BUK - BACSU - GREMLIN Contacts

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BUK - Probable butyrate kinase

UniProt:	P54532	Sequences: MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQRFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDLKSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFHALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSPERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKARFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVYPGENELQSLAQGALRVLQGEEQSKQYRIE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	363 (334)
Sequences:	4305 (3018)
Seq/√Len:	165.2

ECOLI - ACKA TDCD
BACSU - BUK ACKA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
103_K	121_E	4.030	1.00
239_T	242_E	3.463	1.00
319_S	334_Y	3.458	1.00
170_K	173_A	3.347	1.00
266_E	315_K	2.983	1.00
288_A	324_Y	2.968	1.00
94_V	131_Y	2.946	1.00
256_Y	282_A	2.822	1.00
216_F	282_A	2.729	1.00
245_K	250_T	2.717	1.00
287_V	321_I	2.683	1.00
196_G	203_V	2.590	1.00
285_Y	297_A	2.580	1.00
183_K	301_E	2.560	1.00
213_E	223_T	2.527	1.00
149_G	216_F	2.526	1.00
87_I	101_D	2.419	1.00
99_I	124_D	2.361	1.00
268_M	273_D	2.347	1.00
20_T	56_R	2.333	1.00
267_Q	271_G	2.287	1.00
234_F	241_E	2.281	1.00
277_R	281_D	2.267	1.00
284_A	317_F	2.247	1.00
81_G	120_R	2.247	1.00
283_M	311_L	2.207	1.00
138_V	203_V	2.201	1.00
144_L	281_D	2.142	1.00
58_N	62_E	2.120	1.00
52_Q	55_F	2.077	1.00
221_A	247_L	2.057	1.00
145_A	285_Y	2.048	1.00
96_D	124_D	2.032	1.00
319_S	323_S	1.989	1.00
99_I	117_I	1.982	1.00
177_K	182_M	1.960	1.00
191_G	218_P	1.952	1.00
164_Q	186_I	1.938	1.00
101_D	104_S	1.932	1.00
269_I	280_Y	1.929	1.00
268_M	276_A	1.924	1.00
152_E	236_G	1.895	1.00
266_E	316_S	1.873	1.00
295_S	327_W	1.851	1.00
171_A	306_V	1.791	1.00
229_L	243_I	1.788	1.00
151_P	255_G	1.749	1.00
99_I	121_E	1.749	1.00
9_R	73_K	1.741	1.00
269_I	277_R	1.727	1.00
54_E	125_G	1.725	1.00
284_A	320_A	1.722	1.00
82_G	109_Q	1.721	1.00
305_I	330_D	1.717	1.00
186_I	306_V	1.703	1.00
233_C	243_I	1.701	1.00
245_K	249_G	1.684	1.00
143_V	274_E	1.675	1.00
280_Y	320_A	1.660	1.00
100_E	103_K	1.643	1.00
234_F	244_M	1.631	1.00
102_L	131_Y	1.613	1.00
320_A	323_S	1.607	1.00
262_A	280_Y	1.605	1.00
187_T	195_I	1.589	1.00
167_V	308_T	1.580	1.00
185_I	302_V	1.579	1.00
83_L	159_F	1.573	1.00
100_E	104_S	1.548	1.00
184_M	304_A	1.543	1.00
22_I	38_H	1.537	1.00
18_T	191_G	1.517	1.00
181_N	200_R	1.511	1.00
250_T	254_L	1.505	1.00
232_L	236_G	1.503	1.00
81_G	131_Y	1.501	1.00
295_S	302_V	1.495	1.00
177_K	181_N	1.485	1.00
183_K	199_D	1.476	1.00
