GREMLIN Database
MAO1 - Probable NAD-dependent malic enzyme 1
UniProt: P54572 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 439 (351)
Sequences: 4017 (1798)
Seq/√Len: 96.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_K226_E4.2801.00
154_N187_S4.2611.00
263_V284_V3.7471.00
333_P337_R3.5161.00
395_D437_A3.3931.00
382_R386_N3.2231.00
393_N437_A3.1201.00
432_H436_T3.0681.00
310_S313_E3.0461.00
147_T187_S2.9411.00
122_L125_K2.8481.00
265_Q276_C2.8261.00
195_T198_H2.8151.00
191_E194_K2.7891.00
192_I196_V2.7661.00
257_D260_E2.7511.00
244_L282_Y2.7021.00
190_E222_R2.6821.00
212_G215_H2.6481.00
333_P356_A2.6321.00
275_I324_T2.6171.00
190_E193_I2.5401.00
316_E338_S2.5241.00
333_P359_Q2.5151.00
126_E129_K2.5041.00
315_M331_I2.5031.00
251_C261_A2.4501.00
292_K301_E2.3921.00
129_K132_I2.3651.00
145_D215_H2.3411.00
294_E297_M2.2621.00
277_R304_G2.2451.00
127_P158_V2.2221.00
224_K391_E2.1731.00
247_A320_I2.1701.00
221_D225_E2.1641.00
387_A431_E2.1081.00
118_D122_L2.0061.00
222_R226_E1.9811.00
194_K198_H1.9521.00
277_R303_Y1.9351.00
362_A365_A1.9301.00
384_A392_I1.9111.00
130_A136_I1.8951.00
189_P193_I1.8701.00
186_T191_E1.8621.00
118_D121_R1.8361.00
321_V331_I1.8301.00
200_S228_N1.8271.00
339_G363_A1.8231.00
281_A394_H1.8111.00
312_E335_F1.7951.00
266_I330_L1.7781.00
168_A179_G1.7691.00
250_A341_V1.7631.00
248_I402_E1.7181.00
276_C289_G1.7111.00
293_S301_E1.6951.00
149_I155_I1.6931.00
147_T154_N1.6911.00
222_R225_E1.6901.00
100_M111_V1.6451.00
292_K327_V1.6281.00
243_T345_L1.6091.00
336_V342_I1.6081.00
192_I219_I1.6061.00
244_L278_M1.6051.00
252_R409_K1.5941.00
402_E406_A1.5751.00
336_V360_A1.5751.00
433_A437_A1.5501.00
224_K394_H1.5441.00
433_A436_T1.5431.00
273_V304_G1.4941.00
241_V380_I1.4911.00
261_A320_I1.4911.00
349_K353_E1.4891.00
312_E334_A1.4871.00
131_S136_I1.4801.00
200_S227_L1.4741.00
329_G356_A1.4681.00
409_K412_D1.4651.00
145_D212_G1.4591.00
353_E356_A1.4401.00
184_L199_I1.4241.00
189_P218_E1.4241.00
364_Y413_V1.4110.99
268_L289_G1.4080.99
246_A343_L1.4020.99
182_I199_I1.3990.99
393_N433_A1.3800.99
130_A158_V1.3760.99
98_S102_I1.3750.99
335_F338_S1.3700.99
328_P349_K1.3680.99
215_H218_E1.3670.99
120_C155_I1.3660.99
376_G380_I1.3580.99
396_M434_A1.3560.99
355_E359_Q1.3550.99
428_A432_H1.3520.99
186_T198_H1.3470.99
331_I338_S1.3420.99
332_K335_F1.3360.99
394_H397_L1.3290.99
299_R302_Q1.3260.99
143_V196_V1.3260.99
194_K197_K1.3190.99
182_I203_F1.3190.99
312_E338_S1.3180.99
352_I357_A1.3140.99
121_R124_E1.3090.99
225_E391_E1.2960.99
228_N390_T1.2940.99
354_P365_A1.2920.99
190_E194_K1.2890.99
258_L284_V1.2790.99
208_L231_V1.2780.99
240_A278_M1.2690.99
244_L401_A1.2450.99
387_A435_L1.2430.99
261_A284_V1.2420.99
184_L195_T1.2350.99
193_I227_L1.2330.99
272_G324_T1.2320.99
332_K338_S1.2320.99
248_I282_Y1.2280.99
334_A337_R1.2230.99
103_R107_E1.2190.98
