GREMLIN Database
G6PD - Glucose-6-phosphate 1-dehydrogenase
UniProt: P54547 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 489 (466)
Sequences: 3121 (1723)
Seq/√Len: 79.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
274_R326_D5.1051.00
265_E268_K4.8161.00
53_S56_D4.0971.00
227_Y231_S3.9241.00
463_P474_E3.6421.00
119_M127_I3.5651.00
273_L447_F3.4461.00
250_A335_F3.3751.00
209_S484_L3.3721.00
264_S437_H3.3701.00
211_I335_F3.3061.00
154_D157_S3.1091.00
73_I77_T3.1091.00
449_D453_E3.0931.00
62_K66_S3.0251.00
16_A57_L2.9701.00
443_L446_S2.9491.00
54_N58_R2.9361.00
165_I174_I2.8611.00
228_Y233_A2.8561.00
287_R455_W2.8361.00
54_N81_Y2.8051.00
170_T173_Q2.5661.00
146_V427_C2.5261.00
229_E315_T2.3721.00
344_K470_M2.3351.00
114_M427_C2.3301.00
274_R324_L2.3281.00
302_A305_D2.3001.00
264_S439_D2.2851.00
59_Q63_T2.2821.00
233_A339_T2.2801.00
291_H464_N2.2691.00
89_N92_S2.2611.00
288_G464_N2.2311.00
51_P84_P2.2281.00
147_I165_I2.1981.00
153_H157_S2.1301.00
277_A280_E2.1291.00
104_E113_R2.1031.00
97_N101_N2.1011.00
145_L169_F2.0891.00
288_G462_S2.0761.00
349_K377_H2.0701.00
322_K482_D2.0681.00
129_K167_E2.0631.00
258_N261_E2.0441.00
351_V373_L2.0441.00
52_W56_D2.0261.00
120_A123_F2.0261.00
155_L159_Q2.0051.00
26_Y61_V1.9531.00
159_Q442_A1.9481.00
61_V80_F1.9451.00
128_A165_I1.8901.00
203_W208_I1.8901.00
62_K74_D1.8791.00
151_F161_L1.8391.00
293_G300_V1.8341.00
33_Y79_H1.8211.00
354_F374_L1.8161.00
21_A61_V1.7961.00
16_A46_G1.7921.00
245_M350_I1.7671.00
256_K261_E1.7551.00
70_D74_D1.7441.00
233_A316_E1.7341.00
449_D452_S1.7301.00
336_Y482_D1.7271.00
45_V99_L1.7231.00
19_D23_R1.7021.00
264_S271_R1.6981.00
202_L354_F1.6931.00
191_V399_A1.6861.00
10_V43_A1.6591.00
220_G342_R1.6591.00
21_A26_Y1.6581.00
137_T169_F1.6511.00
238_V339_T1.6451.00
211_I250_A1.6431.00
128_A145_L1.6411.00
273_L323_L1.6341.00
252_E329_R1.6321.00
81_Y99_L1.6211.00
328_F358_P1.6191.00
212_Q353_Q1.6131.00
129_K164_E1.6001.00
132_K168_A1.5981.00
54_N99_L1.5901.00
238_V319_V1.5791.00
33_Y75_D1.5781.00
129_K133_S1.5741.00
285_F451_I1.5721.00
237_M339_T1.5591.00
477_D480_V1.5450.99
215_S348_T1.5440.99
85_F92_S1.5310.99
90_P133_S1.5280.99
192_I384_I1.5200.99
52_W60_T1.5190.99
253_P328_F1.5190.99
125_G164_E1.5000.99
210_N484_L1.4940.99
295_I300_V1.4880.99
33_Y76_F1.4830.99
160_A164_E1.4820.99
210_N353_Q1.4810.99
47_V85_F1.4790.99
391_K394_G1.4740.99
112_N142_W1.4560.99
374_L386_L1.4510.99
