GREMLIN Database
P5CR2 - Pyrroline-5-carboxylate reductase 2
UniProt: P54552 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (262)
Sequences: 5200 (3866)
Seq/√Len: 238.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
113_A142_D3.1691.00
127_K212_D2.7591.00
76_A96_L2.7581.00
219_K227_E2.7051.00
212_D216_Q2.4801.00
178_V207_M2.4671.00
117_V130_T2.4361.00
181_Y251_I2.4321.00
182_I214_L2.4241.00
241_A245_S2.2871.00
34_T57_K2.2161.00
5_G60_F2.2101.00
155_D201_A2.1441.00
179_Y210_A2.0841.00
105_Q135_S2.0841.00
147_K158_L2.0741.00
195_D198_T2.0621.00
129_A155_D2.0001.00
186_E200_K1.9991.00
245_S250_A1.9811.00
143_I158_L1.9661.00
147_K151_E1.9641.00
208_A212_D1.9241.00
9_A33_I1.8931.00
174_G206_T1.8531.00
157_T201_A1.8481.00
212_D215_L1.8181.00
185_M255_I1.7821.00
177_Y238_G1.7691.00
219_K223_K1.7661.00
39_D43_I1.7571.00
223_K227_E1.7521.00
122_S128_S1.7511.00
243_Q248_E1.7441.00
134_V143_I1.7251.00
190_Q196_K1.7211.00
131_G167_V1.7161.00
181_Y247_F1.7131.00
151_E156_A1.7081.00
245_S253_H1.6731.00
16_M153_I1.6371.00
139_S142_D1.6041.00
236_E240_R1.5941.00
5_G64_T1.5911.00
93_I146_A1.5541.00
35_N41_R1.5491.00
204_L215_L1.5431.00
165_D262_S1.5431.00
132_F158_L1.5371.00
261_R264_E1.5281.00
32_Y52_R1.5221.00
192_V256_E1.5141.00
223_K226_K1.5141.00
3_K30_H1.5081.00
12_M95_V1.5001.00
66_I91_L1.4961.00
92_V108_F1.4911.00
127_K208_A1.4881.00
33_I51_V1.4711.00
229_T236_E1.4641.00
36_R75_D1.4511.00
32_Y54_C1.4491.00
247_F250_A1.4451.00
140_K144_I1.4391.00
77_A107_Y1.4231.00
244_D253_H1.4171.00
94_S104_I1.4121.00
56_D59_E1.4081.00
14_E41_R1.4011.00
43_I47_E1.3961.00
77_A103_T1.3931.00
41_R44_E1.3901.00
80_I108_F1.3851.00
187_K196_K1.3841.00
205_Q208_A1.3831.00
182_I207_M1.3481.00
159_V164_L1.3441.00
183_E225_R1.3371.00
100_T103_T1.3291.00
173_S234_T1.3271.00
191_K256_E1.3271.00
178_V181_Y1.3181.00
241_A244_D1.3071.00
247_F251_I1.3061.00
115_I146_A1.3021.00
220_Q223_K1.2921.00
256_E260_K1.2921.00
191_K252_I1.2881.00
37_S40_E1.2841.00
129_A205_Q1.2761.00
259_A263_A1.2651.00
44_E48_T1.2581.00
187_K248_E1.2421.00
6_F13_A1.2261.00
6_F17_I1.2201.00
238_G254_C1.2171.00
70_A95_V1.2171.00
249_E253_H1.2021.00
76_A99_L1.1981.00
103_T107_Y1.1951.00
123_A128_S1.1951.00
169_A255_I1.1921.00
96_L99_L1.1901.00
144_I148_A1.1861.00
18_N48_T1.1861.00
87_I92_V1.1801.00
183_E222_E1.1791.00
147_K156_A1.1591.00
32_Y63_H1.1531.00
132_F156_A1.1521.00
159_V167_V1.1371.00
105_Q136_T1.1331.00
160_E163_H1.1321.00
43_I46_K1.1311.00
105_Q137_E1.1211.00
240_R244_D1.1161.00
16_M20_I1.1101.00
127_K205_Q1.1081.00
242_L254_C1.1071.00
66_I145_A1.1071.00
189_A194_L1.1061.00
60_F64_T1.1041.00
6_F68_I1.1031.00
102_E106_H1.0981.00
229_T239_L1.0971.00
13_A17_I1.0971.00
101_I133_S1.0901.00
237_A240_R1.0881.00
42_L53_P1.0731.00
132_F150_L1.0711.00
192_V259_A1.0631.00