107_A	235_S	1.471	1.00
172_A	182_M	1.465	1.00
322_R	330_D	1.464	1.00
87_I	104_S	1.463	1.00
178_R	181_N	1.461	1.00
171_A	175_L	1.450	1.00
238_Y	246_K	1.442	1.00
92_Y	98_M	1.441	1.00
186_I	198_H	1.435	1.00
258_G	275_K	1.414	1.00
93_V	128_I	1.414	1.00
146_K	155_R	1.400	1.00
302_V	305_I	1.380	1.00
233_C	240_K	1.374	1.00
31_I	34_K	1.362	1.00
216_F	256_Y	1.360	1.00
170_K	174_S	1.359	1.00
185_I	291_I	1.349	1.00
292_G	296_A	1.345	1.00
195_I	207_N	1.340	1.00
264_K	267_Q	1.333	1.00
164_Q	196_G	1.331	1.00
144_L	285_Y	1.328	1.00
62_E	66_E	1.315	1.00
274_E	277_R	1.309	1.00
207_N	294_A	1.307	1.00
150_M	221_A	1.306	1.00
322_R	332_L	1.305	1.00
218_P	260_N	1.304	1.00
147_V	282_A	1.293	1.00
289_K	297_A	1.279	1.00
94_V	98_M	1.273	1.00
147_V	278_F	1.273	1.00
193_I	283_M	1.263	1.00
288_A	296_A	1.257	1.00
316_S	320_A	1.256	1.00
96_D	100_E	1.255	1.00
81_G	116_G	1.255	1.00
205_D	289_K	1.246	1.00
186_I	196_G	1.238	1.00
94_V	120_R	1.225	1.00
145_A	204_V	1.220	1.00
175_L	304_A	1.213	1.00
165_K	169_R	1.212	1.00
194_T	209_G	1.209	1.00
277_R	320_A	1.208	1.00
193_I	215_P	1.205	1.00
242_E	250_T	1.205	1.00
195_I	291_I	1.202	1.00
51_D	55_F	1.198	1.00
253_L	262_A	1.198	1.00
335_P	338_N	1.191	1.00
102_L	117_I	1.182	1.00
284_A	288_A	1.179	1.00
97_E	101_D	1.164	1.00
166_A	170_K	1.158	1.00
103_K	106_Y	1.155	1.00
43_L	46_F	1.142	1.00
154_E	228_D	1.142	1.00
143_V	147_V	1.142	1.00
40_I	43_L	1.138	1.00
189_M	311_L	1.136	1.00
26_H	29_R	1.130	1.00
9_R	26_H	1.117	1.00
150_M	246_K	1.117	1.00
256_Y	278_F	1.116	1.00
207_N	290_E	1.111	1.00
230_V	244_M	1.097	1.00
168_A	186_I	1.093	1.00
54_E	58_N	1.083	1.00
266_E	317_F	1.082	1.00
199_D	298_L	1.081	1.00
168_A	198_H	1.074	0.99
230_V	233_C	1.069	0.99
205_D	297_A	1.060	0.99
301_E	327_W	1.058	0.99
148_S	213_E	1.058	0.99
224_V	228_D	1.051	0.99
268_M	271_G	1.050	0.99
59_H	62_E	1.046	0.99
172_A	179_Y	1.037	0.99
145_A	297_A	1.033	0.99
257_L	265_V	1.028	0.99
298_L	301_E	1.027	0.99
120_R	124_D	1.022	0.99
270_Q	316_S	1.021	0.99
31_I	260_N	1.019	0.99
123_A	129_P	1.017	0.99
141_M	146_K	1.015	0.99
77_V	129_P	1.009	0.99
139_D	146_K	1.007	0.99
132_I	162_L	1.007	0.99
195_I	215_P	1.007	0.99
191_G	260_N	1.003	0.99
223_T	290_E	1.003	0.99
124_D	129_P	1.003	0.99
116_G	119_A	1.001	0.99
184_M	306_V	0.998	0.99
187_T	291_I	0.996	0.99
259_T	264_K	0.994	0.99
262_A	311_L	0.992	0.99
221_A	224_V	0.992	0.99
280_Y	284_A	0.989	0.99
295_S	328_I	0.983	0.99
143_V	146_K	0.983	0.99
281_D	320_A	0.979	0.99
195_I	294_A	0.974	0.99
289_K	293_A	0.973	0.99
288_A	325_I	0.971	0.99
286_Q	290_E	0.970	0.99
238_Y	242_E	0.970	0.99