184_Q391_K1.4490.99
300_V342_R1.4480.99
13_I21_A1.4410.99
72_H75_D1.4390.99
83_H99_L1.4360.99
163_K167_E1.4360.99
266_K440_E1.4350.99
90_P130_T1.4310.99
213_I246_V1.4290.99
24_K418_E1.4250.99
342_R467_S1.4200.99
473_K477_D1.4170.99
294_E299_P1.4090.99
65_I73_I1.3980.99
344_K469_S1.3970.99
197_A207_Y1.3860.99
205_N355_K1.3860.99
292_A305_D1.3730.99
267_V437_H1.3480.99
206_R355_K1.3430.98
225_A308_N1.3390.98
353_Q373_L1.3370.98
292_A302_A1.3370.98
295_I298_V1.3320.98
192_I376_I1.3290.98
12_V100_L1.3280.98
209_S355_K1.3240.98
56_D59_Q1.3180.98
242_I337_I1.3150.98
162_N442_A1.3080.98
323_L447_F1.2960.98
75_D78_S1.2960.98
303_Y309_V1.2780.98
318_F476_D1.2770.98
229_E310_A1.2710.98
74_D78_S1.2670.98
281_V454_T1.2660.98
263_R437_H1.2610.98
304_T464_N1.2530.98
91_G94_Q1.2500.98
87_V123_F1.2480.98
243_M448_V1.2470.98
122_E230_K1.2450.98
100_L113_R1.2360.97
197_A201_P1.2340.97
351_V375_V1.2230.97
243_M270_L1.2180.97
388_L404_L1.2160.97
61_V65_I1.2130.97
40_E75_D1.2030.97
238_V321_G1.1990.97
247_A270_L1.1960.97
286_V478_L1.1960.97
47_V92_S1.1910.97
95_E98_V1.1840.97
477_D481_K1.1820.97
287_R316_E1.1800.97
473_K476_D1.1640.96
171_E176_R1.1560.96
155_L442_A1.1470.96
9_A428_L1.1440.96
285_F321_G1.1380.96
156_P159_Q1.1330.96
304_T312_D1.1310.96
55_E59_Q1.1290.96
286_V474_E1.1280.96
103_L111_N1.1280.96
45_V81_Y1.1270.96
59_Q62_K1.1260.96
476_D480_V1.1190.95
184_Q394_G1.1110.95
249_L350_I1.1100.95
48_G82_Y1.1090.95
314_N462_S1.1050.95
205_N333_V1.1020.95
159_Q446_S1.1010.95
24_K180_Y1.0980.95
44_V80_F1.0980.95
323_L337_I1.0970.95
384_I388_L1.0970.95
318_F475_S1.0960.95
291_H466_E1.0940.95
30_H76_F1.0930.95
234_L455_W1.0850.95
50_R87_V1.0800.94
125_G160_A1.0760.94
11_I114_M1.0760.94
58_R77_T1.0750.94
94_Q133_S1.0740.94
87_V127_I1.0730.94
23_R219_L1.0670.94
13_I25_L1.0670.94
407_C410_C1.0630.94
204_T207_Y1.0610.94
43_A81_Y1.0520.94
58_R81_Y1.0520.94
22_K60_T1.0500.93
199_F388_L1.0500.93
392_K400_Q1.0490.93
63_T67_S1.0480.93
289_Q313_S1.0400.93
328_F331_A1.0310.93
201_P207_Y1.0310.93
454_T458_N1.0310.93
200_E329_R1.0230.93
12_V115_F1.0210.93
26_Y57_L1.0200.92
30_H72_H1.0190.92
267_V439_D1.0170.92
292_A299_P1.0170.92
379_Q382_E1.0150.92
225_A306_E1.0150.92
466_E469_S1.0100.92
17_T50_R1.0100.92
11_I25_L1.0090.92
281_V451_I1.0060.92
214_T338_R1.0040.92
43_A103_L1.0000.92
90_P134_E0.9980.92
156_P160_A0.9980.92
238_V337_I0.9950.92
45_V83_H0.9920.91
227_Y230_K0.9910.91
348_T378_I0.9870.91
