MAO1 - BACSU - GREMLIN Contacts

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MAO1 - Probable NAD-dependent malic enzyme 1

UniProt:	P54572	Sequences: MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVGPNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPIRSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAGMPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFEIEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAICRMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPAFVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEINHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	439 (351)
Sequences:	4017 (1798)
Seq/√Len:	96.0

ECOLI - MAO1 MAO2
BACSU - MAO1 MAO2 MAO3 MAO4
HALSA - Q9HPI2
SULSO - Q97UX2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
197_K	226_E	4.280	1.00
154_N	187_S	4.261	1.00
263_V	284_V	3.747	1.00
333_P	337_R	3.516	1.00
395_D	437_A	3.393	1.00
382_R	386_N	3.223	1.00
393_N	437_A	3.120	1.00
432_H	436_T	3.068	1.00
310_S	313_E	3.046	1.00
147_T	187_S	2.941	1.00
122_L	125_K	2.848	1.00
265_Q	276_C	2.826	1.00
195_T	198_H	2.815	1.00
191_E	194_K	2.789	1.00
192_I	196_V	2.766	1.00
257_D	260_E	2.751	1.00
244_L	282_Y	2.702	1.00
190_E	222_R	2.682	1.00
212_G	215_H	2.648	1.00
333_P	356_A	2.632	1.00
275_I	324_T	2.617	1.00
190_E	193_I	2.540	1.00
316_E	338_S	2.524	1.00
333_P	359_Q	2.515	1.00
126_E	129_K	2.504	1.00
315_M	331_I	2.503	1.00
251_C	261_A	2.450	1.00
292_K	301_E	2.392	1.00
129_K	132_I	2.365	1.00
145_D	215_H	2.341	1.00
294_E	297_M	2.262	1.00
277_R	304_G	2.245	1.00
127_P	158_V	2.222	1.00
224_K	391_E	2.173	1.00
247_A	320_I	2.170	1.00
221_D	225_E	2.164	1.00
387_A	431_E	2.108	1.00
118_D	122_L	2.006	1.00
222_R	226_E	1.981	1.00
194_K	198_H	1.952	1.00
277_R	303_Y	1.935	1.00
362_A	365_A	1.930	1.00
384_A	392_I	1.911	1.00
130_A	136_I	1.895	1.00
189_P	193_I	1.870	1.00
186_T	191_E	1.862	1.00
118_D	121_R	1.836	1.00
321_V	331_I	1.830	1.00
200_S	228_N	1.827	1.00
339_G	363_A	1.823	1.00
281_A	394_H	1.811	1.00
312_E	335_F	1.795	1.00
266_I	330_L	1.778	1.00
168_A	179_G	1.769	1.00
250_A	341_V	1.763	1.00
248_I	402_E	1.718	1.00
276_C	289_G	1.711	1.00
293_S	301_E	1.695	1.00
149_I	155_I	1.693	1.00
147_T	154_N	1.691	1.00
222_R	225_E	1.690	1.00
100_M	111_V	1.645	1.00
292_K	327_V	1.628	1.00
243_T	345_L	1.609	1.00
336_V	342_I	1.608	1.00
192_I	219_I	1.606	1.00
244_L	278_M	1.605	1.00
252_R	409_K	1.594	1.00
402_E	406_A	1.575	1.00
336_V	360_A	1.575	1.00
433_A	437_A	1.550	1.00
224_K	394_H	1.544	1.00
433_A	436_T	1.543	1.00
273_V	304_G	1.494	1.00
241_V	380_I	1.491	1.00
261_A	320_I	1.491	1.00
349_K	353_E	1.489	1.00
312_E	334_A	1.487	1.00
131_S	136_I	1.480	1.00
200_S	227_L	1.474	1.00
329_G	356_A	1.468	1.00
409_K	412_D	1.465	1.00
