DXS - BACSU - GREMLIN Contacts

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DXS - 1-deoxy-D-xylulose-5-phosphate synthase

UniProt:	P54523	Sequences: MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGPNLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKRSESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIGDEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKLAATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDGRIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTFLQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKDENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILTFGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEGGFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMPPKTHKGIGS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	633 (590)
Sequences:	6928 (3567)
Seq/√Len:	146.9

ECOLI - DXS TKT1 TKT2
BACSU - DXS TKT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
331_R	355_E	5.652	1.00
611_T	614_Q	4.135	1.00
517_I	532_V	3.980	1.00
522_E	616_A	3.935	1.00
526_E	620_R	3.832	1.00
435_A	562_A	3.437	1.00
446_M	457_M	3.287	1.00
122_A	140_P	3.286	1.00
464_Y	467_G	2.988	1.00
606_E	611_T	2.959	1.00
516_A	559_I	2.735	1.00
531_R	553_G	2.724	1.00
508_T	513_I	2.661	1.00
254_S	257_E	2.659	1.00
24_S	53_V	2.650	1.00
168_V	244_F	2.635	1.00
61_S	107_H	2.635	1.00
503_D	554_L	2.613	1.00
93_Y	603_A	2.612	1.00
132_K	382_M	2.606	1.00
547_K	575_F	2.600	1.00
506_I	516_A	2.558	1.00
504_A	619_I	2.541	1.00
329_M	336_I	2.522	1.00
371_A	413_I	2.465	1.00
600_S	603_A	2.412	1.00
408_N	442_N	2.376	1.00
520_A	532_V	2.376	1.00
559_I	615_V	2.302	1.00
612_K	616_A	2.279	1.00
331_R	356_F	2.277	1.00
543_E	575_F	2.262	1.00
137_Y	165_D	2.254	1.00
449_K	534_N	2.231	1.00
587_D	618_R	2.195	1.00
521_E	525_K	2.178	1.00
285_K	289_T	2.169	1.00
93_Y	599_G	2.159	1.00
93_Y	607_E	2.134	1.00
127_A	373_M	2.131	1.00
377_M	382_M	2.120	1.00
495_W	545_M	2.117	1.00
518_E	612_K	2.109	1.00
169_I	262_L	2.095	1.00
522_E	613_Q	2.075	1.00
383_K	410_N	2.071	1.00
499_R	521_E	2.058	1.00
573_L	588_R	2.051	1.00
496_E	534_N	2.044	1.00
339_I	374_A	2.044	1.00
515_M	518_E	2.036	1.00
522_E	612_K	2.032	1.00
557_L	619_I	2.030	1.00
118_S	142_I	2.023	1.00
328_R	331_R	2.012	1.00
329_M	462_L	1.998	1.00
263_Q	267_K	1.979	1.00
375_A	404_I	1.963	1.00
60_N	63_K	1.960	1.00
