GREMLIN Database
YQKF - Uncharacterized oxidoreductase YqkF
UniProt: P54569 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 306 (260)
Sequences: 32345 (20463)
Seq/√Len: 1269.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_E273_R3.2081.00
102_K142_V2.9291.00
65_Q109_K2.8241.00
27_K62_D2.7681.00
285_T288_E2.6471.00
31_L66_N2.5351.00
98_K136_E2.4851.00
101_V137_L2.4281.00
5_K12_D2.4091.00
36_E40_L2.3421.00
98_K140_E2.3321.00
135_E139_Q2.1331.00
31_L62_D2.0791.00
103_K107_R2.0501.00
255_A289_I2.0481.00
112_Y144_R2.0301.00
237_E241_P1.9931.00
185_L189_H1.9911.00
136_E140_E1.9891.00
269_I273_R1.9831.00
286_E290_K1.9491.00
67_R70_D1.9341.00
36_E269_I1.9041.00
186_L193_V1.9041.00
94_K136_E1.8561.00
17_G44_Y1.8441.00
40_L273_R1.7961.00
157_K161_K1.7531.00
243_L281_A1.7261.00
256_Q293_Q1.7251.00
117_Q167_S1.6851.00
58_E107_R1.6811.00
26_E29_K1.6731.00
136_E139_Q1.6701.00
94_K98_K1.6701.00
31_L35_D1.6611.00
235_A238_E1.6411.00
244_S274_E1.6411.00
36_E39_E1.6381.00
157_K185_L1.6321.00
40_L276_I1.6311.00
73_L110_T1.6241.00
98_K102_K1.6201.00
133_A136_E1.6191.00
37_A42_I1.6151.00
277_Q280_N1.6051.00
290_K294_S1.6051.00
77_A116_Y1.6031.00
238_E291_A1.6031.00
35_D66_N1.6011.00
75_T113_I1.6001.00
31_L63_A1.5881.00
192_S261_S1.5811.00
251_Q281_A1.5661.00
77_A97_I1.5571.00
75_T104_S1.5491.00
181_E184_P1.5461.00
101_V116_Y1.5231.00
27_K31_L1.5061.00
20_C45_L1.4961.00
99_E103_K1.4871.00
74_A117_Q1.4801.00
11_L145_Y1.4711.00
152_R155_V1.4701.00
38_I71_I1.4531.00
29_K32_S1.4481.00
55_R58_E1.4461.00
49_D100_A1.4381.00
243_L247_E1.4121.00
102_K106_T1.4091.00
187_E257_P1.4081.00
34_L63_A1.4081.00
160_V189_H1.3971.00
184_P188_E1.3961.00
273_R277_Q1.3641.00
243_L248_K1.3621.00
117_Q194_V1.3601.00
251_Q255_A1.3351.00
113_I143_I1.3301.00
170_M193_V1.3201.00
32_S36_E1.3181.00
291_A294_S1.3121.00
35_D39_E1.3121.00
160_V185_L1.3071.00
11_L72_I1.2961.00
235_A291_A1.2951.00
94_K132_E1.2891.00
145_Y166_V1.2871.00
103_K106_T1.2801.00
128_D162_K1.2681.00
137_L143_I1.2621.00
143_I146_Y1.2601.00
183_L187_E1.2431.00
98_K133_A1.2381.00
61_G109_K1.2311.00
94_K133_A1.2221.00
62_D109_K1.2181.00
72_I115_L1.2181.00
108_L113_I1.2141.00
244_S247_E1.2121.00
266_A272_L1.2051.00
68_R110_T1.2041.00
239_V248_K1.2041.00
266_A271_Q1.1981.00
28_N32_S1.1981.00
153_P185_L1.1901.00
96_Y99_E1.1861.00
115_L167_S1.1681.00
58_E62_D1.1671.00
135_E138_K1.1641.00
172_F256_Q1.1551.00
138_K166_V1.1441.00
57_E104_S1.1441.00
129_E132_E1.1391.00
95_A99_E1.1381.00
234_K238_E1.1371.00
237_E245_M1.1311.00
270_E273_R1.1281.00
157_K189_H1.1271.00
68_R112_Y1.1271.00
157_K188_E1.1231.00
44_Y194_V1.1231.00
93_S96_Y1.1191.00
121_G155_V1.1181.00
44_Y74_A1.1101.00
134_F146_Y1.1021.00
102_K140_E1.0911.00
45_L60_V1.0891.00
171_Q176_D1.0871.00
253_L262_V1.0861.00
101_V113_I1.0851.00
