32_L170_M1.3191.00
163_E300_T1.3151.00
133_P136_R1.3141.00
65_L117_G1.3061.00
218_G239_G1.3041.00
358_Y362_M1.3041.00
271_S383_G1.3011.00
217_Y221_E1.2881.00
13_M17_I1.2871.00
311_G369_A1.2661.00
207_L242_A1.2581.00
342_T371_G1.2571.00
71_F75_R1.2481.00
18_V188_I1.2271.00
18_V181_V1.2261.00
61_V113_A1.2201.00
12_P131_F1.2191.00
21_A181_V1.2181.00
261_R264_K1.2181.00
103_S106_L1.2161.00
248_V251_L1.2151.00
247_V251_L1.2111.00
293_L361_I1.2091.00
72_L76_F1.2031.00
20_M142_I1.1991.00
160_W164_H1.1871.00
78_Q191_N1.1811.00
340_L344_V1.1781.00
53_W57_G1.1751.00
218_G232_V1.1751.00
221_E225_D1.1741.00
90_T175_V1.1691.00
246_F250_Q1.1611.00
428_Q432_K1.1541.00
330_G333_P1.1541.00
79_R186_F1.1511.00
179_A183_I1.1501.00
421_R425_H1.1351.00
88_C92_G1.1341.00
347_Y351_Q1.1341.00
324_I327_D1.1341.00
363_L366_S1.1311.00
247_V260_F1.1291.00
238_I242_A1.1281.00
18_V184_V1.1261.00
266_D270_L1.1261.00
272_S402_L1.1251.00
27_I147_M1.1211.00
359_T362_M1.1171.00
345_T367_I1.1151.00
29_N174_L1.1111.00
248_V252_R1.1081.00
239_G243_I1.1071.00
338_G375_L1.1041.00
322_S374_L1.1011.00
96_C171_F1.1011.00
70_A74_T1.1011.00
83_L87_F1.0901.00
175_V179_A1.0891.00
184_V187_F1.0871.00
160_W302_L1.0851.00
204_G249_Q1.0841.00
197_K201_D1.0831.00
82_F185_A1.0811.00
318_M373_S1.0781.00
98_I172_Y1.0711.00
207_L245_A1.0701.00
347_Y350_T1.0621.00
90_T94_L1.0591.00
425_H429_I1.0551.00
353_T356_T1.0541.00
332_R336_I1.0541.00
337_I374_L1.0531.00
95_V98_I1.0481.00
245_A248_V1.0441.00
74_T78_Q1.0421.00
134_E138_K1.0421.00
278_I375_L1.0411.00
333_P337_I1.0351.00
293_L307_L1.0341.00
210_V214_S1.0301.00
243_I247_V1.0301.00
325_L329_F1.0291.00
19_L123_V1.0291.00
107_I111_I1.0221.00
259_D394_H1.0181.00
32_L158_S1.0151.00
265_Y269_S1.0121.00
77_G80_S1.0091.00
268_F272_S1.0081.00
338_G371_G1.0071.00
127_I143_F1.0031.00
164_H302_L1.0031.00
159_G301_A1.0021.00
182_I186_F1.0021.00
25_L178_G1.0001.00
421_R424_F0.9981.00
303_Q307_L0.9981.00
423_T427_S0.9971.00
100_P103_S0.9971.00
104_T107_I0.9901.00
68_L205_A0.9871.00
363_L367_I0.9831.00
183_I186_F0.9821.00
228_T233_L0.9811.00
82_F126_T0.9801.00
268_F395_G0.9791.00
14_S188_I0.9791.00
360_H364_I0.9781.00
383_G399_S0.9741.00
86_M181_V0.9711.00
425_H428_Q0.9701.00
348_Q351_Q0.9691.00
157_L160_W0.9671.00
161_I165_Y0.9661.00
225_D231_I0.9661.00
236_V240_A0.9651.00
218_G235_T0.9631.00
128_L392_N0.9621.00
360_H363_L0.9591.00
289_L365_Y0.9561.00
307_L358_Y0.9561.00
406_S410_G0.9551.00
321_I324_I0.9541.00
39_H43_E0.9531.00
161_I173_G0.9501.00
204_G253_H0.9451.00
206_I210_V0.9451.00
61_V65_L0.9441.00
100_P168_R0.9371.00
80_S84_V0.9361.00
240_A244_V0.9321.00
294_Q301_A0.9311.00
30_Q59_M0.9291.00
265_Y391_L0.9281.00
