GREMLIN Database
SDHD - Probable D-serine dehydratase
UniProt: P54555 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 448 (341)
Sequences: 2199 (1313)
Seq/√Len: 71.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_G185_V6.0131.00
195_Q199_D5.8321.00
82_E101_R4.4621.00
188_H225_Q4.0251.00
299_H358_G3.8941.00
221_E224_R3.7181.00
254_L417_V3.6601.00
80_L417_V3.1401.00
184_R207_T3.1381.00
366_T395_Q3.1041.00
309_P313_L2.9961.00
272_F301_F2.8171.00
306_T363_E2.7791.00
224_R228_Q2.6301.00
164_V187_V2.6041.00
335_A368_Y2.5711.00
86_M390_M2.5621.00
315_L359_C2.4581.00
250_A419_W2.4441.00
82_E103_L2.4281.00
161_S186_T2.3831.00
386_A420_G2.2881.00
390_M418_V2.2281.00
193_A196_W2.2191.00
81_F106_C2.2071.00
391_F395_Q2.1661.00
127_K242_Q2.1101.00
163_A232_C2.1101.00
371_L387_L2.0321.00
198_K208_V1.9951.00
273_V290_L1.9891.00
213_T216_S1.9581.00
287_A300_V1.9311.00
101_R415_V1.9241.00
86_M102_W1.8991.00
423_G426_V1.8931.00
275_L282_G1.8741.00
382_L387_L1.8611.00
186_T207_T1.8521.00
389_G418_V1.8451.00
166_S171_G1.8411.00
382_L386_A1.8361.00
165_G222_G1.8321.00
191_A212_E1.8241.00
251_A290_L1.8081.00
272_F299_H1.8061.00
386_A389_G1.7941.00
395_Q399_T1.7751.00
268_E415_V1.7741.00
386_A421_T1.7741.00
307_H331_D1.7661.00
224_R227_E1.7651.00
428_K432_A1.7541.00
432_A436_R1.7221.00
216_S219_V1.6581.00
362_V391_F1.6520.99
303_A360_Y1.6490.99
313_L316_Y1.6240.99
51_A60_P1.5970.99
221_E225_Q1.5950.99
255_K293_L1.5890.99
375_A381_Y1.5860.99
116_I282_G1.5810.99
83_V86_M1.5750.99
161_S184_R1.5710.99
89_K373_M1.5680.99
258_L417_V1.5670.99
411_M414_A1.5620.99
99_P416_H1.5610.99
363_E366_T1.5510.99
48_I292_L1.5410.99
199_D203_Q1.5290.99
254_L419_W1.5270.99
255_K259_D1.5150.99
85_H88_G1.5140.99
308_S332_N1.5130.99
61_Y65_V1.5070.99
360_Y392_G1.4880.99
429_D432_A1.4880.99
199_D202_R1.4800.99
251_A289_G1.4780.99
102_W418_V1.4600.99
382_L420_G1.4550.99
213_T219_V1.4120.98
214_D217_E1.4110.98
82_E87_K1.4100.98
311_M314_G1.4010.98
376_V435_N1.3820.98
366_T391_F1.3750.98
163_A211_Y1.3670.98
214_D219_V1.3660.98
274_Y301_F1.3640.98
370_L391_F1.3580.98
86_M374_L1.3430.98
366_T369_T1.3280.98
319_L323_I1.3250.98
388_A392_G1.3190.98
226_A232_C1.3170.97
202_R207_T1.3110.97
186_T209_M1.3090.97
121_G173_S1.3070.97
286_V419_W1.3060.97
160_Y225_Q1.3050.97
99_P102_W1.2890.97
250_A282_G1.2880.97
277_C302_F1.2850.97
90_L394_V1.2780.97
106_C109_E1.2610.97
49_A53_K1.2590.97
374_L382_L1.2570.97
400_E410_K1.2560.97
269_T296_D1.2510.97
310_C344_P1.2360.96
301_F358_G1.2360.96
396_L399_T1.2330.96
370_L390_M1.2290.96
273_V286_V1.2180.96
198_K210_E1.2160.96
251_A286_V1.2070.96
84_Q87_K1.1990.96
81_F108_H1.1970.96
297_D357_S1.1860.95
352_I356_L1.1840.95
175_G187_V1.1830.95
350_K354_P1.1770.95
89_K377_S1.1740.95