174_L292_L1.0841.00
9_S145_Y1.0751.00
27_K59_I1.0701.00
118_L134_F1.0691.00
20_C60_V1.0691.00
234_K237_E1.0661.00
177_R296_T1.0641.00
43_N72_I1.0611.00
158_E162_K1.0601.00
236_M245_M1.0571.00
175_F233_R1.0521.00
32_S269_I1.0491.00
92_P118_L1.0401.00
35_D63_A1.0401.00
247_E277_Q1.0341.00
33_I272_L1.0261.00
5_K10_D1.0181.00
8_T166_V1.0181.00
137_L142_V1.0161.00
254_L278_A0.9941.00
14_S43_N0.9921.00
148_I165_I0.9851.00
179_P193_V0.9831.00
174_L249_S0.9781.00
62_D66_N0.9751.00
184_P187_E0.9701.00
132_E136_E0.9681.00
153_P157_K0.9621.00
114_D144_R0.9581.00
15_E254_L0.9581.00
64_I71_I0.9571.00
14_S42_I0.9541.00
272_L276_I0.9401.00
194_V261_S0.9401.00
167_S194_V0.9401.00
57_E107_R0.9361.00
9_S166_V0.9361.00
98_K101_V0.9341.00
274_E277_Q0.9321.00
247_E274_E0.9311.00
135_E163_S0.9261.00
137_L140_E0.9261.00
49_D81_W0.9231.00
15_E279_A0.9191.00
238_E241_P0.9181.00
99_E102_K0.9101.00
32_S35_D0.9071.00
133_A137_L0.9041.00
128_D158_E0.9041.00
187_E259_V0.8991.00
268_K271_Q0.8931.00
34_L45_L0.8911.00
38_I67_R0.8911.00
177_R180_E0.8891.00
270_E274_E0.8891.00
290_K293_Q0.8881.00
168_I186_L0.8831.00
255_A283_R0.8831.00
158_E161_K0.8741.00
94_K129_E0.8731.00
287_E290_K0.8691.00
146_Y165_I0.8681.00
58_E106_T0.8641.00
98_K137_L0.8601.00
49_D96_Y0.8591.00
74_A194_V0.8571.00
135_E146_Y0.8551.00
185_L188_E0.8551.00
132_E135_E0.8531.00
256_Q289_I0.8491.00
148_I156_I0.8481.00
74_A115_L0.8471.00
156_I191_I0.8321.00
9_S138_K0.8321.00
250_L278_A0.8291.00
18_L37_A0.8211.00
49_D107_R0.8161.00
287_E291_A0.8061.00
177_R293_Q0.8031.00
249_S253_L0.8001.00
49_D103_K0.7831.00
183_L193_V0.7811.00
36_E272_L0.7811.00
172_F183_L0.7751.00
28_N31_L0.7741.00
227_E231_N0.7741.00
255_A286_E0.7731.00
160_V164_N0.7681.00
40_L277_Q0.7661.00
105_L110_T0.7611.00
105_L142_V0.7581.00
150_S196_R0.7561.00
153_P182_W0.7551.00
20_C56_N0.7551.00
18_L23_L0.7511.00
195_A198_P0.7471.00
198_P264_T0.7441.00
30_A59_I0.7381.00
35_D67_R0.7351.00
252_Y293_Q0.7331.00
120_G150_S0.7331.00
235_A295_H0.7301.00
38_I45_L0.7291.00
47_T60_V0.7281.00
182_W186_L0.7271.00
75_T116_Y0.7241.00
179_P184_P0.7231.00
267_S271_Q0.7211.00
183_L256_Q0.7211.00
16_V254_L0.7201.00
101_V142_V0.7161.00
243_L277_Q0.7151.00
27_K55_R0.7141.00
131_I159_Y0.7101.00
230_T234_K0.7101.00
284_L288_E0.7091.00
246_T274_E0.7081.00
243_L280_N0.7061.00
17_G264_T0.7051.00
131_I146_Y0.7021.00
42_I276_I0.7021.00
100_A103_K0.7001.00
195_A262_V0.7001.00
239_V288_E0.6981.00
131_I163_S0.6971.00
33_I269_I0.6961.00
97_I130_T0.6961.00
251_Q278_A0.6951.00
97_I137_L0.6951.00
248_K288_E0.6861.00
117_Q147_G0.6861.00
231_N234_K0.6851.00
131_I165_I0.6851.00
172_F253_L0.6851.00
69_H112_Y0.6761.00
130_T133_A0.6741.00
148_I151_I0.6731.00
186_L191_I0.6691.00
67_R71_I0.6681.00
153_P181_E0.6671.00
34_L38_I0.6651.00
43_N70_D0.6631.00
