YQIG - BACSU - GREMLIN Contacts

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YQIG - Probable NADH-dependent flavin oxidoreductase YqiG

UniProt:	P54524	Sequences: MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAELDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAVVQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIEAGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAKGAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTRTRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEGREKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	372 (325)
Sequences:	11199 (7495)
Seq/√Len:	415.8

ECOLI - FADH NEMA
BACSU - YQIG NAMA
HALSA - Q9HQZ6
SULSO - Q97WT9 Q97X55

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
141_E	190_R	3.631	1.00
207_D	252_K	3.447	1.00
102_V	165_G	3.133	1.00
66_T	150_A	2.947	1.00
194_S	197_K	2.546	1.00
156_R	212_A	2.494	1.00
137_R	143_E	2.470	1.00
248_A	251_D	2.454	1.00
25_A	314_L	2.444	1.00
152_G	208_E	2.414	1.00
94_I	101_A	2.413	1.00
42_E	89_K	2.366	1.00
13_T	19_T	2.365	1.00
139_L	147_I	2.338	1.00
12_F	314_L	2.318	1.00
238_T	241_E	2.215	1.00
306_A	310_N	2.179	1.00
81_D	157_R	2.174	1.00
55_M	321_I	2.140	1.00
49_I	97_Q	2.097	1.00
224_G	256_Y	2.080	1.00
95_Q	164_D	2.056	1.00
250_G	289_K	2.003	1.00
139_L	143_E	1.995	1.00
123_V	139_L	1.984	1.00
324_D	330_K	1.975	1.00
293_I	316_A	1.971	1.00
159_I	213_A	1.970	1.00
149_K	153_E	1.941	1.00
9_F	332_K	1.937	1.00
127_D	138_A	1.916	1.00
329_V	333_E	1.909	1.00
305_L	309_E	1.905	1.00
176_I	202_P	1.897	1.00
156_R	160_E	1.881	1.00
49_I	93_A	1.875	1.00
88_K	92_Q	1.843	1.00
63_A	103_V	1.836	1.00
176_I	201_F	1.825	1.00
17_G	221_F	1.798	1.00
153_E	157_R	1.784	1.00
146_N	150_A	1.780	1.00
114_S	134_Q	1.774	1.00
7_P	10_E	1.765	1.00
159_I	214_S	1.762	1.00
145_E	204_A	1.753	1.00
92_Q	96_A	1.724	1.00
152_G	212_A	1.712	1.00
84_I	160_E	1.702	1.00
191_W	204_A	1.679	1.00
197_K	200_A	1.677	1.00
244_T	248_A	1.672	1.00
141_E	145_E	1.658	1.00
202_P	225_Y	1.652	1.00
91_A	163_F	1.652	1.00
170_G	225_Y	1.648	1.00
140_T	143_E	1.615	1.00
68_D	146_N	1.612	1.00
7_P	305_L	1.610	1.00
141_E	144_V	1.585	1.00
176_I	205_I	1.579	1.00
281_L	284_E	1.575	1.00
81_D	160_E	1.562	1.00
87_L	163_F	1.559	1.00
141_E	191_W	1.558	1.00
335_R	338_Q	1.558	1.00
199_L	248_A	1.558	1.00
45_L	89_K	1.523	1.00
121_D	137_R	1.503	1.00
155_T	209_V	1.500	1.00
145_E	190_R	1.496	1.00
149_K	208_E	1.491	1.00
213_A	221_F	1.491	1.00
42_E	46_D	1.473	1.00
247_D	287_G	1.465	1.00
