DHLE - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DHLE - Leucine dehydrogenase

UniProt:	P54531	Sequences: MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTRMWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRYIQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKAAAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGARAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEMGIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLAADRLAEERIERMRRSRSQFLQNGHSVLSRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	364 (330)
Sequences:	4925 (2474)
Seq/√Len:	136.2

ECOLI - DHE4
BACSU - DHLE DHE2 GUDB
HALSA - DHE4 DHEB DHE
SULSO - Q97WS2 DHE2 Q97X22 Q97Y81

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
192_L	197_A	4.205	1.00
228_S	250_Q	3.868	1.00
178_V	189_C	3.597	1.00
177_A	231_C	3.326	1.00
231_C	253_A	2.911	1.00
271_D	275_E	2.812	1.00
230_D	252_K	2.755	1.00
252_K	272_Q	2.655	1.00
69_N	291_V	2.648	1.00
76_L	295_A	2.603	1.00
205_N	208_S	2.572	1.00
86_D	89_K	2.548	1.00
158_M	257_A	2.545	1.00
175_T	198_N	2.514	1.00
93_E	97_R	2.482	1.00
104_Q	129_E	2.454	1.00
189_C	201_V	2.451	1.00
160_A	163_K	2.449	1.00
160_A	314_Y	2.417	1.00
169_D	174_K	2.412	1.00
245_D	268_R	2.411	1.00
274_H	330_P	2.355	1.00
116_V	239_L	2.308	1.00
157_G	286_I	2.251	1.00
323_I	327_D	2.207	1.00
323_I	341_E	2.203	1.00
164_A	325_Q	2.190	1.00
32_H	62_A	2.169	1.00
119_T	122_D	2.163	1.00
176_I	192_L	2.155	1.00
154_V	259_A	2.153	1.00
330_P	333_L	2.114	1.00
257_A	286_I	2.089	1.00
190_R	194_E	2.049	1.00
264_L	273_I	2.027	1.00
281_A	286_I	2.005	1.00
212_A	216_F	1.999	1.00
159_K	195_E	1.998	1.00
155_Y	195_E	1.991	1.00
341_E	345_R	1.989	1.00
317_I	321_L	1.981	1.00
227_Y	234_Y	1.949	1.00
30_A	62_A	1.912	1.00
211_R	215_D	1.912	1.00
145_N	303_A	1.905	1.00
17_F	23_S	1.899	1.00
161_A	255_V	1.897	1.00
244_N	247_T	1.891	1.00
160_A	318_E	1.869	1.00
171_L	197_A	1.856	1.00
103_I	126_I	1.841	1.00
39_A	79_G	1.826	1.00
124_D	137_S	1.825	1.00
164_A	321_L	1.819	1.00
176_I	197_A	1.791	1.00
322_E	326_R	1.790	1.00
284_Y	336_D	1.781	1.00
71_A	285_V	1.763	1.00
248_I	272_Q	1.748	1.00
305_R	309_K	1.745	1.00
159_K	311_E	1.708	1.00
206_K	213_V	1.707	1.00
36_L	73_G	1.694	1.00
85_G	90_D	1.691	1.00
43_T	126_I	1.689	1.00
139_A	345_R	1.664	1.00
329_I	337_R	1.645	1.00
272_Q	276_M	1.616	1.00
329_I	334_A	1.573	1.00
164_A	317_I	1.568	1.00
206_K	210_Q	1.557	1.00
101_R	129_E	1.549	1.00
54_A	57_D	1.534	1.00
210_Q	214_E	1.512	1.00
208_S	211_R	1.456	1.00
18_C	91_K	1.442	1.00
156_R	311_E	1.439	1.00
