MLEN - BACSU - GREMLIN Contacts

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MLEN - Malate-2H(+)/Na(+)-lactate antiporter

UniProt:	P54571	Sequences: MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFIAMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLEFIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGAYFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNIDLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQGMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGVLKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDRRVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYTGKFIWYTKNNTVKAEKLG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	468 (426)
Sequences:	2180 (1418)
Seq/√Len:	68.7

BACSU - MLEN NHAC
HALSA - Q9HNF7 Q9HS26 ARCD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
205_L	435_W	6.287	1.00
126_T	129_G	4.902	1.00
350_G	449_Y	4.023	1.00
386_D	392_R	3.981	1.00
246_L	267_L	3.951	1.00
142_G	152_V	3.638	1.00
118_S	199_Y	3.405	1.00
131_V	419_M	3.371	1.00
200_V	204_I	3.150	1.00
348_S	351_N	3.094	1.00
55_S	58_D	3.026	1.00
190_A	394_V	2.978	1.00
111_L	207_T	2.937	1.00
111_L	203_A	2.936	1.00
166_L	192_L	2.932	1.00
139_I	149_L	2.905	1.00
356_T	385_Y	2.731	1.00
201_I	439_V	2.704	1.00
350_G	448_G	2.640	1.00
86_T	287_A	2.618	1.00
279_D	282_H	2.575	1.00
341_T	344_K	2.469	1.00
247_V	264_G	2.406	1.00
354_L	449_Y	2.396	1.00
78_V	309_I	2.364	1.00
110_L	151_L	2.362	1.00
113_T	138_M	2.302	1.00
102_E	227_K	2.261	1.00
330_E	379_K	2.251	1.00
434_M	437_S	2.241	1.00
365_I	410_V	2.235	1.00
95_T	236_I	2.225	1.00
357_L	402_G	2.224	1.00
65_H	331_K	2.222	1.00
114_L	199_Y	2.213	1.00
155_A	206_F	2.194	1.00
359_V	381_M	2.193	1.00
49_G	59_L	2.193	1.00
364_N	406_T	2.176	1.00
249_V	253_M	2.123	1.00
269_A	283_A	2.105	1.00
181_K	392_R	2.064	1.00
390_L	394_V	2.037	1.00
86_T	265_A	2.019	1.00
357_L	445_I	2.009	1.00
95_T	99_Y	2.005	1.00
89_A	286_T	1.990	1.00
264_G	268_G	1.984	1.00
182_V	392_R	1.969	1.00
435_W	439_V	1.968	1.00
230_L	236_I	1.965	1.00
65_H	68_S	1.945	1.00
62_A	331_K	1.940	1.00
204_I	208_V	1.916	1.00
235_D	238_I	1.915	1.00
427_T	431_L	1.913	1.00
420_A	427_T	1.896	1.00
202_T	206_F	1.892	1.00
198_A	439_V	1.876	1.00
207_T	211_F	1.864	1.00
79_S	258_M	1.845	1.00
92_V	243_P	1.831	1.00
95_T	241_L	1.791	1.00
201_I	443_L	1.782	1.00
194_L	401_V	1.779	1.00
442_G	446_I	1.776	1.00
435_W	438_F	1.768	1.00
183_D	186_A	1.733	1.00
288_Y	310_V	1.712	1.00
446_I	450_T	1.668	0.99
285_A	289_N	1.662	0.99
142_G	149_L	1.653	0.99
250_L	263_I	1.649	0.99
151_L	209_V	1.648	0.99
360_A	399_S	1.626	0.99
313_L	317_V	1.624	0.99
147_I	152_V	1.620	0.99
25_S	30_L	1.581	0.99
177_S	182_V	1.577	0.99
