GREMLIN Database
MCPC - Methyl-accepting chemotaxis protein McpC
UniProt: P54576 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 655 (614)
Sequences: 7179 (6173)
Seq/√Len: 249.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
327_S332_G6.0481.00
322_R346_K3.9311.00
8_K329_D3.6781.00
6_H298_K3.4181.00
26_L30_L3.3801.00
140_A174_V3.3641.00
329_D332_G3.2361.00
313_A318_D3.1291.00
199_K266_Q2.9031.00
170_D173_K2.8111.00
311_T341_M2.6291.00
108_Y179_S2.5711.00
312_K333_I2.5621.00
463_D537_E2.4931.00
390_G607_I2.4571.00
450_A555_Q2.4161.00
297_A301_T2.4051.00
466_N469_K2.3771.00
493_S514_R2.3601.00
203_F259_G2.3551.00
250_T257_K2.3541.00
280_W284_I2.3421.00
460_M541_A2.3281.00
276_R280_W2.3221.00
476_T480_N2.2691.00
322_R339_N2.2601.00
560_H564_E2.2461.00
546_V550_R2.1851.00
467_Q533_L2.1671.00
322_R343_E2.1521.00
28_S278_N2.1401.00
472_E535_Q2.1291.00
95_K99_D2.1101.00
470_N473_E2.1101.00
467_Q537_E2.1101.00
137_K141_E2.1081.00
163_T181_D2.1061.00
298_K302_G2.0951.00
307_L311_T2.0671.00
493_S511_D2.0541.00
111_T115_E2.0381.00
436_G566_L2.0031.00
201_F215_P1.9971.00
474_V530_T1.9911.00
515_K518_E1.9751.00
313_A321_V1.9651.00
314_V341_M1.9571.00
414_Q417_E1.9491.00
154_D157_T1.9491.00
511_D514_R1.9441.00
477_A523_S1.9381.00
636_T639_L1.9221.00
196_V200_G1.9091.00
465_E542_S1.9061.00
520_S524_T1.9031.00
422_I580_I1.8861.00
229_Q233_S1.8581.00
169_L174_V1.8561.00
468_T538_T1.8541.00
557_S561_E1.8471.00
617_E620_A1.8451.00
463_D466_N1.8431.00
308_I333_I1.8421.00
4_K7_M1.8311.00
361_D365_Q1.8261.00
138_L141_E1.8111.00
339_N342_V1.8041.00
585_A588_Q1.7631.00
201_F214_H1.7561.00
550_R553_D1.7541.00
438_D442_Q1.7411.00
311_T338_F1.7351.00
32_L274_M1.7331.00
159_D185_S1.7311.00
461_L542_S1.7301.00
293_S297_A1.7251.00
400_T403_E1.7221.00
436_G569_I1.7211.00
464_L541_A1.7171.00
461_L541_A1.7131.00
152_Y181_D1.7111.00
610_E613_A1.7071.00
333_I336_R1.7071.00
312_K337_D1.7031.00
479_S524_T1.7001.00
561_E564_E1.6991.00
129_D132_S1.6961.00
142_T145_Q1.6911.00
602_Q606_A1.6871.00
109_I168_I1.6791.00
443_L562_T1.6781.00
435_K438_D1.6771.00
473_E476_T1.6621.00
396_S399_E1.6621.00
466_N470_N1.6581.00
346_K350_E1.6511.00
424_E428_S1.6481.00
364_E368_A1.6451.00
152_Y163_T1.6421.00
226_Q229_Q1.6421.00
606_A609_Q1.6251.00
613_A617_E1.6241.00
14_S290_I1.6231.00
185_S189_S1.6201.00
25_M29_Y1.6031.00
528_S532_K1.5871.00
460_M540_E1.5851.00
312_K316_A1.5841.00
361_D364_E1.5841.00
432_A568_T1.5831.00
197_P266_Q1.5821.00
334_L338_F1.5761.00
186_A189_S1.5751.00
104_V180_Y1.5731.00
150_E208_S1.5701.00
148_W164_A1.5651.00
447_S555_Q1.5651.00
189_S192_N1.5641.00
568_T571_A1.5631.00
311_T334_L1.5591.00
553_D557_S1.5461.00
