GREMLIN Database
NAMA - NADPH dehydrogenase
UniProt: P54550 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 338 (324)
Sequences: 11182 (7419)
Seq/√Len: 412.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_A185_E3.5941.00
202_D241_Q3.5251.00
100_G160_V3.1231.00
64_N145_E2.9481.00
189_S192_N2.5471.00
151_A207_V2.5201.00
147_K203_E2.4991.00
21_V303_L2.4761.00
132_V138_K2.4551.00
10_T15_T2.4351.00
92_V99_I2.3971.00
237_W240_E2.3931.00
9_I303_L2.3081.00
39_P87_K2.3051.00
270_E300_R2.2961.00
134_M142_T2.2811.00
294_E298_N2.2211.00
53_V310_L2.1601.00
93_K159_D2.1351.00
79_D152_R2.1151.00
239_K277_D2.1001.00
213_F245_L2.0961.00
117_F134_M2.0861.00
46_I95_Q2.0731.00
313_D319_T2.0411.00
134_M138_K2.0171.00
154_K208_W2.0071.00
281_G305_F1.9691.00
6_F321_A1.9511.00
46_I91_Q1.9371.00
144_Q148_Q1.9281.00
318_R322_K1.9031.00
151_A155_E1.8981.00
236_K275_Q1.8931.00
121_A133_E1.8821.00
171_I197_L1.8711.00
293_E297_Q1.8681.00
61_S101_I1.8521.00
86_A90_E1.8441.00
148_Q152_R1.8231.00
171_I196_F1.8211.00
4_K7_T1.8111.00
136_A140_K1.7881.00
141_E145_E1.7861.00
13_D210_G1.7731.00
147_K207_V1.7661.00
140_K199_E1.7271.00
82_I155_E1.7271.00
233_G237_W1.7011.00
90_E94_E1.6861.00
186_Y199_E1.6711.00
4_K293_E1.6591.00
192_N195_R1.6571.00
165_A214_V1.6501.00
197_L214_V1.6481.00
115_D132_V1.6191.00
136_A186_Y1.6121.00
89_T158_F1.5981.00
171_I200_I1.5961.00
135_S138_K1.5911.00
136_A139_V1.5841.00
42_M87_K1.5751.00
270_E274_E1.5741.00
79_D155_E1.5681.00
150_A204_V1.5621.00
144_Q203_E1.5471.00
194_Y237_W1.5401.00
66_Q141_E1.5361.00
85_F158_F1.5351.00
324_L327_E1.5181.00
140_K185_E1.5141.00
177_P225_G1.5131.00
39_P43_A1.4801.00
21_V281_G1.4681.00
197_L234_F1.4661.00
122_I181_H1.4631.00
43_A46_I1.4611.00
273_R302_D1.4561.00
316_F320_A1.4401.00
47_S315_F1.4241.00
76_I101_I1.4121.00
198_R237_W1.4081.00
58_V99_I1.4081.00
194_Y233_G1.4061.00
82_I152_R1.4021.00
154_K210_G1.3961.00
148_Q151_A1.3961.00
25_M307_G1.3741.00
17_K98_K1.3691.00
20_I317_A1.3641.00
198_R241_Q1.3601.00
318_R321_A1.3481.00
37_L85_F1.3471.00
22_M48_R1.3461.00
103_L149_A1.3311.00
147_K151_A1.3301.00
190_P194_Y1.3291.00
227_D230_D1.3251.00
165_A171_I1.3161.00
201_I238_M1.3051.00
16_L55_L1.3051.00
271_K275_Q1.3041.00
42_M91_Q1.2981.00
4_K297_Q1.2931.00
286_I295_I1.2921.00
122_I131_P1.2881.00
143_V203_E1.2871.00
76_I149_A1.2831.00
203_E206_Q1.2701.00
289_G320_A1.2541.00
117_F132_V1.2461.00
194_Y198_R1.2451.00
292_A306_I1.2451.00
283_V305_F1.2411.00
147_K206_Q1.2291.00
203_E207_V1.2281.00
271_K274_E1.2271.00
140_K186_Y1.2211.00
46_I94_E1.1981.00
84_G87_K1.1971.00
