GREMLIN Database
PTB - Probable phosphate butyryltransferase
UniProt: P54530 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (287)
Sequences: 4109 (2389)
Seq/√Len: 141.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_S148_E4.9721.00
49_S53_N4.4111.00
17_T42_R3.4281.00
136_T238_L3.2331.00
196_Y206_V3.0841.00
18_I90_V3.0491.00
191_A194_Q2.9901.00
83_V88_A2.8811.00
44_L88_A2.6571.00
15_N42_R2.4961.00
47_G52_L2.3251.00
82_A87_T2.2971.00
169_K233_N2.2721.00
244_A247_I2.2681.00
34_L284_L2.2641.00
35_A287_I2.2611.00
218_Q222_A2.2521.00
49_S68_H2.1771.00
173_L247_I2.0441.00
146_L191_A2.0021.00
33_K37_E1.9831.00
17_T44_L1.9711.00
20_V287_I1.9291.00
194_Q199_G1.9221.00
36_A64_V1.9011.00
26_E30_R1.8701.00
194_Q197_K1.8671.00
154_Q201_I1.8641.00
56_T61_G1.8511.00
48_D68_H1.8361.00
24_E51_K1.8211.00
90_V290_A1.8191.00
197_K206_V1.8121.00
207_D228_G1.7991.00
46_T82_A1.7791.00
134_F160_A1.7091.00
19_A88_A1.6991.00
147_E195_M1.6961.00
35_A41_A1.6591.00
205_I229_D1.6391.00
65_E87_T1.6241.00
248_L251_S1.6231.00
154_Q200_Q1.5881.00
42_R65_E1.5821.00
26_E55_L1.5721.00
157_V204_C1.5691.00
135_V252_L1.5561.00
172_A206_V1.5531.00
143_A188_N1.5461.00
102_L140_M1.5331.00
121_V134_F1.5201.00
53_N57_S1.5171.00
153_L238_L1.5081.00
150_R195_M1.5011.00
23_A45_L1.4961.00
81_R85_H1.4921.00
241_T244_A1.4891.00
197_K229_D1.4811.00
44_L65_E1.4791.00
17_T89_D1.4781.00
159_V265_T1.4691.00
174_A185_A1.4481.00
218_Q233_N1.4291.00
195_M200_Q1.4271.00
217_S254_Y1.4231.00
17_T65_E1.4191.00
175_A183_M1.4131.00
61_G64_V1.4081.00
126_I258_A1.4031.00
158_H201_I1.4011.00
33_K59_M1.3931.00
109_Q271_I1.3711.00
78_L81_R1.3661.00
26_E58_S1.3661.00
187_V190_A1.3661.00
34_L38_H1.3601.00
190_A194_Q1.3571.00
207_D229_D1.3551.00
196_Y204_C1.3541.00
143_A185_A1.3451.00
207_D210_L1.3371.00
212_L251_S1.3311.00
79_A91_L1.3311.00
117_V148_E1.3301.00
172_A193_A1.3221.00
212_L216_V1.3221.00
54_E58_S1.3181.00
52_L66_I1.3161.00
55_L58_S1.3111.00
93_K101_L1.3081.00
259_S281_E1.3051.00
160_A236_I1.3031.00
143_A184_E1.2971.00
169_K205_I1.2961.00
48_D51_K1.2831.00
56_T59_M1.2791.00
216_V237_L1.2731.00
193_A197_K1.2721.00
136_T156_A1.2651.00
124_F260_V1.2631.00
6_L10_A1.2591.00
160_A165_N1.2481.00
239_V245_G1.2421.00
171_A215_A1.2391.00
147_E191_A1.2381.00
33_K64_V1.2341.00
121_V159_V1.2321.00
15_N39_L1.2251.00
18_I287_I1.2191.00
116_S151_Q1.2131.00
92_M286_S1.1911.00
153_L170_A1.1901.00
105_V271_I1.1791.00
151_Q200_Q1.1791.00
34_L37_E1.1771.00
239_V248_L1.1761.00
171_A234_A1.1661.00
131_R233_N1.1661.00
135_V239_V1.1620.99
149_L189_A1.1530.99
174_A183_M1.1450.99
172_A196_Y1.1420.99
144_P152_I1.1320.99
30_R280_A1.1310.99
272_A290_A1.1210.99
123_V134_F1.1200.99
60_Q63_Q1.1180.99
86_K269_A1.1130.99
21_A79_A1.1120.99
278_D282_N1.1090.99
46_T67_V1.0910.99
140_M264_I1.0890.99
48_D70_N1.0850.99
19_A83_V1.0820.99
201_I204_C1.0720.99
122_A138_S1.0650.99
25_D28_V1.0580.99
51_K54_E1.0560.99
16_K89_D1.0520.99
154_Q196_Y1.0490.99
112_L158_H1.0430.99
76_A93_K1.0420.99
187_V191_A1.0410.99
150_R154_Q1.0320.99
69_A75_S1.0300.99
