GREMLIN Database
DLDH2 - Dihydrolipoyl dehydrogenase
UniProt: P54533 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 474 (444)
Sequences: 13767 (9130)
Seq/√Len: 433.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_I272_A4.3501.00
35_K113_Y4.0691.00
305_N309_Q4.0001.00
183_S206_K3.0541.00
419_V433_A3.0431.00
381_N412_D2.8091.00
206_K238_Q2.8091.00
208_T240_I2.8081.00
5_Y108_D2.7661.00
154_R286_E2.7441.00
118_G128_T2.7191.00
4_E145_K2.6711.00
5_Y31_A2.6531.00
229_E233_K2.6351.00
289_G292_N2.6341.00
4_E143_I2.6051.00
381_N411_R2.5791.00
19_A148_I2.5581.00
128_T141_M2.5151.00
432_E451_H2.4891.00
180_L205_V2.4801.00
222_L373_D2.4721.00
144_P147_V2.4441.00
410_D413_T2.4231.00
156_R282_Q2.4201.00
117_L130_S2.4101.00
31_A110_Y2.4061.00
183_S273_E2.3941.00
154_R284_N2.3731.00
370_L378_N2.2631.00
414_D444_W2.2621.00
370_L375_A2.2461.00
383_K411_R2.2401.00
185_I210_I2.2331.00
8_V142_L2.2281.00
130_S141_M2.2251.00
115_R130_S2.1991.00
7_V23_A2.1811.00
415_D440_D2.1651.00
297_T301_M2.1581.00
338_A342_F2.1181.00
421_M426_V2.0751.00
117_L141_M2.0381.00
161_L247_P2.0141.00
15_G318_I2.0121.00
214_D242_G2.0041.00
128_T143_I2.0001.00
382_V408_V1.9981.00
170_T173_E1.9801.00
194_I209_V1.9731.00
8_V33_V1.9241.00
72_E79_N1.9231.00
154_R282_Q1.9191.00
436_A441_A1.9001.00
8_V129_I1.8611.00
146_Q314_H1.8601.00
372_E376_K1.8231.00
72_E77_S1.8001.00
8_V144_P1.7801.00
201_H206_K1.7661.00
373_D377_A1.7551.00
6_D145_K1.7491.00
116_I147_V1.7451.00
79_N82_K1.7421.00
149_I321_V1.7121.00
407_I419_V1.6971.00
184_I205_V1.6921.00
306_E349_P1.6751.00
148_I342_F1.6681.00
8_V31_A1.6671.00
309_Q313_S1.6661.00
215_R225_S1.6551.00
258_S271_S1.6401.00
194_I361_S1.6351.00
10_L114_G1.6251.00
169_L274_K1.6231.00
364_E427_T1.6231.00
246_L260_Q1.6191.00
372_E406_K1.6181.00
33_V142_L1.6071.00
375_A382_V1.6051.00
184_I200_L1.6031.00
110_Y142_L1.5921.00
223_E386_K1.5801.00
182_Q273_E1.5451.00
6_D29_K1.5401.00
380_H417_L1.5381.00
212_Y244_K1.5251.00
182_Q206_K1.5191.00
169_L177_M1.5161.00
99_N111_T1.5031.00
240_I243_A1.5011.00
7_V28_L1.5001.00
247_P260_Q1.4971.00
442_T445_E1.4961.00
256_D271_S1.4941.00
316_Y341_H1.4931.00
227_E422_I1.4701.00
38_L109_V1.4541.00
82_K85_Q1.4461.00
307_S341_H1.4441.00
374_E377_A1.4431.00
308_C322_I1.4431.00
59_V62_T1.4341.00
146_Q342_F1.4281.00
65_E68_Q1.4211.00
7_V148_I1.4121.00
22_R340_E1.4111.00
151_T321_V1.4111.00
407_I464_A1.4111.00
202_D235_K1.4091.00
201_H237_I1.4031.00
208_T238_Q1.3811.00
5_Y110_Y1.3741.00
120_S314_H1.3731.00
31_A142_L1.3571.00
381_N410_D1.3431.00
253_T256_D1.3421.00
375_A408_V1.3351.00
174_A200_L1.3241.00
185_I259_I1.3231.00
384_I408_V1.3211.00
72_E82_K1.3111.00
88_Q92_D1.3021.00
29_K108_D1.2921.00
253_T258_S1.2901.00
309_Q314_H1.2781.00
260_Q267_T1.2781.00
224_I422_I1.2771.00