128_V	186_Q	1.463	1.00
25_A	293_I	1.434	1.00
60_T	101_A	1.428	1.00
78_I	103_V	1.427	1.00
327_W	331_V	1.419	1.00
84_I	157_R	1.408	1.00
50_P	326_N	1.403	1.00
46_D	49_I	1.401	1.00
40_I	87_L	1.401	1.00
21_N	100_K	1.389	1.00
26_V	51_R	1.387	1.00
202_P	245_L	1.386	1.00
199_L	244_T	1.385	1.00
105_I	154_A	1.378	1.00
7_P	309_E	1.378	1.00
279_M	284_E	1.377	1.00
29_M	318_G	1.376	1.00
153_E	156_R	1.367	1.00
159_I	221_F	1.362	1.00
304_A	317_M	1.362	1.00
329_V	332_K	1.356	1.00
298_I	307_V	1.333	1.00
203_L	252_K	1.325	1.00
152_G	156_R	1.324	1.00
206_V	249_L	1.318	1.00
203_L	248_A	1.317	1.00
24_I	328_T	1.310	1.00
195_D	199_L	1.307	1.00
45_L	93_A	1.305	1.00
78_I	154_A	1.290	1.00
170_G	176_I	1.280	1.00
128_V	136_A	1.273	1.00
20_I	57_M	1.269	1.00
123_V	137_R	1.263	1.00
301_A	331_V	1.252	1.00
148_V	208_E	1.242	1.00
208_E	211_K	1.237	1.00
199_L	203_L	1.227	1.00
145_E	191_W	1.224	1.00
295_V	316_A	1.221	1.00
26_V	58_V	1.219	1.00
208_E	212_A	1.206	1.00
45_L	49_I	1.196	1.00
248_A	252_K	1.191	1.00
152_G	211_K	1.191	1.00
86_G	89_K	1.190	1.00
172_N	260_S	1.186	1.00
49_I	96_A	1.186	1.00
143_E	146_N	1.186	1.00
200_A	204_A	1.180	1.00
138_A	188_T	1.175	1.00
12_F	291_P	1.175	1.00
203_L	207_D	1.172	1.00
280_D	284_E	1.172	1.00
301_A	334_G	1.163	1.00
321_I	328_T	1.156	1.00
250_G	290_V	1.151	1.00
307_V	312_I	1.145	1.00
103_V	158_A	1.136	1.00
18_V	100_K	1.133	1.00
39_T	82_S	1.133	1.00
100_K	164_D	1.130	1.00
149_K	152_G	1.125	1.00
294_A	312_I	1.117	1.00
71_A	108_G	1.111	1.00
170_G	202_P	1.109	1.00
177_Q	181_S	1.107	1.00
213_A	223_V	1.103	1.00
195_D	244_T	1.100	1.00
91_A	101_A	1.095	1.00
148_V	204_A	1.094	1.00
207_D	211_K	1.092	1.00
40_I	86_G	1.089	1.00
129_F	135_I	1.085	1.00
60_T	163_F	1.084	1.00
92_Q	95_Q	1.083	1.00
125_P	184_T	1.082	1.00
124_G	127_D	1.081	1.00
233_E	236_G	1.077	1.00
31_H	43_A	1.075	1.00
126_S	186_Q	1.071	1.00
95_Q	101_A	1.070	1.00
41_S	44_E	1.068	1.00
84_I	161_A	1.064	1.00
225_Y	254_L	1.062	1.00
38_G	70_K	1.059	1.00
293_I	314_L	1.057	1.00
7_P	308_I	1.056	1.00
45_L	90_L	1.055	1.00
81_D	85_P	1.055	1.00
244_T	247_D	1.042	1.00
148_V	152_G	1.041	1.00
64_N	75_Q	1.035	1.00
76_P	87_L	1.035	1.00
49_I	53_K	1.034	1.00
150_A	153_E	1.032	1.00
190_R	200_A	1.029	1.00
53_K	97_Q	1.028	1.00
89_K	92_Q	1.024	1.00
20_I	56_G	1.008	1.00
288_N	291_P	1.002	1.00
91_A	161_A	1.000	1.00
153_E	212_A	0.997	1.00
145_E	148_V	0.996	1.00
301_A	305_L	0.992	1.00
20_I	314_L	0.988	1.00
13_T	17_G	0.987	1.00
279_M	282_L	0.985	1.00
148_V	205_I	0.978	1.00