518_E	521_E	1.951	1.00
412_F	461_A	1.934	1.00
591_I	608_I	1.921	1.00
446_M	537_F	1.916	1.00
129_R	136_E	1.909	1.00
505_V	553_G	1.908	1.00
125_M	380_Q	1.904	1.00
66_F	141_I	1.902	1.00
341_P	347_S	1.894	1.00
434_I	562_A	1.879	1.00
190_R	193_T	1.873	1.00
545_M	549_I	1.868	1.00
53_V	80_L	1.862	1.00
438_R	571_S	1.846	1.00
535_A	568_F	1.834	1.00
410_N	467_G	1.832	1.00
503_D	529_S	1.830	1.00
34_S	88_A	1.830	1.00
547_K	579_Q	1.829	1.00
508_T	516_A	1.827	1.00
502_N	529_S	1.789	1.00
617_N	621_L	1.784	1.00
327_Q	355_E	1.775	1.00
497_V	531_R	1.763	1.00
255_Y	259_I	1.762	1.00
126_A	138_I	1.757	1.00
504_A	530_V	1.726	1.00
324_G	351_G	1.722	1.00
495_W	533_V	1.715	1.00
351_G	354_K	1.715	1.00
30_F	34_S	1.713	1.00
601_V	605_L	1.712	1.00
438_R	574_E	1.707	1.00
449_K	496_E	1.692	1.00
519_A	616_A	1.690	1.00
120_S	369_H	1.686	1.00
237_M	240_E	1.686	1.00
119_L	159_I	1.685	1.00
564_L	590_G	1.679	1.00
542_D	546_M	1.678	1.00
297_G	301_Y	1.670	1.00
371_A	404_I	1.670	1.00
578_D	588_R	1.664	1.00
231_Y	234_V	1.664	1.00
494_T	544_K	1.642	1.00
616_A	620_R	1.641	1.00
575_F	579_Q	1.641	1.00
589_M	618_R	1.638	1.00
285_K	288_E	1.638	1.00
459_H	463_S	1.626	1.00
533_V	549_I	1.623	1.00
326_V	385_F	1.613	1.00
543_E	547_K	1.608	1.00
57_K	259_I	1.607	1.00
491_P	494_T	1.604	1.00
78_K	107_H	1.584	1.00
327_Q	356_F	1.577	1.00
570_S	574_E	1.577	1.00
415_I	470_A	1.573	1.00
100_P	112_T	1.561	1.00
198_Q	224_R	1.560	1.00
385_F	462_L	1.557	1.00
329_M	459_H	1.551	1.00
437_M	470_A	1.546	1.00
102_R	111_E	1.545	1.00
279_K	282_K	1.540	1.00
55_L	66_F	1.529	1.00
524_Q	529_S	1.527	1.00
507_L	535_A	1.521	1.00
45_N	76_V	1.518	1.00
573_L	577_H	1.517	1.00
302_K	305_T	1.510	1.00
587_D	622_L	1.509	1.00
404_I	413_I	1.497	1.00
137_Y	167_I	1.494	1.00
64_D	69_D	1.493	1.00
464_Y	469_I	1.490	1.00
333_D	383_K	1.484	1.00
543_E	579_Q	1.483	1.00
397_Y	439_H	1.481	1.00
328_R	455_Q	1.475	1.00
606_E	613_Q	1.475	1.00
351_G	355_E	1.472	1.00
506_I	619_I	1.470	1.00
363_V	369_H	1.466	1.00
494_T	535_A	1.463	1.00
516_A	532_V	1.462	1.00
79_L	84_G	1.443	1.00
571_S	574_E	1.434	1.00
606_E	614_Q	1.434	1.00
431_V	591_I	1.433	1.00
129_R	138_I	1.432	1.00
229_L	233_L	1.418	1.00
116_S	149_G	1.396	1.00
393_L	415_I	1.391	1.00
426_E	429_Q	1.389	1.00
546_M	550_L	1.384	1.00
310_K	316_P	1.382	1.00
515_M	612_K	1.381	1.00
30_F	79_L	1.380	1.00
549_I	553_G	1.374	1.00
