GREMLIN Database
YQIG - Probable NADH-dependent flavin oxidoreductase YqiG
UniProt: P54524 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 372 (325)
Sequences: 11199 (7495)
Seq/√Len: 415.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_E190_R3.6311.00
207_D252_K3.4471.00
102_V165_G3.1331.00
66_T150_A2.9471.00
194_S197_K2.5461.00
156_R212_A2.4941.00
137_R143_E2.4701.00
248_A251_D2.4541.00
25_A314_L2.4441.00
152_G208_E2.4141.00
94_I101_A2.4131.00
42_E89_K2.3661.00
13_T19_T2.3651.00
139_L147_I2.3381.00
12_F314_L2.3181.00
238_T241_E2.2151.00
306_A310_N2.1791.00
81_D157_R2.1741.00
55_M321_I2.1401.00
49_I97_Q2.0971.00
224_G256_Y2.0801.00
95_Q164_D2.0561.00
250_G289_K2.0031.00
139_L143_E1.9951.00
123_V139_L1.9841.00
324_D330_K1.9751.00
293_I316_A1.9711.00
159_I213_A1.9701.00
149_K153_E1.9411.00
9_F332_K1.9371.00
127_D138_A1.9161.00
329_V333_E1.9091.00
305_L309_E1.9051.00
176_I202_P1.8971.00
156_R160_E1.8811.00
49_I93_A1.8751.00
88_K92_Q1.8431.00
63_A103_V1.8361.00
176_I201_F1.8251.00
17_G221_F1.7981.00
153_E157_R1.7841.00
146_N150_A1.7801.00
114_S134_Q1.7741.00
7_P10_E1.7651.00
159_I214_S1.7621.00
145_E204_A1.7531.00
92_Q96_A1.7241.00
152_G212_A1.7121.00
84_I160_E1.7021.00
191_W204_A1.6791.00
197_K200_A1.6771.00
244_T248_A1.6721.00
141_E145_E1.6581.00
202_P225_Y1.6521.00
91_A163_F1.6521.00
170_G225_Y1.6481.00
140_T143_E1.6151.00
68_D146_N1.6121.00
7_P305_L1.6101.00
141_E144_V1.5851.00
176_I205_I1.5791.00
281_L284_E1.5751.00
81_D160_E1.5621.00
87_L163_F1.5591.00
141_E191_W1.5581.00
335_R338_Q1.5581.00
199_L248_A1.5581.00
45_L89_K1.5231.00
121_D137_R1.5031.00
155_T209_V1.5001.00
145_E190_R1.4961.00
149_K208_E1.4911.00
213_A221_F1.4911.00
42_E46_D1.4731.00
247_D287_G1.4651.00
128_V186_Q1.4631.00
25_A293_I1.4341.00
60_T101_A1.4281.00
78_I103_V1.4271.00
327_W331_V1.4191.00
84_I157_R1.4081.00
50_P326_N1.4031.00
46_D49_I1.4011.00
40_I87_L1.4011.00
21_N100_K1.3891.00
26_V51_R1.3871.00
202_P245_L1.3861.00
199_L244_T1.3851.00
105_I154_A1.3781.00
7_P309_E1.3781.00
279_M284_E1.3771.00
29_M318_G1.3761.00
153_E156_R1.3671.00
159_I221_F1.3621.00
304_A317_M1.3621.00
329_V332_K1.3561.00
298_I307_V1.3331.00
203_L252_K1.3251.00
152_G156_R1.3241.00
206_V249_L1.3181.00
203_L248_A1.3171.00
24_I328_T1.3101.00
195_D199_L1.3071.00
45_L93_A1.3051.00
78_I154_A1.2901.00
170_G176_I1.2801.00
128_V136_A1.2731.00
20_I57_M1.2691.00
123_V137_R1.2631.00
301_A331_V1.2521.00
148_V208_E1.2421.00
208_E211_K1.2371.00
199_L203_L1.2271.00
145_E191_W1.2241.00
295_V316_A1.2211.00
26_V58_V1.2191.00
208_E212_A1.2061.00
45_L49_I1.1961.00
248_A252_K1.1911.00