3_K32_Y1.0601.00
225_R229_T1.0591.00
182_I203_I1.0541.00
101_I114_V1.0541.00
37_S41_R1.0481.00
242_L251_I1.0461.00
91_L142_D1.0461.00
71_F96_L1.0431.00
129_A157_T1.0411.00
165_D263_A1.0341.00
40_E43_I1.0281.00
132_F147_K1.0261.00
208_A215_L1.0241.00
66_I93_I1.0191.00
170_I255_I1.0181.00
11_S227_E1.0101.00
16_M95_V1.0081.00
117_V150_L1.0071.00
20_I149_L0.9971.00
22_Q126_R0.9931.00
101_I104_I0.9871.00
134_V158_L0.9861.00
138_A142_D0.9811.00
155_D205_Q0.9771.00
133_S164_L0.9751.00
18_N49_Y0.9741.00
69_L76_A0.9701.00
167_V202_L0.9701.00
171_A202_L0.9681.00
157_T198_T0.9661.00
180_R239_L0.9641.00
58_N82_S0.9641.00
67_I90_Q0.9631.00
59_E63_H0.9631.00
179_Y213_M0.9581.00
17_I33_I0.9531.00
14_E49_Y0.9531.00
42_L55_R0.9381.00
19_G153_I0.9351.00
167_V171_A0.9331.00
75_D79_S0.9291.00
166_A194_L0.9261.00
214_L221_P0.9251.00
246_R249_E0.9221.00
75_D78_E0.9211.00
58_N86_Y0.9201.00
241_A257_E0.9171.00
77_A81_D0.9151.00
68_I93_I0.9081.00
103_T106_H0.9051.00
99_L103_T0.9041.00
197_E201_A0.9001.00
198_T201_A0.8961.00
241_A253_H0.8900.99
237_A261_R0.8860.99
14_E48_T0.8840.99
186_E190_Q0.8770.99
187_K190_Q0.8760.99
58_N62_T0.8760.99
204_L211_T0.8760.99
35_N42_L0.8750.99
34_T54_C0.8720.99
104_I114_V0.8700.99
180_R243_Q0.8700.99
220_Q226_K0.8630.99
5_G34_T0.8610.99
9_A45_L0.8570.99
115_I134_V0.8560.99
61_F67_I0.8550.99
65_D90_Q0.8440.99
39_D42_L0.8420.99
257_E260_K0.8410.99
170_I189_A0.8340.99
123_A153_I0.8340.99
141_N144_I0.8320.99
138_A143_I0.8300.99
226_K236_E0.8300.99
192_V255_I0.8290.99
18_N124_A0.8220.99
108_F112_L0.8210.99
246_R250_A0.8200.99
129_A202_L0.8190.99
260_K264_E0.8180.99
7_V79_S0.8140.99
4_I20_I0.8120.99
234_T262_S0.8120.99
81_D107_Y0.8120.99
21_L28_P0.8100.99
3_K63_H0.8060.99
200_K204_L0.8030.99
222_E226_K0.8010.99
62_T86_Y0.7980.99
91_L146_A0.7970.99
76_A80_I0.7930.99
184_A248_E0.7930.99
11_S230_S0.7860.99
169_A259_A0.7830.99
32_Y64_T0.7770.99
76_A94_S0.7730.99
44_E47_E0.7690.99
26_T30_H0.7610.98
180_R248_E0.7500.98
189_A203_I0.7490.98
237_A241_A0.7480.98
208_A211_T0.7450.98
61_F83_I0.7400.98
57_K82_S0.7400.98
45_L49_Y0.7380.98
116_R161_E0.7370.98
52_R63_H0.7360.98
3_K65_D0.7320.98
95_V117_V0.7280.98
17_I31_I0.7270.98
109_G112_L0.7260.98
191_K240_R0.7240.98
239_L243_Q0.7240.98
46_K53_P0.7220.98
165_D266_K0.7220.98
77_A99_L0.7190.98
14_E44_E0.7170.98
13_A70_A0.7160.98
238_G258_T0.7150.98
81_D84_R0.7150.98
245_S249_E0.7130.98
238_G241_A0.7110.98
14_E18_N0.7090.98
204_L214_L0.7070.97
17_I45_L0.7050.97
183_E187_K0.7050.97
105_Q111_K0.7040.97
41_R45_L0.7040.97
144_I147_K0.7020.97
59_E62_T0.7020.97
135_S138_A0.7010.97
148_A151_E0.7000.97
125_I212_D0.7000.97
134_V140_K0.7000.97
194_L202_L0.6990.97
260_K263_A0.6980.97
168_T174_G0.6980.97
118_M172_G0.6960.97
173_S258_T0.6950.97
134_V138_A0.6950.97
97_A234_T0.6840.97
67_I92_V0.6840.97
