GREMLIN Database
YQIW - UPF0403 protein YqiW
UniProt: P54534 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 145 (136)
Sequences: 482 (197)
Seq/√Len: 16.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_S138_F5.0641.00
35_D90_R4.1131.00
14_R18_Q3.4561.00
90_R93_D3.1480.99
41_K110_D2.8470.98
63_A105_F2.8210.98
33_E36_E2.7190.97
19_E64_Y2.3010.93
69_Y139_E2.2840.93
56_G130_V2.2840.93
95_F108_L2.2610.92
67_V138_F2.2460.92
115_K137_A2.2160.91
23_A64_Y2.1240.90
45_L134_L2.0630.88
40_K75_Q1.9970.86
18_Q22_A1.8280.81
133_K137_A1.7780.79
17_R27_E1.7300.77
21_T27_E1.6920.75
89_A93_D1.6830.75
48_V95_F1.6510.74
16_A20_I1.5480.69
22_A64_Y1.5250.67
8_F15_Q1.5210.67
26_T33_E1.5150.67
107_I138_F1.5000.66
29_K84_D1.4420.63
88_T94_Y1.4390.63
83_Q88_T1.4200.62
115_K133_K1.4180.62
69_Y135_Q1.4100.61
25_Y76_L1.3990.60
91_A95_F1.3970.60
38_L91_A1.3080.55
8_F56_G1.2700.53
118_E124_G1.2650.53
107_I141_Y1.2620.52
125_H133_K1.2250.50
13_V77_V1.2160.50
106_A116_M1.2090.49
62_A126_E1.1870.48
125_H129_A1.1690.47
52_C102_S1.1680.47
42_G110_D1.1620.46
114_M141_Y1.1550.46
37_A44_T1.1550.46
17_R83_Q1.1510.46
35_D39_T1.1490.46
35_D94_Y1.1410.45
98_Y118_E1.1410.45
127_P131_V1.1380.45
91_A116_M1.1360.45
44_T77_V1.1260.44
67_V76_L1.1180.44
20_I47_M1.1170.44
99_P118_E1.1030.43
108_L113_I1.0990.43
37_A116_M1.0920.42
79_V88_T1.0810.42
9_M58_I1.0710.41
47_M105_F1.0660.41
65_H68_H1.0610.41
50_S54_C1.0430.40
35_D85_K1.0420.39
44_T75_Q1.0300.39
71_K107_I1.0290.39
107_I142_C1.0270.39
17_R62_A1.0220.38
128_M132_A1.0060.37
28_L77_V1.0040.37
97_G118_E0.9920.37
25_Y63_A0.9880.36
96_E112_K0.9750.36
45_L137_A0.9710.36
98_Y116_M0.9700.35
105_F110_D0.9450.34
62_A104_S0.9340.34
65_H131_V0.9220.33
43_T142_C0.9210.33
59_A62_A0.9150.33
91_A110_D0.9080.32
131_V134_L0.9010.32
107_I137_A0.8690.30
99_P127_P0.8440.29
69_Y72_R0.8390.29
94_Y97_G0.8350.28
134_L141_Y0.8320.28
23_A63_A0.8280.28
90_R97_G0.8270.28
104_S128_M0.8250.28
19_E83_Q0.8240.28
98_Y113_I0.8190.28
47_M56_G0.8050.27
81_A92_R0.8040.27
26_T40_K0.8030.27
83_Q95_F0.8030.27
38_L110_D0.7990.27
8_F130_V0.7980.27
38_L94_Y0.7950.27
8_F133_K0.7940.27
7_L10_N0.7920.26
16_A56_G0.7910.26
13_V29_K0.7890.26
29_K33_E0.7840.26
46_V91_A0.7770.26
108_L140_E0.7680.25
47_M130_V0.7570.25
45_L86_E0.7560.25
54_C119_R0.7410.24
50_S119_R0.7410.24
58_I130_V0.7350.24
65_H127_P0.7270.24
66_S135_Q0.7240.23
30_T33_E0.7220.23
40_K117_V0.7210.23
53_G92_R0.7120.23
38_L111_G0.7070.23
30_T40_K0.7060.23
25_Y59_A0.6970.22
91_A111_G0.6970.22
67_V90_R0.6970.22
56_G115_K0.6970.22
82_G102_S0.6960.22
52_C82_G0.6950.22
19_E57_G0.6940.22
112_K141_Y0.6910.22
20_I25_Y0.6830.22
124_G140_E0.6820.22
132_A136_E0.6820.22
71_K74_D0.6810.22
53_G80_F0.6770.21
31_A76_L0.6740.21
73_P142_C0.6680.21
109_K140_E0.6670.21
115_K130_V0.6630.21
62_A67_V0.6620.21
7_L118_E0.6610.21
54_C102_S0.6610.21
50_S102_S0.6610.21
125_H131_V0.6600.21
62_A127_P0.6580.21
37_A40_K0.6510.20
17_R29_K0.6490.20
9_M104_S0.6470.20
31_A124_G0.6390.20
99_P113_I0.6360.20
26_T75_Q0.6360.20
55_A79_V0.6330.20
38_L112_K0.6300.20
90_R94_Y0.6280.20
107_I133_K0.6270.20
41_K72_R0.6210.19
113_I116_M0.6200.19
118_E121_E0.6150.19
126_E129_A0.6120.19
77_V124_G0.6120.19
46_V74_D0.6110.19
33_E93_D0.6050.19
121_E125_H0.6050.19
44_T112_K0.6010.19
67_V135_Q0.5990.19
91_A118_E0.5990.19
114_M133_K0.5890.18
81_A102_S0.5850.18
52_C81_A0.5850.18
33_E38_L0.5820.18
108_L114_M0.5820.18
37_A91_A0.5810.18
80_F92_R0.5750.18
15_Q20_I0.5740.18
41_K74_D0.5690.17
68_H72_R0.5680.17
32_E112_K0.5660.17
37_A77_V0.5610.17
56_G137_A0.5570.17
25_Y58_I0.5540.17
18_Q86_E0.5520.17
26_T136_E0.5470.17
37_A75_Q0.5460.17
40_K44_T0.5420.17
42_G74_D0.5400.16
12_I125_H0.5400.16
37_A111_G0.5360.16
14_R135_Q0.5350.16
65_H70_D0.5350.16
28_L59_A0.5340.16
63_A67_V0.5320.16
39_T111_G0.5310.16
47_M128_M0.5230.16
50_S53_G0.5230.16
43_T107_I0.5210.16
48_V96_E0.5210.16
58_I62_A0.5190.16
15_Q51_V0.5180.16
88_T110_D0.5160.16
57_G83_Q0.5140.16
108_L121_E0.5130.16
54_C80_F0.5110.16
50_S80_F0.5110.16
8_F41_K0.5090.15
14_R21_T0.5040.15
21_T114_M0.5030.15
35_D70_D0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fhkA 4 0.9793 100 0.026 Contact Map
4euyA 1 0.5724 92.9 0.926 Contact Map
2j23A 1 0.7517 92.1 0.928 Contact Map
2qgvA 2 0.8069 90.4 0.931 Contact Map
1ep7A 1 0.731 89.6 0.932 Contact Map
4i8bA 2 0.6966 89.4 0.933 Contact Map
3iv4A 1 0.731 89.4 0.933 Contact Map
1xwbA 2 0.7034 86.8 0.936 Contact Map
4oo4A 2 0.6966 85.5 0.937 Contact Map
2vm1A 1 0.731 85.2 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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