GREMLIN Database
COAA - Pantothenate kinase
UniProt: P54556 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (303)
Sequences: 911 (515)
Seq/√Len: 29.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_E139_K8.3661.00
170_S192_E5.8891.00
239_F281_E4.5321.00
163_D168_K4.0951.00
239_F277_A3.8061.00
135_A182_D3.7461.00
278_S282_S3.7281.00
172_K188_F3.6301.00
235_E289_Y3.3291.00
164_L197_V3.3211.00
304_R312_E3.1561.00
16_N19_S3.0701.00
136_E140_K2.8551.00
175_V186_G2.6781.00
306_G312_E2.6561.00
59_V116_L2.6231.00
281_E285_R2.6121.00
247_R273_D2.5610.99
169_D192_E2.5500.99
159_E163_D2.4830.99
100_V238_I2.4160.99
179_L259_S2.3490.99
41_G44_D2.3380.99
134_T183_R2.2490.99
250_R269_D2.2410.99
14_Q313_E2.1760.98
72_R225_F2.1490.98
303_L314_V2.1430.98
70_A87_K2.1090.98
304_R313_E2.0970.98
49_E52_E2.0360.97
239_F285_R1.9990.97
135_A139_K1.9930.97
240_T244_E1.9840.97
46_L108_I1.9730.97
24_G28_S1.9390.96
113_L196_I1.9330.96
24_G30_A1.9100.96
243_L273_D1.9050.96
72_R76_V1.8890.96
175_V184_E1.8890.96
180_T184_E1.8800.96
62_L301_L1.8600.95
170_S190_V1.8600.95
268_S271_E1.7840.94
145_R150_E1.7710.94
235_E285_R1.7420.93
274_E278_S1.7330.93
275_M279_I1.7170.93
237_R240_T1.6950.92
152_Y259_S1.6800.92
15_H19_S1.6700.92
63_H119_R1.6500.91
227_F301_L1.6400.91
234_E237_R1.6310.91
141_N171_V1.6130.90
43_N47_S1.6050.90
199_I225_F1.5920.90
17_R53_T1.5790.89
175_V183_R1.5480.88
24_G60_R1.5460.88
240_T307_D1.5210.87
134_T143_M1.5140.87
14_Q315_L1.5020.87
169_D193_Q1.4940.86
273_D277_A1.4870.86
194_A197_V1.4850.86
204_V225_F1.4720.86
35_E115_R1.4620.85
59_V62_L1.4610.85
172_K190_V1.4560.85
157_L199_I1.4500.85
94_I106_A1.4430.84
286_P290_E1.4200.83
237_R307_D1.4150.83
60_R116_L1.4140.83
67_K118_D1.4120.83
27_L225_F1.4090.83
49_E53_T1.3820.82
106_A124_L1.3750.81
29_I48_V1.3440.80
33_E37_K1.3410.80
117_P120_P1.3360.79
56_I60_R1.3310.79
246_F272_A1.3220.79
269_D273_D1.3180.79
209_T218_R1.3070.78
265_K268_S1.2990.78
52_E56_I1.2980.77
262_H266_D1.2930.77
306_G311_V1.2920.77
14_Q302_I1.2880.77
306_G310_K1.2800.76
47_S50_E1.2650.76
251_E269_D1.2490.75
267_L279_I1.2430.74
94_I229_I1.2190.73
123_S189_E1.2180.73
106_A153_D1.2100.72
180_T256_N1.2090.72
267_L275_M1.2090.72
93_G225_F1.1970.71
208_P220_F1.1940.71
249_L252_T1.1910.71
255_Q262_H1.1850.71
68_S75_H1.1700.70
157_L221_V1.1680.70
196_I292_I1.1590.69
32_S35_E1.1570.69
144_S282_S1.1520.68
66_V70_A1.1420.68