243_I	251_L	1.431	1.00
32_H	66_T	1.425	1.00
245_D	269_H	1.417	1.00
184_V	259_A	1.391	1.00
176_I	235_A	1.386	1.00
34_T	39_A	1.385	1.00
161_A	281_A	1.377	1.00
260_A	263_Q	1.367	1.00
188_L	235_A	1.365	1.00
162_A	233_I	1.363	1.00
222_D	225_D	1.352	1.00
270_G	332_Y	1.337	1.00
318_E	322_E	1.334	1.00
285_V	320_V	1.325	1.00
317_I	331_A	1.323	1.00
329_I	333_L	1.322	1.00
156_R	307_L	1.319	1.00
164_A	318_E	1.295	1.00
257_A	281_A	1.289	1.00
162_A	171_L	1.279	1.00
175_T	232_D	1.270	1.00
245_D	272_Q	1.268	1.00
188_L	237_C	1.267	1.00
176_I	233_I	1.267	1.00
154_V	257_A	1.265	1.00
271_D	274_H	1.263	1.00
66_T	343_I	1.262	1.00
120_V	147_S	1.258	1.00
158_M	233_I	1.243	1.00
206_K	212_A	1.240	1.00
234_Y	251_L	1.240	1.00
67_Y	284_Y	1.235	1.00
72_A	292_I	1.235	1.00
208_S	212_A	1.235	1.00
46_W	239_L	1.226	1.00
249_K	272_Q	1.223	1.00
208_S	217_G	1.221	1.00
16_V	93_E	1.220	1.00
139_A	349_S	1.206	1.00
192_L	199_L	1.203	1.00
67_Y	343_I	1.199	1.00
205_N	212_A	1.189	1.00
303_A	307_L	1.181	0.99
177_A	229_Q	1.172	0.99
211_R	216_F	1.172	0.99
256_I	273_I	1.171	0.99
152_Y	191_H	1.166	0.99
205_N	215_D	1.158	0.99
323_I	338_L	1.155	0.99
255_V	279_V	1.152	0.99
27_A	102_Y	1.151	0.99
327_D	337_R	1.151	0.99
46_W	51_E	1.151	0.99
326_R	341_E	1.148	0.99
26_K	84_I	1.146	0.99
92_N	121_E	1.145	0.99
225_D	228_S	1.144	0.99
159_K	163_K	1.134	0.99
272_Q	275_E	1.130	0.99
204_I	209_V	1.128	0.99
85_G	98_A	1.127	0.99
175_T	230_D	1.127	0.99
30_A	55_I	1.117	0.99
165_A	254_K	1.113	0.99
345_R	348_R	1.113	0.99
315_G	319_R	1.106	0.99
181_V	201_V	1.106	0.99
207_Q	211_R	1.102	0.99
118_T	123_M	1.095	0.99
155_Y	192_L	1.090	0.99
273_I	278_I	1.088	0.99
154_V	237_C	1.081	0.99
208_S	213_V	1.079	0.99
46_W	52_E	1.079	0.99
302_N	305_R	1.077	0.99
243_I	273_I	1.076	0.99
234_Y	242_T	1.071	0.99
312_G	315_G	1.062	0.99
96_F	100_G	1.057	0.99
28_I	84_I	1.057	0.99
304_E	308_K	1.055	0.99
177_A	200_I	1.041	0.99
205_N	213_V	1.040	0.99
193_H	199_L	1.038	0.99
152_Y	307_L	1.037	0.99
154_V	235_A	1.034	0.99
158_M	235_A	1.030	0.99
33_D	347_R	1.028	0.99
147_S	187_N	1.027	0.99
221_V	229_Q	1.015	0.98
204_I	212_A	1.014	0.98
189_C	199_L	1.014	0.98
311_E	314_Y	1.014	0.98
248_I	269_H	1.013	0.98
90_D	98_A	1.010	0.98
72_A	288_A	1.008	0.98
245_D	249_K	1.008	0.98
188_L	192_L	1.005	0.98
246_D	249_K	1.004	0.98
81_T	99_F	1.002	0.98
169_D	254_K	1.002	0.98
104_Q	131_D	1.000	0.98
223_P	226_I	0.994	0.98
154_V	158_M	0.992	0.98
213_V	217_G	0.991	0.98
46_W	116_V	0.986	0.98
213_V	216_F	0.984	0.98
187_N	190_R	0.984	0.98
80_K	261_N	0.983	0.98
