GREMLIN Database
BUK - Probable butyrate kinase
UniProt: P54532 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (334)
Sequences: 4305 (3018)
Seq/√Len: 165.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_K121_E4.0301.00
239_T242_E3.4631.00
319_S334_Y3.4581.00
170_K173_A3.3471.00
266_E315_K2.9831.00
288_A324_Y2.9681.00
94_V131_Y2.9461.00
256_Y282_A2.8221.00
216_F282_A2.7291.00
245_K250_T2.7171.00
287_V321_I2.6831.00
196_G203_V2.5901.00
285_Y297_A2.5801.00
183_K301_E2.5601.00
213_E223_T2.5271.00
149_G216_F2.5261.00
87_I101_D2.4191.00
99_I124_D2.3611.00
268_M273_D2.3471.00
20_T56_R2.3331.00
267_Q271_G2.2871.00
234_F241_E2.2811.00
277_R281_D2.2671.00
284_A317_F2.2471.00
81_G120_R2.2471.00
283_M311_L2.2071.00
138_V203_V2.2011.00
144_L281_D2.1421.00
58_N62_E2.1201.00
52_Q55_F2.0771.00
221_A247_L2.0571.00
145_A285_Y2.0481.00
96_D124_D2.0321.00
319_S323_S1.9891.00
99_I117_I1.9821.00
177_K182_M1.9601.00
191_G218_P1.9521.00
164_Q186_I1.9381.00
101_D104_S1.9321.00
269_I280_Y1.9291.00
268_M276_A1.9241.00
152_E236_G1.8951.00
266_E316_S1.8731.00
295_S327_W1.8511.00
171_A306_V1.7911.00
229_L243_I1.7881.00
151_P255_G1.7491.00
99_I121_E1.7491.00
9_R73_K1.7411.00
269_I277_R1.7271.00
54_E125_G1.7251.00
284_A320_A1.7221.00
82_G109_Q1.7211.00
305_I330_D1.7171.00
186_I306_V1.7031.00
233_C243_I1.7011.00
245_K249_G1.6841.00
143_V274_E1.6751.00
280_Y320_A1.6601.00
100_E103_K1.6431.00
234_F244_M1.6311.00
102_L131_Y1.6131.00
320_A323_S1.6071.00
262_A280_Y1.6051.00
187_T195_I1.5891.00
167_V308_T1.5801.00
185_I302_V1.5791.00
83_L159_F1.5731.00
100_E104_S1.5481.00
184_M304_A1.5431.00
22_I38_H1.5371.00
18_T191_G1.5171.00
181_N200_R1.5111.00
250_T254_L1.5051.00
232_L236_G1.5031.00
81_G131_Y1.5011.00
295_S302_V1.4951.00
177_K181_N1.4851.00
183_K199_D1.4761.00
107_A235_S1.4711.00
172_A182_M1.4651.00
322_R330_D1.4641.00
87_I104_S1.4631.00
178_R181_N1.4611.00
171_A175_L1.4501.00
238_Y246_K1.4421.00
92_Y98_M1.4411.00
186_I198_H1.4351.00
258_G275_K1.4141.00
93_V128_I1.4141.00
146_K155_R1.4001.00
302_V305_I1.3801.00
233_C240_K1.3741.00
31_I34_K1.3621.00
216_F256_Y1.3601.00
170_K174_S1.3591.00
185_I291_I1.3491.00
292_G296_A1.3451.00
195_I207_N1.3401.00
264_K267_Q1.3331.00
164_Q196_G1.3311.00
144_L285_Y1.3281.00
62_E66_E1.3151.00
274_E277_R1.3091.00
207_N294_A1.3071.00
150_M221_A1.3061.00
322_R332_L1.3051.00
218_P260_N1.3041.00
147_V282_A1.2931.00
289_K297_A1.2791.00
94_V98_M1.2731.00
147_V278_F1.2731.00
193_I283_M1.2631.00
288_A296_A1.2571.00
316_S320_A1.2561.00
96_D100_E1.2551.00
81_G116_G1.2551.00
205_D289_K1.2461.00
186_I196_G1.2381.00
94_V120_R1.2251.00
145_A204_V1.2201.00
175_L304_A1.2131.00
165_K169_R1.2121.00