564_E568_T1.5441.00
56_E60_K1.5441.00
151_P160_M1.5431.00
467_Q470_N1.5421.00
325_S339_N1.5361.00
442_Q445_M1.5331.00
550_R554_E1.5271.00
589_R592_E1.5231.00
314_V342_V1.5081.00
384_I387_V1.5041.00
230_T235_K1.5021.00
25_M282_S1.5011.00
603_S606_A1.4961.00
554_E557_S1.4961.00
595_L599_E1.4951.00
201_F261_Q1.4911.00
431_D435_K1.4891.00
308_I337_D1.4851.00
444_L563_G1.4761.00
456_K459_T1.4731.00
139_A177_V1.4621.00
613_A616_E1.4551.00
264_T268_M1.4551.00
539_K543_H1.4531.00
220_K224_K1.4471.00
197_P200_G1.4471.00
420_G424_E1.4441.00
114_K131_T1.4321.00
623_D627_V1.4251.00
30_L34_P1.4231.00
397_E603_S1.4211.00
427_K431_D1.4201.00
575_S578_Q1.4181.00
624_E627_V1.4071.00
21_V24_L1.4041.00
39_D43_T1.4001.00
210_N221_N1.3911.00
134_P138_L1.3901.00
606_A610_E1.3861.00
202_A260_T1.3791.00
630_D634_H1.3791.00
304_I334_L1.3771.00
29_Y275_N1.3641.00
448_N452_M1.3581.00
596_A599_E1.3541.00
453_E547_E1.3521.00
139_A165_S1.3511.00
365_Q368_A1.3471.00
585_A589_R1.3441.00
237_G248_Y1.3411.00
385_E389_A1.3361.00
20_T285_A1.3351.00
33_K37_T1.3261.00
246_V259_G1.3261.00
522_L525_K1.3251.00
464_L534_I1.3241.00
588_Q592_E1.3221.00
311_T337_D1.3201.00
225_D229_Q1.3161.00
234_E237_G1.3141.00
5_L331_V1.3141.00
322_R342_V1.3121.00
189_S193_K1.3081.00
312_K340_L1.3061.00
403_E407_S1.3061.00
438_D441_G1.2991.00
428_S431_D1.2981.00
307_L334_L1.2981.00
461_L545_M1.2921.00
44_T48_T1.2891.00
386_E389_A1.2861.00
343_E347_E1.2821.00
408_L594_Q1.2821.00
452_M456_K1.2811.00
421_G424_E1.2791.00
571_A575_S1.2781.00
147_V165_S1.2761.00
522_L526_H1.2701.00
431_D434_Y1.2681.00
389_A392_S1.2681.00
525_K529_E1.2631.00
273_K277_A1.2601.00
406_E410_T1.2581.00
22_V26_L1.2511.00
150_E206_D1.2461.00
67_S146_V1.2461.00
170_D175_I1.2451.00
153_K158_G1.2421.00
66_L180_Y1.2411.00
459_T463_D1.2401.00
32_L36_I1.2301.00
272_D275_N1.2211.00
136_Y140_A1.2211.00
616_E620_A1.2181.00
229_Q232_A1.2151.00
144_D169_L1.2071.00
64_I67_S1.2061.00
454_T552_N1.2051.00
146_V166_K1.2021.00
578_Q582_H1.2021.00
299_T302_G1.1991.00
514_R518_E1.1971.00
91_H95_K1.1901.00
445_M448_N1.1881.00
480_N483_D1.1871.00
219_G222_I1.1831.00
116_M119_Y1.1821.00
347_E351_Q1.1811.00
490_L498_R1.1791.00
314_V338_F1.1771.00
462_L466_N1.1761.00
442_Q561_E1.1741.00
446_K554_E1.1731.00
631_K634_H1.1731.00
319_L349_V1.1701.00
108_Y181_D1.1671.00
459_T462_L1.1661.00
338_F342_V1.1641.00
132_S137_K1.1621.00
463_D540_E1.1611.00
417_E421_G1.1591.00
318_D321_V1.1581.00
543_H547_E1.1571.00
165_S177_V1.1571.00
620_A624_E1.1561.00
151_P206_D1.1541.00
609_Q613_A1.1501.00
17_L20_T1.1491.00
627_V630_D1.1421.00
445_M449_E1.1421.00
12_F296_L1.1361.00
86_A89_L1.1341.00
489_A514_R1.1291.00
448_N560_H1.1261.00