54_E	329_V	0.976	1.00
183_K	235_P	0.971	1.00
167_E	258_H	0.969	1.00
110_I	184_T	0.968	1.00
225_Y	249_L	0.967	1.00
243_Y	247_D	0.964	1.00
227_L	242_T	0.959	1.00
17_G	222_L	0.958	1.00
6_K	305_L	0.958	1.00
175_L	201_F	0.954	1.00
144_V	148_V	0.953	1.00
199_L	245_L	0.952	1.00
26_V	321_I	0.950	1.00
127_D	135_I	0.948	1.00
20_I	25_A	0.946	1.00
285_R	288_N	0.945	1.00
257_L	290_V	0.942	1.00
39_T	83_N	0.938	1.00
55_M	328_T	0.938	1.00
312_I	315_V	0.936	1.00
22_N	56_G	0.936	1.00
298_I	315_V	0.935	1.00
24_I	327_W	0.935	1.00
88_K	160_E	0.930	1.00
21_N	99_A	0.928	1.00
168_I	209_V	0.928	1.00
78_I	158_A	0.920	1.00
101_A	164_D	0.913	1.00
199_L	202_P	0.908	1.00
206_V	254_L	0.906	1.00
80_D	83_N	0.906	1.00
195_D	248_A	0.902	1.00
40_I	76_P	0.900	1.00
165_G	224_G	0.900	1.00
77_A	83_N	0.896	1.00
191_W	207_D	0.895	1.00
142_E	145_E	0.894	1.00
180_Y	202_P	0.888	1.00
155_T	213_A	0.886	1.00
102_V	222_L	0.885	1.00
8_L	304_A	0.884	1.00
16_S	255_D	0.878	1.00
168_I	205_I	0.877	1.00
274_P	277_T	0.877	1.00
57_M	102_V	0.874	1.00
27_A	258_H	0.871	1.00
148_V	191_W	0.866	1.00
302_D	334_G	0.865	1.00
148_V	201_F	0.864	1.00
145_E	208_E	0.863	1.00
246_V	257_L	0.862	1.00
209_V	223_V	0.856	1.00
57_M	165_G	0.854	1.00
62_C	106_H	0.853	1.00
50_P	53_K	0.853	1.00
210_K	255_D	0.850	1.00
298_I	304_A	0.849	1.00
18_V	102_V	0.848	1.00
229_P	259_I	0.847	1.00
226_R	258_H	0.845	1.00
250_G	288_N	0.844	1.00
101_A	163_F	0.842	1.00
140_T	145_E	0.837	1.00
12_F	16_S	0.836	1.00
26_V	29_M	0.832	1.00
206_V	252_K	0.829	1.00
138_A	186_Q	0.828	1.00
6_K	10_E	0.828	1.00
256_Y	293_I	0.827	1.00
239_M	243_Y	0.826	1.00
85_P	88_K	0.825	1.00
302_D	306_A	0.825	1.00
317_M	320_E	0.824	1.00
247_D	251_D	0.823	1.00
282_L	286_V	0.819	1.00
285_R	313_P	0.817	1.00
42_E	45_L	0.817	1.00
305_L	308_I	0.814	1.00
259_I	292_L	0.814	1.00
326_N	330_K	0.812	1.00
196_E	244_T	0.811	1.00
60_T	103_V	0.811	1.00
64_N	79_H	0.808	1.00
27_A	318_G	0.806	1.00
123_V	143_E	0.802	1.00
137_R	140_T	0.801	1.00
190_R	197_K	0.799	1.00
300_S	303_D	0.797	1.00
110_I	136_A	0.795	1.00
210_K	223_V	0.792	1.00
201_F	205_I	0.792	1.00
64_N	70_K	0.792	1.00
27_A	316_A	0.788	1.00
204_A	207_D	0.788	1.00
26_V	55_M	0.787	1.00
141_E	148_V	0.787	1.00
168_I	206_V	0.782	1.00
177_Q	242_T	0.778	1.00
93_A	97_Q	0.777	1.00
60_T	87_L	0.776	1.00
102_V	224_G	0.776	1.00
147_I	150_A	0.775	1.00
283_N	286_V	0.775	1.00
152_G	205_I	0.773	1.00
108_G	112_C	0.772	1.00
210_K	214_S	0.769	1.00
111_E	130_D	0.768	1.00
237_L	245_L	0.767	1.00
18_V	222_L	0.765	1.00
