GREMLIN Database
DHLE - Leucine dehydrogenase
UniProt: P54531 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 364 (330)
Sequences: 4925 (2474)
Seq/√Len: 136.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_L197_A4.2051.00
228_S250_Q3.8681.00
178_V189_C3.5971.00
177_A231_C3.3261.00
231_C253_A2.9111.00
271_D275_E2.8121.00
230_D252_K2.7551.00
252_K272_Q2.6551.00
69_N291_V2.6481.00
76_L295_A2.6031.00
205_N208_S2.5721.00
86_D89_K2.5481.00
158_M257_A2.5451.00
175_T198_N2.5141.00
93_E97_R2.4821.00
104_Q129_E2.4541.00
189_C201_V2.4511.00
160_A163_K2.4491.00
160_A314_Y2.4171.00
169_D174_K2.4121.00
245_D268_R2.4111.00
274_H330_P2.3551.00
116_V239_L2.3081.00
157_G286_I2.2511.00
323_I327_D2.2071.00
323_I341_E2.2031.00
164_A325_Q2.1901.00
32_H62_A2.1691.00
119_T122_D2.1631.00
176_I192_L2.1551.00
154_V259_A2.1531.00
330_P333_L2.1141.00
257_A286_I2.0891.00
190_R194_E2.0491.00
264_L273_I2.0271.00
281_A286_I2.0051.00
212_A216_F1.9991.00
159_K195_E1.9981.00
155_Y195_E1.9911.00
341_E345_R1.9891.00
317_I321_L1.9811.00
227_Y234_Y1.9491.00
30_A62_A1.9121.00
211_R215_D1.9121.00
145_N303_A1.9051.00
17_F23_S1.8991.00
161_A255_V1.8971.00
244_N247_T1.8911.00
160_A318_E1.8691.00
171_L197_A1.8561.00
103_I126_I1.8411.00
39_A79_G1.8261.00
124_D137_S1.8251.00
164_A321_L1.8191.00
176_I197_A1.7911.00
322_E326_R1.7901.00
284_Y336_D1.7811.00
71_A285_V1.7631.00
248_I272_Q1.7481.00
305_R309_K1.7451.00
159_K311_E1.7081.00
206_K213_V1.7071.00
36_L73_G1.6941.00
85_G90_D1.6911.00
43_T126_I1.6891.00
139_A345_R1.6641.00
329_I337_R1.6451.00
272_Q276_M1.6161.00
329_I334_A1.5731.00
164_A317_I1.5681.00
206_K210_Q1.5571.00
101_R129_E1.5491.00
54_A57_D1.5341.00
210_Q214_E1.5121.00
208_S211_R1.4561.00
18_C91_K1.4421.00
156_R311_E1.4391.00
243_I251_L1.4311.00
32_H66_T1.4251.00
245_D269_H1.4171.00
184_V259_A1.3911.00
176_I235_A1.3861.00
34_T39_A1.3851.00
161_A281_A1.3771.00
260_A263_Q1.3671.00
188_L235_A1.3651.00
162_A233_I1.3631.00
222_D225_D1.3521.00
270_G332_Y1.3371.00
318_E322_E1.3341.00
285_V320_V1.3251.00
317_I331_A1.3231.00
329_I333_L1.3221.00
156_R307_L1.3191.00
164_A318_E1.2951.00
257_A281_A1.2891.00
162_A171_L1.2791.00
175_T232_D1.2701.00
245_D272_Q1.2681.00
188_L237_C1.2671.00
176_I233_I1.2671.00
154_V257_A1.2651.00
271_D274_H1.2631.00
66_T343_I1.2621.00
120_V147_S1.2581.00
158_M233_I1.2431.00
206_K212_A1.2401.00
234_Y251_L1.2401.00
67_Y284_Y1.2351.00
72_A292_I1.2351.00
208_S212_A1.2351.00
46_W239_L1.2261.00
249_K272_Q1.2231.00
208_S217_G1.2211.00
16_V93_E1.2201.00
139_A349_S1.2061.00
192_L199_L1.2031.00
67_Y343_I1.1991.00
205_N212_A1.1891.00
303_A307_L1.1810.99
177_A229_Q1.1720.99