93_Y130_T0.9810.91
10_V100_L0.9810.91
392_K398_H0.9790.91
159_Q163_K0.9780.91
390_A402_I0.9750.91
320_A475_S0.9740.91
98_V102_Q0.9720.91
225_A309_V0.9680.90
246_V273_L0.9630.90
293_G467_S0.9630.90
249_L352_V0.9610.90
23_R237_M0.9610.90
124_F151_F0.9550.90
271_R443_L0.9540.90
276_I280_E0.9470.89
377_H383_G0.9420.89
187_Q426_D0.9380.89
322_K336_Y0.9360.89
180_Y379_Q0.9350.89
32_L38_I0.9350.89
321_G451_I0.9320.89
300_V467_S0.9300.89
291_H463_P0.9240.88
349_K375_V0.9230.88
62_K77_T0.9230.88
114_M428_L0.9220.88
229_E304_T0.9200.88
199_F386_L0.9200.88
220_G306_E0.9170.88
452_S456_A0.9140.88
117_L128_A0.9080.87
92_S95_E0.9070.87
324_L332_G0.9070.87
62_K73_I0.9010.87
201_P204_T0.9000.87
215_S237_M0.8980.87
228_Y339_T0.8950.87
126_T129_K0.8910.86
184_Q422_K0.8900.86
285_F455_W0.8900.86
30_H69_A0.8820.86
448_V451_I0.8810.86
453_E456_A0.8790.86
375_V387_Y0.8770.85
264_S267_V0.8760.85
99_L102_Q0.8720.85
51_P56_D0.8720.85
24_K28_S0.8710.85
427_C436_A0.8690.85
47_V124_F0.8660.85
347_S377_H0.8630.84
399_A434_N0.8630.84
32_L42_F0.8620.84
221_V228_Y0.8620.84
388_L406_Y0.8580.84
461_L464_N0.8560.84
479_L484_L0.8560.84
314_N464_N0.8530.84
200_E252_E0.8520.84
26_Y80_F0.8520.84
219_L237_M0.8510.84
387_Y403_K0.8510.84
475_S478_L0.8490.84
263_R439_D0.8470.83
212_Q320_A0.8470.83
262_I433_T0.8470.83
38_I428_L0.8460.83
129_K168_A0.8440.83
94_Q98_V0.8430.83
443_L447_F0.8430.83
246_V323_L0.8390.83
137_T143_S0.8390.83
304_T461_L0.8380.83
301_P307_D0.8380.83
56_D60_T0.8370.83
125_G129_K0.8330.82
353_Q371_P0.8300.82
276_I281_V0.8290.82
408_S412_D0.8280.82
219_L346_K0.8270.82
32_L428_L0.8260.82
198_I202_L0.8260.82
37_Q425_H0.8260.82
226_R230_K0.8250.82
253_P358_P0.8230.82
270_L273_L0.8220.81
86_D89_N0.8220.81
252_E327_N0.8210.81
17_T48_G0.8160.81
238_V242_I0.8150.81
32_L425_H0.8140.81
182_G423_L0.8120.81
314_N458_N0.8110.81
171_E439_D0.8110.81
201_P205_N0.8080.80
138_A141_G0.8060.80
146_V177_I0.8050.80
83_H95_E0.8040.80
72_H76_F0.8030.80
215_S337_I0.8000.80
34_Q72_H0.8000.80
32_L37_Q0.7990.80
22_K67_S0.7990.80
21_A118_A0.7980.80
343_M475_S0.7980.80
147_I161_L0.7980.80
270_L440_E0.7960.79
57_L64_S0.7950.79
15_G18_G0.7930.79
175_Y260_E0.7920.79
171_E263_R0.7910.79
55_E58_R0.7900.79
221_V225_A0.7890.79
276_I285_F0.7880.79
223_D307_D0.7870.79
66_S70_D0.7840.78
21_A57_L0.7810.78
90_P94_Q0.7800.78
23_R68_S0.7800.78
113_R143_S0.7800.78
14_F127_I0.7780.78
291_H462_S0.7770.78
