GREMLIN Database
YQIK - Uncharacterized protein YqiK
UniProt: P54527 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (227)
Sequences: 9380 (6939)
Seq/√Len: 460.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_L87_I3.2481.00
200_R226_D2.9211.00
97_S131_F2.5761.00
93_E127_A2.5621.00
24_K27_E2.5251.00
67_A70_E2.4971.00
23_E98_W2.4121.00
12_G232_F2.3971.00
22_F35_L2.3451.00
68_Y72_K2.3171.00
212_N231_D2.2371.00
217_M236_A2.2331.00
72_K94_D2.2081.00
68_Y91_L2.1411.00
107_N140_S2.1191.00
19_M90_P2.0861.00
39_L123_K2.0311.00
93_E130_R2.0181.00
48_I63_V1.9781.00
13_Q234_E1.9661.00
44_R68_Y1.9481.00
53_L74_A1.9271.00
35_L95_V1.8701.00
41_K67_A1.8561.00
40_T46_V1.8321.00
93_E131_F1.8281.00
232_F235_K1.8131.00
23_E27_E1.7851.00
62_F65_D1.7801.00
123_K126_E1.7561.00
5_F32_G1.7551.00
18_T76_A1.7521.00
47_V95_V1.7301.00
35_L47_V1.6831.00
32_G105_L1.6781.00
14_F24_K1.6771.00
26_I104_F1.6491.00
91_L94_D1.6391.00
57_T76_A1.6311.00
59_L74_A1.6121.00
44_R91_L1.6061.00
46_V68_Y1.5901.00
6_A21_A1.5801.00
53_L66_T1.5601.00
24_K28_A1.5551.00
207_R227_G1.5461.00
48_I56_T1.5401.00
92_L108_I1.5401.00
122_E153_L1.5151.00
11_S21_A1.4921.00
54_N60_K1.4901.00
213_R216_D1.4771.00
139_L150_C1.4741.00
208_P225_A1.4641.00
40_T44_R1.4401.00
127_A131_F1.4301.00
121_E146_S1.4181.00
216_D219_R1.4171.00
39_L45_I1.4131.00
125_L154_A1.4061.00
61_G66_T1.3771.00
8_R16_E1.3761.00
71_V89_V1.3741.00
19_M98_W1.3681.00
129_K154_A1.3671.00
22_F95_V1.3591.00
46_V63_V1.3551.00
219_R223_A1.3251.00
75_N86_D1.3031.00
16_E55_R1.3031.00
93_E97_S1.3001.00
193_D197_K1.2641.00
40_T71_V1.2631.00
140_S229_F1.2611.00
125_L150_C1.2561.00
160_A181_G1.2461.00
122_E126_E1.2401.00
10_A13_Q1.2391.00
126_E130_R1.2361.00
149_L153_L1.2301.00
50_D55_R1.2291.00
44_R93_E1.2251.00
43_G119_G1.2161.00
149_L152_R1.2091.00
66_T70_E1.2061.00
37_V45_I1.2001.00
139_L157_I1.1991.00
10_A24_K1.1941.00
43_G123_K1.1931.00
110_L124_V1.1901.00
199_M206_V1.1731.00
59_L66_T1.1681.00
66_T71_V1.1581.00
218_K222_E1.1561.00
128_V139_L1.1541.00
151_A159_R1.1501.00
196_L206_V1.1331.00
40_T68_Y1.1301.00
205_K226_D1.1271.00
54_N61_G1.1211.00
5_F227_G1.1181.00
10_A28_A1.1101.00
38_Q51_E1.1071.00
48_I89_V1.1011.00
45_I124_V1.0961.00
26_I98_W1.0911.00
127_A130_R1.0841.00
197_K201_N1.0831.00
119_G123_K1.0811.00
96_L131_F1.0791.00
199_M204_I1.0691.00
19_M23_E1.0661.00
70_E73_T1.0591.00
121_E149_L1.0571.00
22_F33_I1.0511.00
188_S216_D1.0471.00
