GREMLIN Database
DXS - 1-deoxy-D-xylulose-5-phosphate synthase
UniProt: P54523 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 633 (590)
Sequences: 6928 (3567)
Seq/√Len: 146.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
331_R355_E5.6521.00
611_T614_Q4.1351.00
517_I532_V3.9801.00
522_E616_A3.9351.00
526_E620_R3.8321.00
435_A562_A3.4371.00
446_M457_M3.2871.00
122_A140_P3.2861.00
464_Y467_G2.9881.00
606_E611_T2.9591.00
516_A559_I2.7351.00
531_R553_G2.7241.00
508_T513_I2.6611.00
254_S257_E2.6591.00
24_S53_V2.6501.00
168_V244_F2.6351.00
61_S107_H2.6351.00
503_D554_L2.6131.00
93_Y603_A2.6121.00
132_K382_M2.6061.00
547_K575_F2.6001.00
506_I516_A2.5581.00
504_A619_I2.5411.00
329_M336_I2.5221.00
371_A413_I2.4651.00
600_S603_A2.4121.00
408_N442_N2.3761.00
520_A532_V2.3761.00
559_I615_V2.3021.00
612_K616_A2.2791.00
331_R356_F2.2771.00
543_E575_F2.2621.00
137_Y165_D2.2541.00
449_K534_N2.2311.00
587_D618_R2.1951.00
521_E525_K2.1781.00
285_K289_T2.1691.00
93_Y599_G2.1591.00
93_Y607_E2.1341.00
127_A373_M2.1311.00
377_M382_M2.1201.00
495_W545_M2.1171.00
518_E612_K2.1091.00
169_I262_L2.0951.00
522_E613_Q2.0751.00
383_K410_N2.0711.00
499_R521_E2.0581.00
573_L588_R2.0511.00
496_E534_N2.0441.00
339_I374_A2.0441.00
515_M518_E2.0361.00
522_E612_K2.0321.00
557_L619_I2.0301.00
118_S142_I2.0231.00
328_R331_R2.0121.00
329_M462_L1.9981.00
263_Q267_K1.9791.00
375_A404_I1.9631.00
60_N63_K1.9601.00
518_E521_E1.9511.00
412_F461_A1.9341.00
591_I608_I1.9211.00
446_M537_F1.9161.00
129_R136_E1.9091.00
505_V553_G1.9081.00
125_M380_Q1.9041.00
66_F141_I1.9021.00
341_P347_S1.8941.00
434_I562_A1.8791.00
190_R193_T1.8731.00
545_M549_I1.8681.00
53_V80_L1.8621.00
438_R571_S1.8461.00
535_A568_F1.8341.00
410_N467_G1.8321.00
503_D529_S1.8301.00
34_S88_A1.8301.00
547_K579_Q1.8291.00
508_T516_A1.8271.00
502_N529_S1.7891.00
617_N621_L1.7841.00
327_Q355_E1.7751.00
497_V531_R1.7631.00
255_Y259_I1.7621.00
126_A138_I1.7571.00
504_A530_V1.7261.00
324_G351_G1.7221.00
495_W533_V1.7151.00
351_G354_K1.7151.00
30_F34_S1.7131.00
601_V605_L1.7121.00
438_R574_E1.7071.00
449_K496_E1.6921.00
519_A616_A1.6901.00
120_S369_H1.6861.00
237_M240_E1.6861.00
119_L159_I1.6851.00
564_L590_G1.6791.00
542_D546_M1.6781.00
297_G301_Y1.6701.00
371_A404_I1.6701.00
578_D588_R1.6641.00
231_Y234_V1.6641.00
494_T544_K1.6421.00
616_A620_R1.6411.00
575_F579_Q1.6411.00
589_M618_R1.6381.00
285_K288_E1.6381.00
459_H463_S1.6261.00
533_V549_I1.6231.00
326_V385_F1.6131.00
543_E547_K1.6081.00
57_K259_I1.6071.00
491_P494_T1.6041.00
78_K107_H1.5841.00
327_Q356_F1.5771.00
570_S574_E1.5771.00
415_I470_A1.5731.00
100_P112_T1.5611.00