43_N220_F1.1420.68
35_E41_G1.1390.68
12_Y282_S1.1310.67
250_R306_G1.1280.67
43_N292_I1.1240.66
71_E221_V1.1200.66
94_I306_G1.0870.64
54_I286_P1.0870.64
35_E45_Y1.0650.62
132_F136_E1.0610.62
252_T255_Q1.0560.62
109_L296_K1.0540.61
125_I173_A1.0500.61
162_N224_F1.0460.61
206_Q292_I1.0180.59
59_V120_P1.0160.59
76_V225_F1.0160.59
105_T256_N1.0150.58
13_T219_I1.0150.58
34_E38_A1.0080.58
161_L218_R1.0080.58
16_N313_E1.0060.58
119_R196_I1.0040.58
270_Q274_E1.0030.58
254_F261_F1.0010.57
16_N91_I1.0010.57
51_V108_I1.0000.57
17_R23_F0.9940.57
105_T231_V0.9930.57
71_E74_K0.9920.57
129_G173_A0.9890.56
69_A87_K0.9860.56
44_D50_E0.9860.56
63_H118_D0.9850.56
273_D279_I0.9840.56
32_S307_D0.9570.54
138_K141_N0.9560.54
293_L296_K0.9440.53
234_E304_R0.9430.53
261_F291_N0.9310.52
67_K119_R0.9280.52
48_V68_S0.9090.50
133_P136_E0.9080.50
243_L267_L0.9070.50
67_K74_K0.8950.49
40_E47_S0.8940.49
62_L92_I0.8940.49
173_A189_E0.8930.49
289_Y293_L0.8920.49
88_I218_R0.8920.49
175_V187_V0.8920.49
24_G29_I0.8910.49
207_S220_F0.8910.49
66_V116_L0.8910.49
27_L30_A0.8880.49
73_N76_V0.8840.48
202_I247_R0.8820.48
285_R289_Y0.8780.48
91_I118_D0.8760.48
264_F275_M0.8740.47
94_I197_V0.8690.47
116_L119_R0.8640.47
172_K189_E0.8620.46
87_K121_K0.8590.46
43_N248_L0.8540.46
43_N154_V0.8530.46
25_G28_S0.8470.45
158_L218_R0.8320.44
15_H285_R0.8300.44
130_F160_F0.8290.44
61_L181_Y0.8290.44
68_S316_V0.8280.44
238_I304_R0.8260.44
123_S192_E0.8250.44
13_T26_H0.8250.44
191_V275_M0.8170.43
126_T129_G0.8170.43
165_K318_R0.8170.43
199_I208_P0.8170.43
183_R187_V0.8150.43
93_G199_I0.8100.42
11_L39_V0.8070.42
15_H28_S0.8060.42
181_Y253_A0.8060.42
138_K143_M0.8060.42
53_T108_I0.7970.41
37_K40_E0.7950.41
14_Q219_I0.7950.41
28_S60_R0.7940.41
204_V231_V0.7850.41
15_H54_I0.7850.41
234_E306_G0.7850.41
39_V67_K0.7820.40
259_S291_N0.7800.40
36_A48_V0.7790.40
19_S74_K0.7750.40
29_I116_L0.7750.40
198_I225_F0.7730.40
67_K78_V0.7700.39
280_W284_N0.7700.39
12_Y85_S0.7670.39
37_K54_I0.7660.39
125_I199_I0.7660.39
114_S302_I0.7640.39
161_L231_V0.7640.39
33_E40_E0.7570.38
18_E169_D0.7540.38
64_L78_V0.7490.38
62_L224_F0.7490.38
93_G231_V0.7470.38
134_T138_K0.7460.38
24_G56_I0.7430.37
196_I315_L0.7430.37
184_E187_V0.7420.37
154_V207_S0.7410.37
47_S51_V0.7410.37
32_S53_T0.7390.37
234_E307_D0.7360.37
179_L258_D0.7350.37
44_D207_S0.7350.37
105_T314_V0.7350.37
225_F238_I0.7340.37
129_G222_S0.7330.37