225_V	229_L	1.370	1.00
377_M	380_Q	1.366	1.00
603_A	606_E	1.362	1.00
102_R	379_M	1.361	1.00
453_E	534_N	1.357	1.00
573_L	586_I	1.346	1.00
316_P	324_G	1.338	1.00
225_V	233_L	1.335	1.00
522_E	526_E	1.331	1.00
335_R	382_M	1.330	1.00
443_M	470_A	1.329	1.00
129_R	134_T	1.327	1.00
614_Q	618_R	1.325	1.00
130_D	164_K	1.324	1.00
405_C	440_I	1.322	1.00
541_I	546_M	1.322	1.00
374_A	386_L	1.321	1.00
165_D	269_K	1.319	1.00
25_D	29_Q	1.317	1.00
325_T	455_Q	1.311	1.00
320_G	324_G	1.310	1.00
519_A	559_I	1.309	1.00
505_V	531_R	1.304	1.00
546_M	575_F	1.304	1.00
325_T	459_H	1.301	1.00
533_V	545_M	1.297	1.00
512_T	515_M	1.293	1.00
499_R	524_Q	1.286	1.00
97_C	101_K	1.285	1.00
333_D	336_I	1.285	1.00
158_H	373_M	1.278	1.00
544_K	548_S	1.278	1.00
420_L	604_L	1.275	1.00
444_V	464_Y	1.274	1.00
557_L	589_M	1.272	1.00
59_F	167_I	1.271	1.00
200_V	221_T	1.270	1.00
420_L	608_I	1.270	1.00
301_Y	306_G	1.267	1.00
373_M	377_M	1.266	1.00
483_M	486_Q	1.264	1.00
361_F	373_M	1.260	1.00
278_T	282_K	1.258	1.00
30_F	38_S	1.258	1.00
128_A	380_Q	1.255	1.00
225_V	231_Y	1.253	1.00
546_M	549_I	1.250	1.00
557_L	622_L	1.249	1.00
405_C	595_F	1.246	1.00
228_S	231_Y	1.245	1.00
225_V	234_V	1.236	1.00
206_Y	209_K	1.236	1.00
258_L	262_L	1.236	1.00
408_N	467_G	1.230	1.00
65_K	136_E	1.219	1.00
56_H	77_H	1.217	1.00
499_R	520_A	1.217	1.00
499_R	529_S	1.216	1.00
55_L	139_I	1.209	1.00
131_I	382_M	1.205	1.00
308_F	311_P	1.204	1.00
550_L	576_A	1.203	1.00
519_A	615_V	1.201	1.00
150_G	154_E	1.200	1.00
137_Y	266_K	1.195	1.00
63_K	135_D	1.195	1.00
505_V	549_I	1.193	1.00
374_A	377_M	1.193	1.00
447_M	511_T	1.193	1.00
310_K	315_A	1.192	1.00
338_A	352_F	1.186	1.00
271_P	274_L	1.184	1.00
568_F	572_I	1.182	1.00
178_A	344_P	1.179	1.00
423_A	600_S	1.175	1.00
34_S	38_S	1.174	1.00
420_L	591_I	1.174	1.00
509_F	538_I	1.168	1.00
225_V	232_M	1.166	1.00
352_F	360_M	1.166	1.00
228_S	232_M	1.160	1.00
513_I	532_V	1.158	1.00
275_H	278_T	1.156	1.00
497_V	533_V	1.155	1.00
89_T	92_Q	1.153	1.00
460_T	491_P	1.150	1.00
594_R	607_E	1.149	1.00
613_Q	617_N	1.149	1.00
325_T	329_M	1.146	1.00
98_G	101_K	1.144	1.00
139_I	167_I	1.135	0.99
596_I	608_I	1.127	0.99
344_P	353_A	1.126	0.99
321_L	451_E	1.125	0.99
306_G	317_S	1.121	0.99
545_M	550_L	1.110	0.99
504_A	557_L	1.108	0.99
393_L	437_M	1.107	0.99
123_M	155_A	1.107	0.99
86_E	89_T	1.107	0.99