198_Q224_R1.5601.00
385_F462_L1.5571.00
329_M459_H1.5511.00
437_M470_A1.5461.00
102_R111_E1.5451.00
279_K282_K1.5401.00
55_L66_F1.5291.00
524_Q529_S1.5271.00
507_L535_A1.5211.00
45_N76_V1.5181.00
573_L577_H1.5171.00
302_K305_T1.5101.00
587_D622_L1.5091.00
404_I413_I1.4971.00
137_Y167_I1.4941.00
64_D69_D1.4931.00
464_Y469_I1.4901.00
333_D383_K1.4841.00
543_E579_Q1.4831.00
397_Y439_H1.4811.00
328_R455_Q1.4751.00
606_E613_Q1.4751.00
351_G355_E1.4721.00
506_I619_I1.4701.00
363_V369_H1.4661.00
494_T535_A1.4631.00
516_A532_V1.4621.00
79_L84_G1.4431.00
571_S574_E1.4341.00
606_E614_Q1.4341.00
431_V591_I1.4331.00
129_R138_I1.4321.00
229_L233_L1.4181.00
116_S149_G1.3961.00
393_L415_I1.3911.00
426_E429_Q1.3891.00
546_M550_L1.3841.00
310_K316_P1.3821.00
515_M612_K1.3811.00
30_F79_L1.3801.00
549_I553_G1.3741.00
225_V229_L1.3701.00
377_M380_Q1.3661.00
603_A606_E1.3621.00
102_R379_M1.3611.00
453_E534_N1.3571.00
573_L586_I1.3461.00
316_P324_G1.3381.00
225_V233_L1.3351.00
522_E526_E1.3311.00
335_R382_M1.3301.00
443_M470_A1.3291.00
129_R134_T1.3271.00
614_Q618_R1.3251.00
130_D164_K1.3241.00
405_C440_I1.3221.00
541_I546_M1.3221.00
374_A386_L1.3211.00
165_D269_K1.3191.00
25_D29_Q1.3171.00
325_T455_Q1.3111.00
320_G324_G1.3101.00
519_A559_I1.3091.00
505_V531_R1.3041.00
546_M575_F1.3041.00
325_T459_H1.3011.00
533_V545_M1.2971.00
512_T515_M1.2931.00
499_R524_Q1.2861.00
97_C101_K1.2851.00
333_D336_I1.2851.00
158_H373_M1.2781.00
544_K548_S1.2781.00
420_L604_L1.2751.00
444_V464_Y1.2741.00
557_L589_M1.2721.00
59_F167_I1.2711.00
200_V221_T1.2701.00
420_L608_I1.2701.00
301_Y306_G1.2671.00
373_M377_M1.2661.00
483_M486_Q1.2641.00
361_F373_M1.2601.00
278_T282_K1.2581.00
30_F38_S1.2581.00
128_A380_Q1.2551.00
225_V231_Y1.2531.00
546_M549_I1.2501.00
557_L622_L1.2491.00
405_C595_F1.2461.00
228_S231_Y1.2451.00
225_V234_V1.2361.00
206_Y209_K1.2361.00
258_L262_L1.2361.00
408_N467_G1.2301.00
65_K136_E1.2191.00
56_H77_H1.2171.00
499_R520_A1.2171.00
499_R529_S1.2161.00
55_L139_I1.2091.00
131_I382_M1.2051.00
308_F311_P1.2041.00
550_L576_A1.2031.00
519_A615_V1.2011.00
150_G154_E1.2001.00
137_Y266_K1.1951.00
63_K135_D1.1951.00
505_V549_I1.1931.00
374_A377_M1.1931.00
447_M511_T1.1931.00
310_K315_A1.1921.00
338_A352_F1.1861.00
271_P274_L1.1841.00
568_F572_I1.1821.00
178_A344_P1.1791.00
423_A600_S1.1751.00
34_S38_S1.1741.00
420_L591_I1.1741.00
509_F538_I1.1681.00
225_V232_M1.1661.00
352_F360_M1.1661.00
228_S232_M1.1601.00
513_I532_V1.1581.00
275_H278_T1.1561.00
497_V533_V1.1551.00
89_T92_Q1.1531.00
460_T491_P1.1501.00
594_R607_E1.1491.00
613_Q617_N1.1491.00
325_T329_M1.1461.00
98_G101_K1.1441.00
139_I167_I1.1350.99