322_K325_V1.1690.95
229_D232_C1.1620.95
166_S383_E1.1520.95
167_T197_K1.1420.94
158_S233_Y1.1410.94
284_G348_V1.1400.94
215_Y282_G1.1380.94
395_Q398_S1.1380.94
200_L204_K1.1370.94
374_L390_M1.1330.94
179_A204_K1.1110.93
325_V330_L1.1040.93
262_N268_E1.0910.93
197_K383_E1.0910.93
311_M359_C1.0670.92
303_A387_L1.0600.92
47_E288_F1.0450.91
215_Y310_C1.0400.91
159_R231_F1.0400.91
223_R227_E1.0290.90
336_A367_L1.0260.90
197_K337_D1.0210.90
196_W427_P1.0200.90
49_A52_E1.0150.90
113_S425_M1.0100.90
262_N415_V1.0100.90
256_T260_C1.0080.89
423_G427_P1.0000.89
269_T415_V0.9980.89
302_F359_C0.9980.89
252_S256_T0.9970.89
213_T217_E0.9950.89
373_M377_S0.9940.89
113_S176_I0.9910.89
273_V298_V0.9910.89
187_V332_N0.9850.88
303_A392_G0.9830.88
200_L381_Y0.9810.88
77_E256_T0.9800.88
309_P416_H0.9790.88
88_G412_E0.9760.88
393_P418_V0.9760.88
90_L393_P0.9690.88
50_E54_R0.9680.88
198_K202_R0.9670.87
334_T340_A0.9660.87
103_L415_V0.9650.87
84_Q88_G0.9620.87
313_L317_S0.9580.87
308_S311_M0.9560.87
69_T249_V0.9520.87
223_R234_F0.9450.86
277_C311_M0.9350.86
57_R60_P0.9320.85
313_L318_G0.9320.85
225_Q228_Q0.9310.85
101_R262_N0.9290.85
286_V417_V0.9270.85
232_C284_G0.9220.85
79_P109_E0.9210.85
49_A252_S0.9180.85
363_E412_E0.9130.84
383_E422_G0.9090.84
373_M394_V0.9050.84
167_T383_E0.9020.84
244_F284_G0.8980.83
274_Y303_A0.8950.83
172_L200_L0.8890.83
226_A233_Y0.8890.83
372_H433_A0.8850.82
272_F414_A0.8840.82
163_A226_A0.8800.82
369_T436_R0.8780.82
254_L258_L0.8760.82
309_P361_T0.8760.82
89_K376_V0.8760.82
381_Y431_M0.8750.82
430_E433_A0.8710.81
104_L374_L0.8690.81
410_K414_A0.8660.81
301_F360_Y0.8640.81
104_L420_G0.8630.81
332_N340_A0.8600.81
91_E413_H0.8590.80
273_V300_V0.8580.80
113_S118_A0.8570.80
217_E220_N0.8570.80
52_E245_L0.8560.80
287_A355_L0.8560.80
193_A337_D0.8540.80
255_K290_L0.8510.80
325_V329_G0.8500.80
211_Y218_A0.8500.80
269_T298_V0.8480.80
368_Y433_A0.8460.79
282_G286_V0.8440.79
166_S197_K0.8440.79
66_F256_T0.8410.79
162_I178_G0.8400.79
69_T181_L0.8260.78
311_M315_L0.8240.78
274_Y392_G0.8240.78
299_H357_S0.8230.78
372_H376_V0.8220.77
259_D262_N0.8220.77
220_N224_R0.8220.77
186_T232_C0.8210.77
307_H333_Q0.8170.77
365_N369_T0.8160.77
59_A63_A0.8150.77
362_V388_A0.8130.77
215_Y219_V0.8120.77
102_W397_F0.8070.76
103_L258_L0.8000.76
302_F356_L0.7980.75
291_K357_S0.7980.75
80_L258_L0.7930.75
193_A281_G0.7930.75
163_A225_Q0.7910.75
120_G246_G0.7900.75
362_V367_L0.7840.74
91_E412_E0.7810.74
172_L201_L0.7800.74
252_S289_G0.7790.74
336_A422_G0.7790.74
68_E72_A0.7740.73
375_A435_N0.7670.72
161_S178_G0.7660.72
170_L247_Y0.7650.72
366_T370_L0.7640.72
312_L359_C0.7630.72
50_E53_K0.7570.71
237_D247_Y0.7540.71
81_F380_K0.7520.71
197_K385_S0.7520.71
103_L262_N0.7510.71
189_M348_V0.7480.71