88_E	101_D	0.968	0.99
171_A	184_M	0.962	0.99
335_P	339_E	0.960	0.99
197_V	298_L	0.958	0.99
189_M	287_V	0.950	0.99
20_T	60_I	0.945	0.99
268_M	272_G	0.945	0.99
13_I	123_A	0.939	0.99
288_A	326_D	0.936	0.99
81_G	102_L	0.931	0.99
182_M	200_R	0.931	0.99
280_Y	317_F	0.915	0.98
300_G	326_D	0.914	0.98
89_G	139_D	0.913	0.98
317_F	320_A	0.911	0.98
159_F	203_V	0.905	0.98
50_I	56_R	0.893	0.98
27_N	30_S	0.892	0.98
121_E	124_D	0.890	0.98
290_E	294_A	0.888	0.98
91_T	165_K	0.887	0.98
77_V	127_N	0.879	0.98
232_L	246_K	0.879	0.98
187_T	305_I	0.876	0.98
213_E	286_Q	0.873	0.98
95_N	98_M	0.869	0.98
34_K	40_I	0.868	0.98
106_Y	117_I	0.867	0.98
212_G	248_V	0.865	0.98
120_R	131_Y	0.864	0.98
290_E	293_A	0.861	0.98
143_V	278_F	0.860	0.98
77_V	123_A	0.858	0.98
199_D	204_V	0.857	0.98
273_D	276_A	0.856	0.97
283_M	317_F	0.855	0.97
34_K	38_H	0.854	0.97
305_I	322_R	0.852	0.97
317_F	321_I	0.851	0.97
208_N	211_H	0.850	0.97
117_I	121_E	0.850	0.97
150_M	154_E	0.849	0.97
148_S	256_Y	0.848	0.97
167_V	186_I	0.848	0.97
333_V	337_E	0.846	0.97
230_V	247_L	0.844	0.97
319_S	338_N	0.840	0.97
183_K	327_W	0.839	0.97
300_G	324_Y	0.839	0.97
208_N	212_G	0.837	0.97
9_R	75_D	0.834	0.97
230_V	240_K	0.831	0.97
238_Y	243_I	0.825	0.97
339_E	343_L	0.825	0.97
339_E	342_S	0.823	0.97
182_M	304_A	0.816	0.97
259_T	268_M	0.815	0.97
172_A	177_K	0.814	0.97
183_K	200_R	0.812	0.97
266_E	280_Y	0.810	0.97
262_A	283_M	0.809	0.96
296_A	327_W	0.808	0.96
34_K	39_N	0.808	0.96
189_M	193_I	0.808	0.96
97_E	100_E	0.805	0.96
48_R	51_D	0.794	0.96
172_A	181_N	0.794	0.96
265_V	269_I	0.793	0.96
48_R	59_H	0.788	0.96
336_G	339_E	0.787	0.96
300_G	327_W	0.787	0.96
275_K	278_F	0.784	0.96
284_A	321_I	0.782	0.96
15_P	20_T	0.782	0.96
53_Y	56_R	0.782	0.96
323_S	334_Y	0.782	0.96
141_M	205_D	0.781	0.96
318_V	333_V	0.781	0.96
42_E	45_R	0.781	0.96
77_V	122_I	0.780	0.96
210_L	231_D	0.779	0.96
229_L	247_L	0.771	0.95
254_L	260_N	0.771	0.95
86_P	146_K	0.770	0.95
144_L	324_Y	0.769	0.95
266_E	270_Q	0.769	0.95
340_L	343_L	0.767	0.95
171_A	174_S	0.761	0.95
195_I	287_V	0.758	0.95
183_K	300_G	0.757	0.95
156_K	213_E	0.755	0.95
41_E	44_Q	0.755	0.95
21_K	310_G	0.753	0.95
79_A	129_P	0.748	0.95
264_K	268_M	0.747	0.95
88_E	98_M	0.746	0.94
64_L	69_I	0.744	0.94
142_S	199_D	0.736	0.94
278_F	282_A	0.736	0.94
141_M	206_V	0.728	0.94
162_L	165_K	0.726	0.94
246_K	251_G	0.725	0.94
137_V	158_I	0.718	0.93
66_E	69_I	0.710	0.93
70_N	73_K	0.708	0.93
23_G	340_L	0.706	0.93
334_Y	338_N	0.706	0.93
63_T	66_E	0.704	0.93
102_L	120_R	0.703	0.93
215_P	286_Q	0.703	0.93
86_P	153_I	0.702	0.93
