GREMLIN Database
ARTP - Arginine-binding extracellular protein ArtP
UniProt: P54535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (238)
Sequences: 22449 (16388)
Seq/√Len: 1062.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_G91_V3.8551.00
141_G181_F3.6511.00
33_K73_E3.5861.00
67_K236_E2.9621.00
149_E165_D2.4261.00
166_R175_E2.4141.00
49_E54_V2.3861.00
85_A91_V2.3361.00
112_D235_K2.2811.00
168_R171_D2.2791.00
35_I73_E2.2481.00
100_P217_A2.2471.00
100_P105_K2.1911.00
102_P105_K2.1701.00
149_E153_K2.1461.00
35_I75_Q2.1281.00
242_E245_K2.1271.00
244_E248_K2.1161.00
87_K107_Q2.0651.00
33_K71_E2.0431.00
63_A66_K2.0401.00
65_A72_I2.0131.00
235_K239_D2.0111.00
139_T164_E2.0081.00
108_V219_A1.9751.00
227_T231_N1.9271.00
67_K233_A1.9141.00
109_D227_T1.9041.00
220_F227_T1.9031.00
186_I191_A1.8771.00
220_F230_F1.8531.00
112_D231_N1.8521.00
131_S134_D1.8411.00
172_L184_A1.8251.00
224_S228_D1.7591.00
63_A242_E1.7591.00
122_V191_A1.7221.00
36_M61_A1.7091.00
95_L218_I1.6951.00
130_Q134_D1.6941.00
175_E180_R1.6841.00
139_T162_K1.6801.00
144_L167_N1.6531.00
85_A90_Q1.6371.00
63_A67_K1.6121.00
124_K127_S1.5731.00
111_S231_N1.5711.00
63_A237_M1.5701.00
49_E52_N1.5371.00
124_K179_D1.5191.00
228_D232_K1.5031.00
77_M85_A1.4581.00
67_K240_N1.4441.00
82_L94_V1.4261.00
59_E249_K1.3881.00
229_K232_K1.3871.00
116_T215_G1.3841.00
83_I108_V1.3821.00
150_E154_E1.3781.00
47_Y54_V1.3621.00
167_N171_D1.3601.00
62_K74_V1.3491.00
139_T182_D1.3471.00
26_G30_G1.3471.00
175_E181_F1.3421.00
64_L233_A1.3331.00
188_D192_E1.3181.00
58_V62_K1.3061.00
138_K182_D1.2931.00
126_D205_V1.2901.00
89_K221_R1.2801.00
36_M93_L1.2771.00
68_A233_A1.2751.00
98_M219_A1.2741.00
153_K165_D1.2681.00
48_K76_D1.2501.00
120_M188_D1.2471.00
119_H148_Q1.2431.00
61_A95_L1.2431.00
151_K155_L1.2421.00
57_D114_Y1.2381.00
141_G166_R1.2361.00
40_A76_D1.2271.00
123_S183_A1.2141.00
56_F247_K1.2071.00
121_I183_A1.2021.00
236_E240_N1.1911.00
94_V98_M1.1831.00
142_V149_E1.1761.00
84_T87_K1.1761.00
140_V183_A1.1631.00
17_L20_C1.1611.00
56_F246_L1.1571.00
103_E106_K1.1551.00
174_Q177_K1.1391.00
233_A237_M1.1391.00
84_T88_S1.1311.00
238_E243_L1.1291.00
233_A236_E1.1271.00
77_M91_V1.1191.00
26_G29_S1.1121.00
229_K233_A1.1111.00
27_S31_K1.1111.00
166_R172_L1.1111.00
224_S227_T1.1111.00
109_D224_S1.1051.00
32_K70_Y1.1021.00
174_Q178_S1.0991.00
176_I204_F1.0961.00
62_K66_K1.0861.00
176_I184_A1.0771.00
78_D81_S1.0761.00
61_A74_V1.0651.00
25_S28_E1.0571.00
120_M206_I1.0461.00
125_K202_Q1.0391.00
70_Y229_K1.0381.00
176_I181_F1.0371.00
52_N62_K1.0331.00