230_S233_K1.2751.00
112_G131_V1.2691.00
148_I318_I1.2551.00
293_T312_E1.2471.00
228_M422_I1.2451.00
223_E406_K1.2441.00
115_R289_G1.2401.00
189_G216_I1.2361.00
45_K172_D1.2351.00
410_D415_D1.2341.00
221_D406_K1.2331.00
215_R222_L1.2281.00
84_Q88_Q1.2141.00
372_E384_I1.2031.00
312_E315_I1.1981.00
243_A264_D1.1961.00
222_L226_K1.1951.00
32_V102_M1.1931.00
405_V459_A1.1861.00
439_L445_E1.1851.00
433_A460_I1.1811.00
335_G339_V1.1801.00
224_I404_F1.1791.00
220_E367_S1.1721.00
157_M170_T1.1611.00
210_I270_Y1.1601.00
116_I149_I1.1531.00
220_E357_K1.1441.00
211_E241_T1.1351.00
407_I433_A1.1331.00
290_L295_I1.1331.00
374_E378_N1.1321.00
389_F423_G1.1291.00
231_L234_K1.1281.00
10_L149_I1.1101.00
365_A422_I1.1101.00
187_V275_M1.1081.00
209_V239_F1.1071.00
113_Y287_G1.1041.00
215_R229_E1.1041.00
15_G331_A1.1011.00
169_L173_E1.0961.00
120_S312_E1.0961.00
296_V303_S1.0951.00
431_S452_P1.0941.00
380_H410_D1.0931.00
36_E45_K1.0921.00
229_E241_T1.0911.00
358_C452_P1.0881.00
63_A66_A1.0861.00
167_S274_K1.0861.00
302_I321_V1.0861.00
229_E239_F1.0851.00
304_V317_A1.0831.00
230_S234_K1.0781.00
26_L343_A1.0771.00
303_S311_K1.0761.00
295_I302_I1.0751.00
357_K367_S1.0741.00
21_I105_G1.0731.00
159_P163_V1.0721.00
116_I129_I1.0711.00
386_K404_F1.0701.00
117_L128_T1.0691.00
115_R132_E1.0651.00
108_D140_D1.0641.00
232_L237_I1.0591.00
55_R59_V1.0591.00
102_M107_I1.0581.00
425_H428_D1.0571.00
252_K255_D1.0561.00
233_K238_Q1.0501.00
234_K402_D1.0471.00
228_M365_A1.0471.00
318_I338_A1.0461.00
371_T374_E1.0441.00
261_A270_Y1.0421.00
366_A430_I1.0421.00
308_C338_A1.0401.00
99_N103_K1.0371.00
376_K382_V1.0361.00
184_I274_K1.0351.00
115_R292_N1.0341.00
383_K414_D1.0341.00
304_V322_I1.0331.00
354_L437_K1.0321.00
33_V114_G1.0321.00
431_S457_S1.0291.00
80_F84_Q1.0281.00
110_Y140_D1.0201.00
81_E178_E1.0201.00
441_A445_E1.0191.00
185_I270_Y1.0161.00
297_T323_G1.0131.00
85_Q89_A1.0111.00
131_V142_L1.0081.00
370_L374_E1.0011.00
92_D96_A0.9971.00
194_I232_L0.9971.00
375_A380_H0.9951.00
244_K263_K0.9951.00
414_D443_P0.9931.00
89_A93_K0.9911.00
297_T303_S0.9861.00
368_V437_K0.9851.00
240_I270_Y0.9841.00
372_E382_V0.9831.00
243_A263_K0.9831.00
22_R26_L0.9791.00
183_S271_S0.9751.00
169_L174_A0.9731.00
28_L343_A0.9721.00
405_V421_M0.9711.00
358_C427_T0.9711.00
183_S205_V0.9671.00
337_I350_L0.9671.00
116_I144_P0.9671.00
26_L340_E0.9621.00
179_E274_K0.9611.00
28_L146_Q0.9601.00
12_G38_L0.9571.00
183_S208_T0.9541.00
119_P314_H0.9511.00
74_A77_S0.9511.00
285_I296_V0.9501.00
386_K406_K0.9501.00
224_I420_H0.9471.00
60_Y64_R0.9471.00
147_V315_I0.9451.00
61_R235_K0.9431.00
63_A73_T0.9421.00
295_I312_E0.9391.00
6_D28_L0.9381.00
187_V279_I0.9351.00
227_E230_S0.9341.00
165_G173_E0.9331.00
366_A426_V0.9321.00
210_I261_A0.9281.00
100_H104_K0.9251.00
115_R287_G0.9211.00
