GREMLIN Database
ADPP - ADP-ribose pyrophosphatase
UniProt: P54570 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 185 (169)
Sequences: 5931 (4249)
Seq/√Len: 326.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A74_I2.9211.00
7_K28_E2.7501.00
86_E90_L2.4701.00
103_K127_E2.4601.00
52_T56_K2.4301.00
94_E100_T2.3391.00
155_L176_Q2.3231.00
102_K128_E2.2331.00
56_K150_T2.2321.00
16_S21_D2.2251.00
154_A172_I2.2051.00
12_E24_V2.1941.00
56_K148_E2.1861.00
72_V147_M2.1621.00
156_K160_S2.0501.00
105_T127_E2.0251.00
13_Q16_S2.0101.00
106_K122_H2.0041.00
84_E87_Y1.9941.00
58_I148_E1.9901.00
10_A26_D1.9861.00
52_T148_E1.9671.00
61_K145_E1.9511.00
26_D34_A1.9461.00
109_A120_I1.9451.00
41_K118_D1.9171.00
102_K130_S1.8241.00
83_E91_R1.8071.00
157_L162_E1.8061.00
79_L88_T1.7891.00
24_V36_K1.7841.00
61_K147_M1.7741.00
23_Y41_K1.7731.00
90_L104_L1.7611.00
106_K109_A1.7231.00
48_V89_A1.6871.00
62_Q73_E1.6611.00
149_V157_L1.6571.00
28_E34_A1.6531.00
85_P122_H1.6321.00
103_K128_E1.6041.00
109_A122_H1.5621.00
150_T153_D1.5501.00
8_T65_K1.5401.00
93_L101_A1.4961.00
153_D156_K1.4901.00
11_K23_Y1.4871.00
11_K25_E1.4751.00
17_G38_E1.4511.00
25_E65_K1.4491.00
111_Y164_Y1.4451.00
49_L171_A1.4291.00
9_I28_E1.4131.00
86_E104_L1.4061.00
100_T130_S1.4031.00
87_Y90_L1.3721.00
58_I99_Y1.3481.00
88_T91_R1.3471.00
24_V38_E1.3381.00
74_I171_A1.3341.00
69_R164_Y1.3171.00
26_D36_K1.3031.00
110_F170_Y1.2791.00
79_L85_P1.2661.00
49_L175_L1.2391.00
75_P97_T1.2041.00
90_L94_E1.1821.00
67_L71_I1.1791.00
67_L111_Y1.1781.00
85_P124_F1.1731.00
63_F68_E1.1641.00
149_V154_A1.1631.00
110_F123_V1.1371.00
99_Y131_V1.1041.00
50_A93_L1.1001.00
65_K68_E1.0971.00
44_G79_L1.0951.00
58_I146_V1.0901.00
13_Q23_Y1.0861.00
113_S119_E1.0721.00
156_K159_E1.0671.00
83_E88_T1.0661.00
155_L159_E1.0621.00
153_D157_L1.0521.00
106_K124_F1.0501.00
158_V169_A1.0401.00
55_G151_L1.0401.00
30_P143_F1.0371.00
9_I34_A1.0311.00
13_Q21_D1.0241.00
123_V171_A1.0021.00
134_E137_E0.9981.00
61_K70_T0.9901.00
94_E137_E0.9861.00
107_I125_L0.9771.00
46_V89_A0.9741.00
12_E26_D0.9701.00
25_E39_I0.9381.00
71_I114_P0.9031.00
138_L141_D0.8981.00
165_D168_T0.8881.00
101_A104_L0.8711.00
57_I172_I0.8681.00
45_A121_V0.8671.00
51_V125_L0.8621.00
64_R73_E0.8591.00
42_H119_E0.8571.00
40_V116_F0.8541.00
44_G120_I0.8481.00
170_Y173_Q0.8451.00
89_A104_L0.8441.00
49_L74_I0.8251.00
47_A121_V0.8251.00
49_L57_I0.8221.00
57_I74_I0.8141.00
48_V126_A0.8111.00
155_L172_I0.8011.00
100_T132_L0.7971.00
86_E106_K0.7951.00
59_M72_V0.7911.00
74_I172_I0.7851.00
104_L126_A0.7811.00
104_L124_F0.7791.00
101_A128_E0.7781.00
21_D41_K0.7771.00
47_A167_K0.7751.00
47_A123_V0.7721.00
112_T116_F0.7721.00
90_L100_T0.7711.00
111_Y120_I0.7641.00
52_T99_Y0.7621.00
53_D128_E0.7580.99
158_V163_V0.7580.99
51_V55_G0.7520.99
59_M149_V0.7490.99