59_I	102_V	0.764	1.00
169_H	174_Y	0.762	1.00
127_D	186_Q	0.761	1.00
21_N	54_E	0.758	1.00
80_D	84_I	0.756	1.00
40_I	90_L	0.749	1.00
34_S	44_E	0.743	1.00
59_I	165_G	0.741	1.00
243_Y	287_G	0.740	1.00
66_T	147_I	0.739	1.00
46_D	50_P	0.736	1.00
304_A	331_V	0.735	1.00
237_L	242_T	0.734	1.00
139_L	144_V	0.729	1.00
144_V	202_P	0.726	1.00
18_V	165_G	0.724	1.00
193_G	198_R	0.723	1.00
124_G	184_T	0.722	1.00
79_H	83_N	0.719	1.00
95_Q	100_K	0.718	1.00
159_I	212_A	0.718	1.00
317_M	321_I	0.714	1.00
237_L	241_E	0.712	1.00
25_A	59_I	0.711	1.00
66_T	146_N	0.711	1.00
317_M	327_W	0.710	1.00
182_P	239_M	0.707	1.00
215_E	221_F	0.705	1.00
157_R	160_E	0.704	1.00
19_T	100_K	0.704	1.00
65_V	151_F	0.702	1.00
88_K	91_A	0.701	1.00
52_S	97_Q	0.700	1.00
258_H	316_A	0.696	1.00
224_G	293_I	0.696	1.00
246_V	288_N	0.694	1.00
85_P	89_K	0.694	1.00
65_V	106_H	0.693	1.00
67_P	79_H	0.688	1.00
112_C	122_V	0.688	1.00
93_A	96_A	0.687	1.00
47_Y	51_R	0.684	1.00
52_S	94_I	0.682	1.00
196_E	248_A	0.682	1.00
63_A	78_I	0.681	1.00
48_I	58_V	0.681	1.00
169_H	172_N	0.675	1.00
320_E	327_W	0.671	0.99
24_I	55_M	0.669	0.99
65_V	205_I	0.669	0.99
193_G	197_K	0.668	0.99
280_D	283_N	0.668	0.99
25_A	57_M	0.668	0.99
39_T	86_G	0.667	0.99
21_N	332_K	0.663	0.99
103_V	163_F	0.663	0.99
55_M	58_V	0.662	0.99
214_S	221_F	0.661	0.99
156_R	159_I	0.660	0.99
180_Y	199_L	0.658	0.99
69_G	107_H	0.656	0.99
34_S	76_P	0.653	0.99
94_I	99_A	0.650	0.99
126_S	138_A	0.648	0.99
14_F	291_P	0.648	0.99
9_F	328_T	0.647	0.99
20_I	100_K	0.647	0.99
206_V	225_Y	0.647	0.99
36_E	74_G	0.646	0.99
65_V	150_A	0.646	0.99
84_I	91_A	0.645	0.99
39_T	80_D	0.645	0.99
236_G	241_E	0.644	0.99
306_A	309_E	0.643	0.99
222_L	255_D	0.640	0.99
152_G	209_V	0.640	0.99
78_I	157_R	0.639	0.99
190_R	204_A	0.638	0.99
176_I	209_V	0.634	0.99
256_Y	314_L	0.632	0.99
323_V	338_Q	0.631	0.99
57_M	100_K	0.631	0.99
234_T	237_L	0.629	0.99
258_H	295_V	0.629	0.99
303_D	307_V	0.629	0.99
177_Q	231_E	0.628	0.99
127_D	136_A	0.623	0.99
125_P	128_V	0.620	0.99
28_P	226_R	0.618	0.99
25_A	316_A	0.618	0.99
151_F	176_I	0.617	0.99
303_D	306_A	0.617	0.99
180_Y	245_L	0.616	0.99
245_L	248_A	0.613	0.99
110_I	178_Q	0.613	0.99
51_R	326_N	0.608	0.99
249_L	254_L	0.605	0.99
27_A	59_I	0.604	0.99
210_K	215_E	0.603	0.99
294_A	315_V	0.602	0.99
241_E	244_T	0.601	0.99
121_D	134_Q	0.600	0.99
222_L	256_Y	0.600	0.99
53_K	326_N	0.599	0.99
154_A	157_R	0.596	0.99
68_D	147_I	0.595	0.99
279_M	283_N	0.594	0.99
85_P	92_Q	0.594	0.99
128_V	184_T	0.593	0.99
