GREMLIN Database
YQJP - Probable metallo-hydrolase YqjP
UniProt: P54553 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (269)
Sequences: 3917 (3100)
Seq/√Len: 189.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_S175_E4.4211.00
217_R246_F4.3791.00
220_S243_E4.2251.00
257_R302_A3.8281.00
162_M171_V3.2711.00
29_A61_E3.1001.00
64_V172_L3.0861.00
147_E218_R3.0811.00
178_G225_T3.0551.00
220_S246_F2.8991.00
33_I66_T2.8971.00
174_H177_S2.8441.00
237_S240_A2.8351.00
65_L76_L2.6641.00
266_T269_Q2.6301.00
33_I181_L2.6271.00
31_T62_Q2.5721.00
169_H183_G2.5561.00
260_L303_I2.5451.00
150_G156_G2.4731.00
66_T183_G2.4101.00
159_V170_I2.3821.00
150_G158_S2.3701.00
296_V300_E2.3351.00
152_D156_G2.3111.00
243_E247_D2.2961.00
62_Q86_I2.2071.00
84_E143_K2.0401.00
159_V172_L2.0111.00
62_Q84_E1.9581.00
25_V33_I1.9551.00
89_T146_R1.9491.00
182_G227_V1.9111.00
162_M215_S1.8941.00
88_H161_E1.8741.00
88_H170_I1.8581.00
47_Q82_E1.8361.00
162_M169_H1.8151.00
179_R228_F1.7891.00
208_P211_D1.7811.00
86_I143_K1.7791.00
213_Q246_F1.7481.00
23_Y181_L1.7291.00
217_R221_Q1.6831.00
155_E177_S1.6831.00
44_R48_E1.6761.00
35_A63_V1.6681.00
45_A49_Q1.6611.00
218_R221_Q1.6601.00
223_D239_Q1.6411.00
156_G176_K1.5811.00
298_E305_S1.5791.00
49_Q52_A1.5571.00
43_A78_V1.5141.00
173_F180_M1.5061.00
250_R254_E1.5021.00
87_G91_N1.4851.00
175_E178_G1.4761.00
226_I236_T1.4661.00
143_K149_M1.4551.00
146_R149_M1.4051.00
23_Y228_F1.3711.00
157_W174_H1.3661.00
229_P232_G1.3641.00
217_R250_R1.3591.00
265_M273_Q1.3591.00
180_M222_L1.3541.00
158_S222_L1.3531.00
7_I53_V1.3521.00
220_S239_Q1.3431.00
47_Q51_A1.3371.00
216_L242_I1.3211.00
24_L32_L1.3191.00
31_T157_W1.3071.00
191_S245_R1.3061.00
210_V214_R1.2941.00
295_D298_E1.2881.00
173_F178_G1.2861.00
241_L245_R1.2851.00
31_T64_V1.2771.00
185_L219_L1.2641.00
267_A271_C1.2551.00
186_L242_I1.2061.00
24_L30_L1.2001.00
213_Q250_R1.1921.00
147_E161_E1.1801.00
80_S142_T1.1771.00
179_R226_I1.1731.00
173_F224_P1.1661.00
22_V46_L1.1641.00
150_G175_E1.1641.00
270_V290_T1.1641.00
217_R220_S1.1571.00
220_S242_I1.1571.00
22_V35_A1.1531.00
265_M269_Q1.1441.00
64_V170_I1.1431.00
29_A62_Q1.1281.00
207_K210_V1.1141.00
80_S85_V1.1001.00
43_A47_Q1.0931.00
241_L244_K1.0921.00
164_G215_S1.0871.00
213_Q217_R1.0871.00
224_P227_V1.0871.00
259_M273_Q1.0741.00
23_Y230_G1.0721.00
48_E52_A1.0711.00
158_S173_F1.0701.00
26_K30_L1.0701.00
178_G223_D1.0601.00
145_I159_V1.0561.00
42_A45_A1.0511.00
25_V157_W1.0461.00
248_K252_R1.0461.00
155_E174_H1.0321.00
212_Y216_L1.0301.00
86_I145_I1.0271.00
207_K296_V1.0251.00
30_L60_I1.0241.00
256_V290_T1.0191.00
67_H184_D1.0151.00
32_L60_I1.0151.00
47_Q50_L1.0101.00
254_E258_R1.0101.00
43_A75_L1.0101.00
34_D67_H1.0010.99
91_N166_A0.9990.99
40_K44_R0.9890.99
72_H184_D0.9840.99
30_L55_V0.9840.99
247_D251_N0.9810.99
92_E96_S0.9770.99
139_R142_T0.9690.99
42_A46_L0.9660.99
