GREMLIN Database
RNZ - Ribonuclease Z
UniProt: P54548 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (295)
Sequences: 2411 (1717)
Seq/√Len: 99.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_T118_Q4.7021.00
176_K181_E3.9861.00
97_K101_E3.5091.00
207_V225_C3.5001.00
134_T150_Q3.1241.00
127_E152_K3.0151.00
98_A105_A2.9871.00
32_S57_E2.6561.00
226_D263_K2.6481.00
224_D261_R2.6161.00
139_I213_R2.5521.00
236_K251_E2.4501.00
148_R205_S2.4161.00
182_T193_G2.4031.00
151_E204_R2.3741.00
87_E114_P2.3621.00
205_S225_C2.3541.00
89_T116_A2.2921.00
234_F245_Y2.2841.00
166_M196_F2.2501.00
251_E288_D2.1781.00
99_F103_S2.1771.00
36_F149_V2.1671.00
76_L88_L2.1501.00
95_G119_E2.1481.00
255_V259_E2.1371.00
41_A44_H2.0611.00
132_I150_Q2.0581.00
175_Q179_K1.9941.00
21_S35_L1.9901.00
266_I302_V1.9881.00
266_I296_A1.9451.00
150_Q205_S1.9421.00
220_E223_R1.9291.00
60_F133_V1.9291.00
283_Q287_V1.9061.00
192_N195_D1.9051.00
91_Y118_Q1.8551.00
297_Y300_L1.8541.00
185_L189_R1.8381.00
124_I134_T1.8331.00
191_I196_F1.8321.00
73_P103_S1.8191.00
3_L229_V1.8081.00
230_H248_S1.7971.00
45_Q48_H1.7901.00
159_K162_V1.7901.00
22_V268_T1.7821.00
23_A35_L1.7801.00
264_Q294_V1.7561.00
182_T192_N1.7531.00
162_V165_E1.7461.00
2_E25_K1.7441.00
254_A289_V1.7371.00
2_E301_E1.7331.00
58_K91_Y1.7321.00
49_T299_F1.7281.00
23_A33_V1.7101.00
21_S42_T1.6951.00
87_E116_A1.6701.00
3_L24_L1.6631.00
80_S112_T1.6531.00
9_G14_A1.6531.00
219_K259_E1.6511.00
296_A300_L1.6501.00
207_V222_A1.6091.00
232_A267_L1.5871.00
213_R252_Q1.5821.00
283_Q295_A1.5641.00
184_T190_I1.5291.00
127_E132_I1.5251.00
239_R252_Q1.5141.00
251_E289_V1.5041.00
5_F8_T1.4931.00
223_R261_R1.4911.00
219_K256_T1.4861.00
284_K287_V1.4621.00
136_V221_L1.4611.00
294_V300_L1.4391.00
23_A51_I1.4341.00
2_E303_N1.4311.00
180_G193_G1.3650.99
236_K239_R1.3600.99
45_Q299_F1.3550.99
56_I75_L1.3380.99
222_A260_A1.3380.99
138_V146_G1.3370.99
62_T147_Y1.3170.99
66_G70_Y1.3080.99
217_K220_E1.2930.99
158_L163_L1.2930.99
4_L301_E1.2820.99
18_N44_H1.2820.99
58_K89_T1.2600.99
235_A282_L1.2500.99
24_L149_V1.2450.99
141_G246_Y1.2330.99
146_G209_S1.2270.99
236_K285_E1.2190.99
160_A164_K1.2190.99
250_T254_A1.2110.99
177_I196_F1.1990.99
138_V209_S1.1910.98
139_I246_Y1.1880.98
222_A225_C1.1880.98
255_V258_K1.1860.98
216_D259_E1.1800.98
249_T253_A1.1760.98
77_G109_T1.1660.98
20_T268_T1.1520.98
159_K198_E1.1490.98
124_I127_E1.1490.98
97_K119_E1.1430.98
267_L286_A1.1430.98
3_L227_V1.1350.98
97_K117_I1.1320.98
219_K260_A1.1310.98
228_L262_A1.1310.98
287_V293_S1.1140.98
168_I174_Y1.1140.98
36_F60_F1.1130.98
148_R207_V1.1110.98
193_G196_F1.1070.97
237_E285_E1.0980.97
138_V144_A1.0920.97
184_T188_G1.0880.97
148_R225_C1.0860.97
240_K244_D1.0830.97
5_F296_A1.0810.97
34_W131_F1.0710.97
59_I72_L1.0710.97
243_Y252_Q1.0680.97
132_I152_K1.0670.97
264_Q292_N1.0540.97
251_E255_V1.0480.97
137_S145_F1.0480.97
8_T17_R1.0450.96
61_I96_I1.0420.96
53_P56_I1.0410.96
92_G96_I1.0390.96
193_G197_L1.0380.96
59_I75_L1.0280.96
34_W149_V1.0270.96
251_E285_E1.0180.96
125_V147_Y1.0160.96
286_A290_F1.0150.96
257_A265_L1.0120.96
213_R246_Y0.9950.95
146_G218_L0.9950.95