596_I608_I1.1270.99
344_P353_A1.1260.99
321_L451_E1.1250.99
306_G317_S1.1210.99
545_M550_L1.1100.99
504_A557_L1.1080.99
393_L437_M1.1070.99
123_M155_A1.1070.99
86_E89_T1.1070.99
548_S551_K1.0980.99
21_E25_D1.0930.99
385_F458_V1.0870.99
64_D67_L1.0850.99
531_R549_I1.0770.99
505_V533_V1.0750.99
259_I263_Q1.0750.99
325_T328_R1.0720.99
330_A352_F1.0670.99
522_E525_K1.0630.99
151_M155_A1.0630.99
255_Y258_L1.0620.99
284_Y297_G1.0560.99
65_K380_Q1.0550.99
277_I281_G1.0540.99
257_E261_N1.0540.99
599_G604_L1.0480.99
451_E480_G1.0440.99
65_K129_R1.0430.99
557_L587_D1.0420.99
167_I274_L1.0410.99
506_I520_A1.0390.99
319_S348_K1.0380.99
225_V228_S1.0370.99
328_R332_E1.0340.99
286_P290_D1.0310.99
444_V467_G1.0280.99
311_P316_P1.0230.99
31_L76_V1.0210.99
21_E24_S1.0190.99
30_F84_G1.0160.99
490_I494_T1.0150.99
521_E524_Q1.0080.99
515_M605_L1.0080.99
413_I473_F1.0070.99
558_T568_F1.0070.99
131_I337_V1.0060.99
498_L517_I1.0010.99
506_I530_V1.0010.99
125_M379_M0.9990.99
151_M399_Q0.9980.99
599_G603_A0.9970.99
558_T561_E0.9940.99
71_G100_P0.9920.99
256_H259_I0.9910.99
434_I538_I0.9900.99
618_R621_L0.9900.99
86_E96_L0.9880.99
368_Q399_Q0.9860.99
519_A589_M0.9850.99
127_A361_F0.9820.98
412_F469_I0.9810.98
564_L588_R0.9790.98
385_F461_A0.9730.98
29_Q33_T0.9730.98
159_I166_M0.9710.98
284_Y288_E0.9690.98
459_H487_L0.9640.98
222_A226_K0.9600.98
31_L35_L0.9580.98
254_S258_L0.9560.98
336_I462_L0.9540.98
344_P360_M0.9540.98
555_P585_P0.9520.98
383_K412_F0.9520.98
340_T344_P0.9520.98
451_E478_G0.9510.98
548_S552_E0.9490.98
317_S320_G0.9490.98
187_M191_L0.9470.98
549_I552_E0.9460.98
438_R445_L0.9460.98
314_A317_S0.9440.98
518_E613_Q0.9440.98
589_M614_Q0.9410.98
432_F595_F0.9390.98
322_V458_V0.9380.98
227_D231_Y0.9370.98
431_V563_V0.9370.98
306_G311_P0.9340.98
219_A223_E0.9330.98
555_P622_L0.9330.98
446_M469_I0.9300.98
310_K314_A0.9280.98
558_T572_I0.9250.98
228_S233_L0.9210.98
31_L45_N0.9180.98
67_L110_W0.9170.98
587_D621_L0.9170.98
457_M469_I0.9130.98
132_K335_R0.9130.98
322_V387_A0.9120.98
311_P314_A0.9120.98
63_K69_D0.9110.98
93_Y604_L0.9110.98
457_M536_R0.9080.97
506_I559_I0.9080.97
265_A274_L0.9070.97
460_T492_I0.9070.97
613_Q616_A0.9060.97
558_T569_G0.9060.97
301_Y305_T0.9020.97
247_L265_A0.9020.97
295_W299_G0.9000.97
494_T498_L0.8960.97
226_K231_Y0.8960.97
226_K230_K0.8940.97
298_T301_Y0.8870.97
378_A409_A0.8870.97
229_L232_M0.8860.97
297_G302_K0.8850.97
371_A386_L0.8840.97
474_P511_T0.8830.97
434_I509_F0.8820.97
490_I493_G0.8810.97
528_L620_R0.8810.97
299_G303_I0.8810.97
257_E260_E0.8810.97
36_S301_Y0.8760.97
508_T532_V0.8760.97
493_G497_V0.8740.97
78_K81_T0.8730.97
230_K234_V0.8700.97