548_S	551_K	1.098	0.99
21_E	25_D	1.093	0.99
385_F	458_V	1.087	0.99
64_D	67_L	1.085	0.99
531_R	549_I	1.077	0.99
505_V	533_V	1.075	0.99
259_I	263_Q	1.075	0.99
325_T	328_R	1.072	0.99
330_A	352_F	1.067	0.99
522_E	525_K	1.063	0.99
151_M	155_A	1.063	0.99
255_Y	258_L	1.062	0.99
284_Y	297_G	1.056	0.99
65_K	380_Q	1.055	0.99
277_I	281_G	1.054	0.99
257_E	261_N	1.054	0.99
599_G	604_L	1.048	0.99
451_E	480_G	1.044	0.99
65_K	129_R	1.043	0.99
557_L	587_D	1.042	0.99
167_I	274_L	1.041	0.99
506_I	520_A	1.039	0.99
319_S	348_K	1.038	0.99
225_V	228_S	1.037	0.99
328_R	332_E	1.034	0.99
286_P	290_D	1.031	0.99
444_V	467_G	1.028	0.99
311_P	316_P	1.023	0.99
31_L	76_V	1.021	0.99
21_E	24_S	1.019	0.99
30_F	84_G	1.016	0.99
490_I	494_T	1.015	0.99
521_E	524_Q	1.008	0.99
515_M	605_L	1.008	0.99
413_I	473_F	1.007	0.99
558_T	568_F	1.007	0.99
131_I	337_V	1.006	0.99
498_L	517_I	1.001	0.99
506_I	530_V	1.001	0.99
125_M	379_M	0.999	0.99
151_M	399_Q	0.998	0.99
599_G	603_A	0.997	0.99
558_T	561_E	0.994	0.99
71_G	100_P	0.992	0.99
256_H	259_I	0.991	0.99
434_I	538_I	0.990	0.99
618_R	621_L	0.990	0.99
86_E	96_L	0.988	0.99
368_Q	399_Q	0.986	0.99
519_A	589_M	0.985	0.99
127_A	361_F	0.982	0.98
412_F	469_I	0.981	0.98
564_L	588_R	0.979	0.98
385_F	461_A	0.973	0.98
29_Q	33_T	0.973	0.98
159_I	166_M	0.971	0.98
284_Y	288_E	0.969	0.98
459_H	487_L	0.964	0.98
222_A	226_K	0.960	0.98
31_L	35_L	0.958	0.98
254_S	258_L	0.956	0.98
336_I	462_L	0.954	0.98
344_P	360_M	0.954	0.98
555_P	585_P	0.952	0.98
383_K	412_F	0.952	0.98
340_T	344_P	0.952	0.98
451_E	478_G	0.951	0.98
548_S	552_E	0.949	0.98
317_S	320_G	0.949	0.98
187_M	191_L	0.947	0.98
549_I	552_E	0.946	0.98
438_R	445_L	0.946	0.98
314_A	317_S	0.944	0.98
518_E	613_Q	0.944	0.98
589_M	614_Q	0.941	0.98
432_F	595_F	0.939	0.98
322_V	458_V	0.938	0.98
227_D	231_Y	0.937	0.98
431_V	563_V	0.937	0.98
306_G	311_P	0.934	0.98
219_A	223_E	0.933	0.98
555_P	622_L	0.933	0.98
446_M	469_I	0.930	0.98
310_K	314_A	0.928	0.98
558_T	572_I	0.925	0.98
228_S	233_L	0.921	0.98
31_L	45_N	0.918	0.98
67_L	110_W	0.917	0.98
587_D	621_L	0.917	0.98
457_M	469_I	0.913	0.98
132_K	335_R	0.913	0.98
322_V	387_A	0.912	0.98
311_P	314_A	0.912	0.98
63_K	69_D	0.911	0.98
93_Y	604_L	0.911	0.98
457_M	536_R	0.908	0.97
506_I	559_I	0.908	0.97
265_A	274_L	0.907	0.97
460_T	492_I	0.907	0.97
613_Q	616_A	0.906	0.97