336_K	340_S	1.573	0.99
153_A	423_L	1.571	0.99
361_F	406_T	1.569	0.99
18_V	44_I	1.567	0.99
84_I	132_G	1.564	0.99
99_Y	238_I	1.546	0.99
43_F	262_V	1.537	0.99
354_L	445_I	1.533	0.99
273_V	283_A	1.531	0.99
347_T	351_N	1.527	0.99
70_G	323_L	1.527	0.99
49_G	332_L	1.521	0.99
353_T	394_V	1.479	0.99
271_W	275_F	1.477	0.99
434_M	438_F	1.475	0.99
186_A	393_R	1.475	0.99
418_Y	422_I	1.469	0.99
177_S	181_K	1.460	0.99
239_W	271_W	1.460	0.99
172_S	374_L	1.458	0.99
270_I	274_V	1.446	0.98
158_S	206_F	1.432	0.98
179_L	378_P	1.426	0.98
209_V	435_W	1.425	0.98
428_F	431_L	1.406	0.98
357_L	444_A	1.405	0.98
229_S	301_N	1.402	0.98
382_E	386_D	1.399	0.98
224_E	228_S	1.395	0.98
240_M	275_F	1.395	0.98
33_P	37_A	1.388	0.98
398_N	444_A	1.387	0.98
245_V	249_V	1.383	0.98
201_I	205_L	1.379	0.98
66_G	327_G	1.379	0.98
157_L	416_G	1.377	0.98
205_L	209_V	1.367	0.98
407_S	415_N	1.366	0.98
240_M	271_W	1.362	0.98
447_Y	453_F	1.362	0.98
89_A	272_A	1.362	0.98
148_P	213_Y	1.359	0.98
78_V	313_L	1.357	0.98
152_V	156_I	1.349	0.98
88_I	306_R	1.342	0.97
165_K	400_E	1.337	0.97
407_S	413_S	1.335	0.97
61_N	68_S	1.331	0.97
205_L	439_V	1.331	0.97
182_V	186_A	1.327	0.97
99_Y	241_L	1.321	0.97
86_T	269_A	1.318	0.97
11_E	52_L	1.315	0.97
190_A	393_R	1.310	0.97
154_G	158_S	1.308	0.97
85_G	89_A	1.301	0.97
202_T	439_V	1.294	0.97
115_I	203_A	1.288	0.97
431_L	438_F	1.282	0.97
191_M	400_E	1.280	0.97
146_G	149_L	1.279	0.97
86_T	268_G	1.277	0.97
378_P	399_S	1.271	0.97
227_K	231_Q	1.263	0.96
195_S	440_A	1.260	0.96
198_A	440_A	1.258	0.96
427_T	430_Y	1.255	0.96
383_D	387_R	1.238	0.96
24_L	28_V	1.227	0.96
405_L	440_A	1.226	0.96
110_L	147_I	1.223	0.96
350_G	445_I	1.215	0.95
401_V	444_A	1.209	0.95
272_A	278_M	1.207	0.95
135_G	153_A	1.200	0.95
45_A	328_L	1.189	0.95
139_I	153_A	1.184	0.95
82_A	287_A	1.184	0.95
409_M	438_F	1.179	0.95
165_K	404_T	1.174	0.95
13_I	17_G	1.159	0.94
337_V	341_T	1.159	0.94
400_E	404_T	1.156	0.94
397_R	401_V	1.155	0.94
203_A	207_T	1.152	0.94
352_V	384_S	1.146	0.94
75_L	258_M	1.146	0.94
278_M	286_T	1.144	0.94
181_K	382_E	1.142	0.94
14_I	44_I	1.141	0.94
289_N	310_V	1.133	0.93
118_S	162_F	1.131	0.93
239_W	242_I	1.126	0.93
310_V	313_L	1.123	0.93
161_Y	419_M	1.122	0.93
56_Y	259_P	1.119	0.93
384_S	387_R	1.114	0.93
310_V	314_D	1.112	0.93
384_S	388_L	1.112	0.93
438_F	442_G	1.110	0.93
99_Y	236_I	1.108	0.93
138_M	156_I	1.094	0.92
360_A	403_G	1.092	0.92
369_A	373_S	1.079	0.92
242_I	271_W	1.079	0.92
162_F	400_E	1.079	0.92
238_I	245_V	1.078	0.92
173_T	400_E	1.074	0.91
64_V	68_S	1.065	0.91
353_T	448_G	1.064	0.91
74_V	319_I	1.061	0.91
58_D	61_N	1.060	0.91
63_I	324_G	1.058	0.91
92_V	240_M	1.050	0.91
330_E	336_K	1.047	0.90
100_G	234_F	1.043	0.90
161_Y	413_S	1.042	0.90