198_R202_D1.1961.00
36_K80_E1.1891.00
239_K278_M1.1841.00
237_W241_Q1.1841.00
167_H249_S1.1801.00
22_M56_I1.1791.00
118_A121_A1.1771.00
14_M98_K1.1761.00
101_I153_A1.1751.00
42_M46_I1.1741.00
195_R199_E1.1651.00
133_E183_T1.1641.00
144_Q147_K1.1491.00
98_K159_D1.1451.00
282_A301_A1.1441.00
310_L317_A1.1401.00
9_I279_A1.1311.00
123_A130_T1.1301.00
58_V158_F1.1291.00
90_E93_K1.1291.00
138_K141_E1.1291.00
172_H176_S1.1261.00
289_G323_Q1.1251.00
143_V199_E1.1171.00
228_I271_K1.1161.00
190_P233_G1.1131.00
295_I301_A1.1131.00
281_G303_L1.1071.00
93_K99_I1.1051.00
120_S181_H1.0971.00
89_T99_I1.0961.00
165_A197_L1.0801.00
266_V295_I1.0751.00
143_V147_K1.0701.00
82_I156_A1.0661.00
69_I106_A1.0651.00
79_D83_E1.0641.00
37_L84_G1.0621.00
13_D211_P1.0621.00
289_G293_E1.0571.00
208_W212_L1.0561.00
119_P179_S1.0551.00
27_M40_F1.0541.00
38_T41_H1.0461.00
233_G236_K1.0461.00
214_V243_V1.0451.00
87_K90_E1.0441.00
10_T13_D1.0421.00
185_E195_R1.0371.00
35_G68_R1.0301.00
62_A73_D1.0271.00
202_D206_Q1.0241.00
145_E148_Q1.0231.00
74_L85_F1.0201.00
148_Q207_V1.0151.00
22_M310_L1.0021.00
89_T156_A0.9991.00
4_K296_L0.9971.00
232_I275_Q0.9901.00
16_L54_G0.9901.00
214_V238_M0.9861.00
12_K244_D0.9761.00
140_K143_V0.9731.00
143_V200_I0.9721.00
228_I232_I0.9681.00
194_Y234_F0.9651.00
201_I243_V0.9641.00
16_L21_V0.9621.00
108_R179_S0.9601.00
139_V143_V0.9581.00
42_M88_L0.9571.00
16_L303_L0.9501.00
121_A130_T0.9471.00
175_L197_L0.9421.00
232_I236_K0.9391.00
178_L224_K0.9381.00
18_N54_G0.9381.00
75_G81_H0.9371.00
301_A304_I0.9331.00
232_I271_K0.9321.00
53_V317_A0.9311.00
20_I316_F0.9281.00
216_V231_H0.9261.00
76_I153_A0.9211.00
163_I204_V0.9201.00
52_Q318_R0.9171.00
162_E247_D0.9161.00
154_K209_D0.9151.00
100_G211_P0.9131.00
137_E140_K0.9111.00
286_I304_I0.9111.00
78_S81_H0.9041.00
99_I158_F0.8991.00
36_K81_H0.8981.00
160_V213_F0.8981.00
186_Y202_D0.8971.00
205_K244_D0.8941.00
86_A155_E0.8941.00
17_K97_S0.8911.00
37_L74_L0.8861.00
190_P237_W0.8841.00
204_V212_L0.8841.00
23_S247_D0.8841.00
117_F138_K0.8811.00
99_I159_D0.8811.00
190_P230_D0.8811.00
143_V196_F0.8781.00
170_L196_F0.8771.00
293_E296_L0.8771.00
150_A208_W0.8761.00
290_S323_Q0.8741.00
267_S270_E0.8731.00
60_A104_A0.8691.00
246_I278_M0.8671.00
201_I241_Q0.8661.00
55_L100_G0.8661.00
263_G291_M0.8611.00
199_E202_D0.8601.00
83_E86_A0.8591.00
13_D209_D0.8581.00
140_K203_E0.8571.00
5_L292_A0.8561.00
163_I200_I0.8491.00
9_I12_K0.8461.00
194_Y197_L0.8441.00
55_L160_V0.8361.00
235_A246_I0.8351.00
23_S307_G0.8341.00
143_V186_Y0.8301.00
14_M100_G0.8281.00
23_S305_F0.8261.00
