GREMLIN Database
RIBC - Riboflavin biosynthesis protein RibC
UniProt: P54575 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (291)
Sequences: 3745 (2780)
Seq/√Len: 162.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
198_H201_K3.6971.00
229_V242_C3.1451.00
178_D181_L3.0841.00
180_E282_K2.8661.00
283_R286_S2.8241.00
291_N295_E2.8031.00
82_I93_L2.5361.00
266_D308_I2.5331.00
179_V183_N2.5031.00
231_A276_I2.3791.00
202_R250_F2.2491.00
243_N287_E2.1441.00
42_K46_E2.1431.00
234_N274_A2.1271.00
44_I47_E2.1261.00
304_K308_I2.0341.00
242_C262_V2.0251.00
52_L91_E2.0021.00
229_V240_G2.0021.00
230_K279_E1.9641.00
44_I48_K1.9621.00
241_V300_I1.9461.00
231_A264_L1.9371.00
297_T301_E1.9181.00
229_V262_V1.9001.00
40_T43_Q1.8761.00
138_T141_T1.8731.00
147_D154_M1.8641.00
130_T138_T1.8631.00
230_K237_V1.8561.00
201_K204_R1.8451.00
147_D152_C1.8411.00
109_Q113_Q1.8381.00
19_K121_Q1.8181.00
122_H153_T1.8081.00
230_K239_N1.7971.00
224_T258_P1.7941.00
241_V304_K1.7701.00
163_K169_Y1.7671.00
211_A271_V1.7661.00
241_V307_A1.7511.00
108_K112_D1.7491.00
111_I146_L1.7361.00
284_I306_E1.7321.00
22_M55_M1.6881.00
267_F271_V1.6701.00
200_D259_S1.6651.00
22_M120_V1.6561.00
120_V123_A1.6471.00
55_M96_V1.6441.00
104_S133_K1.6401.00
228_A310_Y1.6271.00
191_F277_K1.6231.00
232_E279_E1.5961.00
231_A240_G1.5821.00
292_G295_E1.5801.00
284_I307_A1.5701.00
191_F279_E1.5691.00
230_K281_Y1.5511.00
96_V102_F1.5421.00
232_E237_V1.5411.00
54_V90_T1.5401.00
108_K149_K1.5391.00
160_E165_I1.5391.00
233_V274_A1.5311.00
208_F301_E1.5231.00
282_K310_Y1.5141.00
45_A52_L1.5081.00
24_L129_F1.5051.00
78_L95_V1.5031.00
173_A181_L1.4781.00
42_K52_L1.4711.00
53_A94_Y1.4671.00
20_S53_A1.4671.00
211_A276_I1.4561.00
250_F293_I1.4451.00
100_E104_S1.4391.00
106_S109_Q1.4321.00
240_G262_V1.4241.00
51_T92_V1.4231.00
301_E304_K1.4201.00
76_T84_Q1.4151.00
306_E309_R1.4151.00
232_E277_K1.3671.00
265_F308_I1.3621.00
127_F157_K1.3561.00
50_L121_Q1.3531.00
223_P283_R1.3491.00
193_K275_A1.3481.00
102_F105_L1.3311.00
173_A178_D1.3171.00
80_D219_Y1.3161.00
193_K277_K1.3161.00
302_K305_Q1.3021.00
202_R205_T1.3011.00
192_I280_W1.2951.00
281_Y310_Y1.2931.00
265_F307_A1.2821.00
299_Q303_D1.2681.00
170_I185_L1.2381.00
194_G213_V1.2351.00
112_D150_A1.2231.00
21_V124_V1.2161.00
298_E302_K1.2161.00
228_A281_Y1.2151.00
302_K306_E1.2071.00
244_I260_I1.2051.00
239_N311_F1.2051.00
140_K143_P1.2011.00
141_T146_L1.1931.00
264_L271_V1.1881.00
172_T176_N1.1861.00
200_D247_K1.1861.00
35_Q39_G1.1671.00
299_Q302_K1.1671.00
169_Y185_L1.1481.00
281_Y311_F1.1441.00
41_A52_L1.1321.00
208_F304_K1.1291.00
52_L90_T1.1261.00
226_V243_N1.1241.00
53_A92_V1.1111.00
183_N189_P1.1051.00
66_G69_K1.1041.00
23_A41_A1.0991.00
158_L165_I1.0981.00
229_V280_W1.0961.00
51_T91_E1.0951.00
38_I88_L1.0911.00
80_D193_K1.0901.00
213_V262_V1.0891.00
64_V99_N1.0861.00
189_P279_E1.0820.99
238_Y264_L1.0760.99
305_Q309_R1.0710.99
36_K39_G1.0700.99
247_K259_S1.0680.99
206_I293_I1.0580.99
21_V122_H1.0550.99
130_T135_G1.0540.99
83_N193_K1.0540.99
73_D175_Q1.0490.99
189_P281_Y1.0390.99
294_K297_T1.0390.99
221_V244_I1.0350.99