73_A	371_Y	1.035	0.90
192_L	196_I	1.032	0.90
424_G	427_T	1.030	0.90
350_G	354_L	1.030	0.90
383_D	386_D	1.025	0.89
439_V	443_L	1.024	0.89
237_H	240_M	1.022	0.89
242_I	267_L	1.018	0.89
113_T	155_A	1.018	0.89
157_L	367_G	1.012	0.89
18_V	48_L	1.007	0.89
39_F	82_A	1.005	0.89
104_I	112_A	1.005	0.89
142_G	146_G	1.004	0.88
187_H	396_S	1.001	0.88
348_S	388_L	0.997	0.88
443_L	446_I	0.987	0.88
226_L	300_L	0.984	0.87
116_I	138_M	0.979	0.87
95_T	240_M	0.977	0.87
11_E	51_R	0.977	0.87
436_L	440_A	0.976	0.87
370_M	441_I	0.971	0.87
315_S	415_N	0.971	0.87
104_I	108_I	0.969	0.87
150_P	429_S	0.967	0.87
198_A	443_L	0.965	0.86
61_N	65_H	0.965	0.86
450_T	453_F	0.964	0.86
250_L	255_K	0.963	0.86
57_K	61_N	0.963	0.86
74_V	316_L	0.962	0.86
349_A	388_L	0.962	0.86
34_I	37_A	0.959	0.86
139_I	143_E	0.957	0.86
361_F	365_I	0.948	0.85
121_S	130_T	0.946	0.85
139_I	425_V	0.944	0.85
278_M	282_H	0.944	0.85
307_G	311_G	0.940	0.85
67_I	75_L	0.939	0.85
110_L	148_P	0.938	0.85
117_C	121_S	0.937	0.85
166_L	196_I	0.936	0.85
117_C	134_A	0.932	0.84
224_E	227_K	0.931	0.84
180_S	396_S	0.931	0.84
346_L	352_V	0.930	0.84
194_L	397_R	0.930	0.84
195_S	400_E	0.927	0.84
62_A	327_G	0.923	0.84
79_S	265_A	0.921	0.84
426_S	429_S	0.920	0.84
57_K	115_I	0.920	0.84
409_M	434_M	0.915	0.83
246_L	249_V	0.914	0.83
175_L	374_L	0.908	0.83
202_T	205_L	0.907	0.83
34_I	414_D	0.906	0.83
165_K	195_S	0.902	0.82
123_A	248_I	0.899	0.82
410_V	413_S	0.894	0.82
225_F	229_S	0.887	0.81
246_L	263_I	0.886	0.81
157_L	419_M	0.884	0.81
197_P	200_V	0.880	0.81
197_P	443_L	0.879	0.81
341_T	345_K	0.876	0.81
128_W	418_Y	0.867	0.80
47_L	51_R	0.867	0.80
198_A	202_T	0.862	0.79
118_S	122_V	0.862	0.79
225_F	228_S	0.861	0.79
153_A	425_V	0.857	0.79
357_L	448_G	0.855	0.79
118_S	121_S	0.850	0.79
187_H	400_E	0.850	0.79
34_I	38_L	0.849	0.78
405_L	436_L	0.845	0.78
425_V	429_S	0.841	0.78
343_E	387_R	0.840	0.78
90_G	271_W	0.834	0.77
416_G	430_Y	0.830	0.77
81_G	312_M	0.830	0.77
148_P	433_F	0.827	0.77
346_L	351_N	0.826	0.77
143_E	149_L	0.826	0.77
349_A	390_L	0.824	0.76
354_L	358_I	0.821	0.76
443_L	447_Y	0.821	0.76
374_L	404_T	0.818	0.76
235_D	274_V	0.817	0.76
145_L	152_V	0.816	0.76
314_D	317_V	0.812	0.75
165_K	187_H	0.809	0.75
86_T	283_A	0.806	0.75
181_K	386_D	0.803	0.74
67_I	320_I	0.800	0.74
172_S	400_E	0.797	0.74
338_I	347_T	0.794	0.74
385_Y	395_L	0.793	0.74
161_Y	206_F	0.792	0.73
173_T	176_A	0.788	0.73
74_V	320_I	0.788	0.73
82_A	265_A	0.788	0.73
85_G	283_A	0.787	0.73
447_Y	450_T	0.786	0.73
255_K	263_I	0.785	0.73
139_I	156_I	0.785	0.73
190_A	390_L	0.784	0.73
126_T	370_M	0.784	0.73
22_L	37_A	0.782	0.73
420_A	426_S	0.781	0.72
257_S	303_L	0.781	0.72
46_M	328_L	0.772	0.72
445_I	449_Y	0.770	0.71