152_G211_K1.1911.00
86_G89_K1.1901.00
172_N260_S1.1861.00
49_I96_A1.1861.00
143_E146_N1.1861.00
200_A204_A1.1801.00
138_A188_T1.1751.00
12_F291_P1.1751.00
203_L207_D1.1721.00
280_D284_E1.1721.00
301_A334_G1.1631.00
321_I328_T1.1561.00
250_G290_V1.1511.00
307_V312_I1.1451.00
103_V158_A1.1361.00
18_V100_K1.1331.00
39_T82_S1.1331.00
100_K164_D1.1301.00
149_K152_G1.1251.00
294_A312_I1.1171.00
71_A108_G1.1111.00
170_G202_P1.1091.00
177_Q181_S1.1071.00
213_A223_V1.1031.00
195_D244_T1.1001.00
91_A101_A1.0951.00
148_V204_A1.0941.00
207_D211_K1.0921.00
40_I86_G1.0891.00
129_F135_I1.0851.00
60_T163_F1.0841.00
92_Q95_Q1.0831.00
125_P184_T1.0821.00
124_G127_D1.0811.00
233_E236_G1.0771.00
31_H43_A1.0751.00
126_S186_Q1.0711.00
95_Q101_A1.0701.00
41_S44_E1.0681.00
84_I161_A1.0641.00
225_Y254_L1.0621.00
38_G70_K1.0591.00
293_I314_L1.0571.00
7_P308_I1.0561.00
45_L90_L1.0551.00
81_D85_P1.0551.00
244_T247_D1.0421.00
148_V152_G1.0411.00
64_N75_Q1.0351.00
76_P87_L1.0351.00
49_I53_K1.0341.00
150_A153_E1.0321.00
190_R200_A1.0291.00
53_K97_Q1.0281.00
89_K92_Q1.0241.00
20_I56_G1.0081.00
288_N291_P1.0021.00
91_A161_A1.0001.00
153_E212_A0.9971.00
145_E148_V0.9961.00
301_A305_L0.9921.00
20_I314_L0.9881.00
13_T17_G0.9871.00
279_M282_L0.9851.00
148_V205_I0.9781.00
54_E329_V0.9761.00
183_K235_P0.9711.00
167_E258_H0.9691.00
110_I184_T0.9681.00
225_Y249_L0.9671.00
243_Y247_D0.9641.00
227_L242_T0.9591.00
17_G222_L0.9581.00
6_K305_L0.9581.00
175_L201_F0.9541.00
144_V148_V0.9531.00
199_L245_L0.9521.00
26_V321_I0.9501.00
127_D135_I0.9481.00
20_I25_A0.9461.00
285_R288_N0.9451.00
257_L290_V0.9421.00
39_T83_N0.9381.00
55_M328_T0.9381.00
312_I315_V0.9361.00
22_N56_G0.9361.00
298_I315_V0.9351.00
24_I327_W0.9351.00
88_K160_E0.9301.00
21_N99_A0.9281.00
168_I209_V0.9281.00
78_I158_A0.9201.00
101_A164_D0.9131.00
199_L202_P0.9081.00
206_V254_L0.9061.00
80_D83_N0.9061.00
195_D248_A0.9021.00
40_I76_P0.9001.00
165_G224_G0.9001.00
77_A83_N0.8961.00
191_W207_D0.8951.00
142_E145_E0.8941.00
180_Y202_P0.8881.00
155_T213_A0.8861.00
102_V222_L0.8851.00
8_L304_A0.8841.00
16_S255_D0.8781.00
168_I205_I0.8771.00
274_P277_T0.8771.00
57_M102_V0.8741.00
27_A258_H0.8711.00
148_V191_W0.8661.00
302_D334_G0.8651.00
148_V201_F0.8641.00
145_E208_E0.8631.00
246_V257_L0.8621.00
209_V223_V0.8561.00
57_M165_G0.8541.00
62_C106_H0.8531.00
50_P53_K0.8531.00
210_K255_D0.8501.00
298_I304_A0.8491.00
18_V102_V0.8481.00
229_P259_I0.8471.00
226_R258_H0.8451.00
250_G288_N0.8441.00
101_A163_F0.8421.00
140_T145_E0.8371.00
12_F16_S0.8361.00
26_V29_M0.8321.00
206_V252_K0.8291.00
138_A186_Q0.8281.00