246_Y258_P1.0330.99
32_L160_E1.0260.99
196_V276_I1.0230.99
265_F304_K1.0210.99
35_Q88_L1.0210.99
98_F103_A1.0190.99
38_I90_T1.0130.99
84_Q188_Q1.0110.99
188_Q191_F1.0050.99
107_P136_K1.0030.99
293_I297_T0.9870.99
56_T93_L0.9870.99
18_A51_T0.9820.99
224_T246_Y0.9810.99
243_N288_R0.9760.99
165_I185_L0.9740.99
78_L82_I0.9730.99
38_I54_V0.9590.99
145_D148_G0.9580.99
128_D164_K0.9580.99
100_E103_A0.9560.99
111_I115_I0.9490.99
44_I122_H0.9480.99
240_G265_F0.9440.99
195_I275_A0.9420.99
239_N265_F0.9410.99
195_I273_G0.9400.99
294_K298_E0.9390.99
109_Q112_D0.9360.99
131_Y141_T0.9350.99
19_K119_N0.9350.99
237_V279_E0.9330.99
301_E305_Q0.9280.98
300_I304_K0.9270.98
36_K158_L0.9260.98
105_L113_Q0.9240.98
39_G43_Q0.9220.98
108_K136_K0.9200.98
32_L35_Q0.9130.98
107_P137_G0.9120.98
21_V41_A0.9090.98
179_V223_P0.9090.98
174_L179_V0.9090.98
107_P141_T0.9070.98
242_C260_I0.9050.98
252_E256_E0.9030.98
54_V85_I0.9010.98
263_N304_K0.8980.98
32_L187_G0.8960.98
113_Q116_I0.8930.98
141_T145_D0.8910.98
55_M94_Y0.8910.98
169_Y173_A0.8890.98
233_V236_E0.8870.98
137_G141_T0.8830.98
282_K306_E0.8780.98
206_I300_I0.8710.98
83_N86_E0.8700.98
236_E269_Q0.8700.98
271_V274_A0.8690.98
157_K164_K0.8680.98
105_L109_Q0.8670.98
85_I93_L0.8570.97
58_H95_V0.8510.97
208_F300_I0.8460.97
44_I124_V0.8460.97
145_D149_K0.8440.97
111_I116_I0.8420.97
223_P286_S0.8420.97
111_I141_T0.8420.97
179_V182_A0.8410.97
125_A139_M0.8400.97
116_I152_C0.8370.97
111_I152_C0.8360.97
32_L165_I0.8360.97
48_K122_H0.8310.97
197_I214_G0.8300.97
246_Y287_E0.8300.97
143_P148_G0.8300.97
232_E235_G0.8250.97
200_D251_Y0.8230.97
262_V278_I0.8200.97
233_V238_Y0.8190.97
202_R293_I0.8190.97
75_I190_Y0.8180.97
64_V100_E0.8120.96
200_D250_F0.8120.96
181_L184_V0.8110.96
163_K172_T0.8100.96
263_N300_I0.8100.96
306_E310_Y0.8090.96
26_Y59_P0.8080.96
84_Q87_Q0.8020.96
241_V265_F0.8000.96
106_S136_K0.7990.96
160_E163_K0.7960.96
244_I280_W0.7950.96
39_G42_K0.7940.96
173_A185_L0.7900.96
251_Y256_E0.7870.96
30_V85_I0.7800.96
127_F156_E0.7780.95
288_R299_Q0.7770.95
233_V271_V0.7770.95
243_N297_T0.7770.95
224_T287_E0.7740.95
298_E301_E0.7660.95
46_E91_E0.7650.95
127_F164_K0.7640.95
285_R299_Q0.7630.95
305_Q308_I0.7630.95
80_D191_F0.7630.95
113_Q117_G0.7630.95
183_N188_Q0.7620.95
167_S171_R0.7610.95
136_K141_T0.7610.95
165_I170_I0.7590.95
288_R295_E0.7590.95
179_V280_W0.7580.95
55_M102_F0.7570.95
20_S50_L0.7570.95
21_V50_L0.7560.95
248_P287_E0.7530.95
241_V263_N0.7520.95
35_Q188_Q0.7490.94
140_K145_D0.7440.94
43_Q47_E0.7400.94
214_G257_Q0.7390.94
82_I95_V0.7380.94
146_L149_K0.7380.94
105_L114_Y0.7370.94
77_P219_Y0.7370.94
250_F297_T0.7360.94
213_V276_I0.7340.94
264_L267_F0.7280.94
32_L158_L0.7260.93
230_K311_F0.7210.93
65_L103_A0.7210.93
82_I86_E0.7210.93
131_Y146_L0.7170.93
41_A124_V0.7150.93
295_E298_E0.7120.93
30_V38_I0.7120.93
56_T95_V0.7100.93
233_V276_I0.7100.93
106_S133_K0.7090.93
197_I259_S0.7090.93
40_T44_I0.7050.92
108_K146_L0.7030.92
48_K121_Q0.6980.92
243_N247_K0.6960.92
26_Y60_H0.6950.92
22_M53_A0.6940.92
161_Q184_V0.6910.92
228_A307_A0.6880.91
62_S66_G0.6870.91
60_H74_L0.6860.91
228_A311_F0.6860.91