145_D	212_G	1.459	1.00
353_E	356_A	1.440	1.00
184_L	199_I	1.424	1.00
189_P	218_E	1.424	1.00
364_Y	413_V	1.411	0.99
268_L	289_G	1.408	0.99
246_A	343_L	1.402	0.99
182_I	199_I	1.399	0.99
393_N	433_A	1.380	0.99
130_A	158_V	1.376	0.99
98_S	102_I	1.375	0.99
335_F	338_S	1.370	0.99
328_P	349_K	1.368	0.99
215_H	218_E	1.367	0.99
120_C	155_I	1.366	0.99
376_G	380_I	1.358	0.99
396_M	434_A	1.356	0.99
355_E	359_Q	1.355	0.99
428_A	432_H	1.352	0.99
186_T	198_H	1.347	0.99
331_I	338_S	1.342	0.99
332_K	335_F	1.336	0.99
394_H	397_L	1.329	0.99
299_R	302_Q	1.326	0.99
143_V	196_V	1.326	0.99
194_K	197_K	1.319	0.99
182_I	203_F	1.319	0.99
312_E	338_S	1.318	0.99
352_I	357_A	1.314	0.99
121_R	124_E	1.309	0.99
225_E	391_E	1.296	0.99
228_N	390_T	1.294	0.99
354_P	365_A	1.292	0.99
190_E	194_K	1.289	0.99
258_L	284_V	1.279	0.99
208_L	231_V	1.278	0.99
240_A	278_M	1.269	0.99
244_L	401_A	1.245	0.99
387_A	435_L	1.243	0.99
261_A	284_V	1.242	0.99
184_L	195_T	1.235	0.99
193_I	227_L	1.233	0.99
272_G	324_T	1.232	0.99
332_K	338_S	1.232	0.99
248_I	282_Y	1.228	0.99
334_A	337_R	1.223	0.99
103_R	107_E	1.219	0.98
157_S	160_G	1.211	0.98
247_A	279_F	1.209	0.98
276_C	287_V	1.206	0.98
291_D	301_E	1.188	0.98
357_A	360_A	1.188	0.98
356_A	359_Q	1.186	0.98
266_I	290_T	1.177	0.98
407_C	421_K	1.176	0.98
160_G	183_L	1.170	0.98
193_I	222_R	1.166	0.98
158_V	185_D	1.165	0.98
194_K	226_E	1.150	0.98
376_G	404_I	1.144	0.98
271_A	324_T	1.138	0.98
127_P	198_H	1.135	0.98
129_K	133_Y	1.135	0.98
218_E	222_R	1.132	0.98
333_P	360_A	1.128	0.97
386_N	431_E	1.119	0.97
315_M	338_S	1.111	0.97
280_M	287_V	1.111	0.97
371_V	414_V	1.101	0.97
185_D	200_S	1.084	0.97
189_P	222_R	1.082	0.97
303_Y	307_A	1.081	0.97
266_I	327_V	1.080	0.97
227_L	231_V	1.075	0.97
199_I	227_L	1.070	0.97
277_R	307_A	1.069	0.96
389_S	396_M	1.063	0.96
243_T	279_F	1.049	0.96
424_H	428_A	1.047	0.96
161_M	183_L	1.042	0.96
282_Y	398_V	1.035	0.96
356_A	360_A	1.031	0.96
186_T	195_T	1.007	0.95
254_A	364_Y	1.005	0.95
247_A	343_L	0.996	0.95
180_I	202_G	0.990	0.95
190_E	226_E	0.986	0.94
310_S	314_L	0.982	0.94
336_V	352_I	0.980	0.94
184_L	201_P	0.977	0.94
131_S	388_K	0.975	0.94
256_V	261_A	0.971	0.94
264_G	314_L	0.970	0.94
297_M	305_G	0.970	0.94
311_I	331_I	0.967	0.94
122_L	129_K	0.964	0.94
252_R	406_A	0.963	0.94
407_C	419_D	0.947	0.93
357_A	363_A	0.944	0.93
249_S	405_A	0.944	0.93
297_M	302_Q	0.944	0.93
124_E	160_G	0.940	0.93
407_C	425_A	0.940	0.93
358_L	365_A	0.939	0.93
282_Y	402_E	0.939	0.93
251_C	258_L	0.938	0.93
87_S	90_E	0.934	0.93
266_I	311_I	0.932	0.93
191_E	195_T	0.926	0.92
393_N	396_M	0.925	0.92
327_V	330_L	0.923	0.92
262_K	286_A	0.918	0.92
135_T	139_S	0.915	0.92
247_A	341_V	0.913	0.92
128_E	388_K	0.913	0.92
86_L	89_H	0.912	0.92