75_Q	108_G	0.591	0.99
124_G	136_A	0.591	0.99
11_P	19_T	0.587	0.99
329_V	335_R	0.587	0.99
308_I	315_V	0.586	0.99
78_I	83_N	0.585	0.99
203_L	244_T	0.580	0.99
210_K	213_A	0.579	0.99
231_E	264_V	0.578	0.99
147_I	175_L	0.576	0.98
317_M	331_V	0.575	0.98
225_Y	257_L	0.574	0.98
84_I	88_K	0.572	0.98
205_I	208_E	0.568	0.98
195_D	245_L	0.566	0.98
40_I	44_E	0.566	0.98
76_P	90_L	0.564	0.98
326_N	329_V	0.564	0.98
89_K	93_A	0.560	0.98
183_K	233_E	0.560	0.98
145_E	149_K	0.559	0.98
206_V	223_V	0.558	0.98
320_E	323_V	0.558	0.98
14_F	20_I	0.557	0.98
139_L	175_L	0.557	0.98
141_E	204_A	0.557	0.98
30_T	71_A	0.556	0.98
283_N	287_G	0.556	0.98
231_E	262_M	0.554	0.98
152_G	213_A	0.553	0.98
195_D	241_E	0.553	0.98
117_V	120_Q	0.553	0.98
91_A	103_V	0.552	0.98
123_V	147_I	0.549	0.98
181_S	231_E	0.549	0.98
167_E	224_G	0.547	0.98
242_T	246_V	0.545	0.98
78_I	91_A	0.544	0.98
44_E	61_A	0.544	0.98
144_V	176_I	0.543	0.98
224_G	258_H	0.540	0.98
258_H	293_I	0.536	0.98
29_M	322_L	0.536	0.98
73_P	116_L	0.536	0.98
264_V	267_K	0.536	0.98
47_Y	61_A	0.535	0.98
168_I	223_V	0.533	0.97
304_A	315_V	0.532	0.97
308_I	312_I	0.531	0.97
278_R	307_V	0.529	0.97
68_D	150_A	0.527	0.97
192_G	198_R	0.527	0.97
195_D	237_L	0.526	0.97
69_G	108_G	0.525	0.97
26_V	318_G	0.524	0.97
227_L	259_I	0.524	0.97
210_K	252_K	0.524	0.97
209_V	212_A	0.524	0.97
71_A	106_H	0.523	0.97
107_H	147_I	0.523	0.97
168_I	176_I	0.522	0.97
75_Q	106_H	0.522	0.97
125_P	178_Q	0.521	0.97
9_F	331_V	0.521	0.97
102_V	255_D	0.521	0.97
16_S	210_K	0.521	0.97
28_P	258_H	0.519	0.97
48_I	61_A	0.519	0.97
144_V	191_W	0.518	0.97
141_E	189_D	0.518	0.97
330_K	335_R	0.518	0.97
124_G	128_V	0.515	0.97
24_I	321_I	0.515	0.97
32_Y	72_F	0.513	0.97
27_A	321_I	0.512	0.97
301_A	327_W	0.508	0.97
228_S	231_E	0.508	0.97
166_V	213_A	0.508	0.97
64_N	108_G	0.508	0.97
54_E	332_K	0.506	0.97
142_E	146_N	0.506	0.97
38_G	64_N	0.503	0.96
147_I	151_F	0.503	0.96
209_V	213_A	0.502	0.96
299_H	303_D	0.502	0.96
328_T	332_K	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1o94A	2	0.9704	100	0.246	Contact Map
3k30A	2	0.9624	100	0.248	Contact Map
3l5aA	1	0.9785	100	0.27	Contact Map
1ps9A	1	0.9624	100	0.277	Contact Map
2hsaB	2	0.9328	100	0.281	Contact Map
4e2bA	1	0.922	100	0.282	Contact Map
4qnwA	1	0.9382	100	0.291	Contact Map
4gbuA	2	0.9651	100	0.292	Contact Map
4tmbA	2	0.9651	100	0.292	Contact Map
3tjlA	2	0.957	100	0.293	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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