77_P80_D0.6850.91
270_E274_A0.6840.91
133_K136_K0.6810.91
146_L150_A0.6790.91
139_M143_P0.6790.91
116_I150_A0.6790.91
21_V48_K0.6780.91
224_T286_S0.6780.91
21_V44_I0.6770.91
42_K45_A0.6760.91
160_E185_L0.6760.91
86_E93_L0.6730.91
23_A52_L0.6720.91
260_I280_W0.6720.91
241_V284_I0.6700.90
83_N277_K0.6680.90
228_A241_V0.6650.90
30_V54_V0.6650.90
26_Y74_L0.6620.90
129_F142_M0.6540.89
147_D151_G0.6530.89
115_I120_V0.6530.89
80_D83_N0.6500.89
229_V278_I0.6500.89
222_P244_I0.6500.89
52_L85_I0.6490.89
79_E275_A0.6480.89
169_Y181_L0.6460.89
125_A142_M0.6450.89
243_N248_P0.6390.88
200_D252_E0.6380.88
67_R71_P0.6370.88
242_C280_W0.6360.88
42_K90_T0.6360.88
249_T289_K0.6350.88
243_N263_N0.6340.88
58_H78_L0.6300.88
116_I120_V0.6270.87
59_P64_V0.6270.87
65_L98_F0.6260.87
58_H97_K0.6240.87
48_K153_T0.6220.87
84_Q88_L0.6200.87
177_G283_R0.6200.87
63_H74_L0.6140.86
24_L55_M0.6110.86
198_H273_G0.6090.86
285_R303_D0.6090.86
149_K152_C0.6070.86
307_A311_F0.6060.85
83_N87_Q0.6050.85
174_L220_I0.6010.85
169_Y172_T0.6010.85
239_N266_D0.6000.85
295_E299_Q0.5990.85
214_G259_S0.5990.85
221_V260_I0.5990.85
160_E184_V0.5980.85
247_K287_E0.5980.85
62_S69_K0.5940.84
42_K88_L0.5920.84
76_T188_Q0.5860.83
20_S92_V0.5850.83
211_A231_A0.5820.83
80_D277_K0.5810.83
201_K205_T0.5800.83
123_A154_M0.5790.83
38_I85_I0.5780.83
175_Q220_I0.5780.83
99_N102_F0.5750.82
233_V237_V0.5750.82
19_K50_L0.5740.82
211_A264_L0.5730.82
288_R291_N0.5720.82
46_E52_L0.5720.82
271_V276_I0.5710.82
112_D149_K0.5670.81
50_L122_H0.5660.81
79_E82_I0.5640.81
127_F139_M0.5630.81
208_F243_N0.5590.81
107_P134_Y0.5580.80
23_A54_V0.5560.80
114_Y117_G0.5550.80
125_A135_G0.5550.80
128_D157_K0.5520.80
138_T142_M0.5520.80
147_D150_A0.5510.80
174_L222_P0.5490.79
82_I85_I0.5490.79
238_Y267_F0.5480.79
18_A119_N0.5440.79
56_T60_H0.5430.79
67_R70_E0.5420.78
79_E193_K0.5380.78
101_V104_S0.5350.78
163_K181_L0.5350.78
112_D146_L0.5340.77
58_H74_L0.5340.77
112_D116_I0.5310.77
40_T124_V0.5300.77
125_A129_F0.5280.77
30_V88_L0.5260.76
137_G142_M0.5250.76
62_S135_G0.5250.76
137_G152_C0.5240.76
215_L221_V0.5240.76
128_D135_G0.5220.76
123_A142_M0.5220.76
59_P78_L0.5200.76
196_V272_Y0.5180.75
111_I142_M0.5180.75
22_M96_V0.5180.75
45_A48_K0.5180.75
174_L223_P0.5170.75
85_I90_T0.5160.75
123_A147_D0.5160.75
62_S65_L0.5150.75
228_A282_K0.5150.75
63_H71_P0.5140.75
59_P95_V0.5140.75
160_E169_Y0.5130.75
220_I227_Y0.5130.75
23_A135_G0.5100.74
172_T175_Q0.5100.74
23_A125_A0.5090.74
129_F241_V0.5090.74
43_Q46_E0.5080.74
192_I260_I0.5080.74
234_N269_Q0.5060.74
36_K40_T0.5050.74
20_S51_T0.5020.73
44_I50_L0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x0kA 5 0.9715 100 0.195 Contact Map
3op1A 4 0.9589 100 0.204 Contact Map
1mrzA 2 0.8449 100 0.232 Contact Map
3bnwA 2 0.3956 100 0.596 Contact Map
1n08A 1 0.443 100 0.601 Contact Map
1nb0A 1 0.4051 100 0.604 Contact Map
3covA 2 0.7532 100 0.706 Contact Map
3hl4A 2 0.4937 100 0.721 Contact Map
2ejcA 2 0.7405 100 0.733 Contact Map
3n8hA 2 0.7184 100 0.737 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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