163_L196_F0.9920.95
177_I183_V0.9920.95
172_P176_K0.9880.95
250_T285_E0.9850.95
90_V100_I0.9840.95
283_Q293_S0.9820.95
258_K289_V0.9800.95
66_G233_T0.9780.95
100_I104_L0.9750.95
225_C262_A0.9550.94
43_Q74_G0.9520.94
227_V266_I0.9490.94
5_F22_V0.9480.94
35_L56_I0.9460.94
224_D263_K0.9400.94
100_I117_I0.9340.93
214_V252_Q0.9320.93
20_T208_F0.9270.93
217_K221_L0.9250.93
63_H68_H0.9230.93
101_E105_A0.9170.93
162_V195_D0.9120.93
92_G119_E0.9120.93
242_A249_T0.9080.92
9_G17_R0.9060.92
173_V176_K0.9030.92
209_S218_L0.9000.92
227_V264_Q0.8970.92
218_L256_T0.8930.92
294_V302_V0.8900.92
252_Q255_V0.8850.91
153_D202_K0.8810.91
177_I193_G0.8810.91
24_L36_F0.8780.91
18_N42_T0.8730.91
214_V256_T0.8720.91
270_I295_A0.8690.91
254_A290_F0.8690.91
153_D203_G0.8670.91
287_V292_N0.8650.91
65_H68_H0.8630.90
84_G113_Y0.8610.90
208_F229_V0.8570.90
137_S143_E0.8530.90
92_G95_G0.8510.90
33_V56_I0.8510.90
90_V96_I0.8430.89
253_A262_A0.8430.89
287_V294_V0.8430.89
108_K143_E0.8380.89
192_N196_F0.8360.89
185_L190_I0.8320.89
72_L76_L0.8260.88
277_D295_A0.8200.88
60_F91_Y0.8150.88
4_L49_T0.8130.88
241_L245_Y0.8090.87
224_D262_A0.8070.87
176_K180_G0.8070.87
40_E43_Q0.8060.87
3_L266_I0.8050.87
57_E86_D0.7990.87
167_N171_G0.7950.86
180_G183_V0.7950.86
70_Y77_G0.7930.86
166_M191_I0.7890.86
239_R243_Y0.7850.86
282_L286_A0.7850.86
229_V268_T0.7850.86
62_T210_G0.7830.86
232_A250_T0.7810.85
297_Y302_V0.7790.85
84_G88_L0.7790.85
25_K33_V0.7790.85
223_R259_E0.7770.85
35_L46_I0.7760.85
266_I294_V0.7760.85
69_V73_P0.7740.85
63_H67_D0.7730.85
290_F293_S0.7720.85
168_I177_I0.7640.84
18_N45_Q0.7640.84
125_V134_T0.7630.84
32_S128_D0.7580.84
205_S226_D0.7570.84
235_A250_T0.7570.84
254_A257_A0.7560.84
182_T190_I0.7550.83
158_L178_K0.7530.83
69_V107_T0.7520.83
171_G175_Q0.7520.83
16_A275_Q0.7510.83
38_C42_T0.7500.83
162_V166_M0.7450.83
270_I296_A0.7430.82
76_L113_Y0.7430.82
177_I180_G0.7400.82
216_D219_K0.7400.82
215_S221_L0.7390.82
11_G19_V0.7360.82
144_A210_G0.7350.82
103_S107_T0.7310.81
236_K250_T0.7310.81
130_Q152_K0.7300.81
181_E193_G0.7290.81
144_A147_Y0.7280.81
120_I145_F0.7230.81
215_S222_A0.7220.81
40_E74_G0.7200.80
15_K48_H0.7160.80
156_G198_E0.7160.80
218_L222_A0.7130.80
268_T296_A0.7070.79
173_V183_V0.7040.79
264_Q302_V0.7030.79
276_G279_S0.7010.79
232_A270_I0.7000.79
70_Y107_T0.6960.78
235_A238_D0.6950.78
287_V291_P0.6950.78
250_T286_A0.6930.78
136_V146_G0.6920.78
24_L206_V0.6870.77
210_G248_S0.6860.77
210_G230_H0.6850.77
10_A20_T0.6810.77
138_V231_E0.6770.76
138_V218_L0.6730.76
206_V229_V0.6720.76
219_K223_R0.6670.75
164_K167_N0.6660.75
26_L30_R0.6640.75
94_K119_E0.6620.75
46_I51_I0.6610.75
37_D67_D0.6600.74
135_A145_F0.6580.74
75_L78_S0.6570.74
70_Y109_T0.6550.74
177_I192_N0.6540.74
76_L109_T0.6540.74
285_E288_D0.6530.74
30_R57_E0.6520.74
53_P75_L0.6520.74
204_R304_V0.6510.73
138_V210_G0.6490.73
211_D247_H0.6480.73
136_V220_E0.6480.73
64_M96_I0.6480.73
124_I132_I0.6470.73
37_D68_H0.6440.73
166_M195_D0.6420.72
96_I100_I0.6420.72
102_T106_V0.6410.72
282_L285_E0.6400.72
241_L244_D0.6390.72
182_T194_N0.6370.72
46_I56_I0.6360.72
124_I152_K0.6360.72
94_K121_E0.6350.72
168_I173_V0.6330.71