33_Y72_H0.7770.78
104_E111_N0.7740.77
13_I16_A0.7720.77
71_K75_D0.7710.77
10_V103_L0.7710.77
293_G299_P0.7710.77
201_P358_P0.7700.77
377_H381_D0.7680.77
211_I352_V0.7680.77
221_V306_E0.7660.77
267_V440_E0.7650.77
251_M262_I0.7640.77
151_F165_I0.7640.77
234_L316_E0.7610.76
270_L447_F0.7610.76
275_P443_L0.7600.76
156_P453_E0.7590.76
10_V45_V0.7590.76
162_N438_W0.7560.76
87_V119_M0.7550.76
160_A163_K0.7530.75
180_Y222_E0.7530.75
180_Y183_K0.7510.75
480_V485_H0.7510.75
15_G20_L0.7510.75
9_A32_L0.7500.75
60_T63_T0.7450.75
285_F319_V0.7450.75
48_G84_P0.7430.75
85_F93_Y0.7430.75
146_V424_I0.7430.75
39_G42_F0.7430.75
316_E456_A0.7400.74
262_I266_K0.7400.74
155_L446_S0.7390.74
293_G298_V0.7390.74
191_V397_A0.7370.74
304_T310_A0.7350.74
387_Y401_P0.7340.74
402_I406_Y0.7330.74
212_Q336_Y0.7330.74
347_S470_M0.7320.73
461_L474_E0.7310.73
13_I158_A0.7300.73
247_A444_S0.7300.73
68_S219_L0.7300.73
304_T309_V0.7290.73
417_P421_E0.7280.73
91_G95_E0.7270.73
166_R438_W0.7260.73
165_I324_L0.7260.73
286_V475_S0.7250.73
212_Q338_R0.7250.73
278_K457_A0.7230.73
71_K74_D0.7220.72
260_E437_H0.7190.72
478_L482_D0.7180.72
172_D260_E0.7180.72
298_V301_P0.7170.72
193_R329_R0.7170.72
14_F119_M0.7160.72
316_E455_W0.7160.72
348_T436_A0.7150.72
294_E300_V0.7140.72
61_V64_S0.7100.71
93_Y127_I0.7080.71
448_V452_S0.7080.71
200_E204_T0.7070.71
197_A357_I0.7070.71
130_T133_S0.7040.71
63_T66_S0.7020.70
36_G40_E0.7010.70
269_V273_L0.6960.70
65_I77_T0.6960.70
10_V104_E0.6920.69
352_V376_I0.6920.69
272_A327_N0.6890.69
340_G343_M0.6880.69
477_D485_H0.6880.69
153_H456_A0.6870.69
460_T464_N0.6870.69
263_R432_A0.6860.69
115_F124_F0.6810.68
269_V325_I0.6780.68
114_M146_V0.6740.67
41_E79_H0.6720.67
53_S59_Q0.6690.67
221_V233_A0.6670.66
94_Q97_N0.6670.66
453_E457_A0.6670.66
85_F447_F0.6670.66
267_V271_R0.6660.66
306_E342_R0.6650.66
114_M142_W0.6650.66
145_L165_I0.6640.66
205_N328_F0.6610.66
257_L397_A0.6610.66
209_S353_Q0.6610.66
57_L118_A0.6610.66
191_V269_V0.6610.66
218_S345_E0.6610.66
383_G417_P0.6590.65
462_S474_E0.6590.65
135_G145_L0.6590.65
246_V337_I0.6580.65
268_K422_K0.6580.65
326_D331_A0.6570.65
242_I246_V0.6560.65
194_F251_M0.6560.65
120_A349_K0.6560.65
289_Q464_N0.6550.65
11_I44_V0.6550.65
188_N391_K0.6540.65
294_E466_E0.6530.65
322_K478_L0.6530.65
137_T145_L0.6520.65
47_V83_H0.6510.64
78_S453_E0.6490.64
77_T80_F0.6490.64
458_N462_S0.6460.64
45_V103_L0.6450.64
31_R35_N0.6450.64
216_S344_K0.6440.64