157_S160_G1.2110.98
247_A279_F1.2090.98
276_C287_V1.2060.98
291_D301_E1.1880.98
357_A360_A1.1880.98
356_A359_Q1.1860.98
266_I290_T1.1770.98
407_C421_K1.1760.98
160_G183_L1.1700.98
193_I222_R1.1660.98
158_V185_D1.1650.98
194_K226_E1.1500.98
376_G404_I1.1440.98
271_A324_T1.1380.98
127_P198_H1.1350.98
129_K133_Y1.1350.98
218_E222_R1.1320.98
333_P360_A1.1280.97
386_N431_E1.1190.97
315_M338_S1.1110.97
280_M287_V1.1110.97
371_V414_V1.1010.97
185_D200_S1.0840.97
189_P222_R1.0820.97
303_Y307_A1.0810.97
266_I327_V1.0800.97
227_L231_V1.0750.97
199_I227_L1.0700.97
277_R307_A1.0690.96
389_S396_M1.0630.96
243_T279_F1.0490.96
424_H428_A1.0470.96
161_M183_L1.0420.96
282_Y398_V1.0350.96
356_A360_A1.0310.96
186_T195_T1.0070.95
254_A364_Y1.0050.95
247_A343_L0.9960.95
180_I202_G0.9900.95
190_E226_E0.9860.94
310_S314_L0.9820.94
336_V352_I0.9800.94
184_L201_P0.9770.94
131_S388_K0.9750.94
256_V261_A0.9710.94
264_G314_L0.9700.94
297_M305_G0.9700.94
311_I331_I0.9670.94
122_L129_K0.9640.94
252_R406_A0.9630.94
407_C419_D0.9470.93
357_A363_A0.9440.93
249_S405_A0.9440.93
297_M302_Q0.9440.93
124_E160_G0.9400.93
407_C425_A0.9400.93
358_L365_A0.9390.93
282_Y402_E0.9390.93
251_C258_L0.9380.93
87_S90_E0.9340.93
266_I311_I0.9320.93
191_E195_T0.9260.92
393_N396_M0.9250.92
327_V330_L0.9230.92
262_K286_A0.9180.92
135_T139_S0.9150.92
247_A341_V0.9130.92
128_E388_K0.9130.92
86_L89_H0.9120.92
273_V289_G0.9110.92
256_V319_D0.9080.92
131_S199_I0.8990.91
189_P219_I0.8990.91
120_C149_I0.8990.91
288_Y306_Q0.8970.91
197_K227_L0.8930.91
144_T183_L0.8870.91
98_S169_A0.8830.91
379_G383_G0.8820.90
185_D201_P0.8800.90
143_V184_L0.8760.90
357_A365_A0.8740.90
336_V356_A0.8730.90
281_A398_V0.8720.90
251_C256_V0.8720.90
296_A302_Q0.8720.90
96_M180_I0.8690.90
105_L416_Q0.8670.90
384_A396_M0.8670.90
188_D191_E0.8600.89
266_I321_V0.8540.89
389_S430_V0.8500.89
383_G387_A0.8420.88
264_G318_C0.8400.88
265_Q322_I0.8390.88
184_L192_I0.8370.88
331_I335_F0.8370.88
383_G389_S0.8350.88
273_V298_N0.8350.88
358_L361_G0.8350.88
173_Q420_S0.8320.88
186_T192_I0.8300.88
264_G290_T0.8290.88
337_R360_A0.8290.88
423_H427_A0.8280.87
103_R106_A0.8250.87
221_D224_K0.8250.87
242_V376_G0.8240.87
354_P358_L0.8220.87
340_Q363_A0.8210.87
399_A433_A0.8210.87
288_Y314_L0.8180.87
298_N301_E0.8160.87
333_P336_V0.8120.86
254_A363_A0.8060.86
230_P384_A0.8050.86
113_T369_R0.8010.86
290_T311_I0.8010.86
403_A406_A0.8010.86
254_A261_A0.7970.85
104_S418_L0.7910.85
383_G430_V0.7900.85
184_L189_P0.7900.85
312_E315_M0.7880.85
398_V402_E0.7860.85
387_A434_A0.7840.84
135_T180_I0.7840.84
98_S173_Q0.7840.84
121_R349_K0.7830.84
161_M202_G0.7810.84
220_E237_H0.7810.84
221_D300_L0.7800.84
395_D433_A0.7800.84
383_G434_A0.7780.84
313_E316_E0.7770.84
329_G349_K0.7770.84
406_A409_K0.7760.84
289_G298_N0.7740.84
343_L366_A0.7700.83
105_L418_L0.7670.83