45_M	118_T	0.979	0.98
123_M	133_V	0.977	0.98
323_I	337_R	0.973	0.98
170_S	173_G	0.973	0.98
36_L	70_A	0.972	0.98
152_Y	311_E	0.972	0.98
340_E	343_I	0.968	0.98
140_F	349_S	0.968	0.98
161_A	257_A	0.966	0.98
201_V	209_V	0.958	0.98
97_R	129_E	0.958	0.98
243_I	264_L	0.956	0.98
243_I	256_I	0.953	0.98
209_V	213_V	0.941	0.97
193_H	207_Q	0.931	0.97
228_S	247_T	0.927	0.97
324_S	329_I	0.925	0.97
45_M	99_F	0.921	0.97
243_I	248_I	0.921	0.97
176_I	199_L	0.916	0.97
164_A	322_E	0.904	0.97
292_I	313_I	0.903	0.97
200_I	231_C	0.899	0.97
175_T	200_I	0.898	0.97
99_F	103_I	0.894	0.97
252_K	276_M	0.890	0.96
43_T	112_T	0.890	0.96
28_I	55_I	0.880	0.96
126_I	133_V	0.880	0.96
157_G	320_V	0.876	0.96
158_M	255_V	0.875	0.96
224_D	228_S	0.875	0.96
154_V	188_L	0.869	0.96
103_I	133_V	0.866	0.96
270_G	274_H	0.863	0.96
213_V	220_A	0.861	0.96
206_K	217_G	0.855	0.95
56_E	59_L	0.849	0.95
35_T	343_I	0.848	0.95
207_Q	212_A	0.839	0.95
40_L	291_V	0.838	0.95
279_V	331_A	0.835	0.95
18_C	29_I	0.834	0.95
101_R	104_Q	0.831	0.95
187_N	191_H	0.828	0.95
165_A	255_V	0.825	0.95
212_A	215_D	0.825	0.95
45_M	83_I	0.821	0.94
123_M	126_I	0.819	0.94
159_K	171_L	0.813	0.94
339_A	343_I	0.808	0.94
137_S	140_F	0.806	0.94
307_L	311_E	0.804	0.94
177_A	226_I	0.801	0.94
235_A	257_A	0.801	0.94
151_A	188_L	0.800	0.94
338_L	342_R	0.796	0.93
143_S	301_Y	0.784	0.93
91_K	94_E	0.782	0.93
134_T	294_V	0.780	0.93
23_S	89_K	0.779	0.93
324_S	328_G	0.779	0.93
123_M	140_F	0.776	0.93
192_L	235_A	0.776	0.93
190_R	210_Q	0.774	0.92
31_I	39_A	0.767	0.92
31_I	109_R	0.766	0.92
212_A	217_G	0.763	0.92
16_V	23_S	0.763	0.92
232_D	254_K	0.760	0.92
291_V	294_V	0.758	0.92
15_L	18_C	0.751	0.91
233_I	255_V	0.750	0.91
314_Y	318_E	0.749	0.91
101_R	105_G	0.749	0.91
249_K	275_E	0.749	0.91
249_K	276_M	0.749	0.91
251_L	256_I	0.745	0.91
157_G	281_A	0.744	0.91
70_A	339_A	0.744	0.91
269_H	272_Q	0.743	0.91
97_R	128_D	0.740	0.91
178_V	201_V	0.740	0.91
345_R	349_S	0.738	0.91
253_A	278_I	0.736	0.90
162_A	174_K	0.733	0.90
114_E	146_P	0.733	0.90
270_G	330_P	0.730	0.90
208_S	216_F	0.729	0.90
323_I	334_A	0.729	0.90
207_Q	213_V	0.723	0.90
189_C	216_F	0.723	0.90
230_D	253_A	0.721	0.90
53_A	82_V	0.720	0.89
189_C	206_K	0.719	0.89
179_Q	242_T	0.715	0.89
211_R	214_E	0.713	0.89
157_G	257_A	0.713	0.89
325_Q	328_G	0.711	0.89
159_K	314_Y	0.705	0.88
165_A	279_V	0.705	0.88
207_Q	216_F	0.703	0.88
323_I	326_R	0.703	0.88
209_V	220_A	0.703	0.88
149_V	310_V	0.698	0.88
43_T	99_F	0.697	0.88
40_L	76_L	0.697	0.88
51_E	86_D	0.697	0.88
59_L	62_A	0.694	0.88
324_S	331_A	0.694	0.88