301_F353_E0.7480.71
268_E398_S0.7470.70
170_L243_L0.7450.70
390_M393_P0.7420.70
170_L237_D0.7420.70
199_D431_M0.7420.70
125_V162_I0.7410.70
291_K295_G0.7400.70
258_L262_N0.7400.70
162_I235_I0.7390.70
250_A286_V0.7390.70
190_S193_A0.7380.69
106_C420_G0.7360.69
387_L390_M0.7330.69
189_M208_V0.7320.69
247_Y279_V0.7310.69
301_F357_S0.7300.69
375_A431_M0.7300.69
100_G415_V0.7290.69
189_M338_G0.7280.68
118_A176_I0.7240.68
301_F396_L0.7240.68
189_M210_E0.7240.68
80_L83_V0.7230.68
293_L390_M0.7220.68
99_P397_F0.7200.68
254_L286_V0.7200.68
393_P416_H0.7190.67
314_G317_S0.7190.67
285_G348_V0.7180.67
163_A222_G0.7170.67
366_T373_M0.7160.67
272_F411_M0.7150.67
170_L240_S0.7140.67
275_L287_A0.7120.67
87_K99_P0.7090.66
303_A388_A0.7090.66
159_R184_R0.7090.66
88_G260_C0.7050.66
116_I286_V0.7050.66
372_H434_Y0.7030.66
209_M273_V0.7020.66
81_F378_E0.7000.65
103_L261_M0.6990.65
309_P318_G0.6990.65
171_G280_G0.6960.65
215_Y279_V0.6940.65
288_F292_L0.6930.65
273_V417_V0.6930.65
121_G174_I0.6920.65
311_M349_G0.6920.65
176_I204_K0.6920.65
256_T259_D0.6900.64
380_K420_G0.6870.64
304_E339_L0.6870.64
352_I359_C0.6850.64
252_S292_L0.6850.64
352_I357_S0.6810.63
63_A379_D0.6810.63
314_G393_P0.6810.63
370_L387_L0.6800.63
87_K91_E0.6790.63
53_K56_Q0.6770.63
368_Y384_P0.6770.63
154_T436_R0.6770.63
375_A379_D0.6760.63
308_S312_L0.6760.63
78_S187_V0.6760.63
110_L118_A0.6740.62
75_I253_R0.6740.62
77_E253_R0.6740.62
309_P317_S0.6720.62
287_A356_L0.6720.62
115_S236_D0.6710.62
306_T309_P0.6700.62
78_S286_V0.6700.62
71_G261_M0.6690.62
262_N267_L0.6690.62
237_D279_V0.6670.62
115_S213_T0.6640.61
300_V356_L0.6630.61
78_S115_S0.6610.61
396_L400_E0.6610.61
178_G315_L0.6590.61
398_S401_E0.6590.61
161_S244_F0.6530.60
208_V363_E0.6530.60
314_G318_G0.6520.60
224_R259_D0.6500.60
166_S336_A0.6490.60
382_L390_M0.6490.60
167_T215_Y0.6470.59
272_F416_H0.6460.59
85_H436_R0.6440.59
167_T385_S0.6430.59
309_P316_Y0.6430.59
270_P417_V0.6430.59
88_G207_T0.6430.59
360_Y428_K0.6420.59
185_V204_K0.6410.59
173_S249_V0.6410.59
426_V429_D0.6400.58
245_L288_F0.6400.58
89_K398_S0.6390.58
113_S172_L0.6380.58
367_L371_L0.6370.58
362_V392_G0.6360.58
385_S389_G0.6360.58
90_L377_S0.6350.58
156_F160_Y0.6340.58
269_T299_H0.6340.58
104_L249_V0.6340.58
369_T372_H0.6340.58
167_T338_G0.6340.58
307_H364_D0.6310.57
128_Y233_Y0.6310.57
315_L318_G0.6280.57
80_L261_M0.6260.57
268_E413_H0.6230.56
273_V291_K0.6220.56
91_E99_P0.6200.56
63_A73_K0.6180.56
86_M100_G0.6160.56
312_L316_Y0.6150.56
278_G338_G0.6150.56
351_L354_P0.6140.55
47_E54_R0.6130.55
277_C421_T0.6120.55
66_F70_K0.6120.55
252_S293_L0.6100.55
195_Q202_R0.6040.54
394_V398_S0.6010.54
52_E56_Q0.6000.54
179_A182_G0.6000.54
167_T337_D0.5960.53
107_D243_L0.5950.53
362_V395_Q0.5940.53