261_A264_D0.9211.00
380_H408_V0.9201.00
216_I241_T0.9201.00
28_L145_K0.9161.00
252_K256_D0.9151.00
5_Y29_K0.9151.00
216_I229_E0.9151.00
309_Q341_H0.9151.00
216_I239_F0.9141.00
162_E165_G0.9131.00
258_S267_T0.9121.00
189_G211_E0.9121.00
12_G32_V0.9111.00
57_A202_D0.9071.00
231_L422_I0.9061.00
184_I276_L0.9021.00
28_L342_F0.8981.00
146_Q316_Y0.8961.00
226_K230_S0.8861.00
293_T315_I0.8841.00
215_R373_D0.8821.00
338_A341_H0.8811.00
231_L235_K0.8801.00
416_I433_A0.8771.00
227_E231_L0.8771.00
18_V332_S0.8761.00
33_V131_V0.8741.00
116_I293_T0.8701.00
436_A446_V0.8651.00
156_R279_I0.8641.00
226_K229_E0.8621.00
33_V112_G0.8581.00
56_S83_V0.8581.00
325_L355_V0.8571.00
295_I311_K0.8561.00
287_G290_L0.8561.00
91_V94_L0.8561.00
10_L129_I0.8551.00
10_L288_I0.8541.00
160_G163_V0.8541.00
23_A339_V0.8531.00
44_H95_A0.8511.00
102_M109_V0.8511.00
339_V343_A0.8491.00
166_K252_K0.8481.00
187_V277_V0.8481.00
112_G135_N0.8461.00
98_V102_M0.8461.00
87_K91_V0.8461.00
410_D417_L0.8451.00
120_S128_T0.8431.00
84_Q87_K0.8431.00
117_L292_N0.8391.00
317_A321_V0.8391.00
73_T76_V0.8371.00
186_I276_L0.8361.00
210_I240_I0.8361.00
337_I341_H0.8341.00
283_A301_M0.8341.00
368_V434_G0.8341.00
22_R25_Q0.8331.00
116_I289_G0.8331.00
177_M181_P0.8291.00
193_G211_E0.8271.00
157_M163_V0.8271.00
253_T271_S0.8251.00
67_D82_K0.8251.00
116_I292_N0.8251.00
168_V277_V0.8241.00
351_D438_V0.8221.00
289_G293_T0.8211.00
441_A446_V0.8211.00
7_V339_V0.8201.00
58_E62_T0.8191.00
231_L402_D0.8191.00
432_E435_L0.8181.00
438_V448_Q0.8171.00
187_V245_V0.8161.00
372_E408_V0.8161.00
294_D312_E0.8151.00
61_R64_R0.8151.00
285_I297_T0.8141.00
309_Q316_Y0.8131.00
19_A335_G0.8101.00
56_S86_R0.8051.00
23_A28_L0.8051.00
54_L199_M0.8041.00
8_V147_V0.8031.00
191_V359_I0.8021.00
224_I365_A0.8021.00
132_E136_G0.7981.00
22_R339_V0.7971.00
215_R226_K0.7951.00
243_A261_A0.7941.00
213_A218_P0.7921.00
210_I243_A0.7921.00
93_K396_L0.7921.00
246_L263_K0.7911.00
147_V314_H0.7911.00
183_S272_A0.7891.00
376_K379_G0.7891.00
42_C47_C0.7881.00
201_H235_K0.7881.00
53_L84_Q0.7831.00
307_S349_P0.7831.00
114_G118_G0.7831.00
173_E176_Q0.7811.00
388_P391_A0.7801.00
61_R202_D0.7791.00
85_Q178_E0.7781.00
81_E85_Q0.7761.00
330_V355_V0.7761.00
364_E425_H0.7751.00
19_A339_V0.7741.00
96_A99_N0.7721.00
167_S250_M0.7681.00
100_H103_K0.7661.00
167_S252_K0.7651.00
293_T311_K0.7631.00
67_D72_E0.7631.00
202_D362_S0.7581.00
340_E345_L0.7581.00
340_E348_H0.7581.00
114_G117_L0.7581.00
228_M361_S0.7571.00
232_L239_F0.7571.00
308_C341_H0.7551.00
301_M326_Q0.7541.00
375_A417_L0.7441.00
383_K409_A0.7441.00
371_T420_H0.7431.00
250_M254_S0.7421.00
9_I16_G0.7391.00
119_P294_D0.7391.00
5_Y8_V0.7381.00
217_L228_M0.7361.00
307_S346_N0.7351.00
19_A338_A0.7331.00
61_R65_E0.7321.00
385_G463_A0.7311.00
183_S256_D0.7311.00
