MISCB - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

MISCB - Membrane protein insertase MisCB

UniProt:	P54544	Sequences: MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYLIEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQVDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIRSTPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAKLMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	275 (214)
Sequences:	4116 (2642)
Seq/√Len:	180.6

ECOLI - YIDC
BACSU - MISCB MISCA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
191_F	229_T	4.144	1.00
128_K	132_E	4.116	1.00
104_D	107_Q	3.902	1.00
125_E	128_K	3.537	1.00
102_Q	105_S	3.516	1.00
100_K	104_D	3.185	1.00
106_I	122_L	2.898	1.00
50_A	54_G	2.736	1.00
104_D	108_V	2.700	1.00
102_Q	132_E	2.682	1.00
193_Q	247_G	2.674	1.00
68_I	245_T	2.461	1.00
172_W	179_D	2.366	1.00
43_Y	47_P	2.345	1.00
103_V	126_M	2.252	1.00
59_F	69_L	2.252	1.00
102_Q	133_H	2.243	1.00
115_D	118_K	2.240	1.00
189_M	244_F	2.219	1.00
149_S	153_I	2.204	1.00
99_I	135_I	2.121	1.00
107_Q	111_K	2.099	1.00
122_L	126_M	2.097	1.00
76_I	249_F	2.049	1.00
227_M	231_F	2.041	1.00
156_Y	160_R	2.037	1.00
99_I	129_L	1.993	1.00
107_Q	122_L	1.936	1.00
153_I	157_Y	1.917	1.00
106_I	129_L	1.903	1.00
117_E	124_M	1.767	1.00
199_K	222_F	1.765	1.00
174_S	177_Q	1.745	1.00
79_L	83_V	1.722	1.00
67_I	238_A	1.721	1.00
124_M	128_K	1.702	1.00
105_S	109_K	1.672	1.00
56_A	63_Y	1.627	1.00
109_K	125_E	1.626	1.00
146_L	150_P	1.604	1.00
252_V	256_V	1.576	1.00
218_K	222_F	1.535	1.00
123_Q	127_M	1.518	1.00
197_A	251_T	1.511	1.00
118_K	125_E	1.468	1.00
55_V	69_L	1.465	1.00
181_L	185_S	1.460	1.00
195_Y	222_F	1.448	1.00
108_V	111_K	1.426	1.00
195_Y	199_K	1.423	1.00
126_M	130_Y	1.407	1.00
95_K	98_V	1.398	1.00
53_K	57_G	1.394	1.00
170_F	173_F	1.392	1.00
83_V	87_K	1.388	1.00
123_Q	126_M	1.383	1.00
103_V	129_L	1.379	1.00
157_Y	161_S	1.376	1.00
145_M	149_S	1.356	1.00
211_P	214_Q	1.344	1.00
90_R	97_A	1.340	1.00
199_K	203_K	1.332	1.00
219_L	223_I	1.332	1.00
65_L	68_I	1.322	1.00
105_S	108_V	1.308	1.00
157_Y	160_R	1.306	1.00
256_V	260_T	1.303	1.00
55_V	73_I	1.295	1.00
78_V	151_I	1.291	1.00
75_R	250_L	1.285	1.00
192_V	196_I	1.279	1.00
65_L	69_L	1.240	1.00
219_L	222_F	1.224	1.00
73_I	77_V	1.223	1.00
85_Q	89_Q	1.213	1.00
52_L	66_S	1.207	1.00
248_L	252_V	1.203	1.00
75_R	253_Q	1.198	1.00
179_D	185_S	1.175	1.00
54_G	58_L	1.172	1.00
224_F	227_M	1.163	1.00
188_I	192_V	1.157	1.00
216_S	219_L	1.148	1.00
84_N	87_K	1.144	1.00
111_K	116_P	1.134	1.00
76_I	79_L	1.130	1.00
51_L	70_V	1.121	1.00
215_Q	219_L	1.113	1.00
216_S	220_M	1.109	1.00
232_S	240_P	1.107	1.00
65_L	170_F	1.098	1.00
255_I	259_M	1.096	1.00
226_V	230_I	1.092	1.00
49_S	162_T	1.085	1.00
230_I	234_N	1.084	1.00
229_T	233_L	1.072	1.00
182_M	185_S	1.062	1.00