404_K407_S1.1261.00
458_E545_M1.1241.00
441_G445_M1.1221.00
291_I295_F1.1211.00
525_K528_S1.1211.00
169_L172_Q1.1191.00
314_V345_M1.1181.00
277_A280_W1.1161.00
574_Q578_Q1.1151.00
231_I259_G1.1141.00
452_M455_K1.1141.00
632_V639_L1.1131.00
63_A67_S1.1131.00
620_A623_D1.1091.00
27_S31_T1.1051.00
460_M544_A1.1041.00
462_L546_V1.1031.00
52_E251_I1.1011.00
450_A552_N1.1011.00
447_S450_A1.1001.00
424_E427_K1.0971.00
279_L283_L1.0971.00
578_Q581_D1.0961.00
96_Q99_D1.0951.00
136_Y177_V1.0951.00
37_T41_K1.0941.00
419_A422_I1.0941.00
582_H585_A1.0921.00
133_R154_D1.0901.00
307_L338_F1.0901.00
502_S513_V1.0891.00
13_V293_S1.0891.00
518_E522_L1.0851.00
486_N514_R1.0851.00
474_V531_V1.0841.00
566_L569_I1.0831.00
319_L345_M1.0821.00
133_R155_V1.0811.00
58_Q62_Y1.0791.00
221_N224_K1.0791.00
314_V319_L1.0771.00
310_K323_A1.0721.00
198_Y269_W1.0721.00
536_L540_E1.0631.00
519_Q522_L1.0611.00
275_N279_L1.0611.00
135_W181_D1.0571.00
393_E396_S1.0541.00
389_A393_E1.0511.00
532_K536_L1.0501.00
307_L335_T1.0421.00
529_E533_L1.0421.00
284_I288_I1.0391.00
442_Q558_A1.0361.00
303_P327_S1.0361.00
159_D183_K1.0301.00
455_K459_T1.0261.00
323_A339_N1.0261.00
206_D210_N1.0251.00
543_H546_V1.0251.00
413_R417_E1.0241.00
521_A525_K1.0241.00
309_V312_K1.0231.00
87_S91_H1.0221.00
226_Q230_T1.0161.00
28_S32_L1.0151.00
308_I312_K1.0131.00
110_G130_P1.0121.00
474_V523_S1.0091.00
519_Q526_H1.0081.00
154_D181_D1.0071.00
433_S570_T1.0071.00
453_E456_K1.0041.00
48_T52_E1.0041.00
437_L567_N1.0031.00
353_R357_G1.0021.00
283_L287_I1.0011.00
63_A148_W1.0011.00
66_L166_K1.0011.00
479_S528_S1.0011.00
408_L590_M0.9981.00
455_K549_S0.9971.00
325_S335_T0.9961.00
203_F214_H0.9941.00
557_S560_H0.9931.00
245_M264_T0.9911.00
240_D264_T0.9891.00
430_E434_Y0.9881.00
396_S400_T0.9881.00
149_T165_S0.9861.00
470_N526_H0.9851.00
17_L289_T0.9851.00
605_S609_Q0.9831.00
110_G136_Y0.9821.00
290_I294_Y0.9811.00
6_H10_A0.9801.00
287_I291_I0.9761.00
10_A14_S0.9761.00
458_E549_S0.9741.00
317_G334_L0.9741.00
334_L341_M0.9731.00
131_T136_Y0.9731.00
350_E354_L0.9721.00
547_E550_R0.9711.00
404_K408_L0.9711.00
25_M278_N0.9701.00
133_R139_A0.9701.00
352_V359_V0.9701.00
297_A300_I0.9671.00
198_Y266_Q0.9671.00
407_S410_T0.9651.00
317_G341_M0.9601.00
464_L538_T0.9591.00
581_D585_A0.9591.00
272_D276_R0.9571.00
416_A419_A0.9551.00
308_I334_L0.9551.00
30_L33_K0.9541.00
483_D494_I0.9531.00
511_D515_K0.9521.00
357_G361_D0.9491.00
149_T152_Y0.9481.00
434_Y438_D0.9481.00
207_A255_G0.9471.00
632_V636_T0.9471.00
313_A341_M0.9471.00
134_P137_K0.9451.00
599_E603_S0.9451.00
474_V524_T0.9441.00
110_G116_M0.9431.00
88_R92_D0.9411.00
135_W152_Y0.9401.00
316_A340_L0.9391.00
153_K160_M0.9391.00