170_P173_V0.6290.71
91_Y125_V0.6280.71
198_E201_K0.6270.71
9_G272_A0.6270.71
15_K49_T0.6270.71
215_S218_L0.6260.71
259_E289_V0.6260.71
62_T209_S0.6260.71
156_G203_G0.6250.70
122_E137_S0.6240.70
160_A174_Y0.6220.70
140_H147_Y0.6220.70
68_H269_H0.6200.70
161_D165_E0.6200.70
35_L42_T0.6190.70
68_H211_D0.6180.70
185_L191_I0.6180.70
156_G197_L0.6170.69
176_K183_V0.6150.69
258_K291_P0.6130.69
21_S38_C0.6110.69
218_L221_L0.6110.69
144_A208_F0.6100.69
136_V148_R0.6080.68
176_K179_K0.6070.68
212_T215_S0.6050.68
284_K288_D0.6020.68
128_D131_F0.6000.67
68_H231_E0.5990.67
104_L109_T0.5990.67
11_G272_A0.5980.67
37_D63_H0.5970.67
216_D220_E0.5960.67
8_T298_D0.5950.67
214_V260_A0.5950.67
30_R128_D0.5940.67
96_I103_S0.5930.66
212_T253_A0.5930.66
150_Q153_D0.5890.66
288_D291_P0.5880.66
156_G194_N0.5860.65
4_L51_I0.5850.65
232_A282_L0.5840.65
279_S282_L0.5810.65
59_I90_V0.5800.65
10_A19_V0.5760.64
99_F107_T0.5760.64
282_L290_F0.5760.64
8_T296_A0.5740.64
249_T257_A0.5710.63
38_C61_I0.5710.63
120_I147_Y0.5700.63
64_M99_F0.5700.63
219_K255_V0.5660.63
211_D269_H0.5660.63
279_S284_K0.5650.63
63_H247_H0.5650.63
286_A293_S0.5640.63
106_V109_T0.5640.63
61_I72_L0.5640.63
63_H269_H0.5630.62
10_A270_I0.5620.62
216_D240_K0.5610.62
124_I128_D0.5610.62
65_H231_E0.5600.62
79_R113_Y0.5590.62
4_L299_F0.5580.62
240_K243_Y0.5560.61
22_V229_V0.5540.61
85_E129_D0.5530.61
170_P175_Q0.5520.61
56_I59_I0.5520.61
289_V292_N0.5510.61
230_H256_T0.5490.60
68_H247_H0.5470.60
76_L90_V0.5450.60
9_G15_K0.5440.60
215_S219_K0.5440.60
163_L177_I0.5430.60
255_V289_V0.5420.59
136_V218_L0.5420.59
62_T208_F0.5420.59
210_G233_T0.5410.59
22_V208_F0.5400.59
43_Q78_S0.5390.59
275_Q278_A0.5370.59
61_I90_V0.5360.59
17_R298_D0.5360.59
189_R195_D0.5350.59
24_L34_W0.5340.58
32_S131_F0.5340.58
126_F172_P0.5310.58
209_S230_H0.5300.58
215_S220_E0.5300.58
61_I64_M0.5290.58
294_V297_Y0.5290.58
11_G233_T0.5270.57
179_K202_K0.5270.57
125_V135_A0.5250.57
257_A290_F0.5250.57
254_A286_A0.5250.57
213_R256_T0.5240.57
172_P175_Q0.5210.57
128_D152_K0.5210.57
92_G103_S0.5200.56
223_R260_A0.5200.56
148_R221_L0.5190.56
210_G214_V0.5190.56
222_A262_A0.5180.56
213_R243_Y0.5180.56
211_D231_E0.5170.56
254_A260_A0.5170.56
25_K206_V0.5160.56
140_H146_G0.5160.56
278_A297_Y0.5150.56
148_R222_A0.5140.56
5_F266_I0.5140.56
134_T221_L0.5130.55
156_G199_P0.5130.55
65_H269_H0.5110.55
209_S248_S0.5110.55
178_K201_K0.5110.55
175_Q183_V0.5100.55
130_Q154_V0.5100.55
247_H269_H0.5070.55
88_L112_T0.5060.54
98_A101_E0.5060.54
250_T282_L0.5060.54
237_E251_E0.5040.54
228_L256_T0.5030.54
72_L90_V0.5010.54
25_K31_R0.5010.54
139_I215_S0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zwfA 2 0.7752 100 0.298 Contact Map
2cbnA 2 0.9805 100 0.349 Contact Map
1y44A 2 1 100 0.35 Contact Map
2e7yA 2 0.8502 100 0.525 Contact Map
1zkpA 2 0.7785 100 0.586 Contact Map
3jxpA 2 0.8339 100 0.592 Contact Map
4ojvA 2 0.8111 100 0.604 Contact Map
3g1pA 2 0.7329 100 0.608 Contact Map
3md7A 2 0.7687 100 0.614 Contact Map
3bk2A 2 0.7752 100 0.692 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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