40_L105_M0.9281.00
231_I235_T0.9221.00
288_L415_T0.9171.00
275_N399_S0.9161.00
318_M374_L0.9161.00
37_M51_I0.9151.00
227_W232_V0.9131.00
84_V87_F0.9121.00
272_S398_M0.9111.00
320_P324_I0.9071.00
33_L54_L0.9071.00
54_L102_F0.9051.00
176_P179_A0.8981.00
318_M321_I0.8971.00
93_T112_Q0.8961.00
43_E168_R0.8951.00
57_G61_V0.8931.00
413_L416_T0.8931.00
432_K436_A0.8931.00
351_Q364_I0.8911.00
276_I402_L0.8901.00
100_P108_G0.8881.00
129_L392_N0.8881.00
176_P180_I0.8841.00
13_M131_F0.8821.00
417_I421_R0.8791.00
318_M322_S0.8791.00
428_Q431_D0.8781.00
74_T394_H0.8771.00
98_I108_G0.8751.00
168_R172_Y0.8731.00
337_I341_V0.8691.00
81_L84_V0.8631.00
249_Q252_R0.8611.00
200_L205_A0.8611.00
258_L398_M0.8581.00
307_L362_M0.8561.00
123_V143_F0.8561.00
265_Y388_P0.8521.00
266_D269_S0.8501.00
80_S83_L0.8501.00
169_I172_Y0.8481.00
90_T179_A0.8481.00
107_I110_L0.8471.00
159_G305_G0.8451.00
85_A115_G0.8401.00
362_M366_S0.8401.00
352_L356_T0.8341.00
293_L297_V0.8321.00
199_K202_T0.8321.00
311_G368_R0.8321.00
307_L310_P0.8321.00
137_G141_G0.8311.00
81_L118_I0.8301.00
55_T287_F0.8301.00
76_F81_L0.8281.00
231_I234_S0.8271.00
410_G413_L0.8271.00
424_F428_Q0.8261.00
219_V222_A0.8241.00
63_G408_S0.8191.00
216_L408_S0.8191.00
26_A119_L0.8191.00
46_V51_I0.8181.00
56_T220_S0.8151.00
293_L299_F0.8101.00
210_V238_I0.8101.00
209_I213_A0.8101.00
78_Q125_T0.8081.00
152_A312_A0.8071.00
346_T368_R0.8061.00
205_A209_I0.8011.00
43_E167_W0.8001.00
92_G95_V0.7981.00
28_L32_L0.7971.00
251_L260_F0.7951.00
137_G323_G0.7951.00
431_D434_S0.7941.00
214_S239_G0.7941.00
37_M55_T0.7931.00
187_F190_K0.7921.00
336_I343_V0.7891.00
425_H432_K0.7881.00
339_L375_L0.7881.00
340_L343_V0.7881.00
268_F383_G0.7861.00
306_L310_P0.7861.00
356_T360_H0.7851.00
50_T103_S0.7851.00
79_R191_N0.7841.00
244_V247_V0.7841.00
70_A397_A0.7831.00
241_I245_A0.7801.00
334_L337_I0.7801.00
36_A40_L0.7781.00
426_Y429_I0.7781.00
154_G158_S0.7781.00
344_V348_Q0.7761.00
211_G247_V0.7761.00
191_N194_E0.7731.00
22_G119_L0.7721.00
60_L408_S0.7721.00
225_D229_D0.7721.00
158_S162_I0.7701.00
325_L334_L0.7691.00
73_I125_T0.7651.00
223_G226_G0.7641.00
96_C99_A0.7621.00
267_I386_Q0.7601.00
245_A249_Q0.7591.00
23_L147_M0.7591.00
145_L149_F0.7581.00
125_T393_S0.7571.00
313_I317_I0.7561.00
136_R385_N0.7551.00
422_T426_Y0.7551.00
217_Y235_T0.7521.00
232_V235_T0.7501.00
336_I340_L0.7481.00
229_D232_V0.7471.00
429_I432_K0.7461.00
337_I340_L0.7411.00
138_K324_I0.7411.00
326_F378_P0.7391.00
290_P304_S0.7391.00
210_V213_A0.7391.00
163_E301_A0.7381.00
29_N109_R0.7341.00
274_I339_L0.7331.00
61_V114_V0.7331.00
67_P208_S0.7311.00
95_V111_I0.7291.00
212_F401_T0.7281.00
341_V370_F0.7251.00
126_T130_I0.7231.00