263_V320_I0.7640.83
121_R125_K0.7610.83
143_V183_L0.7560.82
253_S364_Y0.7540.82
406_A425_A0.7530.82
423_H426_V0.7420.81
241_V397_L0.7410.81
345_L366_A0.7390.81
193_I206_I0.7330.80
273_V301_E0.7330.80
343_L371_V0.7320.80
305_G308_V0.7320.80
206_I227_L0.7300.80
312_E316_E0.7300.80
251_C254_A0.7300.80
193_I208_L0.7280.80
270_A301_E0.7280.80
400_A426_V0.7260.80
218_E221_D0.7260.80
173_Q176_G0.7260.80
403_A425_A0.7250.80
258_L282_Y0.7240.79
395_D436_T0.7230.79
366_A413_V0.7230.79
431_E435_L0.7220.79
410_Q425_A0.7210.79
261_A319_D0.7190.79
116_V120_C0.7140.79
316_E334_A0.7140.79
119_V133_Y0.7130.78
336_V357_A0.7090.78
241_V376_G0.7090.78
406_A429_A0.7070.78
116_V152_L0.7060.78
271_A275_I0.7060.78
172_D178_S0.7040.78
297_M301_E0.6950.77
175_A423_H0.6930.76
306_Q314_L0.6920.76
290_T314_L0.6920.76
280_M307_A0.6900.76
279_F322_I0.6900.76
102_I169_A0.6890.76
278_M401_A0.6870.76
185_D188_D0.6840.75
289_G304_G0.6840.75
147_T215_H0.6830.75
315_M335_F0.6820.75
139_S202_G0.6800.75
248_I258_L0.6790.75
329_G353_E0.6780.75
272_G345_L0.6780.75
120_C152_L0.6740.74
113_T144_T0.6740.74
429_A432_H0.6730.74
294_E301_E0.6680.74
192_I195_T0.6680.74
197_K222_R0.6630.73
136_I202_G0.6630.73
182_I202_G0.6620.73
277_R394_H0.6620.73
304_G308_V0.6620.73
296_A301_E0.6610.73
141_A196_V0.6610.73
243_T275_I0.6600.73
170_L374_V0.6580.73
90_E95_Q0.6580.73
265_Q289_G0.6570.73
380_I384_A0.6550.72
190_E218_E0.6540.72
282_Y401_A0.6540.72
258_L261_A0.6490.72
304_G307_A0.6470.71
294_E302_Q0.6470.71
136_I388_K0.6470.71
262_K318_C0.6460.71
349_K356_A0.6460.71
126_E130_A0.6450.71
96_M139_S0.6450.71
262_K288_Y0.6450.71
412_D419_D0.6440.71
247_A263_V0.6430.71
158_V201_P0.6420.71
195_T199_I0.6410.71
221_D277_R0.6410.71
281_A395_D0.6360.70
250_A253_S0.6350.70
354_P367_D0.6340.70
182_I188_D0.6330.70
285_N307_A0.6320.70
432_H435_L0.6310.70
399_A434_A0.6310.70
255_G259_K0.6310.70
143_V192_I0.6300.69
221_D303_Y0.6280.69
421_K425_A0.6260.69
148_A213_S0.6240.69
251_C341_V0.6210.68
244_L258_L0.6210.68
273_V300_L0.6190.68
217_F301_E0.6180.68
138_N382_R0.6150.68
263_V283_G0.6140.67
311_I321_V0.6100.67
268_L292_K0.6100.67
408_T412_D0.6100.67
193_I219_I0.6090.67
131_S137_S0.6090.67
140_V381_F0.6090.67
404_I426_V0.6080.67
189_P215_H0.6070.67
284_V287_V0.6070.67
124_E149_I0.6070.67
266_I331_I0.6060.66
94_I135_T0.6060.66
337_R362_A0.6020.66
315_M321_V0.6010.66
96_M168_A0.5990.66
157_S185_D0.5960.65
99_K135_T0.5950.65
315_M318_C0.5940.65
95_Q99_K0.5920.65
295_S301_E0.5920.65
403_A429_A0.5910.64
302_Q306_Q0.5880.64
417_P423_H0.5870.64
177_I423_H0.5870.64
191_E198_H0.5870.64
328_P332_K0.5850.64
184_L198_H0.5850.64
205_G392_I0.5840.64
130_A157_S0.5840.64
301_E305_G0.5820.63
181_P379_G0.5820.63
287_V304_G0.5810.63
277_R280_M0.5810.63
148_A152_L0.5810.63
161_M181_P0.5790.63
182_I192_I0.5780.63
347_N372_N0.5780.63
313_E334_A0.5780.63