194_T209_G1.2091.00
277_R320_A1.2081.00
193_I215_P1.2051.00
242_E250_T1.2051.00
195_I291_I1.2021.00
51_D55_F1.1981.00
253_L262_A1.1981.00
335_P338_N1.1911.00
102_L117_I1.1821.00
284_A288_A1.1791.00
97_E101_D1.1641.00
166_A170_K1.1581.00
103_K106_Y1.1551.00
43_L46_F1.1421.00
154_E228_D1.1421.00
143_V147_V1.1421.00
40_I43_L1.1381.00
189_M311_L1.1361.00
26_H29_R1.1301.00
9_R26_H1.1171.00
150_M246_K1.1171.00
256_Y278_F1.1161.00
207_N290_E1.1111.00
230_V244_M1.0971.00
168_A186_I1.0931.00
54_E58_N1.0831.00
266_E317_F1.0821.00
199_D298_L1.0811.00
168_A198_H1.0740.99
230_V233_C1.0690.99
205_D297_A1.0600.99
301_E327_W1.0580.99
148_S213_E1.0580.99
224_V228_D1.0510.99
268_M271_G1.0500.99
59_H62_E1.0460.99
172_A179_Y1.0370.99
145_A297_A1.0330.99
257_L265_V1.0280.99
298_L301_E1.0270.99
120_R124_D1.0220.99
270_Q316_S1.0210.99
31_I260_N1.0190.99
123_A129_P1.0170.99
141_M146_K1.0150.99
77_V129_P1.0090.99
139_D146_K1.0070.99
132_I162_L1.0070.99
195_I215_P1.0070.99
191_G260_N1.0030.99
223_T290_E1.0030.99
124_D129_P1.0030.99
116_G119_A1.0010.99
184_M306_V0.9980.99
187_T291_I0.9960.99
259_T264_K0.9940.99
262_A311_L0.9920.99
221_A224_V0.9920.99
280_Y284_A0.9890.99
295_S328_I0.9830.99
143_V146_K0.9830.99
281_D320_A0.9790.99
195_I294_A0.9740.99
289_K293_A0.9730.99
288_A325_I0.9710.99
286_Q290_E0.9700.99
238_Y242_E0.9700.99
88_E101_D0.9680.99
171_A184_M0.9620.99
335_P339_E0.9600.99
197_V298_L0.9580.99
189_M287_V0.9500.99
20_T60_I0.9450.99
268_M272_G0.9450.99
13_I123_A0.9390.99
288_A326_D0.9360.99
81_G102_L0.9310.99
182_M200_R0.9310.99
280_Y317_F0.9150.98
300_G326_D0.9140.98
89_G139_D0.9130.98
317_F320_A0.9110.98
159_F203_V0.9050.98
50_I56_R0.8930.98
27_N30_S0.8920.98
121_E124_D0.8900.98
290_E294_A0.8880.98
91_T165_K0.8870.98
77_V127_N0.8790.98
232_L246_K0.8790.98
187_T305_I0.8760.98
213_E286_Q0.8730.98
95_N98_M0.8690.98
34_K40_I0.8680.98
106_Y117_I0.8670.98
212_G248_V0.8650.98
120_R131_Y0.8640.98
290_E293_A0.8610.98
143_V278_F0.8600.98
77_V123_A0.8580.98
199_D204_V0.8570.98
273_D276_A0.8560.97
283_M317_F0.8550.97
34_K38_H0.8540.97
305_I322_R0.8520.97
317_F321_I0.8510.97
208_N211_H0.8500.97
117_I121_E0.8500.97
150_M154_E0.8490.97
148_S256_Y0.8480.97
167_V186_I0.8480.97
333_V337_E0.8460.97
230_V247_L0.8440.97
319_S338_N0.8400.97
183_K327_W0.8390.97
300_G324_Y0.8390.97
208_N212_G0.8370.97
9_R75_D0.8340.97
230_V240_K0.8310.97
238_Y243_I0.8250.97
339_E343_L0.8250.97
339_E342_S0.8230.97
182_M304_A0.8160.97
259_T268_M0.8150.97
172_A177_K0.8140.97
183_K200_R0.8120.97
266_E280_Y0.8100.97
262_A283_M0.8090.96
296_A327_W0.8080.96
34_K39_N0.8080.96
189_M193_I0.8080.96
97_E100_E0.8050.96
48_R51_D0.7940.96
172_A181_N0.7940.96