185_A243_E1.0160.99
70_N73_E1.0120.99
221_A231_A1.0110.99
214_N220_A1.0100.99
158_H161_H1.0060.99
105_V267_A1.0020.98
76_A96_V0.9890.98
19_A82_A0.9860.98
125_D259_S0.9860.98
29_I59_M0.9820.98
219_I222_A0.9800.98
84_H269_A0.9770.98
130_D233_N0.9720.98
46_T79_A0.9710.98
252_L256_A0.9590.98
175_A243_E0.9570.98
195_M199_G0.9550.98
161_H203_G0.9540.98
72_P78_L0.9540.98
19_A46_T0.9540.98
6_L9_K0.9490.98
212_L237_L0.9470.98
153_L172_A0.9460.98
146_L193_A0.9460.98
118_L267_A0.9410.98
8_G11_S0.9380.98
35_A284_L0.9350.98
179_V209_P0.9280.97
100_V103_K0.9190.97
193_A206_V0.9180.97
138_S249_Y0.9150.97
161_H168_P0.9150.97
35_A40_S0.9130.97
69_A74_E0.9100.97
50_K54_E0.9080.97
8_G12_I0.9040.97
34_L281_E0.9010.97
17_T43_F0.8960.97
157_V170_A0.8950.97
161_H166_N0.8940.97
25_D96_V0.8930.97
67_V82_A0.8920.97
149_L192_L0.8920.97
15_N291_I0.8910.97
184_E187_V0.8900.97
117_V141_N0.8890.97
83_V269_A0.8830.97
244_A248_L0.8830.97
117_V151_Q0.8730.96
50_K53_N0.8720.96
284_L288_A0.8700.96
49_S71_T0.8700.96
119_S152_I0.8680.96
172_A189_A0.8540.96
30_R59_M0.8520.96
219_I223_Q0.8490.96
149_L152_I0.8490.96
184_E188_N0.8490.96
214_N226_I0.8470.96
38_H284_L0.8440.96
16_K294_S0.8420.96
178_T210_L0.8400.96
126_I131_R0.8350.95
146_L188_N0.8320.95
93_K97_P0.8280.95
77_K107_N0.8270.95
41_A287_I0.8240.95
181_P186_T0.8190.95
142_I183_M0.8180.95
160_A164_G0.8180.95
222_A227_S0.8170.95
120_H139_A0.8170.95
7_I10_A0.8170.95
120_H138_S0.8140.95
261_A285_Y0.8070.94
205_I231_A0.8070.94
121_V160_A0.8060.94
20_V32_V0.8060.94
126_I256_A0.8060.94
141_N152_I0.8050.94
183_M186_T0.8030.94
46_T78_L0.7960.94
4_K8_G0.7950.94
106_L118_L0.7950.94
221_A230_V0.7940.94
230_V233_N0.7920.94
149_L188_N0.7850.94
29_I52_L0.7820.93
19_A79_A0.7810.93
82_A85_H0.7770.93
211_A214_N0.7730.93
36_A63_Q0.7710.93
210_L225_K0.7700.93
54_E57_S0.7700.93
5_D9_K0.7690.93
20_V35_A0.7690.93
131_R235_D0.7670.93
228_G231_A0.7660.93
136_T236_I0.7650.93
237_L251_S0.7640.93
104_A107_N0.7630.93
97_P100_V0.7630.93
104_A110_E0.7620.93
161_H204_C0.7620.93
36_A42_R0.7620.93
182_K187_V0.7610.92
212_L255_F0.7570.92
116_S147_E0.7530.92
274_T283_K0.7530.92
68_H71_T0.7530.92
224_K275_S0.7500.92
170_A236_I0.7500.92
115_A155_N0.7440.92
20_V92_M0.7430.92
84_H108_R0.7420.92
249_Y260_V0.7410.91
121_V265_T0.7410.91
147_E200_Q0.7400.91
96_V223_Q0.7370.91
121_V136_T0.7360.91
103_K106_L0.7360.91
84_H268_K0.7320.91
103_K107_N0.7300.91
90_V291_I0.7290.91
99_S103_K0.7260.91
156_A236_I0.7250.91
90_V272_A0.7240.91
196_Y201_I0.7200.90
34_L280_A0.7190.90
9_K12_I0.7180.90
24_E48_D0.7160.90
18_I41_A0.7160.90
123_V289_L0.7140.90
18_I272_A0.7130.90
84_H110_E0.7070.89
30_R34_L0.7030.89
101_L105_V0.7030.89
133_M255_F0.7010.89
33_K36_A0.6990.89
272_A287_I0.6990.89
152_I155_N0.6960.89
139_A249_Y0.6950.89
74_E100_V0.6920.88
250_K276_R0.6910.88
122_A260_V0.6900.88
124_F135_V0.6880.88
153_L206_V0.6880.88
29_I55_L0.6870.88
169_K234_A0.6870.88
148_E151_Q0.6840.88
238_L245_G0.6830.88
172_A238_L0.6830.88
11_S38_H0.6820.88
178_T225_K0.6810.88
124_F249_Y0.6790.88