96_L106_I1.0351.00
37_V92_L1.0341.00
20_L24_K1.0291.00
96_L128_V1.0231.00
46_V71_V1.0231.00
75_N88_K1.0191.00
6_A11_S1.0161.00
5_F107_N1.0111.00
147_L159_R1.0091.00
37_V124_V1.0071.00
196_L200_R1.0041.00
107_N207_R0.9971.00
99_A106_I0.9971.00
72_K88_K0.9951.00
45_I123_K0.9931.00
57_T61_G0.9831.00
34_E49_H0.9831.00
154_A157_I0.9831.00
53_L59_L0.9711.00
11_S231_D0.9541.00
195_V199_M0.9531.00
133_V137_V0.9511.00
37_V108_I0.9501.00
45_I127_A0.9471.00
211_V217_M0.9451.00
52_R62_F0.9441.00
211_V220_L0.9351.00
66_T74_A0.9351.00
194_E198_K0.9281.00
22_F47_V0.9281.00
217_M228_M0.9271.00
209_Y229_F0.9211.00
6_A30_A0.9191.00
52_R55_R0.9161.00
214_P218_K0.9161.00
41_K65_D0.9151.00
13_Q28_A0.9131.00
140_S183_H0.9111.00
107_N138_I0.9081.00
72_K91_L0.8971.00
110_L146_S0.8951.00
10_A234_E0.8851.00
125_L129_K0.8851.00
17_N22_F0.8831.00
107_N229_F0.8821.00
133_V136_R0.8781.00
129_K156_H0.8771.00
109_E142_F0.8751.00
230_T236_A0.8701.00
54_N58_S0.8641.00
6_A10_A0.8601.00
175_A202_G0.8601.00
122_E149_L0.8581.00
200_R206_V0.8551.00
92_L96_L0.8541.00
4_I237_S0.8541.00
14_F20_L0.8511.00
198_K202_G0.8491.00
140_S160_A0.8491.00
90_P95_V0.8471.00
58_S61_G0.8411.00
197_K200_R0.8271.00
35_L106_I0.8261.00
196_L223_A0.8211.00
221_I236_A0.8211.00
142_F162_L0.8201.00
123_K127_A0.8181.00
151_A180_S0.8151.00
129_K134_E0.8151.00
134_E154_A0.8101.00
7_H49_H0.8061.00
4_I236_A0.8051.00
39_L120_M0.7981.00
10_A233_P0.7901.00
125_L153_L0.7841.00
143_N146_S0.7781.00
45_I120_M0.7781.00
17_N90_P0.7761.00
198_K201_N0.7701.00
26_I102_K0.7691.00
119_G122_E0.7661.00
208_P220_L0.7641.00
9_G22_F0.7641.00
23_E99_A0.7611.00
217_M235_K0.7601.00
176_S179_A0.7601.00
214_P235_K0.7571.00
110_L120_M0.7501.00
174_I177_I0.7441.00
39_L43_G0.7431.00
44_R123_K0.7331.00
58_S62_F0.7321.00
96_L127_A0.7311.00
150_C159_R0.7241.00
57_T74_A0.7221.00
144_H161_V0.7141.00
7_H34_E0.7131.00
214_P238_A0.7081.00
173_Y176_S0.7081.00
228_M236_A0.7021.00
38_Q64_K0.6991.00
102_K136_R0.6981.00
52_R60_K0.6971.00
124_V128_V0.6961.00
36_D49_H0.6941.00
183_H207_R0.6911.00
212_N230_T0.6901.00
184_P208_P0.6891.00
30_A233_P0.6891.00
23_E87_I0.6861.00
75_N78_A0.6851.00
95_V106_I0.6841.00
13_Q232_F0.6831.00
140_S162_L0.6821.00
144_H148_A0.6781.00
134_E137_V0.6781.00
191_V208_P0.6701.00
217_M221_I0.6691.00
95_V99_A0.6671.00
210_T230_T0.6661.00
128_V137_V0.6631.00
33_I104_F0.6621.00
13_Q24_K0.6601.00
195_V198_K0.6591.00
216_D220_L0.6581.00