226_L234_F0.8181.00
135_S140_K0.8171.00
306_I309_E0.8161.00
286_I292_A0.8161.00
22_M25_M0.8131.00
39_P42_M0.8131.00
57_I100_G0.8101.00
62_A68_R0.8081.00
245_L281_G0.8081.00
215_R247_D0.8031.00
191_E233_G0.8031.00
100_G213_F0.8001.00
62_A77_W0.8001.00
37_L88_L0.7971.00
315_F319_T0.7961.00
51_G318_R0.7951.00
91_Q95_Q0.7921.00
236_K240_E0.7921.00
133_E181_H0.7921.00
121_A181_H0.7911.00
17_K52_Q0.7901.00
185_E192_N0.7891.00
250_S265_Q0.7861.00
136_A143_V0.7831.00
109_K124_F0.7831.00
205_K212_L0.7821.00
14_M211_P0.7821.00
218_A248_C0.7761.00
22_M53_V0.7731.00
142_T145_E0.7721.00
106_A110_A0.7721.00
58_V101_I0.7711.00
132_V135_S0.7681.00
147_K200_I0.7671.00
43_A47_S0.7641.00
163_I201_I0.7611.00
248_C280_T0.7611.00
196_F200_I0.7611.00
290_S294_E0.7561.00
77_W81_H0.7521.00
115_D129_A0.7521.00
57_I160_V0.7521.00
30_S41_H0.7471.00
188_G193_R0.7461.00
306_I310_L0.7461.00
152_R155_E0.7451.00
63_V146_F0.7441.00
154_K207_V0.7421.00
58_V85_F0.7401.00
108_R131_P0.7361.00
272_I276_A0.7271.00
78_S82_I0.7271.00
91_Q94_E0.7241.00
172_H231_H0.7231.00
125_D224_K0.7211.00
134_M139_V0.7181.00
164_H169_Y0.7181.00
306_I316_F0.7161.00
266_V282_A0.7151.00
230_D233_G0.7131.00
226_L231_H0.7121.00
248_C272_I0.7121.00
64_N142_T0.7101.00
120_S133_E0.7061.00
292_A320_A0.7041.00
14_M160_V0.7041.00
21_V57_I0.7021.00
139_V197_L0.6971.00
226_L229_A0.6971.00
45_Y56_I0.6961.00
51_G317_A0.6961.00
247_D305_F0.6951.00
86_A89_T0.6951.00
178_L222_T0.6941.00
191_E237_W0.6931.00
109_K223_D0.6901.00
235_A276_A0.6881.00
44_H48_R0.6851.00
63_V200_I0.6841.00
49_A95_Q0.6811.00
229_A232_I0.6801.00
151_A154_K0.6801.00
16_L98_K0.6801.00
49_A92_V0.6781.00
15_T98_K0.6781.00
93_K98_K0.6761.00
83_E87_K0.6761.00
21_V55_L0.6730.99
36_K78_S0.6700.99
235_A272_I0.6690.99
118_A179_S0.6690.99
226_L230_D0.6690.99
20_I53_V0.6670.99
63_V145_E0.6660.99
11_I279_A0.6660.99
92_V97_S0.6650.99
188_G192_N0.6630.99
276_A279_A0.6610.99
64_N141_E0.6600.99
213_F281_G0.6590.99
36_K84_G0.6530.99
147_K204_V0.6500.99
291_M294_E0.6500.99
291_M295_I0.6480.99
63_V104_A0.6480.99
273_R276_A0.6480.99
24_P215_R0.6480.99
101_I158_F0.6460.99
287_T291_M0.6440.99
67_G105_H0.6430.99
214_V246_I0.6420.99
201_I214_V0.6390.99
61_S76_I0.6390.99
65_P77_W0.6370.99
288_D291_M0.6360.99
33_K72_Q0.6360.99
294_E297_Q0.6350.99
53_V56_I0.6340.99
175_L194_Y0.6330.99
309_E316_F0.6330.99
164_H167_H0.6330.99
17_K321_A0.6260.99
6_F317_A0.6260.99
8_P15_T0.6250.99
30_S74_L0.6240.99
247_D283_V0.6230.99
21_V305_F0.6220.99
239_K276_A0.6220.99
295_I300_R0.6190.99
201_I212_L0.6180.99
245_L303_L0.6160.99