26_K58_S0.9610.99
282_E285_L0.9590.99
78_V82_E0.9540.99
262_E265_M0.9520.99
46_L49_Q0.9480.99
185_L215_S0.9470.99
22_V32_L0.9460.99
161_E170_I0.9460.99
91_N168_S0.9450.99
76_L85_V0.9410.99
208_P299_A0.9390.99
6_V25_V0.9360.99
33_I172_L0.9340.99
227_V238_V0.9270.99
89_T144_S0.9220.99
88_H91_N0.9130.99
157_W181_L0.9120.99
44_R47_Q0.9100.99
51_A82_E0.9100.99
160_L173_F0.9090.99
165_H184_D0.9060.99
226_I234_P0.9050.99
239_Q243_E0.9040.99
163_P215_S0.9040.99
63_V83_I0.8960.99
65_L73_A0.8940.99
246_F250_R0.8900.99
5_D177_S0.8780.99
254_E257_R0.8770.99
67_H72_H0.8680.99
61_E84_E0.8680.99
11_V22_V0.8660.99
240_A244_K0.8640.98
27_G154_L0.8640.98
210_V300_E0.8590.98
22_V36_G0.8590.98
32_L79_F0.8580.98
40_K78_V0.8560.98
48_E51_A0.8530.98
157_W172_L0.8520.98
187_L191_S0.8450.98
171_V180_M0.8440.98
68_H91_N0.8420.98
257_R261_D0.8400.98
91_N94_Y0.8390.98
187_L190_S0.8360.98
269_Q272_Q0.8360.98
35_A76_L0.8350.98
171_V185_L0.8330.98
84_E142_T0.8300.98
145_I172_L0.8240.98
274_L290_T0.8230.98
63_V79_F0.8140.98
262_E273_Q0.8120.98
25_V174_H0.8100.98
46_L50_L0.8030.98
164_G169_H0.8000.98
173_F222_L0.7970.97
21_I230_G0.7950.97
92_E144_S0.7940.97
267_A291_A0.7920.97
187_L192_S0.7910.97
259_M264_P0.7900.97
188_A235_I0.7850.97
38_N75_L0.7840.97
6_V179_R0.7820.97
258_R261_D0.7800.97
56_K59_D0.7790.97
227_V235_I0.7780.97
298_E303_I0.7750.97
210_V296_V0.7710.97
26_K29_A0.7700.97
97_Q100_A0.7660.97
249_Q293_H0.7600.97
268_F287_M0.7590.97
72_H231_H0.7580.97
96_S101_F0.7570.97
98_N101_F0.7530.96
155_E176_K0.7490.96
258_R262_E0.7470.96
192_S245_R0.7470.96
30_L59_D0.7440.96
145_I170_I0.7420.96
212_Y249_Q0.7410.96
149_M159_V0.7390.96
133_Y136_S0.7390.96
216_L246_F0.7290.96
13_T16_A0.7230.96
62_Q143_K0.7200.95
285_L288_S0.7190.95
148_G158_S0.7190.95
69_H72_H0.7140.95
11_V16_A0.7110.95
277_A280_E0.7110.95
267_A290_T0.7030.95
209_L212_Y0.6970.95
181_L228_F0.6970.95
24_L60_I0.6970.95
235_I241_L0.6960.95
80_S139_R0.6940.94
6_V174_H0.6920.94
185_L212_Y0.6920.94
162_M185_L0.6880.94
278_V283_L0.6880.94
77_D81_D0.6880.94
51_A57_L0.6870.94
66_T72_H0.6850.94
259_M270_V0.6830.94
45_A48_E0.6830.94
214_R218_R0.6820.94
71_D231_H0.6820.94
253_T296_V0.6810.94
89_T93_P0.6790.94
212_Y252_R0.6790.94
271_C287_M0.6770.94
32_L35_A0.6770.94
9_I24_L0.6770.94
282_E289_E0.6760.94
66_T69_H0.6760.94
42_A47_Q0.6760.94
282_E286_T0.6760.94
171_V219_L0.6740.94
174_H179_R0.6720.93
256_V270_V0.6710.93
31_T61_E0.6710.93
186_L238_V0.6690.93
286_T289_E0.6670.93
16_A19_D0.6650.93
73_A76_L0.6600.93
13_T17_V0.6600.93
67_H165_H0.6570.93
78_V81_D0.6560.93
295_D305_S0.6550.93
180_M227_V0.6550.93
272_Q283_L0.6540.92
40_K43_A0.6530.92
211_D214_R0.6520.92
298_E304_T0.6510.92
50_L53_V0.6490.92
249_Q253_T0.6480.92
169_H230_G0.6450.92
249_Q252_R0.6450.92
217_R243_E0.6400.92
276_P283_L0.6380.92
261_D304_T0.6370.91
28_D153_G0.6370.91
247_D250_R0.6360.91
148_G159_V0.6350.91