363_A	377_T	0.767	0.71
42_W	46_M	0.767	0.71
19_F	436_L	0.765	0.71
373_S	377_T	0.764	0.71
369_A	407_S	0.761	0.70
346_L	355_S	0.761	0.70
288_Y	314_D	0.761	0.70
115_I	231_Q	0.759	0.70
42_W	321_F	0.759	0.70
23_V	27_T	0.757	0.70
42_W	325_F	0.756	0.70
54_Y	58_D	0.753	0.70
385_Y	398_N	0.752	0.70
357_L	361_F	0.748	0.69
237_H	275_F	0.748	0.69
45_A	48_L	0.747	0.69
206_F	435_W	0.747	0.69
21_A	233_T	0.746	0.69
406_T	437_S	0.745	0.69
46_M	50_I	0.743	0.69
158_S	434_M	0.741	0.68
15_V	45_A	0.740	0.68
370_M	407_S	0.739	0.68
17_G	232_N	0.739	0.68
231_Q	266_L	0.737	0.68
129_G	243_P	0.737	0.68
171_D	176_A	0.737	0.68
57_K	340_S	0.734	0.68
369_A	413_S	0.728	0.67
165_K	171_D	0.728	0.67
416_G	420_A	0.727	0.67
130_T	160_A	0.725	0.67
89_A	92_V	0.723	0.67
369_A	414_D	0.722	0.66
108_I	111_L	0.721	0.66
272_A	283_A	0.721	0.66
224_E	316_L	0.720	0.66
208_V	233_T	0.718	0.66
166_L	172_S	0.717	0.66
228_S	231_Q	0.716	0.66
173_T	188_V	0.716	0.66
15_V	19_F	0.715	0.66
202_T	442_G	0.715	0.66
127_S	172_S	0.714	0.66
306_R	311_G	0.714	0.66
76_I	80_V	0.714	0.66
353_T	454_I	0.714	0.66
309_I	317_V	0.713	0.65
49_G	355_S	0.711	0.65
83_L	261_I	0.710	0.65
126_T	371_Y	0.710	0.65
127_S	160_A	0.709	0.65
193_Y	452_K	0.709	0.65
151_L	158_S	0.708	0.65
370_M	415_N	0.708	0.65
142_G	145_L	0.707	0.65
118_S	284_I	0.706	0.65
127_S	171_D	0.704	0.64
267_L	271_W	0.703	0.64
277_G	309_I	0.703	0.64
323_L	364_N	0.703	0.64
145_L	210_G	0.702	0.64
174_V	184_V	0.700	0.64
432_P	435_W	0.699	0.64
353_T	398_N	0.699	0.64
111_L	121_S	0.698	0.64
374_L	399_S	0.697	0.64
17_G	249_V	0.695	0.63
164_D	400_E	0.694	0.63
187_H	191_M	0.693	0.63
377_T	403_G	0.692	0.63
340_S	387_R	0.691	0.63
157_L	434_M	0.690	0.63
66_G	323_L	0.689	0.63
36_L	376_L	0.687	0.63
172_S	177_S	0.686	0.62
137_A	320_I	0.685	0.62
77_L	161_Y	0.682	0.62
182_V	391_D	0.682	0.62
176_A	187_H	0.680	0.62
263_I	267_L	0.679	0.62
394_V	398_N	0.679	0.62
90_G	390_L	0.679	0.62
286_T	309_I	0.677	0.61
119_I	245_V	0.676	0.61
323_L	378_P	0.676	0.61
408_G	437_S	0.674	0.61
195_S	401_V	0.672	0.61
251_L	268_G	0.672	0.61
81_G	308_G	0.669	0.61
132_G	136_I	0.665	0.60
30_L	280_I	0.663	0.60
49_G	250_L	0.662	0.60
15_V	334_V	0.661	0.60
73_A	129_G	0.660	0.59
130_T	371_Y	0.660	0.59
204_I	349_A	0.659	0.59
180_S	392_R	0.659	0.59
200_V	279_D	0.658	0.59
77_L	80_V	0.658	0.59
110_L	142_G	0.656	0.59
420_A	430_Y	0.655	0.59
113_T	117_C	0.654	0.59
161_Y	406_T	0.652	0.59
216_K	270_I	0.652	0.59
408_G	419_M	0.652	0.59
205_L	208_V	0.652	0.59
273_V	280_I	0.651	0.58
405_L	441_I	0.651	0.58
174_V	178_S	0.651	0.58
129_G	371_Y	0.648	0.58
80_V	131_V	0.646	0.58
55_S	347_T	0.646	0.58
394_V	448_G	0.644	0.58
161_Y	437_S	0.644	0.58
364_N	407_S	0.643	0.57