64_R75_G0.7281.00
177_M274_K0.7271.00
148_I338_A0.7231.00
208_T272_A0.7231.00
407_I463_A0.7221.00
47_C51_K0.7181.00
302_I317_A0.7141.00
65_E399_G0.7131.00
120_S143_I0.7111.00
167_S257_I0.7101.00
186_I193_G0.7101.00
286_E291_E0.7091.00
137_E140_D0.7081.00
310_T317_A0.7071.00
156_R159_P0.7071.00
435_L441_A0.7051.00
419_V437_K0.7051.00
72_E75_G0.7041.00
246_L267_T0.7041.00
298_E303_S0.7001.00
151_T288_I0.6961.00
55_R58_E0.6961.00
220_E359_I0.6941.00
211_E218_P0.6931.00
290_L293_T0.6931.00
435_L449_T0.6931.00
308_C337_I0.6931.00
263_K266_E0.6931.00
415_D442_T0.6921.00
56_S69_F0.6921.00
163_V168_V0.6901.00
66_A69_F0.6901.00
353_T378_N0.6881.00
168_V250_M0.6841.00
199_M203_F0.6831.00
89_A92_D0.6821.00
37_K45_K0.6821.00
295_I315_I0.6811.00
409_A443_P0.6801.00
97_G101_L0.6801.00
34_E37_K0.6781.00
77_S80_F0.6761.00
385_G409_A0.6761.00
334_E352_P0.6751.00
433_A437_K0.6731.00
392_I395_A0.6731.00
160_G245_V0.6721.00
197_A209_V0.6711.00
301_M323_G0.6711.00
119_P293_T0.6711.00
24_A107_I0.6711.00
285_I321_V0.6701.00
250_M255_D0.6701.00
443_P447_G0.6701.00
98_V101_L0.6691.00
85_Q88_Q0.6681.00
50_S196_W0.6661.00
158_L162_E0.6641.00
88_Q176_Q0.6631.00
193_G212_Y0.6631.00
445_E448_Q0.6631.00
428_D457_S0.6611.00
257_I275_M0.6591.00
304_V308_C0.6591.00
423_G426_V0.6581.00
435_L446_V0.6570.99
194_I216_I0.6560.99
389_F459_A0.6560.99
333_H336_I0.6560.99
63_A71_V0.6550.99
240_I261_A0.6530.99
214_D222_L0.6530.99
243_A266_E0.6530.99
197_A237_I0.6520.99
435_L439_L0.6520.99
153_S281_R0.6520.99
416_I437_K0.6510.99
84_Q178_E0.6510.99
163_V170_T0.6470.99
23_A30_T0.6460.99
421_M429_M0.6460.99
446_V464_A0.6460.99
221_D420_H0.6450.99
409_A414_D0.6430.99
309_Q312_E0.6410.99
413_T440_D0.6380.99
212_Y218_P0.6370.99
9_I20_A0.6360.99
50_S54_L0.6360.99
6_D31_A0.6350.99
35_K114_G0.6340.99
81_E84_Q0.6330.99
24_A30_T0.6320.99
87_K176_Q0.6320.99
55_R62_T0.6300.99
183_S201_H0.6280.99
96_A100_H0.6270.99
158_L161_L0.6260.99
157_M277_V0.6260.99
62_T65_E0.6240.99
132_E137_E0.6220.99
158_L163_V0.6190.99
158_L277_V0.6180.99
72_E76_V0.6170.99
26_L345_L0.6160.99
157_M162_E0.6160.99
220_E365_A0.6150.99
227_E404_F0.6140.99
71_V78_L0.6140.99
250_M253_T0.6130.99
205_V273_E0.6120.99
119_P312_E0.6110.99
200_L205_V0.6100.99
354_L438_V0.6100.99
23_A342_F0.6090.99
66_A73_T0.6080.99
86_R90_V0.6070.99
191_V357_K0.6070.99
408_V411_R0.6060.99
240_I266_E0.6060.99
293_T296_V0.6050.99
419_V460_I0.6030.99
38_L102_M0.6000.99
132_E140_D0.5980.99
48_I51_K0.5970.99
198_S235_K0.5950.99
78_L83_V0.5950.99
364_E456_L0.5940.99
264_D267_T0.5930.99
235_K362_S0.5920.99
35_K284_N0.5920.99
99_N109_V0.5910.99
210_I272_A0.5910.99
21_I25_Q0.5890.99
58_E362_S0.5870.99
370_L380_H0.5860.99
86_R89_A0.5850.99
198_S232_L0.5850.99
453_H458_E0.5850.99
161_L164_D0.5840.99