163_P	166_A	1.062	1.00
180_I	183_S	1.054	1.00
182_M	233_L	1.043	1.00
111_K	122_L	1.042	1.00
180_I	185_S	1.027	1.00
223_I	227_M	1.021	0.99
252_V	255_I	1.015	0.99
169_S	172_W	1.009	0.99
55_V	70_V	0.981	0.99
180_I	184_L	0.978	0.99
172_W	237_A	0.968	0.99
56_A	66_S	0.968	0.99
110_L	118_K	0.965	0.99
64_G	170_F	0.956	0.99
99_I	133_H	0.953	0.99
118_K	124_M	0.949	0.99
68_I	241_L	0.948	0.99
215_Q	218_K	0.947	0.99
71_T	246_S	0.945	0.99
189_M	193_Q	0.935	0.99
193_Q	197_A	0.932	0.99
87_K	95_K	0.921	0.99
99_I	130_Y	0.918	0.99
112_K	118_K	0.915	0.99
72_I	249_F	0.913	0.99
84_N	88_K	0.911	0.99
178_S	182_M	0.904	0.99
235_V	243_W	0.901	0.99
128_K	131_Q	0.898	0.99
247_G	250_L	0.892	0.99
243_W	247_G	0.880	0.98
64_G	241_L	0.865	0.98
196_I	199_K	0.862	0.98
127_M	131_Q	0.855	0.98
130_Y	137_P	0.853	0.98
58_L	61_G	0.852	0.98
246_S	250_L	0.848	0.98
193_Q	244_F	0.847	0.98
118_K	122_L	0.831	0.98
210_N	214_Q	0.826	0.98
78_V	148_Q	0.824	0.98
35_S	39_F	0.824	0.98
46_E	50_A	0.823	0.98
163_P	167_S	0.822	0.98
235_V	239_L	0.821	0.98
98_V	133_H	0.817	0.97
179_D	182_M	0.811	0.97
75_R	78_V	0.810	0.97
193_Q	248_L	0.809	0.97
59_F	65_L	0.807	0.97
80_P	84_N	0.807	0.97
72_I	245_T	0.801	0.97
83_V	257_L	0.799	0.97
102_Q	129_L	0.799	0.97
221_V	225_P	0.791	0.97
212_A	215_Q	0.786	0.97
55_V	59_F	0.785	0.97
129_L	133_H	0.782	0.97
232_S	243_W	0.782	0.97
198_Q	201_S	0.780	0.97
200_L	255_I	0.779	0.97
95_K	133_H	0.777	0.97
125_E	132_E	0.777	0.97
54_G	57_G	0.776	0.97
149_S	152_M	0.771	0.96
57_G	61_G	0.770	0.96
260_T	263_K	0.766	0.96
75_R	82_F	0.762	0.96
75_R	246_S	0.758	0.96
197_A	250_L	0.754	0.96
49_S	53_K	0.754	0.96
169_S	174_S	0.753	0.96
226_V	229_T	0.750	0.96
184_L	241_L	0.745	0.96
184_L	237_A	0.744	0.96
156_Y	235_V	0.743	0.96
70_V	155_L	0.741	0.96
50_A	53_K	0.740	0.96
42_D	46_E	0.738	0.95
136_N	142_C	0.734	0.95
55_V	66_S	0.733	0.95
75_R	148_Q	0.733	0.95
51_L	54_G	0.732	0.95
79_L	256_V	0.729	0.95
214_Q	218_K	0.729	0.95
118_K	128_K	0.726	0.95
190_Y	193_Q	0.719	0.95
67_I	159_I	0.716	0.95
214_Q	217_A	0.711	0.94
36_N	40_F	0.710	0.94
244_F	248_L	0.706	0.94
106_I	111_K	0.699	0.94
98_V	265_K	0.699	0.94
83_V	86_F	0.698	0.94
45_I	161_S	0.696	0.94
223_I	226_V	0.695	0.94
136_N	139_A	0.693	0.94
190_Y	229_T	0.693	0.94
231_F	235_V	0.688	0.93
145_M	148_Q	0.685	0.93
191_F	195_Y	0.684	0.93
47_P	51_L	0.681	0.93
42_D	231_F	0.681	0.93
190_Y	197_A	0.680	0.93
39_F	43_Y	0.680	0.93
109_K	122_L	0.675	0.93
90_R	258_Q	0.675	0.93
86_F	89_Q	0.671	0.93
227_M	230_I	0.667	0.92
112_K	122_L	0.667	0.92
172_W	184_L	0.663	0.92
107_Q	130_Y	0.661	0.92
55_V	58_L	0.660	0.92
135_I	139_A	0.657	0.92
56_A	59_F	0.657	0.92
169_S	173_F	0.657	0.92
36_N	39_F	0.655	0.92
152_M	250_L	0.655	0.92
172_W	178_S	0.648	0.91
229_T	232_S	0.647	0.91
42_D	45_I	0.646	0.91
116_P	123_Q	0.645	0.91