366_F	408_G	0.642	0.57
114_L	129_G	0.641	0.57
249_V	252_A	0.640	0.57
235_D	275_F	0.640	0.57
394_V	447_Y	0.636	0.57
193_Y	197_P	0.634	0.56
18_V	49_G	0.633	0.56
241_L	268_G	0.633	0.56
192_L	205_L	0.631	0.56
93_V	322_G	0.630	0.56
131_V	261_I	0.629	0.56
46_M	59_L	0.628	0.56
77_L	316_L	0.626	0.55
364_N	373_S	0.626	0.55
98_Y	102_E	0.626	0.55
356_T	398_N	0.623	0.55
340_S	442_G	0.623	0.55
281_A	435_W	0.622	0.55
117_C	130_T	0.622	0.55
105_H	112_A	0.620	0.55
36_L	41_S	0.618	0.55
142_G	147_I	0.618	0.55
115_I	438_F	0.617	0.54
129_G	370_M	0.615	0.54
173_T	187_H	0.614	0.54
42_W	437_S	0.614	0.54
256_P	259_P	0.614	0.54
402_G	444_A	0.614	0.54
190_A	397_R	0.614	0.54
157_L	413_S	0.611	0.54
352_V	356_T	0.610	0.54
274_V	277_G	0.609	0.53
439_V	442_G	0.609	0.53
42_W	63_I	0.608	0.53
375_I	410_V	0.608	0.53
174_V	377_T	0.607	0.53
209_V	433_F	0.607	0.53
273_V	282_H	0.606	0.53
118_S	203_A	0.605	0.53
74_V	93_V	0.603	0.53
360_A	377_T	0.603	0.53
322_G	326_G	0.602	0.53
240_M	244_A	0.600	0.52
11_E	14_I	0.599	0.52
182_V	366_F	0.599	0.52
27_T	261_I	0.598	0.52
132_G	418_Y	0.598	0.52
279_D	286_T	0.598	0.52
359_V	396_S	0.596	0.52
382_E	392_R	0.595	0.52
122_V	171_D	0.595	0.52
104_I	127_S	0.593	0.52
364_N	370_M	0.592	0.51
50_I	59_L	0.585	0.51
183_D	189_R	0.585	0.51
11_E	48_L	0.585	0.51
264_G	375_I	0.585	0.51
38_L	77_L	0.584	0.50
46_M	49_G	0.584	0.50
357_L	398_N	0.584	0.50
85_G	240_M	0.582	0.50
398_N	402_G	0.582	0.50
47_L	50_I	0.581	0.50
77_L	369_A	0.580	0.50
202_T	435_W	0.578	0.50
442_G	445_I	0.578	0.50
362_L	366_F	0.578	0.50
138_M	417_I	0.578	0.50
94_P	234_F	0.576	0.49
19_F	23_V	0.576	0.49
47_L	386_D	0.575	0.49
282_H	286_T	0.575	0.49
313_L	316_L	0.574	0.49
36_L	50_I	0.574	0.49
161_Y	408_G	0.573	0.49
100_G	137_A	0.573	0.49
195_S	404_T	0.572	0.49
243_P	251_L	0.572	0.49
48_L	52_L	0.572	0.49
21_A	49_G	0.571	0.49
172_S	176_A	0.571	0.49
27_T	34_I	0.570	0.49
80_V	261_I	0.570	0.49
232_N	362_L	0.570	0.49
39_F	321_F	0.570	0.49
164_D	170_S	0.568	0.49
199_Y	203_A	0.568	0.49
108_I	112_A	0.568	0.49
368_C	407_S	0.567	0.48
281_A	285_A	0.566	0.48
178_S	441_I	0.565	0.48
450_T	454_I	0.565	0.48
329_L	332_L	0.565	0.48
209_V	213_Y	0.565	0.48
111_L	372_V	0.564	0.48
64_V	71_L	0.564	0.48
208_V	212_M	0.564	0.48
319_I	372_V	0.563	0.48
167_S	308_G	0.563	0.48
199_Y	436_L	0.562	0.48
85_G	286_T	0.562	0.48
128_W	440_A	0.561	0.48
121_S	168_P	0.561	0.48
55_S	196_I	0.560	0.48
96_L	171_D	0.560	0.48
20_L	363_A	0.559	0.47
244_A	261_I	0.557	0.47
139_I	422_I	0.557	0.47
19_F	45_A	0.557	0.47
345_K	348_S	0.556	0.47
12_I	337_V	0.555	0.47
216_K	246_L	0.554	0.47
343_E	346_L	0.553	0.47
250_L	260_V	0.550	0.46
109_F	149_L	0.550	0.46
110_L	155_A	0.550	0.46
191_M	338_I	0.549	0.46