519_A612_K0.8680.97
148_T180_N0.8670.97
125_M376_A0.8670.97
452_N484_D0.8640.97
282_K288_E0.8640.97
58_E259_I0.8640.97
56_H61_S0.8610.97
280_K283_G0.8590.96
54_A258_L0.8590.96
523_L619_I0.8580.96
101_K426_E0.8570.96
42_I297_G0.8560.96
123_M159_I0.8550.96
59_F139_I0.8550.96
489_T493_G0.8540.96
274_L277_I0.8510.96
125_M138_I0.8510.96
508_T512_T0.8500.96
322_V454_G0.8470.96
44_P48_V0.8470.96
539_K542_D0.8460.96
300_P303_I0.8430.96
456_H484_D0.8430.96
263_Q266_K0.8430.96
160_G183_A0.8400.96
147_L152_A0.8390.96
519_A522_E0.8390.96
295_W298_T0.8370.96
151_M368_Q0.8360.96
38_S90_L0.8340.96
187_M190_R0.8330.96
65_K125_M0.8320.96
48_V52_T0.8310.96
515_M611_T0.8300.96
58_E262_L0.8280.96
306_G309_V0.8270.96
189_G193_T0.8260.96
299_G304_N0.8260.96
290_D293_G0.8250.96
307_D310_K0.8250.96
64_D68_W0.8240.96
564_L578_D0.8230.96
278_T281_G0.8210.95
459_H489_T0.8180.95
51_L169_I0.8180.95
163_K186_S0.8180.95
24_S27_I0.8170.95
111_E407_Q0.8160.95
272_V275_H0.8160.95
48_V76_V0.8140.95
434_I447_M0.8140.95
515_M615_V0.8130.95
519_A614_Q0.8120.95
28_R34_S0.8120.95
286_P289_T0.8090.95
547_K551_K0.8080.95
500_P548_S0.8060.95
550_L553_G0.8040.95
371_A400_V0.8030.95
619_I622_L0.8020.95
297_G300_P0.8010.95
497_V500_P0.8010.95
136_E380_Q0.8010.95
77_H82_G0.8000.95
531_R552_E0.8000.95
294_T298_T0.7990.95
306_G310_K0.7990.95
283_G286_P0.7990.95
332_E459_H0.7980.95
310_K317_S0.7940.95
75_Y96_L0.7930.95
337_V382_M0.7920.94
127_A162_E0.7900.94
260_E264_Y0.7860.94
47_G171_N0.7850.94
297_G303_I0.7830.94
61_S66_F0.7820.94
412_F462_L0.7810.94
505_V554_L0.7780.94
504_A555_P0.7780.94
192_R226_K0.7780.94
87_F90_L0.7770.94
443_M468_P0.7770.94
31_L38_S0.7740.94
353_A360_M0.7740.94
189_G201_K0.7730.94
330_A336_I0.7730.94
507_L558_T0.7710.94
396_A400_V0.7710.94
65_K69_D0.7700.94
614_Q617_N0.7700.94
456_H488_K0.7700.94
44_P73_Q0.7690.94
453_E536_R0.7690.94
32_I303_I0.7680.94
240_E244_F0.7660.93
191_L195_G0.7650.93
490_I496_E0.7610.93
515_M519_A0.7600.93
560_E569_G0.7530.93
63_K134_T0.7530.93
140_P166_M0.7530.93
56_H62_P0.7520.93
220_A224_R0.7510.93
546_M576_A0.7500.93
456_H459_H0.7500.93
577_H588_R0.7490.93
63_K67_L0.7470.93
222_A229_L0.7470.93
281_G288_E0.7470.93
115_S149_G0.7440.92
275_H280_K0.7430.92
248_G251_D0.7430.92
257_E265_A0.7420.92
456_H487_L0.7420.92
65_K68_W0.7420.92
261_N265_A0.7410.92
410_N464_Y0.7400.92
262_L265_A0.7390.92
128_A382_M0.7370.92
514_E518_E0.7370.92
543_E546_M0.7360.92
330_A338_A0.7350.92
112_T117_T0.7350.92
67_L122_A0.7350.92
283_G288_E0.7340.92
258_L261_N0.7340.92
350_E354_K0.7330.92
558_T562_A0.7320.92
121_G379_M0.7280.92
78_K82_G0.7270.92
550_L556_I0.7270.92
449_K513_I0.7260.92