265_V269_I0.7930.96
48_R59_H0.7880.96
336_G339_E0.7870.96
300_G327_W0.7870.96
275_K278_F0.7840.96
284_A321_I0.7820.96
15_P20_T0.7820.96
53_Y56_R0.7820.96
323_S334_Y0.7820.96
141_M205_D0.7810.96
318_V333_V0.7810.96
42_E45_R0.7810.96
77_V122_I0.7800.96
210_L231_D0.7790.96
229_L247_L0.7710.95
254_L260_N0.7710.95
86_P146_K0.7700.95
144_L324_Y0.7690.95
266_E270_Q0.7690.95
340_L343_L0.7670.95
171_A174_S0.7610.95
195_I287_V0.7580.95
183_K300_G0.7570.95
156_K213_E0.7550.95
41_E44_Q0.7550.95
21_K310_G0.7530.95
79_A129_P0.7480.95
264_K268_M0.7470.95
88_E98_M0.7460.94
64_L69_I0.7440.94
142_S199_D0.7360.94
278_F282_A0.7360.94
141_M206_V0.7280.94
162_L165_K0.7260.94
246_K251_G0.7250.94
137_V158_I0.7180.93
66_E69_I0.7100.93
70_N73_K0.7080.93
23_G340_L0.7060.93
334_Y338_N0.7060.93
63_T66_E0.7040.93
102_L120_R0.7030.93
215_P286_Q0.7030.93
86_P153_I0.7020.93
257_L268_M0.7020.93
140_E202_R0.7020.93
189_M283_M0.6980.92
233_C236_G0.6960.92
285_Y289_K0.6940.92
168_A184_M0.6940.92
216_F283_M0.6930.92
145_A205_D0.6920.92
286_Q289_K0.6880.92
92_Y95_N0.6840.92
89_G136_V0.6830.91
39_N43_L0.6820.91
150_M247_L0.6790.91
333_V336_G0.6770.91
221_A226_A0.6760.91
57_K123_A0.6760.91
281_D284_A0.6760.91
24_V74_F0.6720.91
178_R182_M0.6710.91
53_Y191_G0.6690.91
121_E125_G0.6690.91
240_K243_I0.6660.90
149_G282_A0.6630.90
246_K250_T0.6610.90
93_V130_S0.6610.90
168_A172_A0.6590.90
154_E231_D0.6570.90
284_A287_V0.6570.90
204_V297_A0.6570.90
16_G21_K0.6560.90
283_M287_V0.6550.90
266_E314_G0.6540.90
318_V337_E0.6540.90
39_N42_E0.6490.89
185_I295_S0.6480.89
62_E65_H0.6480.89
230_V234_F0.6470.89
140_E203_V0.6420.89
41_E46_F0.6420.89
311_L317_F0.6410.89
295_S298_L0.6400.89
269_I272_G0.6400.89
230_V241_E0.6380.88
142_S145_A0.6300.88
87_I97_E0.6290.88
307_L321_I0.6290.88
302_V327_W0.6250.87
164_Q168_A0.6240.87
55_F58_N0.6230.87
61_L65_H0.6220.87
54_E118_I0.6220.87
40_I44_Q0.6210.87
298_L302_V0.6210.87
280_Y316_S0.6190.87
91_T133_V0.6170.87
205_D285_Y0.6150.87
204_V298_L0.6130.86
296_A324_Y0.6130.86
233_C238_Y0.6130.86
256_Y275_K0.6120.86
12_T123_A0.6110.86
179_Y198_H0.6110.86
332_L337_E0.6090.86
257_L279_I0.6040.86
296_A300_G0.6040.86
163_N308_T0.6030.86
269_I320_A0.6020.85
266_E269_I0.6000.85
183_K298_L0.5990.85
141_M145_A0.5980.85
63_T67_Q0.5970.85
32_F36_L0.5970.85
184_M198_H0.5950.85
93_V96_D0.5950.85
122_I125_G0.5950.85
288_A297_A0.5950.85
177_K303_E0.5950.85
31_I46_F0.5950.85
242_E245_K0.5950.85
185_I298_L0.5940.85
314_G340_L0.5940.85
101_D105_G0.5930.85
326_D331_V0.5930.85
295_S301_E0.5930.85
19_S191_G0.5930.85
93_V129_P0.5920.84
148_S209_G0.5910.84
150_M232_L0.5910.84
256_Y279_I0.5910.84
316_S319_S0.5900.84
234_F240_K0.5900.84
