GREMLIN Database
FUR - Ferric uptake regulation protein
UniProt: P54574 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (132)
Sequences: 7181 (4720)
Seq/√Len: 410.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_M130_K4.2621.00
102_E139_I3.8831.00
128_K144_N3.3201.00
105_A142_R3.2271.00
30_L72_V2.8341.00
29_V46_L2.4221.00
129_I136_F2.3761.00
19_L24_E2.2751.00
126_K141_H2.2551.00
67_T74_K2.1331.00
101_M137_H2.1121.00
9_K24_E2.0421.00
101_M139_I1.9751.00
40_A63_L1.8641.00
74_K82_S1.8461.00
67_T72_V1.8401.00
45_L48_K1.8151.00
44_Y56_L1.7781.00
17_Y69_L1.7161.00
10_K14_S1.6881.00
130_K139_I1.6851.00
34_E46_L1.6751.00
64_E74_K1.6611.00
26_T62_T1.6541.00
103_C140_C1.6241.00
120_I124_D1.5361.00
37_H85_D1.5221.00
96_H132_H1.5221.00
98_L107_D1.5031.00
29_V43_V1.4931.00
28_R32_E1.4161.00
44_Y48_K1.3971.00
107_D127_F1.3891.00
11_Q15_S1.3771.00
98_L127_F1.3771.00
100_C103_C1.3681.00
37_H97_H1.3561.00
94_F132_H1.3561.00
39_S42_D1.3551.00
25_A50_K1.3151.00
27_V66_L1.3021.00
24_E28_R1.2971.00
46_L49_E1.2971.00
103_C143_C1.2751.00
25_A28_R1.2671.00
127_F141_H1.2531.00
87_R93_H1.2401.00
29_V47_V1.2021.00
22_Q58_T1.1861.00
44_Y59_V1.1771.00
100_C140_C1.1141.00
11_Q14_S1.1111.00
62_T65_L1.1011.00
116_D120_I1.0851.00
38_L46_L1.0701.00
140_C143_C1.0611.00
99_V104_G1.0551.00
99_V137_H1.0461.00
34_E38_L1.0451.00
65_L69_L1.0351.00
119_E123_R1.0321.00
107_D125_W1.0271.00
29_V38_L1.0241.00
128_K139_I1.0171.00
98_L138_G0.9881.00
9_K13_H0.9841.00
37_H95_H0.9781.00
66_L71_V0.9771.00
38_L83_R0.9721.00
22_Q54_I0.9721.00
139_I144_N0.9681.00
23_R65_L0.9621.00
99_V135_T0.9371.00
36_D46_L0.9361.00
141_H145_G0.9321.00
21_P25_A0.9311.00
30_L38_L0.9271.00
111_E114_L0.9271.00
37_H108_E0.9261.00
17_Y65_L0.9251.00
131_D137_H0.9221.00
95_H108_E0.9171.00
127_F138_G0.9111.00
29_V50_K0.8901.00
47_V54_I0.8891.00
126_K144_N0.8811.00
38_L43_V0.8651.00
118_E132_H0.8601.00
101_M131_D0.8571.00
36_D42_D0.8521.00
41_E45_L0.8451.00
47_V51_S0.8421.00
96_H109_I0.8381.00
111_E117_V0.8371.00
40_A59_V0.8371.00
71_V86_L0.8361.00
25_A51_S0.8241.00
113_L116_D0.8231.00
23_R62_T0.8201.00
64_E67_T0.8201.00
21_P24_E0.8121.00
45_L49_E0.8111.00
48_K56_L0.8011.00
13_H19_L0.7941.00
27_V71_V0.7901.00
132_H136_F0.7881.00
28_R50_K0.7881.00
79_D83_R0.7801.00
75_I108_E0.7791.00
37_H106_V0.7741.00
96_H112_D0.7601.00
120_I123_R0.7571.00
100_C143_C0.7451.00
110_E113_L0.7441.00
104_G107_D0.7401.00
42_D45_L0.7381.00
32_E46_L0.7251.00
41_E81_V0.7241.00
41_E56_L0.7161.00
63_L67_T0.7161.00
26_T43_V0.7141.00
112_D132_H0.7091.00
98_L125_W0.7071.00
22_Q55_G0.7021.00
114_L117_V0.6911.00
133_R137_H0.6861.00
64_E68_E0.6821.00
75_I135_T0.6781.00
96_H134_L0.6740.99
114_L118_E0.6720.99
119_E122_E0.6680.99
96_H118_E0.6650.99
31_L86_L0.6650.99
27_V31_L0.6650.99
97_H108_E0.6610.99
29_V34_E0.6520.99
73_D87_R0.6450.99
10_K13_H0.6440.99
58_T62_T0.6400.99
12_L27_V0.6350.99
41_E44_Y0.6330.99
122_E144_N0.6280.99
40_A56_L0.6250.99
29_V32_E0.6240.99
132_H137_H0.6230.99
26_T29_V0.6210.99
35_E87_R0.6190.99
22_Q62_T0.6170.99
9_K19_L0.6050.99
32_E50_K0.6040.99
37_H55_G0.6030.99
63_L72_V0.6000.99
142_R145_G0.6000.99
43_V72_V0.5960.99
43_V59_V0.5840.99
81_V84_Y0.5810.99
40_A81_V0.5800.98
94_F115_E0.5770.98
39_S83_R0.5770.98
44_Y54_I0.5720.98
77_F133_R0.5700.98
111_E124_D0.5690.98
30_L43_V0.5670.98
25_A47_V0.5660.98
20_T58_T0.5630.98
99_V106_V0.5610.98
96_H136_F0.5580.98
94_F112_D0.5570.98
39_S81_V0.5560.98
73_D133_R0.5520.98
122_E129_I0.5510.98
66_L72_V0.5490.98
11_Q31_L0.5470.98
111_E116_D0.5440.98
19_L27_V0.5390.98
116_D119_E0.5350.97
111_E120_I0.5310.97
25_A54_I0.5280.97
12_L19_L0.5270.97
15_S69_L0.5260.97
30_L39_S0.5260.97
130_K138_G0.5240.97
77_F82_S0.5230.97
20_T24_E0.5220.97
37_H41_E0.5190.97
12_L17_Y0.5170.97
100_C127_F0.5150.97
62_T84_Y0.5150.97
85_D88_K0.5150.97
141_H144_N0.5140.97
85_D94_F0.5120.97
25_A29_V0.5100.97
40_A67_T0.5080.97
107_D142_R0.5040.96
17_Y23_R0.5030.96
42_D46_L0.5010.96
76_N80_G0.5000.96
30_L86_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fe3A 2 0.953 100 0.118 Contact Map
2xigA 4 0.9664 100 0.125 Contact Map
4mtdA 2 0.9866 100 0.133 Contact Map
3eyyA 2 0.8926 100 0.15 Contact Map
4etsA 2 0.9732 100 0.157 Contact Map
3mwmA 2 0.8523 100 0.159 Contact Map
2w57A 2 0.8725 100 0.176 Contact Map
2o03A 2 0.8658 100 0.192 Contact Map
4lmyA 2 0.9664 100 0.196 Contact Map
1mzbA 4 0.8859 100 0.209 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0062 seconds.