337_V377_M0.7260.92
50_E210_K0.7260.92
497_V545_M0.7250.91
236_G241_E0.7240.91
268_T272_V0.7240.91
21_E256_H0.7240.91
589_M610_L0.7230.91
464_Y492_I0.7230.91
570_S573_L0.7220.91
417_R474_P0.7220.91
306_G312_K0.7200.91
310_K313_A0.7190.91
555_P558_T0.7170.91
511_T561_E0.7170.91
85_K89_T0.7160.91
72_H392_F0.7160.91
30_F88_A0.7150.91
239_F244_F0.7130.91
302_K306_G0.7130.91
62_P65_K0.7110.91
618_R622_L0.7110.91
223_E227_D0.7100.91
200_V232_M0.7090.91
539_K593_D0.7090.91
262_L274_L0.7060.90
293_G345_V0.7040.90
236_G240_E0.7020.90
256_H265_A0.7020.90
89_T96_L0.7020.90
594_R597_E0.7020.90
438_R539_K0.7010.90
345_V350_E0.7010.90
122_A138_I0.7010.90
111_E426_E0.7000.90
407_Q466_E0.7000.90
308_F312_K0.6990.90
346_G349_L0.6980.90
542_D545_M0.6980.90
616_A619_I0.6980.90
253_H257_E0.6970.90
400_V413_I0.6970.90
498_L513_I0.6960.90
27_I76_V0.6960.90
282_K286_P0.6940.90
277_I280_K0.6940.90
444_V492_I0.6930.90
456_H467_G0.6920.89
479_L514_E0.6910.89
122_A168_V0.6910.89
120_S372_T0.6900.89
275_H279_K0.6890.89
239_F243_G0.6890.89
262_L266_K0.6880.89
350_E353_A0.6880.89
256_H260_E0.6870.89
251_D254_S0.6840.89
34_S37_A0.6840.89
155_A373_M0.6840.89
561_E605_L0.6830.89
229_L234_V0.6820.89
560_E567_G0.6820.89
178_A345_V0.6810.89
294_T297_G0.6810.89
429_Q596_I0.6800.89
110_W407_Q0.6790.89
158_H162_E0.6780.88
224_R232_M0.6780.88
439_H563_V0.6770.88
283_G290_D0.6770.88
109_V125_M0.6760.88
231_Y237_M0.6760.88
59_F266_K0.6750.88
97_C426_E0.6750.88
320_G351_G0.6750.88
523_L528_L0.6740.88
64_D137_Y0.6740.88
488_K492_I0.6740.88
122_A166_M0.6730.88
111_E406_R0.6700.88
131_I377_M0.6670.88
594_R608_I0.6670.88
400_V437_M0.6670.88
436_F439_H0.6660.88
456_H489_T0.6660.88
577_H586_I0.6640.87
504_A528_L0.6640.87
284_Y287_A0.6630.87
604_L608_I0.6630.87
281_G284_Y0.6630.87
243_G246_Y0.6620.87
257_E262_L0.6620.87
575_F578_D0.6590.87
435_A563_V0.6590.87
401_V440_I0.6580.87
300_P304_N0.6580.87
67_L125_M0.6570.87
311_P317_S0.6560.87
284_Y301_Y0.6560.87
325_T458_V0.6550.87
301_Y304_N0.6550.87
222_A225_V0.6540.87
571_S575_F0.6540.87
63_K136_E0.6540.87
85_K88_A0.6540.87
319_S323_S0.6500.86
253_H258_L0.6500.86
560_E568_F0.6500.86
309_V317_S0.6490.86
271_P278_T0.6490.86
22_K26_E0.6490.86
490_I495_W0.6480.86
296_H300_P0.6480.86
283_G289_T0.6480.86
549_I556_I0.6470.86
456_H490_I0.6470.86
493_G496_E0.6460.86
500_P529_S0.6460.86
551_K554_L0.6450.86
494_T499_R0.6440.86
508_T511_T0.6420.86
434_I445_L0.6410.86
295_W301_Y0.6400.85
597_E607_E0.6400.85
547_K550_L0.6370.85
490_I498_L0.6370.85
151_M372_T0.6360.85
278_T287_A0.6350.85
226_K234_V0.6340.85
559_I589_M0.6340.85
456_H460_T0.6330.85
595_F598_H0.6320.85