348_T441_V0.6430.64
328_F359_M0.6420.63
229_E309_V0.6410.63
303_Y313_S0.6380.63
65_I310_A0.6360.63
319_V322_K0.6350.63
31_R421_E0.6350.63
235_R452_S0.6330.62
24_K177_I0.6320.62
64_S68_S0.6300.62
164_E167_E0.6300.62
271_R439_D0.6300.62
336_Y484_L0.6270.62
71_K299_P0.6260.61
479_L482_D0.6260.61
250_A325_I0.6240.61
46_G80_F0.6210.61
227_Y237_M0.6210.61
423_L443_L0.6190.61
270_L444_S0.6180.60
128_A169_F0.6180.60
117_L357_I0.6170.60
302_A464_N0.6170.60
402_I405_D0.6160.60
175_Y430_G0.6150.60
195_A267_V0.6150.60
161_L165_I0.6140.60
233_A287_R0.6140.60
94_Q134_E0.6130.60
28_S417_P0.6120.60
32_L227_Y0.6100.59
234_L238_V0.6100.59
194_F394_G0.6090.59
336_Y479_L0.6080.59
151_F158_A0.6070.59
85_F351_V0.6070.59
251_M254_P0.6060.59
50_R84_P0.6060.59
175_Y344_K0.6040.59
53_S89_N0.6030.59
183_K379_Q0.6020.58
432_A436_A0.6010.58
87_V120_A0.5990.58
319_V323_L0.5990.58
175_Y394_G0.5970.58
162_N169_F0.5970.58
98_V325_I0.5960.58
293_G468_G0.5960.58
314_N461_L0.5960.58
56_D84_P0.5950.58
443_L450_S0.5930.57
314_N460_T0.5930.57
12_V120_A0.5920.57
260_E271_R0.5910.57
215_S442_A0.5910.57
377_H422_K0.5910.57
126_T130_T0.5880.57
481_K484_L0.5880.57
22_K64_S0.5870.57
35_N353_Q0.5850.56
132_K137_T0.5850.56
47_V86_D0.5850.56
261_E271_R0.5840.56
17_T441_V0.5840.56
13_I118_A0.5830.56
125_G128_A0.5820.56
280_E285_F0.5800.56
189_I378_I0.5790.56
222_E306_E0.5770.55
47_V349_K0.5760.55
124_F288_G0.5760.55
98_V279_D0.5760.55
115_F131_L0.5760.55
257_L361_L0.5750.55
191_V257_L0.5740.55
276_I451_I0.5740.55
245_M378_I0.5740.55
185_M382_E0.5730.55
62_K70_D0.5730.55
112_N141_G0.5730.55
71_K318_F0.5730.55
86_D92_S0.5720.55
55_E62_K0.5710.55
229_E303_Y0.5710.55
22_K68_S0.5710.55
213_I355_K0.5710.55
389_N399_A0.5710.55
82_Y93_Y0.5700.54
350_I376_I0.5700.54
287_R451_I0.5700.54
193_R251_M0.5690.54
211_I302_A0.5680.54
59_Q78_S0.5680.54
289_Q304_T0.5680.54
17_T87_V0.5670.54
98_V101_N0.5650.54
287_R319_V0.5650.54
97_N102_Q0.5640.54
328_F362_Y0.5640.54
13_I29_I0.5630.54
193_R252_E0.5630.54
60_T384_I0.5630.54
124_F240_N0.5630.54
293_G342_R0.5620.53
187_Q434_N0.5610.53
49_R226_R0.5600.53
30_H33_Y0.5590.53
239_Q444_S0.5590.53
46_G121_P0.5590.53
189_I249_L0.5590.53
16_A21_A0.5580.53
184_Q393_L0.5570.53
375_V385_T0.5560.53
353_Q375_V0.5560.53
260_E263_R0.5550.52
88_T126_T0.5550.52
9_A142_W0.5540.52
99_L281_V0.5540.52
205_N358_P0.5530.52
86_D123_F0.5530.52
238_V448_V0.5520.52
390_A416_T0.5510.52
218_S346_K0.5500.52