15_V	240_M	0.549	0.46
128_W	414_D	0.548	0.46
34_I	314_D	0.548	0.46
94_P	304_L	0.546	0.46
389_H	392_R	0.544	0.46
190_A	453_F	0.544	0.46
200_V	249_V	0.542	0.45
41_S	45_A	0.542	0.45
362_L	387_R	0.541	0.45
41_S	439_V	0.541	0.45
128_W	407_S	0.540	0.45
211_F	242_I	0.540	0.45
16_L	63_I	0.540	0.45
75_L	93_V	0.539	0.45
118_S	436_L	0.539	0.45
229_S	232_N	0.538	0.45
301_N	318_V	0.538	0.45
54_Y	331_K	0.537	0.45
49_G	334_V	0.537	0.45
172_S	415_N	0.537	0.45
317_V	380_I	0.536	0.45
121_S	284_I	0.536	0.45
130_T	144_G	0.536	0.45
425_V	431_L	0.535	0.45
153_A	419_M	0.534	0.44
107_S	232_N	0.534	0.44
29_F	375_I	0.530	0.44
349_A	451_G	0.530	0.44
187_H	404_T	0.529	0.44
16_L	366_F	0.528	0.44
124_T	210_G	0.528	0.44
65_H	246_L	0.527	0.44
346_L	381_M	0.526	0.44
162_F	166_L	0.526	0.44
100_G	168_P	0.525	0.43
303_L	390_L	0.525	0.43
234_F	276_Q	0.524	0.43
141_I	234_F	0.524	0.43
40_V	284_I	0.522	0.43
60_Q	93_V	0.521	0.43
343_E	384_S	0.521	0.43
124_T	130_T	0.521	0.43
139_I	148_P	0.520	0.43
228_S	232_N	0.520	0.43
27_T	35_Q	0.520	0.43
46_M	132_G	0.519	0.43
29_F	206_F	0.519	0.43
157_L	341_T	0.519	0.43
166_L	188_V	0.519	0.43
114_L	243_P	0.518	0.43
236_I	240_M	0.516	0.42
17_G	344_K	0.516	0.42
92_V	179_L	0.515	0.42
12_I	15_V	0.515	0.42
370_M	436_L	0.514	0.42
408_G	415_N	0.514	0.42
246_L	250_L	0.513	0.42
348_S	449_Y	0.513	0.42
104_I	119_I	0.513	0.42
252_A	358_I	0.513	0.42
111_L	409_M	0.512	0.42
30_L	151_L	0.512	0.42
165_K	173_T	0.512	0.42
235_D	239_W	0.511	0.42
39_F	323_L	0.511	0.42
59_L	332_L	0.511	0.42
62_A	318_V	0.511	0.42
147_I	213_Y	0.510	0.42
33_P	314_D	0.510	0.42
266_L	270_I	0.509	0.42
398_N	448_G	0.509	0.42
155_A	198_A	0.509	0.42
43_F	280_I	0.508	0.41
426_S	431_L	0.507	0.41
129_G	372_V	0.507	0.41
123_A	169_L	0.506	0.41
115_I	442_G	0.505	0.41
115_I	302_G	0.505	0.41
103_F	209_V	0.505	0.41
196_I	216_K	0.504	0.41
248_I	252_A	0.504	0.41
317_V	320_I	0.504	0.41
150_P	428_F	0.504	0.41
154_G	376_L	0.503	0.41
244_A	251_L	0.503	0.41
67_I	322_G	0.503	0.41
184_V	417_I	0.502	0.41
360_A	402_G	0.502	0.41
46_M	63_I	0.501	0.41
50_I	55_S	0.501	0.41
71_L	74_V	0.501	0.41
372_V	390_L	0.501	0.41
206_F	436_L	0.500	0.40
204_I	207_T	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4f35D	2	0.859	99.9	0.815	Contact Map
4r1iA	2	0.9252	99.8	0.841	Contact Map
4r0cA	3	0.4573	99.6	0.871	Contact Map
4pd6A	3	0.4316	69.5	0.968	Contact Map
3qe7A	2	0.7457	55.5	0.971	Contact Map
4rp9A	2	0.438	35.3	0.974	Contact Map
4eneA	2	0.6709	26.7	0.976	Contact Map
3nd0A	2	0.656	23.9	0.977	Contact Map
4bwzA	2	0.6261	19.7	0.977	Contact Map
4czbA	2	0.6688	14.5	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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