273_V	289_G	0.911	0.92
256_V	319_D	0.908	0.92
131_S	199_I	0.899	0.91
189_P	219_I	0.899	0.91
120_C	149_I	0.899	0.91
288_Y	306_Q	0.897	0.91
197_K	227_L	0.893	0.91
144_T	183_L	0.887	0.91
98_S	169_A	0.883	0.91
379_G	383_G	0.882	0.90
185_D	201_P	0.880	0.90
143_V	184_L	0.876	0.90
357_A	365_A	0.874	0.90
336_V	356_A	0.873	0.90
281_A	398_V	0.872	0.90
251_C	256_V	0.872	0.90
296_A	302_Q	0.872	0.90
96_M	180_I	0.869	0.90
105_L	416_Q	0.867	0.90
384_A	396_M	0.867	0.90
188_D	191_E	0.860	0.89
266_I	321_V	0.854	0.89
389_S	430_V	0.850	0.89
383_G	387_A	0.842	0.88
264_G	318_C	0.840	0.88
265_Q	322_I	0.839	0.88
184_L	192_I	0.837	0.88
331_I	335_F	0.837	0.88
383_G	389_S	0.835	0.88
273_V	298_N	0.835	0.88
358_L	361_G	0.835	0.88
173_Q	420_S	0.832	0.88
186_T	192_I	0.830	0.88
264_G	290_T	0.829	0.88
337_R	360_A	0.829	0.88
423_H	427_A	0.828	0.87
103_R	106_A	0.825	0.87
221_D	224_K	0.825	0.87
242_V	376_G	0.824	0.87
354_P	358_L	0.822	0.87
340_Q	363_A	0.821	0.87
399_A	433_A	0.821	0.87
288_Y	314_L	0.818	0.87
298_N	301_E	0.816	0.87
333_P	336_V	0.812	0.86
254_A	363_A	0.806	0.86
230_P	384_A	0.805	0.86
113_T	369_R	0.801	0.86
290_T	311_I	0.801	0.86
403_A	406_A	0.801	0.86
254_A	261_A	0.797	0.85
104_S	418_L	0.791	0.85
383_G	430_V	0.790	0.85
184_L	189_P	0.790	0.85
312_E	315_M	0.788	0.85
398_V	402_E	0.786	0.85
387_A	434_A	0.784	0.84
135_T	180_I	0.784	0.84
98_S	173_Q	0.784	0.84
121_R	349_K	0.783	0.84
161_M	202_G	0.781	0.84
220_E	237_H	0.781	0.84
221_D	300_L	0.780	0.84
395_D	433_A	0.780	0.84
383_G	434_A	0.778	0.84
313_E	316_E	0.777	0.84
329_G	349_K	0.777	0.84
406_A	409_K	0.776	0.84
289_G	298_N	0.774	0.84
343_L	366_A	0.770	0.83
105_L	418_L	0.767	0.83
263_V	320_I	0.764	0.83
121_R	125_K	0.761	0.83
143_V	183_L	0.756	0.82
253_S	364_Y	0.754	0.82
406_A	425_A	0.753	0.82
423_H	426_V	0.742	0.81
241_V	397_L	0.741	0.81
345_L	366_A	0.739	0.81
193_I	206_I	0.733	0.80
273_V	301_E	0.733	0.80
343_L	371_V	0.732	0.80
305_G	308_V	0.732	0.80
206_I	227_L	0.730	0.80
312_E	316_E	0.730	0.80
251_C	254_A	0.730	0.80
193_I	208_L	0.728	0.80
270_A	301_E	0.728	0.80
400_A	426_V	0.726	0.80
218_E	221_D	0.726	0.80
173_Q	176_G	0.726	0.80
403_A	425_A	0.725	0.80
258_L	282_Y	0.724	0.79
395_D	436_T	0.723	0.79
366_A	413_V	0.723	0.79
431_E	435_L	0.722	0.79
410_Q	425_A	0.721	0.79
261_A	319_D	0.719	0.79
116_V	120_C	0.714	0.79
316_E	334_A	0.714	0.79
119_V	133_Y	0.713	0.78
336_V	357_A	0.709	0.78
241_V	376_G	0.709	0.78
406_A	429_A	0.707	0.78
116_V	152_L	0.706	0.78
271_A	275_I	0.706	0.78
172_D	178_S	0.704	0.78
297_M	301_E	0.695	0.77
175_A	423_H	0.693	0.76
306_Q	314_L	0.692	0.76
290_T	314_L	0.692	0.76
280_M	307_A	0.690	0.76
279_F	322_I	0.690	0.76
102_I	169_A	0.689	0.76
278_M	401_A	0.687	0.76
185_D	188_D	0.684	0.75
289_G	304_G	0.684	0.75