211_R216_F1.1720.99
256_I273_I1.1710.99
152_Y191_H1.1660.99
205_N215_D1.1580.99
323_I338_L1.1550.99
255_V279_V1.1520.99
27_A102_Y1.1510.99
327_D337_R1.1510.99
46_W51_E1.1510.99
326_R341_E1.1480.99
26_K84_I1.1460.99
92_N121_E1.1450.99
225_D228_S1.1440.99
159_K163_K1.1340.99
272_Q275_E1.1300.99
204_I209_V1.1280.99
85_G98_A1.1270.99
175_T230_D1.1270.99
30_A55_I1.1170.99
165_A254_K1.1130.99
345_R348_R1.1130.99
315_G319_R1.1060.99
181_V201_V1.1060.99
207_Q211_R1.1020.99
118_T123_M1.0950.99
155_Y192_L1.0900.99
273_I278_I1.0880.99
154_V237_C1.0810.99
208_S213_V1.0790.99
46_W52_E1.0790.99
302_N305_R1.0770.99
243_I273_I1.0760.99
234_Y242_T1.0710.99
312_G315_G1.0620.99
96_F100_G1.0570.99
28_I84_I1.0570.99
304_E308_K1.0550.99
177_A200_I1.0410.99
205_N213_V1.0400.99
193_H199_L1.0380.99
152_Y307_L1.0370.99
154_V235_A1.0340.99
158_M235_A1.0300.99
33_D347_R1.0280.99
147_S187_N1.0270.99
221_V229_Q1.0150.98
204_I212_A1.0140.98
189_C199_L1.0140.98
311_E314_Y1.0140.98
248_I269_H1.0130.98
90_D98_A1.0100.98
72_A288_A1.0080.98
245_D249_K1.0080.98
188_L192_L1.0050.98
246_D249_K1.0040.98
81_T99_F1.0020.98
169_D254_K1.0020.98
104_Q131_D1.0000.98
223_P226_I0.9940.98
154_V158_M0.9920.98
213_V217_G0.9910.98
46_W116_V0.9860.98
213_V216_F0.9840.98
187_N190_R0.9840.98
80_K261_N0.9830.98
45_M118_T0.9790.98
123_M133_V0.9770.98
323_I337_R0.9730.98
170_S173_G0.9730.98
36_L70_A0.9720.98
152_Y311_E0.9720.98
340_E343_I0.9680.98
140_F349_S0.9680.98
161_A257_A0.9660.98
201_V209_V0.9580.98
97_R129_E0.9580.98
243_I264_L0.9560.98
243_I256_I0.9530.98
209_V213_V0.9410.97
193_H207_Q0.9310.97
228_S247_T0.9270.97
324_S329_I0.9250.97
45_M99_F0.9210.97
243_I248_I0.9210.97
176_I199_L0.9160.97
164_A322_E0.9040.97
292_I313_I0.9030.97
200_I231_C0.8990.97
175_T200_I0.8980.97
99_F103_I0.8940.97
252_K276_M0.8900.96
43_T112_T0.8900.96
28_I55_I0.8800.96
126_I133_V0.8800.96
157_G320_V0.8760.96
158_M255_V0.8750.96
224_D228_S0.8750.96
154_V188_L0.8690.96
103_I133_V0.8660.96
270_G274_H0.8630.96
213_V220_A0.8610.96
206_K217_G0.8550.95
56_E59_L0.8490.95
35_T343_I0.8480.95
207_Q212_A0.8390.95
40_L291_V0.8380.95
279_V331_A0.8350.95
18_C29_I0.8340.95
101_R104_Q0.8310.95
187_N191_H0.8280.95
165_A255_V0.8250.95
212_A215_D0.8250.95
45_M83_I0.8210.94
123_M126_I0.8190.94
159_K171_L0.8130.94
339_A343_I0.8080.94
137_S140_F0.8060.94
307_L311_E0.8040.94
177_A226_I0.8010.94
235_A257_A0.8010.94
151_A188_L0.8000.94
338_L342_R0.7960.93
143_S301_Y0.7840.93
91_K94_E0.7820.93
134_T294_V0.7800.93
23_S89_K0.7790.93
324_S328_G0.7790.93
123_M140_F0.7760.93
192_L235_A0.7760.93
190_R210_Q0.7740.92
31_I39_A0.7670.92
31_I109_R0.7660.92
212_A217_G0.7630.92