558_T	569_G	0.906	0.97
301_Y	305_T	0.902	0.97
247_L	265_A	0.902	0.97
295_W	299_G	0.900	0.97
494_T	498_L	0.896	0.97
226_K	231_Y	0.896	0.97
226_K	230_K	0.894	0.97
298_T	301_Y	0.887	0.97
378_A	409_A	0.887	0.97
229_L	232_M	0.886	0.97
297_G	302_K	0.885	0.97
371_A	386_L	0.884	0.97
474_P	511_T	0.883	0.97
434_I	509_F	0.882	0.97
490_I	493_G	0.881	0.97
528_L	620_R	0.881	0.97
299_G	303_I	0.881	0.97
257_E	260_E	0.881	0.97
36_S	301_Y	0.876	0.97
508_T	532_V	0.876	0.97
493_G	497_V	0.874	0.97
78_K	81_T	0.873	0.97
230_K	234_V	0.870	0.97
519_A	612_K	0.868	0.97
148_T	180_N	0.867	0.97
125_M	376_A	0.867	0.97
452_N	484_D	0.864	0.97
282_K	288_E	0.864	0.97
58_E	259_I	0.864	0.97
56_H	61_S	0.861	0.97
280_K	283_G	0.859	0.96
54_A	258_L	0.859	0.96
523_L	619_I	0.858	0.96
101_K	426_E	0.857	0.96
42_I	297_G	0.856	0.96
123_M	159_I	0.855	0.96
59_F	139_I	0.855	0.96
489_T	493_G	0.854	0.96
274_L	277_I	0.851	0.96
125_M	138_I	0.851	0.96
508_T	512_T	0.850	0.96
322_V	454_G	0.847	0.96
44_P	48_V	0.847	0.96
539_K	542_D	0.846	0.96
300_P	303_I	0.843	0.96
456_H	484_D	0.843	0.96
263_Q	266_K	0.843	0.96
160_G	183_A	0.840	0.96
147_L	152_A	0.839	0.96
519_A	522_E	0.839	0.96
295_W	298_T	0.837	0.96
151_M	368_Q	0.836	0.96
38_S	90_L	0.834	0.96
187_M	190_R	0.833	0.96
65_K	125_M	0.832	0.96
48_V	52_T	0.831	0.96
515_M	611_T	0.830	0.96
58_E	262_L	0.828	0.96
306_G	309_V	0.827	0.96
189_G	193_T	0.826	0.96
299_G	304_N	0.826	0.96
290_D	293_G	0.825	0.96
307_D	310_K	0.825	0.96
64_D	68_W	0.824	0.96
564_L	578_D	0.823	0.96
278_T	281_G	0.821	0.95
459_H	489_T	0.818	0.95
51_L	169_I	0.818	0.95
163_K	186_S	0.818	0.95
24_S	27_I	0.817	0.95
111_E	407_Q	0.816	0.95
272_V	275_H	0.816	0.95
48_V	76_V	0.814	0.95
434_I	447_M	0.814	0.95
515_M	615_V	0.813	0.95
519_A	614_Q	0.812	0.95
28_R	34_S	0.812	0.95
286_P	289_T	0.809	0.95
547_K	551_K	0.808	0.95
500_P	548_S	0.806	0.95
550_L	553_G	0.804	0.95
371_A	400_V	0.803	0.95
619_I	622_L	0.802	0.95
297_G	300_P	0.801	0.95
497_V	500_P	0.801	0.95
136_E	380_Q	0.801	0.95
77_H	82_G	0.800	0.95
531_R	552_E	0.800	0.95
294_T	298_T	0.799	0.95
306_G	310_K	0.799	0.95
283_G	286_P	0.799	0.95
332_E	459_H	0.798	0.95
310_K	317_S	0.794	0.95
75_Y	96_L	0.793	0.95
337_V	382_M	0.792	0.94
127_A	162_E	0.790	0.94
260_E	264_Y	0.786	0.94
47_G	171_N	0.785	0.94
297_G	303_I	0.783	0.94
61_S	66_F	0.782	0.94
412_F	462_L	0.781	0.94