618_V621_S0.9371.00
446_K449_E0.9311.00
406_E409_S0.9251.00
517_A520_S0.9241.00
361_D368_A0.9241.00
325_S329_D0.9221.00
21_V282_S0.9191.00
394_Q608_S0.9181.00
625_Q629_L0.9171.00
227_T232_A0.9171.00
154_D161_I0.9161.00
9_I13_V0.9151.00
350_E353_R0.9141.00
469_K539_K0.9121.00
454_T545_M0.9101.00
564_E567_N0.9101.00
384_I390_G0.9101.00
487_L494_I0.9091.00
306_Q324_E0.9081.00
306_Q309_V0.9081.00
408_L411_K0.9051.00
489_A513_V0.9031.00
305_Q308_I0.9021.00
289_T293_S0.9021.00
457_V548_A0.9001.00
415_I587_I0.9001.00
538_T541_A0.8991.00
135_W163_T0.8981.00
60_K63_A0.8961.00
137_K140_A0.8951.00
328_K332_G0.8941.00
526_H529_E0.8931.00
276_R279_L0.8931.00
114_K117_F0.8931.00
585_A592_E0.8911.00
449_E551_M0.8901.00
394_Q398_V0.8871.00
592_E596_A0.8871.00
311_T314_V0.8871.00
440_L443_L0.8851.00
356_S363_S0.8841.00
451_N556_N0.8841.00
294_Y298_K0.8831.00
230_T234_E0.8811.00
453_E551_M0.8801.00
238_I241_V0.8781.00
407_S593_E0.8781.00
234_E250_T0.8771.00
449_E452_M0.8771.00
348_M352_V0.8771.00
354_L358_K0.8771.00
468_T474_V0.8771.00
398_V604_I0.8761.00
325_S336_R0.8751.00
310_K338_F0.8731.00
364_E367_T0.8710.99
458_E546_V0.8700.99
146_V164_A0.8680.99
625_Q632_V0.8660.99
629_L639_L0.8660.99
37_T268_M0.8560.99
457_V545_M0.8560.99
420_G588_Q0.8540.99
383_A387_V0.8530.99
531_V535_Q0.8520.99
388_A392_S0.8510.99
351_Q354_L0.8500.99
567_N571_A0.8470.99
443_L559_I0.8440.99
403_E406_E0.8410.99
341_M345_M0.8410.99
108_Y116_M0.8400.99
110_G179_S0.8390.99
636_T640_K0.8380.99
614_A617_E0.8380.99
191_V202_A0.8360.99
271_S275_N0.8350.99
92_D96_Q0.8340.99
354_L357_G0.8340.99
338_F341_M0.8320.99
161_I181_D0.8320.99
340_L343_E0.8310.99
582_H586_E0.8310.99
394_Q401_I0.8300.99
432_A435_K0.8300.99
105_A154_D0.8280.99
205_A259_G0.8270.99
383_A614_A0.8270.99
443_L447_S0.8260.99
168_I175_I0.8260.99
48_T260_T0.8250.99
269_W273_K0.8250.99
65_S68_R0.8240.99
436_G440_L0.8230.99
18_I22_V0.8190.99
401_I408_L0.8190.99
474_V520_S0.8190.99
163_T179_S0.8190.99
571_A574_Q0.8170.99
347_E350_E0.8170.99
535_Q542_S0.8140.99
433_S437_L0.8140.99
165_S179_S0.8140.99
608_S612_A0.8130.99
244_K265_D0.8130.99
632_V640_K0.8120.99
427_K581_D0.8120.99
335_T339_N0.8120.99
43_T46_N0.8120.99
138_L142_T0.8110.99
303_P331_V0.8100.99
61_S64_I0.8100.99
126_E130_P0.8100.99
38_E42_N0.8080.99
555_Q562_T0.8070.99
426_S576_L0.8070.99
56_E253_E0.8060.99
410_T414_Q0.8050.99
440_L566_L0.8050.99
70_A166_K0.8040.99
412_I590_M0.8040.99
342_V346_K0.8040.99
306_Q310_K0.8030.99
45_Q49_Q0.8020.99
20_T289_T0.8010.99
203_F261_Q0.8010.99
7_M11_V0.8010.99
541_A545_M0.8000.99
135_W139_A0.7990.99
417_E420_G0.7990.99
360_S364_E0.7990.99
301_T305_Q0.7980.99
164_A182_L0.7970.99
408_L415_I0.7960.99