232_K236_E1.0331.00
60_L237_M1.0271.00
61_A72_I1.0261.00
109_D222_K1.0141.00
36_M72_I1.0121.00
54_V59_E1.0101.00
225_E229_K1.0101.00
31_K35_I1.0091.00
60_L243_L1.0061.00
123_S207_P1.0031.00
143_Q146_S1.0001.00
59_E62_K0.9991.00
242_E246_L0.9931.00
231_N234_L0.9901.00
193_G197_S0.9871.00
48_K51_D0.9841.00
28_E32_K0.9761.00
56_F243_L0.9751.00
177_K198_N0.9731.00
101_T104_R0.9721.00
87_K108_V0.9711.00
59_E250_W0.9701.00
156_S159_Y0.9651.00
144_L165_D0.9641.00
150_E153_K0.9611.00
93_L220_F0.9611.00
141_G172_L0.9601.00
64_L230_F0.9531.00
171_D174_Q0.9501.00
93_L230_F0.9481.00
28_E70_Y0.9461.00
123_S127_S0.9441.00
67_K242_E0.9381.00
237_M242_E0.9301.00
53_I58_V0.9261.00
83_I98_M0.9261.00
243_L247_K0.9131.00
245_K248_K0.9111.00
28_E31_K0.9031.00
133_K136_K0.8921.00
102_P106_K0.8911.00
117_A189_I0.8901.00
170_S174_Q0.8851.00
110_F219_A0.8761.00
231_N235_K0.8721.00
111_S230_F0.8681.00
13_I16_A0.8681.00
93_L218_I0.8671.00
79_F82_L0.8651.00
34_L93_L0.8611.00
112_D238_E0.8601.00
43_K47_Y0.8581.00
81_S85_A0.8581.00
45_F115_Y0.8541.00
151_K154_E0.8501.00
104_R110_F0.8451.00
61_A218_I0.8451.00
125_K205_V0.8441.00
121_I185_I0.8401.00
40_A53_I0.8371.00
48_K53_I0.8351.00
245_K249_K0.8321.00
105_K222_K0.8311.00
34_L70_Y0.8241.00
236_E239_D0.8191.00
94_V219_A0.8181.00
25_S29_S0.8111.00
38_T58_V0.8071.00
63_A233_A0.7921.00
164_E175_E0.7921.00
99_T214_A0.7891.00
64_L68_A0.7871.00
169_I186_I0.7851.00
118_N188_D0.7831.00
198_N201_L0.7811.00
38_T74_V0.7801.00
29_S32_K0.7791.00
68_A229_K0.7751.00
100_P113_V0.7741.00
237_M240_N0.7721.00
12_C15_F0.7721.00
16_A19_A0.7711.00
61_A93_L0.7701.00
109_D223_D0.7691.00
177_K200_D0.7641.00
75_Q90_Q0.7591.00
36_M74_V0.7591.00
155_L159_Y0.7511.00
244_E247_K0.7511.00
111_S220_F0.7441.00
135_L183_A0.7411.00
173_V177_K0.7371.00
67_K237_M0.7371.00
122_V204_F0.7361.00
62_K72_I0.7351.00
18_T21_G0.7341.00
64_L95_L0.7341.00
38_T96_S0.7291.00
34_L65_A0.7231.00
117_A188_D0.7221.00
154_E157_P0.7201.00
141_G175_E0.7171.00
120_M191_A0.7161.00
237_M243_L0.7131.00
232_K235_K0.7091.00
35_I92_D0.7071.00
129_I134_D0.7061.00
47_Y250_W0.7041.00
86_L94_V0.7011.00
142_V165_D0.6981.00
10_A14_T0.6981.00
39_S79_F0.6961.00
99_T104_R0.6951.00
218_I230_F0.6861.00
171_D175_E0.6851.00
86_L91_V0.6841.00
166_R181_F0.6841.00
83_I87_K0.6821.00
20_C23_S0.6811.00
40_A46_E0.6801.00
63_A246_L0.6791.00
39_S46_E0.6771.00
237_M241_G0.6761.00
192_E206_I0.6761.00
60_L234_L0.6741.00
192_E196_K0.6731.00
54_V250_W0.6711.00
81_S84_T0.6691.00
225_E228_D0.6661.00
16_A20_C0.6621.00
193_G196_K0.6611.00
42_Y97_G0.6601.00