167_V171_A0.5880.84
31_I35_T0.5860.84
103_K117_I0.5860.84
292_G297_A0.5830.84
243_I246_K0.5830.84
13_I22_I0.5830.84
34_K66_E0.5810.83
138_V141_M0.5810.83
15_P79_A0.5790.83
338_N341_Q0.5790.83
232_L238_Y0.5790.83
323_S326_D0.5790.83
253_L265_V0.5770.83
116_G227_G0.5740.83
17_S21_K0.5710.82
141_M155_R0.5700.82
302_V328_I0.5700.82
149_G213_E0.5700.82
79_A119_A0.5690.82
269_I276_A0.5680.82
262_A315_K0.5670.82
32_F49_I0.5660.82
59_H63_T0.5650.82
78_C133_V0.5650.82
288_A321_I0.5620.81
122_I126_L0.5620.81
139_D155_R0.5600.81
74_F127_N0.5600.81
180_E200_R0.5600.81
278_F281_D0.5590.81
286_Q292_G0.5590.81
33_E36_L0.5580.81
86_P105_G0.5570.81
172_A178_R0.5570.81
291_I325_I0.5550.81
37_R44_Q0.5550.81
20_T115_G0.5540.80
58_N125_G0.5510.80
80_R134_D0.5510.80
264_K309_G0.5500.80
233_C237_E0.5500.80
105_G117_I0.5490.80
82_G136_V0.5480.80
304_A332_L0.5480.80
15_P119_A0.5470.80
25_F30_S0.5470.80
99_I120_R0.5470.80
168_A308_T0.5470.80
253_L280_Y0.5470.80
170_K343_L0.5460.79
50_I59_H0.5450.79
274_E278_F0.5440.79
291_I305_I0.5440.79
244_M248_V0.5400.79
35_T38_H0.5400.79
288_A330_D0.5380.78
93_V124_D0.5370.78
265_V280_Y0.5370.78
35_T40_I0.5370.78
34_K67_Q0.5360.78
265_V268_M0.5350.78
230_V243_I0.5350.78
115_G119_A0.5340.78
102_L132_I0.5340.78
216_F286_Q0.5340.78
189_M307_L0.5330.78
99_I103_K0.5300.77
238_Y250_T0.5290.77
138_V196_G0.5290.77
77_V128_I0.5280.77
257_L275_K0.5230.77
99_I102_L0.5220.76
137_V198_H0.5220.76
169_R173_A0.5220.76
254_L259_T0.5210.76
221_A251_G0.5210.76
281_D316_S0.5200.76
171_A304_A0.5200.76
285_Y324_Y0.5190.76
259_T265_V0.5180.76
232_L243_I0.5180.76
57_K61_L0.5170.76
149_G256_Y0.5140.75
269_I317_F0.5130.75
12_T22_I0.5130.75
137_V212_G0.5120.75
291_I321_I0.5110.75
119_A123_A0.5110.75
168_A179_Y0.5100.75
257_L276_A0.5090.75
18_T218_P0.5080.74
234_F243_I0.5070.74
80_R192_G0.5070.74
98_M102_L0.5070.74
262_A265_V0.5060.74
169_R179_Y0.5050.74
90_G165_K0.5050.74
119_A122_I0.5040.74
106_Y114_L0.5040.74
291_I295_S0.5040.74
267_Q270_Q0.5040.74
152_E246_K0.5040.74
99_I106_Y0.5030.74
38_H46_F0.5030.74
179_Y184_M0.5030.74
123_A127_N0.5020.74
307_L312_A0.5020.74
31_I38_H0.5010.73
38_H43_L0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3sk3A 2 0.9559 100 0.115 Contact Map
4h0pA 2 0.9752 100 0.131 Contact Map
4h0oA 6 0.9504 100 0.158 Contact Map
2iirA 2 0.9725 100 0.223 Contact Map
2e1zA 2 0.9669 100 0.23 Contact Map
1g99A 2 0.9669 100 0.23 Contact Map
3khyA 2 0.9532 100 0.284 Contact Map
3r9pA 2 0.9614 100 0.408 Contact Map
1sazA 3 0.9835 100 0.441 Contact Map
4ijnA 2 0.9532 100 0.562 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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