16_V23_S0.7630.92
232_D254_K0.7600.92
291_V294_V0.7580.92
15_L18_C0.7510.91
233_I255_V0.7500.91
314_Y318_E0.7490.91
101_R105_G0.7490.91
249_K275_E0.7490.91
249_K276_M0.7490.91
251_L256_I0.7450.91
157_G281_A0.7440.91
70_A339_A0.7440.91
269_H272_Q0.7430.91
97_R128_D0.7400.91
178_V201_V0.7400.91
345_R349_S0.7380.91
253_A278_I0.7360.90
162_A174_K0.7330.90
114_E146_P0.7330.90
270_G330_P0.7300.90
208_S216_F0.7290.90
323_I334_A0.7290.90
207_Q213_V0.7230.90
189_C216_F0.7230.90
230_D253_A0.7210.90
53_A82_V0.7200.89
189_C206_K0.7190.89
179_Q242_T0.7150.89
211_R214_E0.7130.89
157_G257_A0.7130.89
325_Q328_G0.7110.89
159_K314_Y0.7050.88
165_A279_V0.7050.88
207_Q216_F0.7030.88
323_I326_R0.7030.88
209_V220_A0.7030.88
149_V310_V0.6980.88
43_T99_F0.6970.88
40_L76_L0.6970.88
51_E86_D0.6970.88
59_L62_A0.6940.88
324_S331_A0.6940.88
23_S90_D0.6940.88
17_F21_E0.6940.88
210_Q213_V0.6890.87
52_E57_D0.6870.87
146_P183_N0.6860.87
251_L273_I0.6850.87
243_I283_D0.6840.87
117_G184_V0.6820.87
181_V209_V0.6790.87
143_S293_N0.6780.86
18_C102_Y0.6770.86
256_I278_I0.6720.86
125_I128_D0.6720.86
80_K150_T0.6720.86
327_D341_E0.6710.86
243_I280_Y0.6710.86
73_G315_G0.6710.86
208_S215_D0.6690.86
244_N264_L0.6670.86
192_L233_I0.6660.86
155_Y159_K0.6650.85
45_M85_G0.6650.85
264_L270_G0.6640.85
240_G262_N0.6620.85
17_F25_L0.6620.85
64_G262_N0.6610.85
247_T269_H0.6610.85
191_H307_L0.6580.85
163_K318_E0.6560.85
135_G294_V0.6550.85
264_L269_H0.6550.85
155_Y188_L0.6550.85
222_D226_I0.6540.84
293_N306_A0.6530.84
252_K278_I0.6520.84
267_T270_G0.6510.84
15_L55_I0.6490.84
280_Y283_D0.6450.84
161_A321_L0.6440.84
270_G280_Y0.6440.84
219_R225_D0.6430.83
86_D91_K0.6430.83
202_T227_Y0.6410.83
154_V286_I0.6400.83
218_A222_D0.6400.83
44_R61_L0.6370.83
295_A299_Y0.6370.83
281_A331_A0.6370.83
68_K261_N0.6340.83
340_E344_E0.6330.83
80_K113_A0.6310.82
205_N209_V0.6300.82
224_D246_D0.6280.82
67_Y340_E0.6250.82
163_K314_Y0.6230.82
154_V184_V0.6230.82
171_L176_I0.6180.81
35_T347_R0.6170.81
321_L325_Q0.6170.81
337_R340_E0.6170.81
146_P294_V0.6160.81
225_D247_T0.6140.81
75_N299_Y0.6130.80
220_A223_P0.6110.80
158_M188_L0.6110.80
43_T102_Y0.6110.80
148_P187_N0.6100.80
150_T290_G0.6100.80
103_I129_E0.6090.80
259_A286_I0.6090.80
151_A259_A0.6060.80
72_A313_I0.6060.80
281_A317_I0.6060.80
68_K80_K0.6050.80
34_T79_G0.6050.80
15_L20_D0.6050.80
256_I280_Y0.6040.79
204_I216_F0.6040.79
155_Y191_H0.6030.79
226_I229_Q0.6030.79
36_L342_R0.6030.79
186_Y216_F0.6030.79
60_R262_N0.5990.79
177_A230_D0.5990.79
280_Y332_Y0.5980.79
186_Y190_R0.5980.79
40_L69_N0.5970.79
96_F125_I0.5960.79
151_A184_V0.5940.78
105_G108_G0.5930.78
113_A146_P0.5920.78