98_N102_M0.6350.91
21_I229_P0.6340.91
256_V293_H0.6340.91
31_T155_E0.6320.91
98_N103_D0.6310.91
166_A169_H0.6300.91
92_E95_I0.6290.91
21_I232_G0.6280.91
76_L80_S0.6280.91
242_I246_F0.6260.91
38_N43_A0.6260.91
20_V230_G0.6240.91
77_D137_C0.6230.91
301_E306_Y0.6220.90
24_L50_L0.6210.90
188_A233_E0.6200.90
75_L78_V0.6190.90
43_A82_E0.6190.90
184_D231_H0.6180.90
271_C290_T0.6180.90
191_S248_K0.6160.90
267_A294_L0.6160.90
288_S291_A0.6130.90
255_D259_M0.6120.90
11_V19_D0.6120.90
64_V157_W0.6080.89
281_K285_L0.6070.89
289_E293_H0.6070.89
205_R211_D0.6060.89
228_F234_P0.6060.89
182_G229_P0.6030.89
224_P238_V0.6020.89
69_H166_A0.6000.89
179_R182_G0.5980.89
5_D155_E0.5980.89
280_E283_L0.5970.89
207_K299_A0.5970.89
160_L218_R0.5960.89
11_V15_F0.5920.88
141_L144_S0.5920.88
160_L171_V0.5890.88
145_I151_I0.5870.88
67_H71_D0.5870.88
271_C275_F0.5850.88
209_L249_Q0.5840.88
284_F288_S0.5830.87
296_V299_A0.5820.87
293_H296_V0.5820.87
215_S218_R0.5810.87
12_P45_A0.5810.87
270_V274_L0.5780.87
272_Q280_E0.5770.87
74_G77_D0.5770.87
255_D258_R0.5770.87
148_G161_E0.5760.87
15_F19_D0.5730.87
94_Y97_Q0.5700.86
95_I99_Q0.5670.86
298_E301_E0.5650.86
208_P295_D0.5640.86
68_H73_A0.5620.86
174_H181_L0.5610.85
256_V274_L0.5610.85
23_Y26_K0.5580.85
99_Q102_M0.5580.85
276_P279_Y0.5570.85
259_M274_L0.5560.85
88_H168_S0.5540.85
34_D184_D0.5540.85
33_I157_W0.5520.84
193_N289_E0.5520.84
260_L270_V0.5520.84
294_L298_E0.5510.84
194_P209_L0.5480.84
42_A52_A0.5480.84
291_A295_D0.5470.84
47_Q57_L0.5450.84
251_N255_D0.5450.84
5_D179_R0.5410.83
212_Y248_K0.5400.83
275_F280_E0.5400.83
259_M265_M0.5390.83
286_T293_H0.5390.83
283_L287_M0.5380.83
43_A52_A0.5340.83
229_P235_I0.5340.83
269_Q273_Q0.5280.82
94_Y98_N0.5270.82
145_I149_M0.5230.81
87_G92_E0.5230.81
10_R19_D0.5230.81
20_V183_G0.5220.81
93_P100_A0.5200.81
64_V151_I0.5180.81
287_M291_A0.5180.81
267_A287_M0.5180.81
161_E218_R0.5170.80
29_A59_D0.5160.80
132_A260_L0.5150.80
224_P239_Q0.5130.80
275_F278_V0.5130.80
19_D22_V0.5120.80
182_G186_L0.5110.80
171_V215_S0.5110.80
32_L46_L0.5100.80
50_L55_V0.5100.80
294_L303_I0.5090.79
43_A49_Q0.5080.79
131_S134_A0.5070.79
171_V230_G0.5070.79
73_A87_G0.5050.79
245_R249_Q0.5050.79
37_P73_A0.5040.79
187_L241_L0.5030.79
193_N275_F0.5030.79
9_I49_Q0.5020.79
36_G212_Y0.5020.79
268_F272_Q0.5020.79
77_D138_T0.5010.78
248_K251_N0.5000.78
259_M262_E0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.931 100 0.276 Contact Map
4ad9A 4 0.8307 100 0.396 Contact Map
2yheA 3 0.953 100 0.433 Contact Map
2cfuA 2 0.9467 100 0.447 Contact Map
4pdxA 2 0.9373 100 0.454 Contact Map
4nurA 2 0.953 100 0.459 Contact Map
2fhxA 2 0.7053 100 0.492 Contact Map
2vw8A 2 0.8589 100 0.493 Contact Map
3q6vA 1 0.6708 100 0.516 Contact Map
3vpeA 1 0.7147 100 0.525 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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