51_V151_L0.7430.99
55_G152_E0.7380.99
8_T25_E0.7360.99
39_I65_K0.7360.99
44_G122_H0.7350.99
14_I22_L0.7310.99
14_I24_V0.7310.99
72_V149_V0.7280.99
75_P93_L0.7230.99
59_M147_M0.7180.99
101_A129_L0.7160.99
110_F166_A0.7160.99
138_L144_V0.7110.99
108_T170_Y0.7100.99
53_D130_S0.7040.99
113_S117_A0.6920.99
51_V57_I0.6910.99
70_T143_F0.6900.99
157_L160_S0.6890.99
8_T68_E0.6870.99
105_T125_L0.6840.99
50_A125_L0.6820.99
101_A126_A0.6810.99
121_V167_K0.6760.99
94_E135_K0.6750.99
120_I164_Y0.6740.99
135_K138_L0.6690.99
60_V144_V0.6680.99
139_D142_E0.6570.99
61_K72_V0.6550.99
53_D127_E0.6540.99
48_V75_P0.6470.98
94_E134_E0.6470.98
110_F169_A0.6460.98
46_V85_P0.6440.98
103_K106_K0.6430.98
57_I151_L0.6420.98
54_E148_E0.6420.98
86_E124_F0.6370.98
59_M154_A0.6370.98
89_A124_F0.6370.98
50_A60_V0.6350.98
108_T174_Y0.6320.98
22_L40_V0.6300.98
10_A13_Q0.6290.98
109_A164_Y0.6280.98
28_E32_G0.6270.98
131_V135_K0.6260.98
51_V127_E0.6240.98
20_I40_V0.6160.98
150_T155_L0.6140.98
43_P78_K0.6140.98
31_N143_F0.6130.98
27_V35_S0.6110.98
151_L155_L0.6110.98
154_A158_V0.6070.98
51_V175_L0.6050.98
89_A93_L0.5990.97
163_V168_T0.5950.97
50_A101_A0.5940.97
151_L176_Q0.5910.97
50_A74_I0.5910.97
132_L135_K0.5900.97
42_H117_A0.5830.97
170_Y174_Y0.5810.97
79_L122_H0.5800.97
76_A167_K0.5780.97
72_V157_L0.5780.97
112_T166_A0.5730.97
149_V153_D0.5710.97
108_T169_A0.5710.97
29_L33_K0.5700.96
44_G78_K0.5700.96
13_Q41_K0.5670.96
57_I175_L0.5670.96
64_R115_G0.5610.96
112_T117_A0.5600.96
47_A76_A0.5600.96
45_A78_K0.5600.96
52_T58_I0.5600.96
157_L163_V0.5570.96
76_A115_G0.5560.96
71_I111_Y0.5530.96
18_K24_V0.5530.96
105_T108_T0.5520.96
152_E155_L0.5520.96
15_F18_K0.5510.96
12_E36_K0.5500.96
15_F40_V0.5500.96
15_F22_L0.5490.96
153_D162_E0.5480.96
42_H116_F0.5430.95
11_K41_K0.5420.95
147_M157_L0.5400.95
48_V104_L0.5370.95
173_Q176_Q0.5340.95
8_T11_K0.5310.95
84_E124_F0.5300.95
154_A163_V0.5290.95
57_I154_A0.5290.95
168_T172_I0.5290.95
22_L38_E0.5280.95
172_I176_Q0.5280.95
100_T134_E0.5270.95
27_V65_K0.5260.95
48_V93_L0.5220.94
39_I66_P0.5220.94
35_S141_D0.5210.94
18_K36_K0.5190.94
94_E132_L0.5190.94
108_T161_R0.5180.94
108_T123_V0.5150.94
42_H76_A0.5120.94
116_F121_V0.5110.94
76_A113_S0.5080.93
56_K153_D0.5070.93
20_I23_Y0.5060.93
58_I97_T0.5040.93
85_P106_K0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1g0sA 2 0.9946 100 0.274 Contact Map
1vhzA 2 0.9838 100 0.302 Contact Map
2dscA 2 0.9459 100 0.31 Contact Map
1mk1A 2 0.8919 100 0.342 Contact Map
3o6zA 2 0.9568 100 0.399 Contact Map
2yvpA 2 0.9676 100 0.4 Contact Map
1v8yA 2 0.8054 100 0.422 Contact Map
3q91A 2 0.7135 100 0.458 Contact Map
2w4eA 2 0.7405 99.9 0.523 Contact Map
2fvvA 1 0.7297 99.9 0.562 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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