120_C160_G0.5770.63
182_I196_V0.5760.63
88_A132_I0.5750.62
123_I159_A0.5750.62
199_I206_I0.5750.62
97_K176_G0.5730.62
290_T315_M0.5720.62
142_I179_G0.5720.62
201_P227_L0.5710.62
263_V279_F0.5710.62
248_I251_C0.5710.62
152_L155_I0.5700.62
291_D294_E0.5700.62
146_G156_G0.5690.62
221_D299_R0.5680.61
171_F205_G0.5680.61
171_F207_L0.5680.61
353_E365_A0.5660.61
247_A261_A0.5660.61
376_G426_V0.5640.61
106_A110_R0.5630.61
207_L232_M0.5630.61
187_S192_I0.5630.61
123_I165_E0.5620.61
268_L305_G0.5620.61
275_I322_I0.5610.60
382_R424_H0.5610.60
299_R303_Y0.5600.60
251_C284_V0.5600.60
138_N386_N0.5590.60
94_I169_A0.5580.60
254_A341_V0.5580.60
249_S413_V0.5570.60
217_F273_V0.5550.60
337_R340_Q0.5540.60
280_M304_G0.5540.60
196_V206_I0.5520.59
145_D157_S0.5510.59
89_H93_K0.5510.59
374_V417_P0.5510.59
358_L363_A0.5500.59
380_I392_I0.5500.59
250_A343_L0.5500.59
427_A431_E0.5490.59
314_L318_C0.5490.59
206_I231_V0.5460.58
103_R173_Q0.5440.58
391_E395_D0.5430.58
355_E358_L0.5420.58
113_T377_F0.5410.58
246_A414_V0.5380.57
399_A402_E0.5350.57
331_I336_V0.5350.57
116_V166_G0.5340.57
121_R160_G0.5340.57
297_M300_L0.5330.57
205_G230_P0.5330.57
331_I342_I0.5320.56
108_L374_V0.5320.56
148_A375_L0.5320.56
169_A173_Q0.5290.56
425_A428_A0.5290.56
245_A415_P0.5290.56
148_A162_P0.5280.56
146_G183_L0.5270.56
422_V426_V0.5270.56
290_T310_S0.5260.56
128_E390_T0.5260.56
147_T212_G0.5240.55
184_L188_D0.5240.55
182_I185_D0.5230.55
287_V314_L0.5230.55
290_T335_F0.5230.55
213_S270_A0.5220.55
165_E284_V0.5220.55
189_P195_T0.5210.55
87_S91_G0.5200.55
311_I335_F0.5200.55
301_E327_V0.5190.55
142_I207_L0.5190.55
290_T346_S0.5180.55
244_L279_F0.5180.55
177_I382_R0.5170.54
273_V293_S0.5150.54
150_L373_N0.5130.54
344_A365_A0.5130.54
90_E99_K0.5130.54
338_S360_A0.5130.54
389_S431_E0.5120.54
181_P361_G0.5120.54
246_A366_A0.5120.54
135_T168_A0.5110.54
202_G388_K0.5110.54
251_C257_D0.5100.53
197_K206_I0.5100.53
396_M399_A0.5100.53
212_G270_A0.5100.53
102_I111_V0.5100.53
122_L133_Y0.5100.53
186_T201_P0.5080.53
139_S177_I0.5070.53
243_T301_E0.5070.53
174_L374_V0.5070.53
128_E132_I0.5060.53
288_Y308_V0.5060.53
342_I363_A0.5050.53
174_L324_T0.5050.53
247_A250_A0.5040.53
291_D296_A0.5040.53
142_I168_A0.5040.53
347_N373_N0.5030.52
150_L372_N0.5020.52
287_V306_Q0.5020.52
357_A361_G0.5010.52
280_M306_Q0.5010.52
266_I289_G0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o0sA 4 0.9932 100 0.148 Contact Map
1gq2A 6 0.9431 100 0.153 Contact Map
1pj3A 4 0.9476 100 0.157 Contact Map
3nv9A 2 0.8929 100 0.323 Contact Map
1vl6A 4 0.7995 100 0.373 Contact Map
2a9fA 2 0.8132 100 0.448 Contact Map
2dvmA 2 0.8223 100 0.489 Contact Map
1v8bA 4 0.8497 100 0.813 Contact Map
4ppmA 2 0 99.9 0.855 Contact Map
4xijA 1 0.549 99.6 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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