118_T149_V0.5890.78
264_L280_Y0.5890.78
161_A279_V0.5850.77
99_F122_D0.5850.77
35_T346_M0.5850.77
76_L298_L0.5840.77
204_I207_Q0.5800.77
65_M80_K0.5790.77
25_L85_G0.5770.76
308_K311_E0.5750.76
237_C259_A0.5750.76
227_Y247_T0.5740.76
162_A255_V0.5730.76
25_L98_A0.5690.75
114_E123_M0.5690.75
206_K209_V0.5680.75
143_S297_E0.5680.75
157_G317_I0.5660.75
105_G129_E0.5650.75
114_E183_N0.5610.74
205_N217_G0.5600.74
138_P144_G0.5580.74
186_Y212_A0.5570.74
81_T102_Y0.5570.74
205_N211_R0.5570.74
207_Q215_D0.5560.74
152_Y190_R0.5550.74
227_Y242_T0.5540.73
219_R222_D0.5530.73
324_S327_D0.5530.73
40_L294_V0.5530.73
294_V297_E0.5520.73
30_A79_G0.5520.73
200_I229_Q0.5510.73
63_R67_Y0.5510.73
205_N216_F0.5510.73
235_A259_A0.5500.73
65_M261_N0.5500.73
302_N312_G0.5490.73
32_H63_R0.5490.73
270_G273_I0.5460.72
27_A43_T0.5460.72
202_T223_P0.5460.72
149_V293_N0.5440.72
202_T226_I0.5410.72
158_M259_A0.5400.72
321_L331_A0.5400.72
315_G318_E0.5390.71
191_H195_E0.5390.71
332_Y336_D0.5390.71
150_T183_N0.5390.71
221_V225_D0.5380.71
104_Q132_Y0.5380.71
165_A169_D0.5370.71
184_V287_N0.5370.71
114_E294_V0.5360.71
161_A317_I0.5360.71
28_I58_A0.5360.71
204_I213_V0.5360.71
188_L259_A0.5340.71
211_R217_G0.5330.71
189_C193_H0.5320.70
199_L206_K0.5320.70
323_I333_L0.5320.70
62_A66_T0.5320.70
156_R314_Y0.5300.70
99_F126_I0.5290.70
121_E124_D0.5270.70
100_G128_D0.5270.70
207_Q210_Q0.5270.70
113_A134_T0.5260.70
234_Y256_I0.5260.70
309_K312_G0.5260.70
58_A62_A0.5260.70
16_V22_Q0.5250.69
143_S300_G0.5240.69
248_I273_I0.5240.69
72_A316_N0.5240.69
246_D250_Q0.5230.69
186_Y215_D0.5220.69
53_A57_D0.5210.69
85_G91_K0.5200.69
114_E293_N0.5150.68
150_T153_G0.5140.68
273_I280_Y0.5120.68
113_A135_G0.5120.68
193_H206_K0.5120.68
95_M99_F0.5110.67
155_Y158_M0.5100.67
71_A319_R0.5090.67
181_V186_Y0.5080.67
178_V192_L0.5070.67
198_N219_R0.5070.67
21_E24_G0.5070.67
193_H216_F0.5070.67
149_V183_N0.5050.66
30_A59_L0.5050.66
321_L324_S0.5050.66
40_L134_T0.5040.66
46_W53_A0.5020.66
243_I249_K0.5020.66
341_E348_R0.5010.66
81_T110_Y0.5010.66
186_Y210_Q0.5010.66
17_F28_I0.5010.66
81_T112_T0.5010.66
92_N95_M0.5000.66
34_T350_R0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xgiA 6 0.9533 100 0.187 Contact Map
2yfqA 5 0.9066 100 0.188 Contact Map
3aoeE 3 0.9533 100 0.199 Contact Map
2tmgA 5 0.9423 100 0.2 Contact Map
3aogA 8 0.9533 100 0.205 Contact Map
1v9lA 4 0.9505 100 0.207 Contact Map
1bgvA 5 0.9533 100 0.211 Contact Map
3mw9A 5 0.9588 100 0.212 Contact Map
3k92A 5 0.9505 100 0.213 Contact Map
4fccA 5 0.9505 100 0.214 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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