194_I239_F0.5840.99
382_V417_L0.5830.99
344_G347_P0.5820.99
37_K95_A0.5820.99
36_E172_D0.5820.99
90_V94_L0.5810.99
25_Q105_G0.5810.99
370_L418_G0.5810.99
400_E424_P0.5800.99
198_S202_D0.5790.99
92_D95_A0.5790.99
82_K86_R0.5790.99
224_I227_E0.5770.99
163_V277_V0.5770.99
393_G396_L0.5770.99
302_I310_T0.5760.99
34_E109_V0.5760.99
114_G119_P0.5750.99
177_M200_L0.5730.99
88_Q91_V0.5730.99
57_A60_Y0.5730.99
113_Y118_G0.5720.99
296_V300_G0.5710.99
323_G326_Q0.5690.99
438_V449_T0.5690.99
59_V66_A0.5680.99
172_D281_R0.5680.99
91_V95_A0.5660.99
55_R398_Y0.5630.98
330_V334_E0.5630.98
159_P164_D0.5630.98
296_V302_I0.5610.98
193_G278_S0.5600.98
87_K90_V0.5590.98
148_I339_V0.5590.98
318_I335_G0.5580.98
434_G438_V0.5580.98
113_Y132_E0.5580.98
90_V93_K0.5580.98
367_S420_H0.5560.98
351_D354_L0.5550.98
83_V203_F0.5540.98
118_G292_N0.5540.98
373_D376_K0.5530.98
171_S281_R0.5520.98
429_M456_L0.5520.98
340_E344_G0.5510.98
80_F180_L0.5480.98
316_Y342_F0.5480.98
155_P171_S0.5470.98
63_A76_V0.5470.98
59_V63_A0.5460.98
444_W448_Q0.5460.98
26_L339_V0.5450.98
39_G43_L0.5450.98
250_M257_I0.5450.98
32_V38_L0.5430.98
333_H337_I0.5430.98
396_L401_S0.5430.98
434_G449_T0.5420.98
68_Q399_G0.5420.98
15_G150_A0.5400.98
382_V411_R0.5390.98
208_T270_Y0.5380.98
120_S147_V0.5380.98
405_V463_A0.5370.98
185_I275_M0.5370.98
222_L225_S0.5360.98
38_L99_N0.5360.98
81_E179_E0.5350.98
80_F178_E0.5340.98
94_L98_V0.5340.98
94_L396_L0.5320.98
297_T300_G0.5310.98
395_A456_L0.5310.98
381_N384_I0.5310.98
354_L434_G0.5310.98
9_I30_T0.5280.98
211_E245_V0.5280.98
333_H461_G0.5280.98
336_I340_E0.5270.98
48_I393_G0.5260.98
330_V352_P0.5260.98
115_R118_G0.5240.98
32_V107_I0.5230.98
161_L165_G0.5230.98
76_V79_N0.5220.97
416_I419_V0.5210.97
435_L451_H0.5210.97
432_E457_S0.5180.97
7_V19_A0.5180.97
150_A318_I0.5160.97
287_G291_E0.5140.97
420_H433_A0.5140.97
12_G34_E0.5130.97
212_Y279_I0.5130.97
184_I207_V0.5130.97
193_G218_P0.5130.97
165_G250_M0.5120.97
362_S400_E0.5110.97
33_V110_Y0.5110.97
354_L368_V0.5110.97
86_R399_G0.5100.97
172_D175_L0.5100.97
333_H350_L0.5100.97
196_W199_M0.5090.97
9_I19_A0.5090.97
385_G407_I0.5080.97
332_S461_G0.5070.97
271_S274_K0.5060.97
168_V275_M0.5040.97
398_Y456_L0.5040.97
389_F405_V0.5020.97
185_I257_I0.5020.97
196_W276_L0.5010.97
110_Y131_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 0.9747 100 0.202 Contact Map
3ladA 2 0.9726 100 0.209 Contact Map
1zmdA 4 0.9768 100 0.214 Contact Map
1lvlA 2 0.9578 100 0.22 Contact Map
1xdiA 3 0.9515 100 0.22 Contact Map
2a8xA 2 0.9705 100 0.221 Contact Map
3urhA 2 0.962 100 0.222 Contact Map
3ic9A 2 0.9662 100 0.223 Contact Map
2qaeA 2 0.9662 100 0.229 Contact Map
2eq6A 2 0.9557 100 0.231 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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