6_K10_E0.8281.00
256_Y293_I0.8271.00
239_M243_Y0.8261.00
85_P88_K0.8251.00
302_D306_A0.8251.00
317_M320_E0.8241.00
247_D251_D0.8231.00
282_L286_V0.8191.00
285_R313_P0.8171.00
42_E45_L0.8171.00
305_L308_I0.8141.00
259_I292_L0.8141.00
326_N330_K0.8121.00
196_E244_T0.8111.00
60_T103_V0.8111.00
64_N79_H0.8081.00
27_A318_G0.8061.00
123_V143_E0.8021.00
137_R140_T0.8011.00
190_R197_K0.7991.00
300_S303_D0.7971.00
110_I136_A0.7951.00
210_K223_V0.7921.00
201_F205_I0.7921.00
64_N70_K0.7921.00
27_A316_A0.7881.00
204_A207_D0.7881.00
26_V55_M0.7871.00
141_E148_V0.7871.00
168_I206_V0.7821.00
177_Q242_T0.7781.00
93_A97_Q0.7771.00
60_T87_L0.7761.00
102_V224_G0.7761.00
147_I150_A0.7751.00
283_N286_V0.7751.00
152_G205_I0.7731.00
108_G112_C0.7721.00
210_K214_S0.7691.00
111_E130_D0.7681.00
237_L245_L0.7671.00
18_V222_L0.7651.00
59_I102_V0.7641.00
169_H174_Y0.7621.00
127_D186_Q0.7611.00
21_N54_E0.7581.00
80_D84_I0.7561.00
40_I90_L0.7491.00
34_S44_E0.7431.00
59_I165_G0.7411.00
243_Y287_G0.7401.00
66_T147_I0.7391.00
46_D50_P0.7361.00
304_A331_V0.7351.00
237_L242_T0.7341.00
139_L144_V0.7291.00
144_V202_P0.7261.00
18_V165_G0.7241.00
193_G198_R0.7231.00
124_G184_T0.7221.00
79_H83_N0.7191.00
95_Q100_K0.7181.00
159_I212_A0.7181.00
317_M321_I0.7141.00
237_L241_E0.7121.00
25_A59_I0.7111.00
66_T146_N0.7111.00
317_M327_W0.7101.00
182_P239_M0.7071.00
215_E221_F0.7051.00
157_R160_E0.7041.00
19_T100_K0.7041.00
65_V151_F0.7021.00
88_K91_A0.7011.00
52_S97_Q0.7001.00
258_H316_A0.6961.00
224_G293_I0.6961.00
246_V288_N0.6941.00
85_P89_K0.6941.00
65_V106_H0.6931.00
67_P79_H0.6881.00
112_C122_V0.6881.00
93_A96_A0.6871.00
47_Y51_R0.6841.00
52_S94_I0.6821.00
196_E248_A0.6821.00
63_A78_I0.6811.00
48_I58_V0.6811.00
169_H172_N0.6751.00
320_E327_W0.6710.99
24_I55_M0.6690.99
65_V205_I0.6690.99
193_G197_K0.6680.99
280_D283_N0.6680.99
25_A57_M0.6680.99
39_T86_G0.6670.99
21_N332_K0.6630.99
103_V163_F0.6630.99
55_M58_V0.6620.99
214_S221_F0.6610.99
156_R159_I0.6600.99
180_Y199_L0.6580.99
69_G107_H0.6560.99
34_S76_P0.6530.99
94_I99_A0.6500.99
126_S138_A0.6480.99
14_F291_P0.6480.99
9_F328_T0.6470.99
20_I100_K0.6470.99
206_V225_Y0.6470.99
36_E74_G0.6460.99
65_V150_A0.6460.99
84_I91_A0.6450.99
39_T80_D0.6450.99
236_G241_E0.6440.99
306_A309_E0.6430.99
222_L255_D0.6400.99
152_G209_V0.6400.99
78_I157_R0.6390.99
190_R204_A0.6380.99
176_I209_V0.6340.99
256_Y314_L0.6320.99
323_V338_Q0.6310.99
57_M100_K0.6310.99
234_T237_L0.6290.99
258_H295_V0.6290.99
303_D307_V0.6290.99
177_Q231_E0.6280.99
127_D136_A0.6230.99
125_P128_V0.6200.99
28_P226_R0.6180.99
25_A316_A0.6180.99