147_T	215_H	0.683	0.75
315_M	335_F	0.682	0.75
139_S	202_G	0.680	0.75
248_I	258_L	0.679	0.75
329_G	353_E	0.678	0.75
272_G	345_L	0.678	0.75
120_C	152_L	0.674	0.74
113_T	144_T	0.674	0.74
429_A	432_H	0.673	0.74
294_E	301_E	0.668	0.74
192_I	195_T	0.668	0.74
197_K	222_R	0.663	0.73
136_I	202_G	0.663	0.73
182_I	202_G	0.662	0.73
277_R	394_H	0.662	0.73
304_G	308_V	0.662	0.73
296_A	301_E	0.661	0.73
141_A	196_V	0.661	0.73
243_T	275_I	0.660	0.73
170_L	374_V	0.658	0.73
90_E	95_Q	0.658	0.73
265_Q	289_G	0.657	0.73
380_I	384_A	0.655	0.72
190_E	218_E	0.654	0.72
282_Y	401_A	0.654	0.72
258_L	261_A	0.649	0.72
304_G	307_A	0.647	0.71
294_E	302_Q	0.647	0.71
136_I	388_K	0.647	0.71
262_K	318_C	0.646	0.71
349_K	356_A	0.646	0.71
126_E	130_A	0.645	0.71
96_M	139_S	0.645	0.71
262_K	288_Y	0.645	0.71
412_D	419_D	0.644	0.71
247_A	263_V	0.643	0.71
158_V	201_P	0.642	0.71
195_T	199_I	0.641	0.71
221_D	277_R	0.641	0.71
281_A	395_D	0.636	0.70
250_A	253_S	0.635	0.70
354_P	367_D	0.634	0.70
182_I	188_D	0.633	0.70
285_N	307_A	0.632	0.70
432_H	435_L	0.631	0.70
399_A	434_A	0.631	0.70
255_G	259_K	0.631	0.70
143_V	192_I	0.630	0.69
221_D	303_Y	0.628	0.69
421_K	425_A	0.626	0.69
148_A	213_S	0.624	0.69
251_C	341_V	0.621	0.68
244_L	258_L	0.621	0.68
273_V	300_L	0.619	0.68
217_F	301_E	0.618	0.68
138_N	382_R	0.615	0.68
263_V	283_G	0.614	0.67
311_I	321_V	0.610	0.67
268_L	292_K	0.610	0.67
408_T	412_D	0.610	0.67
193_I	219_I	0.609	0.67
131_S	137_S	0.609	0.67
140_V	381_F	0.609	0.67
404_I	426_V	0.608	0.67
189_P	215_H	0.607	0.67
284_V	287_V	0.607	0.67
124_E	149_I	0.607	0.67
266_I	331_I	0.606	0.66
94_I	135_T	0.606	0.66
337_R	362_A	0.602	0.66
315_M	321_V	0.601	0.66
96_M	168_A	0.599	0.66
157_S	185_D	0.596	0.65
99_K	135_T	0.595	0.65
315_M	318_C	0.594	0.65
95_Q	99_K	0.592	0.65
295_S	301_E	0.592	0.65
403_A	429_A	0.591	0.64
302_Q	306_Q	0.588	0.64
417_P	423_H	0.587	0.64
177_I	423_H	0.587	0.64
191_E	198_H	0.587	0.64
328_P	332_K	0.585	0.64
184_L	198_H	0.585	0.64
205_G	392_I	0.584	0.64
130_A	157_S	0.584	0.64
301_E	305_G	0.582	0.63
181_P	379_G	0.582	0.63
287_V	304_G	0.581	0.63
277_R	280_M	0.581	0.63
148_A	152_L	0.581	0.63
161_M	181_P	0.579	0.63
182_I	192_I	0.578	0.63
347_N	372_N	0.578	0.63
313_E	334_A	0.578	0.63
120_C	160_G	0.577	0.63
182_I	196_V	0.576	0.63
88_A	132_I	0.575	0.62
123_I	159_A	0.575	0.62
199_I	206_I	0.575	0.62
97_K	176_G	0.573	0.62
290_T	315_M	0.572	0.62
142_I	179_G	0.572	0.62
201_P	227_L	0.571	0.62
263_V	279_F	0.571	0.62
248_I	251_C	0.571	0.62
152_L	155_I	0.570	0.62
291_D	294_E	0.570	0.62
146_G	156_G	0.569	0.62
221_D	299_R	0.568	0.61
171_F	205_G	0.568	0.61
171_F	207_L	0.568	0.61
353_E	365_A	0.566	0.61
247_A	261_A	0.566	0.61
376_G	426_V	0.564	0.61
106_A	110_R	0.563	0.61
207_L	232_M	0.563	0.61