505_V	554_L	0.778	0.94
504_A	555_P	0.778	0.94
192_R	226_K	0.778	0.94
87_F	90_L	0.777	0.94
443_M	468_P	0.777	0.94
31_L	38_S	0.774	0.94
353_A	360_M	0.774	0.94
189_G	201_K	0.773	0.94
330_A	336_I	0.773	0.94
507_L	558_T	0.771	0.94
396_A	400_V	0.771	0.94
65_K	69_D	0.770	0.94
614_Q	617_N	0.770	0.94
456_H	488_K	0.770	0.94
44_P	73_Q	0.769	0.94
453_E	536_R	0.769	0.94
32_I	303_I	0.768	0.94
240_E	244_F	0.766	0.93
191_L	195_G	0.765	0.93
490_I	496_E	0.761	0.93
515_M	519_A	0.760	0.93
560_E	569_G	0.753	0.93
63_K	134_T	0.753	0.93
140_P	166_M	0.753	0.93
56_H	62_P	0.752	0.93
220_A	224_R	0.751	0.93
546_M	576_A	0.750	0.93
456_H	459_H	0.750	0.93
577_H	588_R	0.749	0.93
63_K	67_L	0.747	0.93
222_A	229_L	0.747	0.93
281_G	288_E	0.747	0.93
115_S	149_G	0.744	0.92
275_H	280_K	0.743	0.92
248_G	251_D	0.743	0.92
257_E	265_A	0.742	0.92
456_H	487_L	0.742	0.92
65_K	68_W	0.742	0.92
261_N	265_A	0.741	0.92
410_N	464_Y	0.740	0.92
262_L	265_A	0.739	0.92
128_A	382_M	0.737	0.92
514_E	518_E	0.737	0.92
543_E	546_M	0.736	0.92
330_A	338_A	0.735	0.92
112_T	117_T	0.735	0.92
67_L	122_A	0.735	0.92
283_G	288_E	0.734	0.92
258_L	261_N	0.734	0.92
350_E	354_K	0.733	0.92
558_T	562_A	0.732	0.92
121_G	379_M	0.728	0.92
78_K	82_G	0.727	0.92
550_L	556_I	0.727	0.92
449_K	513_I	0.726	0.92
337_V	377_M	0.726	0.92
50_E	210_K	0.726	0.92
497_V	545_M	0.725	0.91
236_G	241_E	0.724	0.91
268_T	272_V	0.724	0.91
21_E	256_H	0.724	0.91
589_M	610_L	0.723	0.91
464_Y	492_I	0.723	0.91
570_S	573_L	0.722	0.91
417_R	474_P	0.722	0.91
306_G	312_K	0.720	0.91
310_K	313_A	0.719	0.91
555_P	558_T	0.717	0.91
511_T	561_E	0.717	0.91
85_K	89_T	0.716	0.91
72_H	392_F	0.716	0.91
30_F	88_A	0.715	0.91
239_F	244_F	0.713	0.91
302_K	306_G	0.713	0.91
62_P	65_K	0.711	0.91
618_R	622_L	0.711	0.91
223_E	227_D	0.710	0.91
200_V	232_M	0.709	0.91
539_K	593_D	0.709	0.91
262_L	274_L	0.706	0.90
293_G	345_V	0.704	0.90
236_G	240_E	0.702	0.90
256_H	265_A	0.702	0.90
89_T	96_L	0.702	0.90
594_R	597_E	0.702	0.90
438_R	539_K	0.701	0.90
345_V	350_E	0.701	0.90
122_A	138_I	0.701	0.90
111_E	426_E	0.700	0.90
407_Q	466_E	0.700	0.90
308_F	312_K	0.699	0.90
346_G	349_L	0.698	0.90
542_D	545_M	0.698	0.90
616_A	619_I	0.698	0.90
253_H	257_E	0.697	0.90
400_V	413_I	0.697	0.90
498_L	513_I	0.696	0.90
27_I	76_V	0.696	0.90
282_K	286_P	0.694	0.90
277_I	280_K	0.694	0.90
444_V	492_I	0.693	0.90