50_K70_N0.6750.87
185_A241_T0.6730.87
112_L268_K0.6720.87
48_D52_L0.6670.87
117_V152_I0.6650.86
98_T275_S0.6610.86
80_V91_L0.6590.86
76_A91_L0.6590.86
263_V286_S0.6530.85
53_N66_I0.6520.85
221_A232_G0.6510.85
67_V72_P0.6500.85
207_D230_V0.6470.85
154_Q202_K0.6470.85
77_K81_R0.6440.85
242_I246_N0.6430.85
59_M64_V0.6410.84
23_A29_I0.6400.84
32_V36_A0.6400.84
107_N110_E0.6390.84
207_D225_K0.6390.84
36_A43_F0.6360.84
5_D8_G0.6340.84
133_M216_V0.6330.84
28_V283_K0.6330.84
134_F163_V0.6330.84
173_L237_L0.6320.84
205_I230_V0.6280.83
56_T60_Q0.6280.83
43_F287_I0.6240.83
120_H264_I0.6240.83
70_N74_E0.6210.82
77_K104_A0.6180.82
78_L82_A0.6180.82
175_A181_P0.6150.82
98_T102_L0.6140.82
24_E75_S0.6120.82
190_A193_A0.6110.81
45_L64_V0.6080.81
239_V244_A0.6080.81
119_S155_N0.6020.80
25_D95_N0.6020.80
112_L115_A0.6000.80
45_L52_L0.5970.80
211_A277_A0.5960.80
16_K291_I0.5950.80
125_D132_L0.5940.80
127_P257_K0.5920.79
173_L212_L0.5920.79
29_I33_K0.5910.79
39_L63_Q0.5910.79
240_P247_I0.5890.79
193_A196_Y0.5890.79
113_R268_K0.5890.79
21_A88_A0.5880.79
27_E280_A0.5860.79
75_S97_P0.5850.79
210_L214_N0.5830.78
76_A104_A0.5830.78
177_E214_N0.5780.78
210_L226_I0.5760.78
23_A52_L0.5760.78
139_A275_S0.5740.77
153_L192_L0.5730.77
126_I257_K0.5720.77
183_M242_I0.5720.77
6_L11_S0.5710.77
68_H72_P0.5690.77
165_N168_P0.5690.77
126_I255_F0.5680.77
259_S285_Y0.5680.77
182_K190_A0.5670.76
191_A195_M0.5650.76
120_H273_L0.5650.76
4_K11_S0.5640.76
166_N205_I0.5640.76
18_I118_L0.5580.75
209_P251_S0.5580.75
216_V255_F0.5580.75
51_K55_L0.5570.75
4_K10_A0.5570.75
123_V132_L0.5560.75
150_R192_L0.5540.75
9_K13_H0.5530.75
135_V237_L0.5530.75
212_L248_L0.5520.74
220_A254_Y0.5520.74
246_N249_Y0.5490.74
12_I39_L0.5490.74
251_S256_A0.5480.74
36_A61_G0.5480.74
146_L195_M0.5460.74
23_A28_V0.5460.74
173_L240_P0.5460.74
246_N250_K0.5450.74
126_I133_M0.5430.73
120_H136_T0.5420.73
24_E55_L0.5420.73
109_Q268_K0.5410.73
150_R196_Y0.5360.72
37_E60_Q0.5360.72
149_L172_A0.5360.72
234_A237_L0.5340.72
75_S96_V0.5340.72
246_N276_R0.5340.72
77_K110_E0.5320.72
147_E150_R0.5310.72
155_N158_H0.5300.72
214_N221_A0.5250.71
183_M187_V0.5250.71
221_A227_S0.5250.71
21_A46_T0.5240.71
41_A288_A0.5230.71
80_V104_A0.5230.71
212_L252_L0.5230.71
193_A210_L0.5220.70
110_E268_K0.5220.70
49_S66_I0.5190.70
27_E95_N0.5170.70
141_N148_E0.5170.70
144_P148_E0.5140.69
254_Y277_A0.5140.69
134_F156_A0.5120.69
80_V271_I0.5100.69
116_S145_S0.5070.68
25_D45_L0.5070.68
249_Y274_T0.5070.68
123_V261_A0.5060.68
235_D244_A0.5020.67
229_D233_N0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ycoA 2 0.9064 100 0.33 Contact Map
3uf6A 2 0.9565 100 0.339 Contact Map
4e4rA 2 0.9699 100 0.344 Contact Map
1r5jA 4 0.9833 100 0.348 Contact Map
1td9A 3 0.9699 100 0.352 Contact Map
1vmiA 2 0.9766 100 0.354 Contact Map
2af4C 2 0.99 100 0.357 Contact Map
4jqpA 2 0.8796 100 0.533 Contact Map
3lxyA 2 0.8763 100 0.535 Contact Map
1vi1A 2 0.8729 100 0.539 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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