187_S	192_I	0.563	0.61
123_I	165_E	0.562	0.61
268_L	305_G	0.562	0.61
275_I	322_I	0.561	0.60
382_R	424_H	0.561	0.60
299_R	303_Y	0.560	0.60
251_C	284_V	0.560	0.60
138_N	386_N	0.559	0.60
94_I	169_A	0.558	0.60
254_A	341_V	0.558	0.60
249_S	413_V	0.557	0.60
217_F	273_V	0.555	0.60
337_R	340_Q	0.554	0.60
280_M	304_G	0.554	0.60
196_V	206_I	0.552	0.59
145_D	157_S	0.551	0.59
89_H	93_K	0.551	0.59
374_V	417_P	0.551	0.59
358_L	363_A	0.550	0.59
380_I	392_I	0.550	0.59
250_A	343_L	0.550	0.59
427_A	431_E	0.549	0.59
314_L	318_C	0.549	0.59
206_I	231_V	0.546	0.58
103_R	173_Q	0.544	0.58
391_E	395_D	0.543	0.58
355_E	358_L	0.542	0.58
113_T	377_F	0.541	0.58
246_A	414_V	0.538	0.57
399_A	402_E	0.535	0.57
331_I	336_V	0.535	0.57
116_V	166_G	0.534	0.57
121_R	160_G	0.534	0.57
297_M	300_L	0.533	0.57
205_G	230_P	0.533	0.57
331_I	342_I	0.532	0.56
108_L	374_V	0.532	0.56
148_A	375_L	0.532	0.56
169_A	173_Q	0.529	0.56
425_A	428_A	0.529	0.56
245_A	415_P	0.529	0.56
148_A	162_P	0.528	0.56
146_G	183_L	0.527	0.56
422_V	426_V	0.527	0.56
290_T	310_S	0.526	0.56
128_E	390_T	0.526	0.56
147_T	212_G	0.524	0.55
184_L	188_D	0.524	0.55
182_I	185_D	0.523	0.55
287_V	314_L	0.523	0.55
290_T	335_F	0.523	0.55
213_S	270_A	0.522	0.55
165_E	284_V	0.522	0.55
189_P	195_T	0.521	0.55
87_S	91_G	0.520	0.55
311_I	335_F	0.520	0.55
301_E	327_V	0.519	0.55
142_I	207_L	0.519	0.55
290_T	346_S	0.518	0.55
244_L	279_F	0.518	0.55
177_I	382_R	0.517	0.54
273_V	293_S	0.515	0.54
150_L	373_N	0.513	0.54
344_A	365_A	0.513	0.54
90_E	99_K	0.513	0.54
338_S	360_A	0.513	0.54
389_S	431_E	0.512	0.54
181_P	361_G	0.512	0.54
246_A	366_A	0.512	0.54
135_T	168_A	0.511	0.54
202_G	388_K	0.511	0.54
251_C	257_D	0.510	0.53
197_K	206_I	0.510	0.53
396_M	399_A	0.510	0.53
212_G	270_A	0.510	0.53
102_I	111_V	0.510	0.53
122_L	133_Y	0.510	0.53
186_T	201_P	0.508	0.53
139_S	177_I	0.507	0.53
243_T	301_E	0.507	0.53
174_L	374_V	0.507	0.53
128_E	132_I	0.506	0.53
288_Y	308_V	0.506	0.53
342_I	363_A	0.505	0.53
174_L	324_T	0.505	0.53
247_A	250_A	0.504	0.53
291_D	296_A	0.504	0.53
142_I	168_A	0.504	0.53
347_N	373_N	0.503	0.52
150_L	372_N	0.502	0.52
287_V	306_Q	0.502	0.52
357_A	361_G	0.501	0.52
280_M	306_Q	0.501	0.52
266_I	289_G	0.500	0.52

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1o0sA	4	0.9932	100	0.148	Contact Map
1gq2A	6	0.9431	100	0.153	Contact Map
1pj3A	4	0.9476	100	0.157	Contact Map
3nv9A	2	0.8929	100	0.323	Contact Map
1vl6A	4	0.7995	100	0.373	Contact Map
2a9fA	2	0.8132	100	0.448	Contact Map
2dvmA	2	0.8223	100	0.489	Contact Map
1v8bA	4	0.8497	100	0.813	Contact Map
4ppmA	2	0	99.9	0.855	Contact Map
4xijA	1	0.549	99.6	0.907	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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