185_E199_E0.6140.99
48_R315_F0.6120.99
172_H220_D0.6120.99
108_R173_E0.6100.99
119_P122_I0.6070.99
190_P226_L0.6060.99
175_L234_F0.6040.99
117_F142_T0.6040.99
211_P244_D0.5980.99
87_K91_Q0.5950.99
118_A131_P0.5940.99
122_I179_S0.5930.99
76_I81_H0.5880.99
55_L98_K0.5870.99
140_K144_Q0.5860.99
296_L304_I0.5860.99
205_K208_W0.5860.99
234_F237_W0.5850.99
318_R324_L0.5850.99
312_R327_E0.5840.99
82_I89_T0.5830.99
200_I203_E0.5820.99
23_S57_I0.5810.99
76_I152_R0.5810.99
220_D253_L0.5810.99
146_F171_I0.5800.99
238_M243_V0.5800.99
66_Q142_T0.5790.98
306_I320_A0.5780.98
136_A199_E0.5770.98
171_I204_V0.5760.98
134_M170_L0.5730.98
309_E312_R0.5720.98
121_A131_P0.5710.98
315_F318_R0.5690.98
105_H142_T0.5690.98
211_P245_L0.5670.98
142_T170_L0.5650.98
149_A152_R0.5640.98
266_V269_A0.5570.98
198_R233_G0.5550.98
82_I86_A0.5530.98
162_E213_F0.5490.98
147_K208_W0.5480.98
17_K96_G0.5480.98
294_E300_R0.5480.98
110_A116_I0.5470.98
74_L88_L0.5440.98
66_Q145_E0.5430.98
296_L301_A0.5420.98
163_I212_L0.5420.98
268_F271_K0.5410.98
26_C69_I0.5390.98
139_V171_I0.5390.98
73_D106_A0.5380.98
218_A268_F0.5380.98
187_G193_R0.5370.98
62_A106_A0.5350.97
41_H59_E0.5350.97
213_F247_D0.5350.97
11_I16_L0.5340.97
205_K209_D0.5330.97
219_S268_F0.5330.97
319_T324_L0.5320.97
248_C282_A0.5310.97
37_L41_H0.5310.97
123_A128_S0.5310.97
83_E90_E0.5280.97
204_V208_W0.5270.97
190_P234_F0.5260.97
119_P173_E0.5250.97
142_T146_F0.5230.97
25_M311_L0.5210.97
124_F129_A0.5210.97
161_I208_W0.5180.97
139_V186_Y0.5170.97
52_Q321_A0.5160.97
289_G316_F0.5150.97
231_H235_A0.5140.97
270_E273_R0.5140.97
216_V248_C0.5140.97
58_V61_S0.5100.97
69_I73_D0.5100.97
51_G315_F0.5090.97
136_A184_D0.5090.97
125_D128_S0.5090.97
269_A280_T0.5070.97
176_S220_D0.5070.97
231_H272_I0.5060.96
292_A304_I0.5060.96
204_V207_V0.5060.96
267_S271_K0.5060.96
201_I205_K0.5050.96
124_F128_S0.5050.96
250_S268_F0.5040.96
220_D251_G0.5040.96
89_T101_I0.5020.96
235_A275_Q0.5020.96
209_D242_G0.5020.96
100_G244_D0.5020.96
217_S220_D0.5000.96
44_H59_E0.5000.96
69_I104_A0.5000.96
24_P247_D0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k30A 2 0.9822 100 0.218 Contact Map
2hsaB 2 0.9822 100 0.221 Contact Map
1o94A 2 0.9822 100 0.223 Contact Map
4qnwA 1 0.9793 100 0.23 Contact Map
3tjlA 2 0.9941 100 0.231 Contact Map
4tmbA 2 0.9941 100 0.232 Contact Map
4e2bA 1 0.9675 100 0.233 Contact Map
3l5aA 1 0.9882 100 0.235 Contact Map
4gbuA 2 0.9882 100 0.238 Contact Map
1ps9A 1 0.9911 100 0.24 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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