23_S	90_D	0.694	0.88
17_F	21_E	0.694	0.88
210_Q	213_V	0.689	0.87
52_E	57_D	0.687	0.87
146_P	183_N	0.686	0.87
251_L	273_I	0.685	0.87
243_I	283_D	0.684	0.87
117_G	184_V	0.682	0.87
181_V	209_V	0.679	0.87
143_S	293_N	0.678	0.86
18_C	102_Y	0.677	0.86
256_I	278_I	0.672	0.86
125_I	128_D	0.672	0.86
80_K	150_T	0.672	0.86
327_D	341_E	0.671	0.86
243_I	280_Y	0.671	0.86
73_G	315_G	0.671	0.86
208_S	215_D	0.669	0.86
244_N	264_L	0.667	0.86
192_L	233_I	0.666	0.86
155_Y	159_K	0.665	0.85
45_M	85_G	0.665	0.85
264_L	270_G	0.664	0.85
240_G	262_N	0.662	0.85
17_F	25_L	0.662	0.85
64_G	262_N	0.661	0.85
247_T	269_H	0.661	0.85
191_H	307_L	0.658	0.85
163_K	318_E	0.656	0.85
135_G	294_V	0.655	0.85
264_L	269_H	0.655	0.85
155_Y	188_L	0.655	0.85
222_D	226_I	0.654	0.84
293_N	306_A	0.653	0.84
252_K	278_I	0.652	0.84
267_T	270_G	0.651	0.84
15_L	55_I	0.649	0.84
280_Y	283_D	0.645	0.84
161_A	321_L	0.644	0.84
270_G	280_Y	0.644	0.84
219_R	225_D	0.643	0.83
86_D	91_K	0.643	0.83
202_T	227_Y	0.641	0.83
154_V	286_I	0.640	0.83
218_A	222_D	0.640	0.83
44_R	61_L	0.637	0.83
295_A	299_Y	0.637	0.83
281_A	331_A	0.637	0.83
68_K	261_N	0.634	0.83
340_E	344_E	0.633	0.83
80_K	113_A	0.631	0.82
205_N	209_V	0.630	0.82
224_D	246_D	0.628	0.82
67_Y	340_E	0.625	0.82
163_K	314_Y	0.623	0.82
154_V	184_V	0.623	0.82
171_L	176_I	0.618	0.81
35_T	347_R	0.617	0.81
321_L	325_Q	0.617	0.81
337_R	340_E	0.617	0.81
146_P	294_V	0.616	0.81
225_D	247_T	0.614	0.81
75_N	299_Y	0.613	0.80
220_A	223_P	0.611	0.80
158_M	188_L	0.611	0.80
43_T	102_Y	0.611	0.80
148_P	187_N	0.610	0.80
150_T	290_G	0.610	0.80
103_I	129_E	0.609	0.80
259_A	286_I	0.609	0.80
151_A	259_A	0.606	0.80
72_A	313_I	0.606	0.80
281_A	317_I	0.606	0.80
68_K	80_K	0.605	0.80
34_T	79_G	0.605	0.80
15_L	20_D	0.605	0.80
256_I	280_Y	0.604	0.79
204_I	216_F	0.604	0.79
155_Y	191_H	0.603	0.79
226_I	229_Q	0.603	0.79
36_L	342_R	0.603	0.79
186_Y	216_F	0.603	0.79
60_R	262_N	0.599	0.79
177_A	230_D	0.599	0.79
280_Y	332_Y	0.598	0.79
186_Y	190_R	0.598	0.79
40_L	69_N	0.597	0.79
96_F	125_I	0.596	0.79
151_A	184_V	0.594	0.78
105_G	108_G	0.593	0.78
113_A	146_P	0.592	0.78
118_T	149_V	0.589	0.78
264_L	280_Y	0.589	0.78
161_A	279_V	0.585	0.77
99_F	122_D	0.585	0.77
35_T	346_M	0.585	0.77
76_L	298_L	0.584	0.77
204_I	207_Q	0.580	0.77
65_M	80_K	0.579	0.77
25_L	85_G	0.577	0.76
308_K	311_E	0.575	0.76
237_C	259_A	0.575	0.76
227_Y	247_T	0.574	0.76
162_A	255_V	0.573	0.76
25_L	98_A	0.569	0.75
114_E	123_M	0.569	0.75
206_K	209_V	0.568	0.75
143_S	297_E	0.568	0.75
157_G	317_I	0.566	0.75
105_G	129_E	0.565	0.75