204_G250_Q0.7221.00
291_I295_N0.7191.00
346_T350_T0.7191.00
265_Y386_Q0.7191.00
27_I150_A0.7181.00
94_L172_Y0.7181.00
127_I139_G0.7141.00
64_V213_A0.7131.00
196_Q200_L0.7131.00
18_V185_A0.7111.00
69_S85_A0.7101.00
24_F146_A0.7091.00
236_V239_G0.7091.00
108_G111_I0.7081.00
322_S373_S0.7081.00
22_G86_M0.7071.00
87_F91_L0.7061.00
78_Q192_M0.7031.00
62_N404_Q0.7011.00
264_K269_S0.6981.00
124_M143_F0.6981.00
238_I245_A0.6961.00
89_F115_G0.6921.00
329_F334_L0.6901.00
198_I255_D0.6901.00
86_M182_I0.6901.00
97_G168_R0.6891.00
40_L51_I0.6891.00
34_N55_T0.6881.00
79_R190_K0.6871.00
339_L343_V0.6871.00
317_I320_P0.6871.00
203_L206_I0.6871.00
427_S431_D0.6811.00
374_L378_P0.6801.00
299_F358_Y0.6801.00
203_L207_L0.6791.00
40_L44_F0.6771.00
13_M139_G0.6751.00
199_K254_D0.6751.00
242_A245_A0.6741.00
229_D234_S0.6731.00
172_Y176_P0.6731.00
314_V370_F0.6731.00
344_V347_Y0.6701.00
384_M396_T0.6691.00
148_M315_M0.6681.00
400_N403_R0.6681.00
225_D232_V0.6661.00
228_T231_I0.6651.00
31_T151_P0.6631.00
237_I241_I0.6611.00
208_S212_F0.6611.00
138_K327_D0.6591.00
172_Y175_V0.6581.00
431_D435_T0.6571.00
11_N14_S0.6561.00
240_A243_I0.6551.00
427_S432_K0.6541.00
140_M381_T0.6541.00
200_L204_G0.6501.00
212_F405_I0.6501.00
272_S399_S0.6501.00
65_L68_L0.6461.00
222_A226_G0.6451.00
51_I54_L0.6441.00
208_S257_M0.6441.00
162_I170_M0.6411.00
19_L130_I0.6411.00
197_K200_L0.6381.00
138_K142_I0.6371.00
15_L18_V0.6341.00
74_T77_G0.6331.00
268_F387_L0.6301.00
140_M144_G0.6301.00
329_F333_P0.6301.00
62_N116_G0.6281.00
384_M392_N0.6281.00
251_L264_K0.6281.00
234_S237_I0.6271.00
29_N89_F0.6261.00
147_M151_P0.6251.00
348_Q360_H0.6231.00
141_G145_L0.6221.00
256_P259_D0.6211.00
380_M399_S0.6211.00
422_T427_S0.6201.00
59_M407_G0.6191.00
205_A257_M0.6181.00
92_G112_Q0.6171.00
44_F102_F0.6161.00
128_L140_M0.6151.00
310_P314_V0.6141.00
93_T175_V0.6131.00
203_L253_H0.6131.00
24_F153_V0.6121.00
211_G214_S0.6111.00
434_S437_D0.6101.00
267_I382_A0.6061.00
341_V367_I0.6061.00
199_K203_L0.6051.00
96_C112_Q0.6051.00
129_L192_M0.6051.00
11_N190_K0.6011.00
150_A154_G0.6001.00
130_I190_K0.5971.00
221_E231_I0.5961.00
287_F411_T0.5951.00
429_I433_T0.5941.00
153_V156_T0.5941.00
109_R112_Q0.5931.00
330_G334_L0.5921.00
221_E232_V0.5921.00
211_G215_L0.5921.00
321_I325_L0.5911.00
292_Y296_L0.5901.00
431_D437_D0.5901.00
306_L309_L0.5901.00
64_V205_A0.5891.00
75_R199_K0.5891.00
196_Q199_K0.5891.00
41_M47_S0.5891.00
42_T45_G0.5881.00
342_T345_T0.5871.00
126_T189_F0.5871.00
40_L43_E0.5861.00
63_G405_I0.5861.00
41_M48_A0.5851.00
230_P233_L0.5851.00
28_L174_L0.5851.00
325_L328_K0.5841.00
274_I379_V0.5831.00
300_T304_S0.5821.00
412_S416_T0.5821.00
310_P362_M0.5791.00