129_A201_A0.6830.97
168_T262_S0.6820.97
101_I135_S0.6790.97
80_I96_L0.6790.97
131_G164_L0.6770.97
42_L46_K0.6760.97
187_K191_K0.6740.97
127_K155_D0.6730.97
164_L262_S0.6730.97
171_A206_T0.6700.97
196_K200_K0.6670.96
240_R253_H0.6650.96
163_H166_A0.6650.96
68_I150_L0.6610.96
145_A148_A0.6530.96
5_G67_I0.6530.96
97_A265_I0.6520.96
17_I51_V0.6510.96
4_I26_T0.6490.96
35_N95_V0.6380.95
255_I258_T0.6350.95
188_A255_I0.6350.95
240_R243_Q0.6330.95
101_I105_Q0.6320.95
222_E225_R0.6320.95
179_Y214_L0.6300.95
78_E81_D0.6300.95
100_T266_K0.6280.95
142_D145_A0.6250.95
34_T56_D0.6230.95
115_I138_A0.6220.95
189_A199_A0.6210.95
166_A192_V0.6200.95
186_E221_P0.6190.95
15_A19_G0.6180.95
186_E203_I0.6180.95
54_C60_F0.6180.95
79_S82_S0.6170.94
20_I25_I0.6170.94
170_I185_M0.6140.94
78_E82_S0.6120.94
32_Y60_F0.6090.94
57_K61_F0.6090.94
113_A135_S0.6070.94
174_G258_T0.6010.94
91_L115_I0.6000.94
114_V135_S0.5990.94
163_H198_T0.5970.93
72_K230_S0.5950.93
83_I87_I0.5940.93
5_G32_Y0.5930.93
179_Y224_L0.5930.93
249_E252_I0.5900.93
256_E259_A0.5890.93
66_I149_L0.5870.93
176_A235_T0.5850.93
122_S175_P0.5840.93
105_Q114_V0.5830.93
55_R59_E0.5800.92
34_T60_F0.5790.92
168_T173_S0.5780.92
133_S161_E0.5750.92
130_T153_I0.5730.92
113_A138_A0.5730.92
57_K60_F0.5710.92
69_L96_L0.5700.92
33_I45_L0.5680.92
131_G157_T0.5670.92
236_E239_L0.5650.92
155_D215_L0.5640.91
11_S72_K0.5630.91
61_F90_Q0.5600.91
130_T154_G0.5600.91
84_R109_G0.5600.91
25_I148_A0.5590.91
126_R153_I0.5590.91
230_S234_T0.5580.91
92_V112_L0.5570.91
82_S85_P0.5560.91
164_L167_V0.5550.91
118_M164_L0.5540.91
251_I255_I0.5520.91
176_A238_G0.5520.91
36_R42_L0.5490.90
131_G171_A0.5480.90
69_L83_I0.5460.90
39_D55_R0.5440.90
91_L113_A0.5440.90
207_M247_F0.5430.90
174_G255_I0.5410.90
172_G234_T0.5400.90
166_A189_A0.5390.90
177_Y258_T0.5390.90
64_T90_Q0.5390.90
242_L247_F0.5380.89
182_I221_P0.5370.89
26_T29_E0.5340.89
163_H195_D0.5340.89
16_M150_L0.5280.89
188_A252_I0.5270.88
61_F86_Y0.5270.88
125_I213_M0.5250.88
121_T227_E0.5250.88
120_N172_G0.5250.88
22_Q216_Q0.5240.88
54_C59_E0.5210.88
21_L24_G0.5190.88
115_I143_I0.5170.88
91_L145_A0.5160.87
240_R252_I0.5160.87
133_S160_E0.5100.87
140_K143_I0.5080.87
123_A130_T0.5050.86
23_S126_R0.5050.86
186_E189_A0.5030.86
159_V163_H0.5030.86
61_F64_T0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2izzA 5 0.9712 100 0.383 Contact Map
2rcyA 5 0.9317 100 0.394 Contact Map
2ahrA 5 0.9245 100 0.403 Contact Map
1yqgA 2 0.9424 100 0.409 Contact Map
3triA 2 0.964 100 0.424 Contact Map
3gt0A 3 0.7734 100 0.457 Contact Map
4kqwA 2 0.964 100 0.461 Contact Map
4wjiA 2 0.9424 100 0.524 Contact Map
3fr7A 2 0.946 100 0.528 Contact Map
2i76A 2 0.8417 100 0.564 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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