296_K308_G0.7320.37
268_S275_M0.7250.36
270_Q273_D0.7230.36
308_G312_E0.7200.36
250_R291_N0.7180.36
247_R267_L0.7150.35
17_R231_V0.7140.35
38_A190_V0.7140.35
36_A66_V0.7130.35
22_G268_S0.7130.35
12_Y19_S0.7110.35
73_N199_I0.7100.35
106_A286_P0.7100.35
278_S281_E0.7100.35
62_L311_V0.7090.35
40_E46_L0.7080.35
125_I189_E0.7080.35
275_M282_S0.7070.35
236_S308_G0.7050.35
12_Y106_A0.7000.34
39_V49_E0.6990.34
197_V281_E0.6960.34
95_A250_R0.6930.34
155_K161_L0.6920.34
123_S265_K0.6890.33
65_H69_A0.6860.33
48_V190_V0.6860.33
57_P178_H0.6800.33
13_T138_K0.6780.33
30_A35_E0.6760.33
25_G255_Q0.6750.32
179_L239_F0.6750.32
134_T260_Y0.6740.32
109_L197_V0.6740.32
105_T157_L0.6710.32
243_L275_M0.6650.32
268_S273_D0.6650.32
32_S290_E0.6650.32
24_G68_S0.6640.32
123_S169_D0.6640.32
227_F316_V0.6620.32
91_I94_I0.6620.32
33_E52_E0.6620.32
66_V119_R0.6600.31
88_I166_S0.6570.31
10_T50_E0.6540.31
121_K239_F0.6520.31
158_L216_N0.6510.31
117_P162_N0.6490.31
29_I52_E0.6490.31
154_V161_L0.6440.30
32_S315_L0.6430.30
25_G145_R0.6430.30
218_R285_R0.6410.30
63_H67_K0.6390.30
297_F314_V0.6370.30
22_G169_D0.6360.30
9_H16_N0.6360.30
190_V193_Q0.6340.30
139_K191_V0.6310.30
32_S109_L0.6280.29
92_I113_L0.6270.29
35_E316_V0.6260.29
12_Y15_H0.6260.29
164_L187_V0.6250.29
91_I153_D0.6240.29
236_S240_T0.6230.29
178_H181_Y0.6220.29
118_D138_K0.6210.29
29_I180_T0.6200.29
73_N302_I0.6200.29
21_S69_A0.6190.29
29_I111_K0.6180.29
250_R265_K0.6170.29
247_R283_V0.6160.29
68_S119_R0.6150.28
271_E274_E0.6140.28
275_M286_P0.6120.28
36_A50_E0.6120.28
90_F111_K0.6120.28
65_H76_V0.6100.28
72_R122_V0.6100.28
181_Y204_V0.6090.28
90_F225_F0.6080.28
87_K193_Q0.6070.28
31_V56_I0.6060.28
24_G43_N0.6050.28
47_S57_P0.6050.28
90_F277_A0.6030.28
229_I301_L0.6030.28
54_I133_P0.6020.28
103_S195_D0.6020.28
47_S260_Y0.5970.27
265_K269_D0.5950.27
256_N296_K0.5950.27
121_K197_V0.5940.27
24_G111_K0.5940.27
260_Y316_V0.5930.27
25_G29_I0.5920.27
54_I108_I0.5920.27
73_N108_I0.5920.27
109_L113_L0.5910.27
32_S94_I0.5880.27
169_D308_G0.5860.27
101_G201_G0.5860.27
102_K201_G0.5860.27
66_V69_A0.5860.27
45_Y156_A0.5830.26
105_T228_S0.5830.26
35_E51_V0.5820.26
37_K251_E0.5810.26
32_S77_N0.5770.26
192_E197_V0.5760.26
22_G25_G0.5750.26
240_T308_G0.5750.26
142_M307_D0.5740.26
27_L63_H0.5720.26
228_S233_A0.5720.26
52_E60_R0.5720.26
45_Y273_D0.5710.26
199_I249_L0.5710.26
27_L114_S0.5700.26
127_T148_F0.5680.26