37_G82_L0.6591.00
19_A22_S0.6521.00
155_L158_E0.6511.00
164_E181_F0.6511.00
33_K70_Y0.6461.00
235_K238_E0.6431.00
42_Y45_F0.6431.00
139_T181_F0.6391.00
228_D231_N0.6391.00
111_S218_I0.6341.00
75_Q91_V0.6341.00
13_I17_L0.6321.00
100_P110_F0.6311.00
21_G24_N0.6311.00
17_L21_G0.6301.00
152_G156_S0.6271.00
122_V173_V0.6271.00
44_P47_Y0.6231.00
110_F217_A0.6221.00
221_R224_S0.6211.00
112_D234_L0.6201.00
152_G185_I0.6181.00
86_L108_V0.6171.00
38_T53_I0.6161.00
87_K221_R0.6161.00
118_N212_E0.6151.00
113_V116_T0.6121.00
147_I214_A0.6101.00
79_F98_M0.6091.00
20_C24_N0.6091.00
98_M108_V0.6081.00
120_M208_D0.6041.00
123_S205_V0.6041.00
116_T213_E0.6031.00
25_S70_Y0.6021.00
65_A68_A0.6011.00
153_K163_T0.6001.00
77_M82_L0.5971.00
152_G163_T0.5971.00
42_Y79_F0.5941.00
58_V74_V0.5921.00
122_V195_F0.5901.00
39_S143_Q0.5891.00
46_E96_S0.5881.00
37_G94_V0.5871.00
66_K242_E0.5861.00
241_G245_K0.5841.00
119_H185_I0.5831.00
118_N213_E0.5831.00
65_A70_Y0.5821.00
65_A69_G0.5781.00
191_A195_F0.5781.00
11_A14_T0.5751.00
140_V152_G0.5751.00
111_S234_L0.5741.00
27_S30_G0.5701.00
126_D179_D0.5691.00
90_Q180_R0.5681.00
86_L221_R0.5681.00
25_S31_K0.5661.00
39_S96_S0.5651.00
57_D97_G0.5651.00
64_L218_I0.5641.00
186_I190_V0.5631.00
61_A65_A0.5621.00
128_G138_K0.5611.00
136_K158_E0.5581.00
181_F184_A0.5551.00
118_N210_K0.5551.00
31_K71_E0.5551.00
115_Y216_S0.5531.00
136_K156_S0.5491.00
79_F104_R0.5481.00
105_K109_D0.5481.00
29_S229_K0.5471.00
15_F18_T0.5471.00
40_A48_K0.5421.00
237_M246_L0.5401.00
10_A13_I0.5401.00
82_L98_M0.5391.00
144_L149_E0.5361.00
201_L204_F0.5351.00
128_G205_V0.5351.00
109_D221_R0.5341.00
121_I135_L0.5341.00
241_G244_E0.5341.00
136_K157_P0.5331.00
238_E241_G0.5331.00
99_T147_I0.5291.00
68_A226_L0.5271.00
34_L68_A0.5251.00
31_K92_D0.5251.00
142_V152_G0.5221.00
50_G54_V0.5221.00
35_I89_K0.5181.00
223_D226_L0.5141.00
175_E178_S0.5141.00
143_Q169_I0.5141.00
11_A15_F0.5121.00
32_K229_K0.5111.00
195_F199_D0.5101.00
82_L85_A0.5091.00
136_K159_Y0.5061.00
61_A64_L0.5051.00
75_Q85_A0.5011.00
56_F250_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kbrA 4 0.8863 100 0.254 Contact Map
1xt8A 1 0.8941 100 0.258 Contact Map
1pb7A 1 0.9412 100 0.263 Contact Map
2vhaA 2 0.9333 100 0.267 Contact Map
2ylnA 1 0.902 100 0.267 Contact Map
4ohnA 1 0.9176 100 0.268 Contact Map
3hv1A 2 0.9373 100 0.272 Contact Map
2yjpA 1 0.898 100 0.274 Contact Map
4powA 1 0.8706 100 0.274 Contact Map
2ieeA 1 0.8941 100 0.279 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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