574_E578_D0.6320.85
567_G570_S0.6300.85
230_K233_L0.6300.85
491_P495_W0.6300.85
66_F69_D0.6290.84
567_G572_I0.6290.84
111_E379_M0.6290.84
295_W305_T0.6280.84
440_I443_M0.6280.84
557_L618_R0.6270.84
500_P552_E0.6260.84
44_P47_G0.6260.84
435_A439_H0.6230.84
385_F412_F0.6230.84
110_W379_M0.6220.84
99_F102_R0.6210.84
383_K462_L0.6210.84
90_L96_L0.6200.84
280_K284_Y0.6190.84
444_V469_I0.6180.83
338_A385_F0.6170.83
446_M461_A0.6160.83
31_L34_S0.6150.83
568_F571_S0.6140.83
450_D517_I0.6130.83
495_W535_A0.6120.83
495_W498_L0.6110.83
495_W499_R0.6100.83
244_F247_L0.6100.83
45_N48_V0.6100.83
249_P254_S0.6100.83
484_D488_K0.6090.83
295_W303_I0.6090.83
542_D547_K0.6090.83
281_G289_T0.6080.82
499_R532_V0.6080.82
312_K315_A0.6080.82
220_A223_E0.6080.82
282_K287_A0.6070.82
406_R426_E0.6070.82
461_A469_I0.6070.82
533_V553_G0.6070.82
240_E243_G0.6070.82
543_E578_D0.6060.82
321_L454_G0.6050.82
503_D530_V0.6030.82
603_A607_E0.6020.82
307_D311_P0.6010.82
489_T494_T0.6010.82
154_E157_N0.6010.82
183_A186_S0.6010.82
273_L276_V0.6000.82
313_A317_S0.5990.82
572_I576_A0.5990.82
388_I393_L0.5990.82
374_A378_A0.5990.82
296_H299_G0.5970.81
259_I262_L0.5960.81
159_I244_F0.5960.81
45_N53_V0.5960.81
121_G407_Q0.5960.81
559_I610_L0.5960.81
298_T303_I0.5950.81
23_L26_E0.5950.81
522_E617_N0.5930.81
378_A384_P0.5920.81
283_G287_A0.5920.81
142_I152_A0.5920.81
338_A349_L0.5910.81
315_A477_N0.5900.81
404_I468_P0.5900.81
258_L266_K0.5860.80
90_L98_G0.5860.80
423_A601_V0.5860.80
38_S92_Q0.5850.80
148_T184_I0.5840.80
449_K453_E0.5840.80
307_D315_A0.5840.80
393_L400_V0.5830.80
291_T296_H0.5830.80
158_H369_H0.5830.80
558_T586_I0.5830.80
235_S240_E0.5820.80
476_G601_V0.5820.80
250_V261_N0.5810.80
526_E616_A0.5810.80
412_F471_M0.5810.80
117_T372_T0.5800.79
167_I225_V0.5800.79
558_T564_L0.5800.79
412_F458_V0.5790.79
299_G302_K0.5790.79
281_G296_H0.5790.79
450_D497_V0.5780.79
512_T559_I0.5780.79
41_H72_H0.5760.79
363_V370_A0.5760.79
158_H161_D0.5740.79
297_G305_T0.5740.79
296_H301_Y0.5730.79
75_Y78_K0.5730.79
617_N620_R0.5720.78
273_L277_I0.5720.78
507_L556_I0.5700.78
506_I557_L0.5700.78
22_K25_D0.5690.78
421_V475_R0.5690.78
511_T515_M0.5690.78
524_Q530_V0.5680.78
228_S234_V0.5680.78
496_E499_R0.5680.78
434_I472_R0.5680.78
558_T567_G0.5670.78
335_R383_K0.5660.78
572_I580_G0.5650.78
145_G176_S0.5600.77
336_I385_F0.5600.77
577_H580_G0.5590.77
218_L234_V0.5590.77
323_S327_Q0.5590.77
77_H81_T0.5580.77
258_L276_V0.5580.77
324_G328_R0.5570.77
33_T36_S0.5560.77
309_V313_A0.5560.77
570_S575_F0.5560.77
541_I575_F0.5560.77
374_A380_Q0.5550.76
412_F464_Y0.5550.76
494_T542_D0.5530.76
385_F414_G0.5520.76
323_S351_G0.5520.76