322_K427_C0.5500.52
291_H312_D0.5490.52
255_I328_F0.5490.52
168_A175_Y0.5480.52
186_V263_R0.5480.52
219_L339_T0.5480.52
184_Q193_R0.5470.51
23_R374_L0.5470.51
185_M328_F0.5460.51
285_F454_T0.5460.51
389_N401_P0.5460.51
250_A269_V0.5460.51
201_P393_L0.5450.51
145_L478_L0.5430.51
325_I330_W0.5420.51
383_G408_S0.5410.51
255_I271_R0.5400.51
131_L143_S0.5400.51
330_W335_F0.5380.50
292_A298_V0.5380.50
146_V432_A0.5370.50
33_Y42_F0.5370.50
205_N331_A0.5360.50
65_I69_A0.5360.50
328_F357_I0.5360.50
268_K382_E0.5340.50
423_L444_S0.5340.50
348_T427_C0.5340.50
23_R222_E0.5340.50
233_A455_W0.5340.50
263_R441_V0.5330.50
419_A425_H0.5330.50
118_A440_E0.5330.50
219_L248_L0.5320.49
294_E477_D0.5320.49
382_E419_A0.5320.49
436_A447_F0.5310.49
172_D208_I0.5310.49
322_K481_K0.5300.49
16_A114_M0.5300.49
29_I44_V0.5290.49
250_A329_R0.5290.49
24_K49_R0.5290.49
201_P328_F0.5290.49
153_H231_S0.5270.49
268_K379_Q0.5270.49
373_L387_Y0.5270.49
76_F80_F0.5260.49
71_K101_N0.5260.49
65_I441_V0.5250.49
197_A200_E0.5250.49
357_I360_N0.5250.49
81_Y198_I0.5250.49
75_D81_Y0.5240.48
473_K480_V0.5230.48
188_N394_G0.5230.48
210_N482_D0.5230.48
204_T394_G0.5220.48
436_A444_S0.5220.48
47_V87_V0.5210.48
384_I392_K0.5200.48
60_T452_S0.5200.48
265_E358_P0.5190.48
114_M175_Y0.5180.48
440_E444_S0.5180.48
247_A269_V0.5140.47
234_L287_R0.5130.47
25_L399_A0.5130.47
184_Q194_F0.5120.47
13_I68_S0.5120.47
193_R254_P0.5110.47
13_I185_M0.5110.47
130_T134_E0.5110.47
253_P329_R0.5100.47
53_S145_L0.5100.47
243_M440_E0.5100.47
286_V319_V0.5090.47
131_L137_T0.5090.47
45_V100_L0.5090.47
71_K167_E0.5090.47
288_G474_E0.5080.46
194_F327_N0.5070.46
119_M147_I0.5070.46
41_E78_S0.5070.46
258_N310_A0.5070.46
161_L447_F0.5060.46
121_P212_Q0.5060.46
15_G19_D0.5040.46
201_P394_G0.5040.46
336_Y486_W0.5040.46
239_Q436_A0.5030.46
343_M411_N0.5030.46
202_L233_A0.5020.46
239_Q243_M0.5020.46
253_P264_S0.5000.45
314_N456_A0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dpgA 2 0.9857 100 -0.01 Contact Map
2bh9A 2 0.9734 100 0.005 Contact Map
4e9iA 3 0.9693 100 0.019 Contact Map
4lgvA 4 0.9202 100 0.045 Contact Map
3i23A 2 0.6748 97.3 0.958 Contact Map
3rc1A 1 0.638 97.1 0.959 Contact Map
3f4lA 2 0.6585 97 0.959 Contact Map
3u3xA 2 0.638 97 0.96 Contact Map
4koaA 2 0.6442 96.8 0.961 Contact Map
1zh8A 2 0.6258 96.7 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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