46_L313_E0.5680.26
9_H163_D0.5670.25
37_K312_E0.5660.25
59_V117_P0.5660.25
34_E273_D0.5650.25
32_S46_L0.5650.25
59_V301_L0.5630.25
87_K108_I0.5620.25
196_I206_Q0.5610.25
92_I234_E0.5600.25
40_E145_R0.5600.25
72_R93_G0.5590.25
24_G33_E0.5560.25
24_G27_L0.5560.25
186_G191_V0.5560.25
30_A62_L0.5540.25
224_F235_E0.5540.25
300_D315_L0.5530.25
121_K170_S0.5530.25
157_L231_V0.5530.25
30_A53_T0.5520.25
164_L257_P0.5520.25
179_L262_H0.5520.25
19_S111_K0.5480.24
63_H116_L0.5480.24
155_K183_R0.5470.24
82_H168_K0.5470.24
199_I252_T0.5440.24
244_E273_D0.5440.24
19_S26_H0.5440.24
36_A282_S0.5430.24
12_Y75_H0.5420.24
116_L316_V0.5420.24
41_G51_V0.5420.24
111_K115_R0.5410.24
21_S216_N0.5400.24
32_S48_V0.5390.24
181_Y264_F0.5390.24
158_L314_V0.5380.24
18_E22_G0.5370.24
80_L171_V0.5350.24
220_F300_D0.5340.24
154_V217_P0.5330.24
58_L94_I0.5330.24
15_H29_I0.5310.23
63_H158_L0.5300.23
243_L277_A0.5300.23
88_I314_V0.5290.23
159_E297_F0.5290.23
71_E308_G0.5280.23
18_E49_E0.5270.23
114_S281_E0.5270.23
81_K123_S0.5260.23
38_A216_N0.5240.23
24_G64_L0.5240.23
53_T56_I0.5240.23
115_R171_V0.5230.23
133_P284_N0.5230.23
61_L227_F0.5220.23
31_V317_R0.5210.23
86_A307_D0.5200.23
254_F291_N0.5190.23
198_I283_V0.5190.23
35_E196_I0.5190.23
216_N219_I0.5180.23
47_S310_K0.5180.23
163_D172_K0.5170.23
231_V315_L0.5170.23
22_G33_E0.5150.23
36_A42_L0.5150.23
262_H273_D0.5150.23
115_R314_V0.5140.22
35_E114_S0.5140.22
35_E38_A0.5130.22
148_F241_W0.5130.22
235_E290_E0.5130.22
34_E191_V0.5130.22
93_G238_I0.5120.22
49_E307_D0.5120.22
83_P175_V0.5120.22
51_V90_F0.5110.22
286_P317_R0.5100.22
44_D80_L0.5100.22
18_E21_S0.5100.22
138_K142_M0.5100.22
158_L217_P0.5090.22
17_R64_L0.5090.22
37_K74_K0.5080.22
155_K231_V0.5070.22
54_I234_E0.5070.22
100_V124_L0.5060.22
43_N293_L0.5060.22
170_S270_Q0.5050.22
71_E75_H0.5040.22
19_S142_M0.5030.22
9_H12_Y0.5000.22
10_T18_E0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tqcA 2 0.9561 100 0.516 Contact Map
4ne2A 2 0.953 100 0.633 Contact Map
4bfzA 2 0.9498 100 0.643 Contact Map
1odfA 1 0.768 100 0.689 Contact Map
2ga8A 1 0.6803 100 0.73 Contact Map
2jeoA 3 0.6144 99.9 0.797 Contact Map
1a7jA 5 0.6771 99.9 0.803 Contact Map
1rz3A 1 0.5455 99.8 0.817 Contact Map
3c8uA 1 0.6458 99.8 0.824 Contact Map
1uj2A 3 0.627 99.8 0.832 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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