29_N173_G0.5791.00
162_I166_T0.5791.00
82_F123_V0.5781.00
41_M46_V0.5781.00
229_D233_L0.5781.00
25_L29_N0.5771.00
381_T385_N0.5771.00
150_A155_P0.5761.00
267_I271_S0.5761.00
149_F153_V0.5751.00
134_E137_G0.5721.00
285_G368_R0.5721.00
59_M408_S0.5711.00
161_I170_M0.5701.00
198_I202_T0.5681.00
276_I409_I0.5681.00
336_I339_L0.5671.00
86_M185_A0.5661.00
246_F258_L0.5661.00
76_F80_S0.5661.00
269_S272_S0.5661.00
270_L273_V0.5651.00
70_A393_S0.5631.00
156_T309_L0.5621.00
362_M365_Y0.5621.00
134_E327_D0.5621.00
64_V117_G0.5611.00
263_F268_F0.5611.00
326_F330_G0.5581.00
338_G378_P0.5561.00
267_I270_L0.5551.00
408_S412_S0.5521.00
177_I180_I0.5521.00
66_I400_N0.5521.00
218_G222_A0.5501.00
364_I367_I0.5501.00
98_I104_T0.5501.00
19_L126_T0.5501.00
192_M195_P0.5481.00
13_M138_K0.5481.00
211_G244_V0.5471.00
162_I165_Y0.5471.00
73_I393_S0.5461.00
326_F381_T0.5451.00
275_N379_V0.5451.00
14_S17_I0.5451.00
40_L162_I0.5441.00
131_F135_S0.5441.00
146_A150_A0.5431.00
121_P124_M0.5431.00
416_T419_T0.5431.00
349_Y352_L0.5421.00
29_N93_T0.5411.00
348_Q363_L0.5411.00
334_L374_L0.5391.00
352_L364_I0.5381.00
128_L384_M0.5381.00
32_L35_V0.5361.00
144_G148_M0.5341.00
63_G404_Q0.5321.00
58_Y109_R0.5321.00
174_L178_G0.5311.00
415_T419_T0.5311.00
200_L203_L0.5311.00
180_I184_V0.5271.00
392_N396_T0.5251.00
239_G242_A0.5251.00
25_L174_L0.5241.00
125_T396_T0.5241.00
16_L139_G0.5241.00
75_R197_K0.5241.00
39_H162_I0.5221.00
148_M319_S0.5221.00
279_T403_R0.5221.00
433_T436_A0.5221.00
366_S370_F0.5201.00
227_W233_L0.5201.00
88_C114_V0.5201.00
46_V106_L0.5191.00
145_L148_M0.5181.00
138_K141_G0.5161.00
33_L40_L0.5141.00
22_G181_V0.5141.00
311_G365_Y0.5141.00
207_L211_G0.5141.00
26_A116_G0.5141.00
375_L379_V0.5131.00
349_Y365_Y0.5131.00
15_L126_T0.5131.00
24_F28_L0.5131.00
69_S121_P0.5111.00
428_Q436_A0.5111.00
222_A232_V0.5111.00
424_F427_S0.5111.00
427_S433_T0.5091.00
54_L57_G0.5091.00
345_T348_Q0.5081.00
86_M178_G0.5081.00
302_L306_L0.5081.00
159_G302_L0.5081.00
426_Y433_T0.5071.00
186_F190_K0.5071.00
222_A225_D0.5071.00
191_N195_P0.5071.00
416_T420_N0.5071.00
351_Q360_H0.5021.00
427_S435_T0.5021.00
314_V362_M0.5021.00
335_A378_P0.5001.00
110_L114_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.7801 100 0.45 Contact Map
4pypA 1 0.7782 100 0.463 Contact Map
3wdoA 1 0.844 100 0.466 Contact Map
4j05A 3 0.718 100 0.466 Contact Map
2gfpA 2 0.7049 100 0.485 Contact Map
4gc0A 1 0.8139 100 0.496 Contact Map
4zw9A 1 0.8195 100 0.496 Contact Map
3o7qA 1 0.7218 100 0.504 Contact Map
4tphA 2 0.7932 100 0.507 Contact Map
4w6vA 1 0.8177 100 0.513 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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