92_L124_V0.6571.00
5_F229_F0.6551.00
172_R176_S0.6541.00
128_V134_E0.6531.00
158_E180_S0.6521.00
117_Y120_M0.6501.00
213_R235_K0.6471.00
75_N79_G0.6471.00
10_A14_F0.6461.00
48_I57_T0.6441.00
69_D73_T0.6431.00
25_G30_A0.6421.00
4_I30_A0.6421.00
53_L71_V0.6391.00
38_Q63_V0.6381.00
179_A182_Y0.6371.00
94_D97_S0.6360.99
158_E205_K0.6340.99
193_D223_A0.6340.99
142_F209_Y0.6330.99
180_S183_H0.6290.99
26_I103_D0.6270.99
41_K70_E0.6260.99
53_L61_G0.6260.99
181_G184_P0.6250.99
179_A184_P0.6240.99
109_E141_T0.6230.99
147_L151_A0.6220.99
33_I99_A0.6190.99
174_I179_A0.6170.99
5_F207_R0.6110.99
111_K142_F0.6100.99
54_N59_L0.6070.99
181_G205_K0.6060.99
160_A183_H0.6060.99
71_V74_A0.6050.99
193_D196_L0.6020.99
46_V91_L0.5980.99
76_A90_P0.5960.99
177_I180_S0.5950.99
35_L108_I0.5950.99
160_A207_R0.5940.99
28_A237_S0.5940.99
141_T147_L0.5910.99
103_D136_R0.5900.99
10_A30_A0.5860.99
56_T76_A0.5830.99
208_P211_V0.5820.99
20_L23_E0.5800.99
148_A152_R0.5800.99
108_I137_V0.5800.99
167_L171_D0.5780.99
220_L223_A0.5780.99
28_A234_E0.5780.99
121_E125_L0.5760.99
34_E111_K0.5660.99
172_R175_A0.5650.99
15_P56_T0.5620.99
166_V170_A0.5620.99
15_P87_I0.5610.99
57_T60_K0.5600.99
109_E162_L0.5600.99
124_V139_L0.5590.99
173_Y177_I0.5550.99
196_L225_A0.5520.99
19_M22_F0.5520.99
145_D148_A0.5480.99
28_A233_P0.5470.98
54_N57_T0.5470.98
112_N117_Y0.5450.98
207_R229_F0.5450.98
38_Q112_N0.5440.98
32_G107_N0.5430.98
69_D72_K0.5430.98
206_V225_A0.5360.98
52_R56_T0.5340.98
79_G84_Y0.5320.98
18_T21_A0.5300.98
178_P184_P0.5300.98
64_K116_R0.5260.98
29_G237_S0.5250.98
176_S182_Y0.5230.98
92_L127_A0.5200.98
181_G207_R0.5200.98
105_L136_R0.5180.98
167_L170_A0.5170.98
191_V223_A0.5160.98
98_W101_K0.5150.98
32_G140_S0.5150.98
98_W102_K0.5140.98
78_A84_Y0.5140.98
34_E109_E0.5140.98
25_G33_I0.5130.98
4_I233_P0.5120.98
128_V133_V0.5110.98
23_E101_K0.5080.98
138_I207_R0.5060.97
107_N183_H0.5040.97
121_E124_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pz0A 2 0.9918 100 0.056 Contact Map
3qvqA 4 0.9918 100 0.072 Contact Map
2otdA 1 0.9835 100 0.074 Contact Map
3ks6A 1 0.9712 100 0.091 Contact Map
1zccA 5 0.9588 100 0.092 Contact Map
4r7oA 4 0.9794 100 0.097 Contact Map
4oecA 1 0.93 100 0.103 Contact Map
3l12A 2 0.9835 100 0.104 Contact Map
2o55A 1 0.9588 100 0.104 Contact Map
3ch0A 1 0.9712 100 0.111 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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