106_M119_Y0.7940.99
584_Y588_Q0.7930.99
230_T233_S0.7920.99
8_K327_S0.7890.99
529_E532_K0.7880.99
92_D95_K0.7880.99
633_K637_E0.7860.99
135_W177_V0.7850.99
433_S436_G0.7830.99
67_S166_K0.7830.99
118_T121_K0.7820.99
331_V335_T0.7750.99
51_L54_N0.7750.99
399_E403_E0.7680.99
618_V625_Q0.7680.99
470_N533_L0.7680.99
359_V362_T0.7630.99
405_S601_I0.7630.99
246_V261_Q0.7630.99
465_E469_K0.7620.99
617_E621_S0.7620.99
447_S559_I0.7610.99
513_V519_Q0.7610.99
454_T548_A0.7610.99
559_I562_T0.7590.99
241_V246_V0.7590.99
28_S274_M0.7570.99
110_G135_W0.7570.99
548_A555_Q0.7560.99
520_S530_T0.7540.99
57_L60_K0.7540.99
174_V177_V0.7520.99
313_A316_A0.7520.99
447_S556_N0.7510.99
142_T167_A0.7500.98
415_I419_A0.7490.98
273_K276_R0.7460.98
204_L258_V0.7450.98
284_I291_I0.7450.98
363_S367_T0.7430.98
599_E602_Q0.7420.98
475_V479_S0.7390.98
270_I273_K0.7380.98
363_S366_L0.7360.98
551_M554_E0.7350.98
211_L214_H0.7330.98
570_T574_Q0.7320.98
244_K263_D0.7300.98
569_I572_E0.7290.98
188_Q213_A0.7270.98
533_L537_E0.7260.98
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388_A391_A0.5340.90
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601_I605_S0.5340.90
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576_L580_I0.5240.89
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37_T40_G0.5220.89
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422_I576_L0.5180.89
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548_A552_N0.5180.89
635_S639_L0.5170.89
419_A583_I0.5170.89
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479_S483_D0.5170.89
106_M156_V0.5160.88
418_E582_H0.5160.88
404_K593_E0.5160.88
203_F211_L0.5140.88
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411_K589_R0.5130.88
128_Y131_T0.5120.88
450_A576_L0.5120.88
471_I524_T0.5120.88
94_I98_K0.5120.88
566_L576_L0.5110.88
383_A390_G0.5090.88
335_T338_F0.5090.88
436_G562_T0.5090.88
268_M272_D0.5070.88
409_S412_I0.5070.88
429_S436_G0.5070.88
76_H170_D0.5060.88
595_L598_S0.5060.88
634_H637_E0.5060.88
398_V405_S0.5060.88
613_A620_A0.5050.87
106_M110_G0.5040.87
34_P38_E0.5030.87
66_L70_A0.5020.87
62_Y180_Y0.5010.87
14_S17_L0.5010.87
470_N530_T0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.4611 100 0.514 Contact Map
2ch7A 2 0.4718 100 0.591 Contact Map
1qu7A 2 0.342 100 0.621 Contact Map
3g67A 2 0.3191 100 0.672 Contact Map
4i3mA 2 0.2244 99.9 0.795 Contact Map
3lifA 1 0.3573 99.9 0.808 Contact Map
3lidA 2 0.3786 99.9 0.81 Contact Map
3e4oA 2 0.3344 99.9 0.813 Contact Map
3li9A 2 0.3389 99.9 0.824 Contact Map
3c8cA 2 0.3527 99.9 0.825 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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