114_E	183_N	0.561	0.74
205_N	217_G	0.560	0.74
138_P	144_G	0.558	0.74
186_Y	212_A	0.557	0.74
81_T	102_Y	0.557	0.74
205_N	211_R	0.557	0.74
207_Q	215_D	0.556	0.74
152_Y	190_R	0.555	0.74
227_Y	242_T	0.554	0.73
219_R	222_D	0.553	0.73
324_S	327_D	0.553	0.73
40_L	294_V	0.553	0.73
294_V	297_E	0.552	0.73
30_A	79_G	0.552	0.73
200_I	229_Q	0.551	0.73
63_R	67_Y	0.551	0.73
205_N	216_F	0.551	0.73
235_A	259_A	0.550	0.73
65_M	261_N	0.550	0.73
302_N	312_G	0.549	0.73
32_H	63_R	0.549	0.73
270_G	273_I	0.546	0.72
27_A	43_T	0.546	0.72
202_T	223_P	0.546	0.72
149_V	293_N	0.544	0.72
202_T	226_I	0.541	0.72
158_M	259_A	0.540	0.72
321_L	331_A	0.540	0.72
315_G	318_E	0.539	0.71
191_H	195_E	0.539	0.71
332_Y	336_D	0.539	0.71
150_T	183_N	0.539	0.71
221_V	225_D	0.538	0.71
104_Q	132_Y	0.538	0.71
165_A	169_D	0.537	0.71
184_V	287_N	0.537	0.71
114_E	294_V	0.536	0.71
161_A	317_I	0.536	0.71
28_I	58_A	0.536	0.71
204_I	213_V	0.536	0.71
188_L	259_A	0.534	0.71
211_R	217_G	0.533	0.71
189_C	193_H	0.532	0.70
199_L	206_K	0.532	0.70
323_I	333_L	0.532	0.70
62_A	66_T	0.532	0.70
156_R	314_Y	0.530	0.70
99_F	126_I	0.529	0.70
121_E	124_D	0.527	0.70
100_G	128_D	0.527	0.70
207_Q	210_Q	0.527	0.70
113_A	134_T	0.526	0.70
234_Y	256_I	0.526	0.70
309_K	312_G	0.526	0.70
58_A	62_A	0.526	0.70
16_V	22_Q	0.525	0.69
143_S	300_G	0.524	0.69
248_I	273_I	0.524	0.69
72_A	316_N	0.524	0.69
246_D	250_Q	0.523	0.69
186_Y	215_D	0.522	0.69
53_A	57_D	0.521	0.69
85_G	91_K	0.520	0.69
114_E	293_N	0.515	0.68
150_T	153_G	0.514	0.68
273_I	280_Y	0.512	0.68
113_A	135_G	0.512	0.68
193_H	206_K	0.512	0.68
95_M	99_F	0.511	0.67
155_Y	158_M	0.510	0.67
71_A	319_R	0.509	0.67
181_V	186_Y	0.508	0.67
178_V	192_L	0.507	0.67
198_N	219_R	0.507	0.67
21_E	24_G	0.507	0.67
193_H	216_F	0.507	0.67
149_V	183_N	0.505	0.66
30_A	59_L	0.505	0.66
321_L	324_S	0.505	0.66
40_L	134_T	0.504	0.66
46_W	53_A	0.502	0.66
243_I	249_K	0.502	0.66
341_E	348_R	0.501	0.66
81_T	110_Y	0.501	0.66
186_Y	210_Q	0.501	0.66
17_F	28_I	0.501	0.66
81_T	112_T	0.501	0.66
92_N	95_M	0.500	0.66
34_T	350_R	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4xgiA	6	0.9533	100	0.187	Contact Map
2yfqA	5	0.9066	100	0.188	Contact Map
3aoeE	3	0.9533	100	0.199	Contact Map
2tmgA	5	0.9423	100	0.2	Contact Map
3aogA	8	0.9533	100	0.205	Contact Map
1v9lA	4	0.9505	100	0.207	Contact Map
1bgvA	5	0.9533	100	0.211	Contact Map
3mw9A	5	0.9588	100	0.212	Contact Map
3k92A	5	0.9505	100	0.213	Contact Map
4fccA	5	0.9505	100	0.214	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0112 seconds.