151_F176_I0.6170.99
303_D306_A0.6170.99
180_Y245_L0.6160.99
245_L248_A0.6130.99
110_I178_Q0.6130.99
51_R326_N0.6080.99
249_L254_L0.6050.99
27_A59_I0.6040.99
210_K215_E0.6030.99
294_A315_V0.6020.99
241_E244_T0.6010.99
121_D134_Q0.6000.99
222_L256_Y0.6000.99
53_K326_N0.5990.99
154_A157_R0.5960.99
68_D147_I0.5950.99
279_M283_N0.5940.99
85_P92_Q0.5940.99
128_V184_T0.5930.99
75_Q108_G0.5910.99
124_G136_A0.5910.99
11_P19_T0.5870.99
329_V335_R0.5870.99
308_I315_V0.5860.99
78_I83_N0.5850.99
203_L244_T0.5800.99
210_K213_A0.5790.99
231_E264_V0.5780.99
147_I175_L0.5760.98
317_M331_V0.5750.98
225_Y257_L0.5740.98
84_I88_K0.5720.98
205_I208_E0.5680.98
195_D245_L0.5660.98
40_I44_E0.5660.98
76_P90_L0.5640.98
326_N329_V0.5640.98
89_K93_A0.5600.98
183_K233_E0.5600.98
145_E149_K0.5590.98
206_V223_V0.5580.98
320_E323_V0.5580.98
14_F20_I0.5570.98
139_L175_L0.5570.98
141_E204_A0.5570.98
30_T71_A0.5560.98
283_N287_G0.5560.98
231_E262_M0.5540.98
152_G213_A0.5530.98
195_D241_E0.5530.98
117_V120_Q0.5530.98
91_A103_V0.5520.98
123_V147_I0.5490.98
181_S231_E0.5490.98
167_E224_G0.5470.98
242_T246_V0.5450.98
78_I91_A0.5440.98
44_E61_A0.5440.98
144_V176_I0.5430.98
224_G258_H0.5400.98
258_H293_I0.5360.98
29_M322_L0.5360.98
73_P116_L0.5360.98
264_V267_K0.5360.98
47_Y61_A0.5350.98
168_I223_V0.5330.97
304_A315_V0.5320.97
308_I312_I0.5310.97
278_R307_V0.5290.97
68_D150_A0.5270.97
192_G198_R0.5270.97
195_D237_L0.5260.97
69_G108_G0.5250.97
26_V318_G0.5240.97
227_L259_I0.5240.97
210_K252_K0.5240.97
209_V212_A0.5240.97
71_A106_H0.5230.97
107_H147_I0.5230.97
168_I176_I0.5220.97
75_Q106_H0.5220.97
125_P178_Q0.5210.97
9_F331_V0.5210.97
102_V255_D0.5210.97
16_S210_K0.5210.97
28_P258_H0.5190.97
48_I61_A0.5190.97
144_V191_W0.5180.97
141_E189_D0.5180.97
330_K335_R0.5180.97
124_G128_V0.5150.97
24_I321_I0.5150.97
32_Y72_F0.5130.97
27_A321_I0.5120.97
301_A327_W0.5080.97
228_S231_E0.5080.97
166_V213_A0.5080.97
64_N108_G0.5080.97
54_E332_K0.5060.97
142_E146_N0.5060.97
38_G64_N0.5030.96
147_I151_F0.5030.96
209_V213_A0.5020.96
299_H303_D0.5020.96
328_T332_K0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1o94A 2 0.9704 100 0.246 Contact Map
3k30A 2 0.9624 100 0.248 Contact Map
3l5aA 1 0.9785 100 0.27 Contact Map
1ps9A 1 0.9624 100 0.277 Contact Map
2hsaB 2 0.9328 100 0.281 Contact Map
4e2bA 1 0.922 100 0.282 Contact Map
4qnwA 1 0.9382 100 0.291 Contact Map
4gbuA 2 0.9651 100 0.292 Contact Map
4tmbA 2 0.9651 100 0.292 Contact Map
3tjlA 2 0.957 100 0.293 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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