257_L	268_M	0.702	0.93
140_E	202_R	0.702	0.93
189_M	283_M	0.698	0.92
233_C	236_G	0.696	0.92
285_Y	289_K	0.694	0.92
168_A	184_M	0.694	0.92
216_F	283_M	0.693	0.92
145_A	205_D	0.692	0.92
286_Q	289_K	0.688	0.92
92_Y	95_N	0.684	0.92
89_G	136_V	0.683	0.91
39_N	43_L	0.682	0.91
150_M	247_L	0.679	0.91
333_V	336_G	0.677	0.91
221_A	226_A	0.676	0.91
57_K	123_A	0.676	0.91
281_D	284_A	0.676	0.91
24_V	74_F	0.672	0.91
178_R	182_M	0.671	0.91
53_Y	191_G	0.669	0.91
121_E	125_G	0.669	0.91
240_K	243_I	0.666	0.90
149_G	282_A	0.663	0.90
246_K	250_T	0.661	0.90
93_V	130_S	0.661	0.90
168_A	172_A	0.659	0.90
154_E	231_D	0.657	0.90
284_A	287_V	0.657	0.90
204_V	297_A	0.657	0.90
16_G	21_K	0.656	0.90
283_M	287_V	0.655	0.90
266_E	314_G	0.654	0.90
318_V	337_E	0.654	0.90
39_N	42_E	0.649	0.89
185_I	295_S	0.648	0.89
62_E	65_H	0.648	0.89
230_V	234_F	0.647	0.89
140_E	203_V	0.642	0.89
41_E	46_F	0.642	0.89
311_L	317_F	0.641	0.89
295_S	298_L	0.640	0.89
269_I	272_G	0.640	0.89
230_V	241_E	0.638	0.88
142_S	145_A	0.630	0.88
87_I	97_E	0.629	0.88
307_L	321_I	0.629	0.88
302_V	327_W	0.625	0.87
164_Q	168_A	0.624	0.87
55_F	58_N	0.623	0.87
61_L	65_H	0.622	0.87
54_E	118_I	0.622	0.87
40_I	44_Q	0.621	0.87
298_L	302_V	0.621	0.87
280_Y	316_S	0.619	0.87
91_T	133_V	0.617	0.87
205_D	285_Y	0.615	0.87
204_V	298_L	0.613	0.86
296_A	324_Y	0.613	0.86
233_C	238_Y	0.613	0.86
256_Y	275_K	0.612	0.86
12_T	123_A	0.611	0.86
179_Y	198_H	0.611	0.86
332_L	337_E	0.609	0.86
257_L	279_I	0.604	0.86
296_A	300_G	0.604	0.86
163_N	308_T	0.603	0.86
269_I	320_A	0.602	0.85
266_E	269_I	0.600	0.85
183_K	298_L	0.599	0.85
141_M	145_A	0.598	0.85
63_T	67_Q	0.597	0.85
32_F	36_L	0.597	0.85
184_M	198_H	0.595	0.85
93_V	96_D	0.595	0.85
122_I	125_G	0.595	0.85
288_A	297_A	0.595	0.85
177_K	303_E	0.595	0.85
31_I	46_F	0.595	0.85
242_E	245_K	0.595	0.85
185_I	298_L	0.594	0.85
314_G	340_L	0.594	0.85
101_D	105_G	0.593	0.85
326_D	331_V	0.593	0.85
295_S	301_E	0.593	0.85
19_S	191_G	0.593	0.85
93_V	129_P	0.592	0.84
148_S	209_G	0.591	0.84
150_M	232_L	0.591	0.84
256_Y	279_I	0.591	0.84
316_S	319_S	0.590	0.84
234_F	240_K	0.590	0.84
167_V	171_A	0.588	0.84
31_I	35_T	0.586	0.84
103_K	117_I	0.586	0.84
292_G	297_A	0.583	0.84
243_I	246_K	0.583	0.84
13_I	22_I	0.583	0.84
34_K	66_E	0.581	0.83
138_V	141_M	0.581	0.83
15_P	79_A	0.579	0.83
338_N	341_Q	0.579	0.83
232_L	238_Y	0.579	0.83
323_S	326_D	0.579	0.83
253_L	265_V	0.577	0.83
116_G	227_G	0.574	0.83
17_S	21_K	0.571	0.82
141_M	155_R	0.570	0.82
302_V	328_I	0.570	0.82
149_G	213_E	0.570	0.82
79_A	119_A	0.569	0.82
269_I	276_A	0.568	0.82