233_R237_E0.6621.00
192_S260_A0.6601.00
11_L144_R0.6571.00
253_L260_A0.6561.00
104_S116_Y0.6561.00
50_L78_G0.6561.00
40_L272_L0.6531.00
127_I162_K0.6531.00
243_L251_Q0.6531.00
240_A248_K0.6471.00
13_I261_S0.6451.00
248_K284_L0.6441.00
23_L33_I0.6431.00
172_F193_V0.6411.00
284_L289_I0.6401.00
240_A245_M0.6401.00
77_A92_P0.6391.00
155_V158_E0.6391.00
160_V163_S0.6381.00
157_K160_V0.6381.00
288_E291_A0.6381.00
127_I130_T0.6361.00
138_K145_Y0.6341.00
148_I168_I0.6331.00
38_I43_N0.6321.00
17_G261_S0.6311.00
134_F138_K0.6281.00
8_T164_N0.6251.00
97_I133_A0.6241.00
198_P253_L0.6221.00
29_K269_I0.6201.00
138_K143_I0.6201.00
22_S201_K0.6201.00
271_Q274_E0.6191.00
55_R59_I0.6181.00
105_L113_I0.6181.00
239_V291_A0.6161.00
113_I116_Y0.6141.00
248_K292_L0.6111.00
93_S130_T0.6101.00
38_I70_D0.6101.00
236_M292_L0.6091.00
179_P183_L0.6091.00
236_M249_S0.6071.00
248_K281_A0.6041.00
39_E269_I0.6031.00
172_F180_E0.5991.00
98_K142_V0.5991.00
34_L60_V0.5961.00
231_N235_A0.5931.00
92_P130_T0.5911.00
8_T190_Q0.5911.00
33_I266_A0.5901.00
81_W96_Y0.5861.00
101_V105_L0.5861.00
23_L30_A0.5851.00
122_T125_D0.5831.00
172_F260_A0.5811.00
105_L112_Y0.5791.00
26_E30_A0.5771.00
197_G201_K0.5761.00
128_D132_E0.5761.00
46_D169_M0.5751.00
254_L262_V0.5711.00
118_L130_T0.5691.00
247_E281_A0.5671.00
148_I159_Y0.5661.00
256_Q260_A0.5651.00
154_N157_K0.5651.00
6_L192_S0.5641.00
160_V191_I0.5621.00
21_M197_G0.5601.00
116_Y134_F0.5571.00
18_L33_I0.5561.00
60_V63_A0.5561.00
116_Y143_I0.5531.00
239_V295_H0.5521.00
175_F203_L0.5521.00
195_A259_V0.5511.00
47_T56_N0.5501.00
25_T29_K0.5501.00
251_Q283_R0.5481.00
38_I63_A0.5431.00
127_I158_E0.5401.00
49_D78_G0.5371.00
17_G263_I0.5361.00
105_L111_D0.5351.00
203_L233_R0.5341.00
25_T30_A0.5301.00
13_I44_Y0.5301.00
127_I155_V0.5291.00
94_K97_I0.5261.00
16_V279_A0.5251.00
64_I67_R0.5231.00
58_E109_K0.5231.00
76_K119_H0.5221.00
230_T233_R0.5191.00
101_V133_A0.5191.00
138_K164_N0.5171.00
77_A100_A0.5151.00
176_D179_P0.5151.00
174_L252_Y0.5151.00
154_N158_E0.5141.00
138_K146_Y0.5141.00
62_D65_Q0.5131.00
79_N120_G0.5111.00
44_Y72_I0.5101.00
174_L296_T0.5091.00
121_G151_I0.5081.00
266_A275_N0.5071.00
195_A253_L0.5061.00
23_L265_G0.5061.00
45_L64_I0.5061.00
24_G56_N0.5051.00
50_L79_N0.5031.00
269_I272_L0.5011.00
147_G167_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pyfA 1 0.9641 100 0.103 Contact Map
3v0sA 1 0.8725 100 0.108 Contact Map
1ynpA 1 0.9673 100 0.109 Contact Map
1pz1A 1 0.9902 100 0.113 Contact Map
3n2tA 1 0.9935 100 0.118 Contact Map
4xk2A 5 0.9542 100 0.119 Contact Map
3eauA 3 0.9771 100 0.122 Contact Map
3lutA 3 0.9706 100 0.123 Contact Map
3erpA 6 0.9248 100 0.129 Contact Map
3n6qA 5 0.9314 100 0.134 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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