125_V174_I0.5940.53
384_P422_G0.5930.53
319_L322_K0.5910.53
189_M193_A0.5910.53
88_G252_S0.5910.53
428_K431_M0.5880.52
290_L355_L0.5870.52
225_Q229_D0.5870.52
63_A70_K0.5860.52
430_E434_Y0.5860.52
99_P412_E0.5860.52
91_E231_F0.5850.52
82_E306_T0.5840.52
258_L270_P0.5830.52
250_A254_L0.5810.51
371_L384_P0.5800.51
228_Q412_E0.5800.51
99_P401_E0.5790.51
111_P176_I0.5790.51
338_G385_S0.5780.51
115_S164_V0.5780.51
108_H215_Y0.5780.51
303_A434_Y0.5770.51
69_T72_A0.5760.51
83_V104_L0.5760.51
184_R228_Q0.5760.51
77_E257_Q0.5760.51
189_M251_A0.5760.51
314_G349_G0.5710.50
164_V174_I0.5700.50
79_P106_C0.5690.50
247_Y386_A0.5670.50
341_V386_A0.5670.50
90_L373_M0.5670.50
245_L248_A0.5640.49
296_D412_E0.5630.49
400_E414_A0.5620.49
110_L113_S0.5610.49
269_T417_V0.5610.49
236_D243_L0.5610.49
248_A252_S0.5610.49
117_K169_N0.5550.48
167_T172_L0.5520.48
122_I177_I0.5510.48
167_T170_L0.5510.48
369_T398_S0.5500.48
126_L181_L0.5490.47
86_M373_M0.5480.47
255_K292_L0.5480.47
61_Y180_A0.5470.47
88_G401_E0.5460.47
105_K253_R0.5460.47
59_A67_P0.5460.47
342_G364_D0.5450.47
363_E395_Q0.5450.47
155_G159_R0.5440.47
385_S388_A0.5440.47
54_R58_F0.5430.47
201_L206_V0.5430.47
99_P393_P0.5420.47
216_S279_V0.5410.46
369_T394_V0.5410.46
277_C345_S0.5400.46
336_A383_E0.5390.46
258_L268_E0.5380.46
62_I69_T0.5380.46
234_F237_D0.5380.46
286_V291_K0.5380.46
81_F84_Q0.5350.46
189_M201_L0.5320.45
391_F396_L0.5310.45
255_K289_G0.5310.45
308_S342_G0.5310.45
274_Y393_P0.5300.45
187_V339_L0.5290.45
108_H382_L0.5280.45
171_G338_G0.5280.45
305_P385_S0.5270.45
53_K82_E0.5260.45
67_P155_G0.5260.45
87_K100_G0.5250.45
100_G413_H0.5230.44
308_S314_G0.5220.44
85_H377_S0.5210.44
85_H155_G0.5210.44
48_I55_M0.5200.44
54_R57_R0.5200.44
124_E337_D0.5190.44
194_K429_D0.5190.44
368_Y372_H0.5170.44
81_F103_L0.5160.43
73_K179_A0.5160.43
69_T122_I0.5160.43
83_V87_K0.5150.43
335_A430_E0.5140.43
312_L361_T0.5120.43
248_A288_F0.5110.43
377_S384_P0.5100.43
118_A235_I0.5090.43
121_G166_S0.5090.43
85_H227_E0.5090.43
170_L279_V0.5070.42
384_P387_L0.5070.42
244_F345_S0.5050.42
217_E221_E0.5050.42
127_K156_F0.5040.42
335_A425_M0.5030.42
194_K335_A0.5020.42
400_E413_H0.5020.42
387_L391_F0.5010.42
74_G78_S0.5010.42
170_L236_D0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ss7X 1 0.9576 100 0.27 Contact Map
1tdjA 2 0.7545 100 0.401 Contact Map
2gn0A 2 0.7344 100 0.431 Contact Map
4d9iA 2 0.8371 100 0.431 Contact Map
1v71A 2 0.7098 100 0.432 Contact Map
2zsjA 2 0.7433 100 0.438 Contact Map
1e5xA 2 0.8259 100 0.438 Contact Map
2rkbA 2 0.7031 100 0.441 Contact Map
3aeyA 2 0.7411 100 0.441 Contact Map
2d1fA 2 0.7478 100 0.441 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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