110_L	122_L	0.645	0.91
86_F	257_L	0.643	0.91
241_L	245_T	0.642	0.91
152_M	246_S	0.642	0.91
82_F	257_L	0.637	0.91
64_G	68_I	0.637	0.91
194_A	247_G	0.636	0.90
179_D	237_A	0.636	0.90
49_S	158_A	0.635	0.90
106_I	126_M	0.634	0.90
124_M	127_M	0.631	0.90
88_K	141_G	0.628	0.90
213_A	218_K	0.625	0.90
172_W	182_M	0.620	0.89
198_Q	202_A	0.620	0.89
193_Q	251_T	0.620	0.89
111_K	118_K	0.619	0.89
165_I	176_G	0.614	0.89
38_G	41_H	0.614	0.89
96_M	100_K	0.609	0.88
184_L	244_F	0.607	0.88
74_V	155_L	0.605	0.88
260_T	264_S	0.596	0.87
85_Q	139_A	0.594	0.87
173_F	237_A	0.592	0.87
181_L	184_L	0.590	0.87
70_V	74_V	0.590	0.87
74_V	242_Y	0.589	0.87
89_Q	96_M	0.586	0.87
190_Y	244_F	0.585	0.86
197_A	200_L	0.585	0.86
69_L	73_I	0.585	0.86
95_K	134_N	0.584	0.86
162_T	165_I	0.579	0.86
47_P	156_Y	0.578	0.86
178_S	181_L	0.572	0.85
144_P	225_P	0.571	0.85
51_L	73_I	0.571	0.85
63_Y	165_I	0.571	0.85
65_L	171_L	0.570	0.85
85_Q	151_I	0.570	0.85
68_I	170_F	0.568	0.85
44_L	154_G	0.568	0.85
211_P	215_Q	0.566	0.85
151_I	155_L	0.565	0.84
75_R	264_S	0.565	0.84
191_F	194_A	0.564	0.84
172_W	185_S	0.559	0.84
75_R	249_F	0.556	0.84
56_A	61_G	0.556	0.84
82_F	86_F	0.547	0.83
82_F	85_Q	0.546	0.82
99_I	102_Q	0.544	0.82
45_I	153_I	0.543	0.82
166_A	174_S	0.543	0.82
56_A	62_E	0.542	0.82
201_S	208_P	0.537	0.81
83_V	256_V	0.537	0.81
180_I	188_I	0.536	0.81
175_L	241_L	0.535	0.81
116_P	122_L	0.535	0.81
72_I	76_I	0.533	0.81
251_T	255_I	0.533	0.81
179_D	184_L	0.531	0.81
156_Y	243_W	0.531	0.81
127_M	137_P	0.530	0.81
202_A	221_V	0.529	0.80
195_Y	198_Q	0.525	0.80
99_I	103_V	0.524	0.80
41_H	47_P	0.524	0.80
48_F	51_L	0.522	0.80
166_A	176_G	0.521	0.79
122_L	125_E	0.519	0.79
78_V	85_Q	0.519	0.79
216_S	221_V	0.519	0.79
40_F	43_Y	0.516	0.79
81_L	236_P	0.515	0.79
45_I	165_I	0.515	0.79
167_S	233_L	0.514	0.79
210_N	215_Q	0.513	0.78
105_S	110_L	0.513	0.78
232_S	235_V	0.513	0.78
191_F	228_M	0.513	0.78
190_Y	228_M	0.513	0.78
85_Q	145_M	0.512	0.78
150_P	154_G	0.512	0.78
178_S	234_N	0.512	0.78
95_K	135_I	0.509	0.78
168_H	172_W	0.509	0.78
197_A	201_S	0.509	0.78
90_R	261_H	0.508	0.78
154_G	159_I	0.508	0.78
147_I	150_P	0.507	0.78
152_M	235_V	0.507	0.78
193_Q	196_I	0.506	0.77
85_Q	255_I	0.503	0.77
47_P	50_A	0.503	0.77
190_Y	239_L	0.503	0.77
84_N	139_A	0.502	0.77
107_Q	126_M	0.501	0.77
174_S	179_D	0.500	0.77
36_N	41_H	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3wvfA	1	0.7855	100	0.197	Contact Map
3wo6A	1	0.7636	100	0.21	Contact Map
3blcA	4	0.1636	22.8	0.955	Contact Map
3pjsK	4	0.44	7.8	0.963	Contact Map
3effK	4	0.44	5.9	0.965	Contact Map
3rvyA	3	0.3091	5	0.966	Contact Map
3vouA	4	0.4073	4.5	0.967	Contact Map
4il3A	1	0.7236	3.3	0.969	Contact Map
4c7rA	3	0.4327	2.7	0.97	Contact Map
4n7bA	1	0	2.6	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.