262_A	315_K	0.567	0.82
32_F	49_I	0.566	0.82
59_H	63_T	0.565	0.82
78_C	133_V	0.565	0.82
288_A	321_I	0.562	0.81
122_I	126_L	0.562	0.81
139_D	155_R	0.560	0.81
74_F	127_N	0.560	0.81
180_E	200_R	0.560	0.81
278_F	281_D	0.559	0.81
286_Q	292_G	0.559	0.81
33_E	36_L	0.558	0.81
86_P	105_G	0.557	0.81
172_A	178_R	0.557	0.81
291_I	325_I	0.555	0.81
37_R	44_Q	0.555	0.81
20_T	115_G	0.554	0.80
58_N	125_G	0.551	0.80
80_R	134_D	0.551	0.80
264_K	309_G	0.550	0.80
233_C	237_E	0.550	0.80
105_G	117_I	0.549	0.80
82_G	136_V	0.548	0.80
304_A	332_L	0.548	0.80
15_P	119_A	0.547	0.80
25_F	30_S	0.547	0.80
99_I	120_R	0.547	0.80
168_A	308_T	0.547	0.80
253_L	280_Y	0.547	0.80
170_K	343_L	0.546	0.79
50_I	59_H	0.545	0.79
274_E	278_F	0.544	0.79
291_I	305_I	0.544	0.79
244_M	248_V	0.540	0.79
35_T	38_H	0.540	0.79
288_A	330_D	0.538	0.78
93_V	124_D	0.537	0.78
265_V	280_Y	0.537	0.78
35_T	40_I	0.537	0.78
34_K	67_Q	0.536	0.78
265_V	268_M	0.535	0.78
230_V	243_I	0.535	0.78
115_G	119_A	0.534	0.78
102_L	132_I	0.534	0.78
216_F	286_Q	0.534	0.78
189_M	307_L	0.533	0.78
99_I	103_K	0.530	0.77
238_Y	250_T	0.529	0.77
138_V	196_G	0.529	0.77
77_V	128_I	0.528	0.77
257_L	275_K	0.523	0.77
99_I	102_L	0.522	0.76
137_V	198_H	0.522	0.76
169_R	173_A	0.522	0.76
254_L	259_T	0.521	0.76
221_A	251_G	0.521	0.76
281_D	316_S	0.520	0.76
171_A	304_A	0.520	0.76
285_Y	324_Y	0.519	0.76
259_T	265_V	0.518	0.76
232_L	243_I	0.518	0.76
57_K	61_L	0.517	0.76
149_G	256_Y	0.514	0.75
269_I	317_F	0.513	0.75
12_T	22_I	0.513	0.75
137_V	212_G	0.512	0.75
291_I	321_I	0.511	0.75
119_A	123_A	0.511	0.75
168_A	179_Y	0.510	0.75
257_L	276_A	0.509	0.75
18_T	218_P	0.508	0.74
234_F	243_I	0.507	0.74
80_R	192_G	0.507	0.74
98_M	102_L	0.507	0.74
262_A	265_V	0.506	0.74
169_R	179_Y	0.505	0.74
90_G	165_K	0.505	0.74
119_A	122_I	0.504	0.74
106_Y	114_L	0.504	0.74
291_I	295_S	0.504	0.74
267_Q	270_Q	0.504	0.74
152_E	246_K	0.504	0.74
99_I	106_Y	0.503	0.74
38_H	46_F	0.503	0.74
179_Y	184_M	0.503	0.74
123_A	127_N	0.502	0.74
307_L	312_A	0.502	0.74
31_I	38_H	0.501	0.73
38_H	43_L	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3sk3A	2	0.9559	100	0.115	Contact Map
4h0pA	2	0.9752	100	0.131	Contact Map
4h0oA	6	0.9504	100	0.158	Contact Map
2iirA	2	0.9725	100	0.223	Contact Map
2e1zA	2	0.9669	100	0.23	Contact Map
1g99A	2	0.9669	100	0.23	Contact Map
3khyA	2	0.9532	100	0.284	Contact Map
3r9pA	2	0.9614	100	0.408	Contact Map
1sazA	3	0.9835	100	0.441	Contact Map
4ijnA	2	0.9532	100	0.562	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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