371_A396_A0.5520.76
432_F563_V0.5510.76
237_M241_E0.5510.76
53_V57_K0.5510.76
34_S87_F0.5510.76
444_V460_T0.5500.76
503_D531_R0.5500.76
422_G429_Q0.5500.76
596_I599_G0.5500.76
420_L429_Q0.5490.76
213_A221_T0.5490.76
392_F428_H0.5480.75
460_T463_S0.5480.75
219_A222_A0.5470.75
241_E246_Y0.5470.75
127_A158_H0.5460.75
404_I411_V0.5450.75
259_I265_A0.5430.75
118_S152_A0.5430.75
312_K317_S0.5430.75
318_W478_G0.5430.75
572_I579_Q0.5420.75
252_G256_H0.5410.75
312_K316_P0.5410.75
589_M615_V0.5400.74
519_A619_I0.5380.74
202_D205_E0.5380.74
281_G286_P0.5380.74
507_L533_V0.5370.74
460_T469_I0.5370.74
311_P315_A0.5360.74
135_D165_D0.5350.74
460_T464_Y0.5350.74
520_A524_Q0.5340.74
444_V537_F0.5340.74
595_F599_G0.5330.73
568_F573_L0.5330.73
308_F314_A0.5320.73
226_K229_L0.5320.73
165_D229_L0.5320.73
252_G278_T0.5310.73
395_R398_D0.5310.73
609_G614_Q0.5300.73
280_K286_P0.5300.73
571_S580_G0.5300.73
79_L87_F0.5290.73
330_A360_M0.5290.73
67_L118_S0.5280.73
318_W321_L0.5270.73
287_A290_D0.5260.73
33_T37_A0.5260.73
278_T283_G0.5260.73
193_T198_Q0.5250.72
327_Q351_G0.5250.72
123_M197_Y0.5250.72
429_Q604_L0.5240.72
231_Y241_E0.5230.72
84_G96_L0.5210.72
201_K237_M0.5210.72
425_G428_H0.5210.72
284_Y291_T0.5210.72
96_L101_K0.5210.72
523_L620_R0.5200.72
74_S100_P0.5200.72
492_I496_E0.5190.72
523_L527_G0.5180.71
55_L141_I0.5170.71
290_D294_T0.5160.71
414_G473_F0.5160.71
221_T225_V0.5150.71
210_K240_E0.5150.71
271_P275_H0.5140.71
279_K284_Y0.5140.71
98_G102_R0.5140.71
463_S489_T0.5130.71
115_S368_Q0.5120.71
308_F316_P0.5110.70
280_K290_D0.5110.70
489_T497_V0.5110.70
200_V204_L0.5110.70
575_F580_G0.5100.70
410_N466_E0.5100.70
192_R197_Y0.5100.70
63_K66_F0.5090.70
413_I443_M0.5090.70
593_D596_I0.5090.70
51_L55_L0.5090.70
48_V51_L0.5090.70
204_L209_K0.5080.70
494_T497_V0.5080.70
612_K615_V0.5070.70
97_C100_P0.5070.70
338_A360_M0.5050.69
172_D177_I0.5030.69
399_Q403_D0.5030.69
327_Q360_M0.5030.69
247_L272_V0.5030.69
530_V619_I0.5020.69
576_A579_Q0.5020.69
326_V347_S0.5020.69
239_F246_Y0.5010.69
295_W300_P0.5010.69
573_L578_D0.5010.69
186_S189_G0.5000.69
591_I596_I0.5000.69
563_V593_D0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o1xA 2 0.9068 100 0.236 Contact Map
2o1sA 2 0.8389 100 0.246 Contact Map
1r9jA 2 0.9321 100 0.291 Contact Map
3rimA 2 0.9447 100 0.292 Contact Map
4kxvA 2 0.9336 100 0.296 Contact Map
1itzA 2 0.9258 100 0.297 Contact Map
2qtcA 2 0.9542 100 0.299 Contact Map
3uk1A 2 0.9258 100 0.301 Contact Map
1gpuA 2 0.9336 100 0.306 Contact Map
2r8oA 2 0.9321 100 0.312 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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