456_H	467_G	0.692	0.89
479_L	514_E	0.691	0.89
122_A	168_V	0.691	0.89
120_S	372_T	0.690	0.89
275_H	279_K	0.689	0.89
239_F	243_G	0.689	0.89
262_L	266_K	0.688	0.89
350_E	353_A	0.688	0.89
256_H	260_E	0.687	0.89
251_D	254_S	0.684	0.89
34_S	37_A	0.684	0.89
155_A	373_M	0.684	0.89
561_E	605_L	0.683	0.89
229_L	234_V	0.682	0.89
560_E	567_G	0.682	0.89
178_A	345_V	0.681	0.89
294_T	297_G	0.681	0.89
429_Q	596_I	0.680	0.89
110_W	407_Q	0.679	0.89
158_H	162_E	0.678	0.88
224_R	232_M	0.678	0.88
439_H	563_V	0.677	0.88
283_G	290_D	0.677	0.88
109_V	125_M	0.676	0.88
231_Y	237_M	0.676	0.88
59_F	266_K	0.675	0.88
97_C	426_E	0.675	0.88
320_G	351_G	0.675	0.88
523_L	528_L	0.674	0.88
64_D	137_Y	0.674	0.88
488_K	492_I	0.674	0.88
122_A	166_M	0.673	0.88
111_E	406_R	0.670	0.88
131_I	377_M	0.667	0.88
594_R	608_I	0.667	0.88
400_V	437_M	0.667	0.88
436_F	439_H	0.666	0.88
456_H	489_T	0.666	0.88
577_H	586_I	0.664	0.87
504_A	528_L	0.664	0.87
284_Y	287_A	0.663	0.87
604_L	608_I	0.663	0.87
281_G	284_Y	0.663	0.87
243_G	246_Y	0.662	0.87
257_E	262_L	0.662	0.87
575_F	578_D	0.659	0.87
435_A	563_V	0.659	0.87
401_V	440_I	0.658	0.87
300_P	304_N	0.658	0.87
67_L	125_M	0.657	0.87
311_P	317_S	0.656	0.87
284_Y	301_Y	0.656	0.87
325_T	458_V	0.655	0.87
301_Y	304_N	0.655	0.87
222_A	225_V	0.654	0.87
571_S	575_F	0.654	0.87
63_K	136_E	0.654	0.87
85_K	88_A	0.654	0.87
319_S	323_S	0.650	0.86
253_H	258_L	0.650	0.86
560_E	568_F	0.650	0.86
309_V	317_S	0.649	0.86
271_P	278_T	0.649	0.86
22_K	26_E	0.649	0.86
490_I	495_W	0.648	0.86
296_H	300_P	0.648	0.86
283_G	289_T	0.648	0.86
549_I	556_I	0.647	0.86
456_H	490_I	0.647	0.86
493_G	496_E	0.646	0.86
500_P	529_S	0.646	0.86
551_K	554_L	0.645	0.86
494_T	499_R	0.644	0.86
508_T	511_T	0.642	0.86
434_I	445_L	0.641	0.86
295_W	301_Y	0.640	0.85
597_E	607_E	0.640	0.85
547_K	550_L	0.637	0.85
490_I	498_L	0.637	0.85
151_M	372_T	0.636	0.85
278_T	287_A	0.635	0.85
226_K	234_V	0.634	0.85
559_I	589_M	0.634	0.85
456_H	460_T	0.633	0.85
595_F	598_H	0.632	0.85
574_E	578_D	0.632	0.85
567_G	570_S	0.630	0.85
230_K	233_L	0.630	0.85
491_P	495_W	0.630	0.85
66_F	69_D	0.629	0.84
567_G	572_I	0.629	0.84
111_E	379_M	0.629	0.84
295_W	305_T	0.628	0.84
440_I	443_M	0.628	0.84
557_L	618_R	0.627	0.84
500_P	552_E	0.626	0.84
44_P	47_G	0.626	0.84
435_A	439_H	0.623	0.84
385_F	412_F	0.623	0.84
110_W	379_M	0.622	0.84
99_F	102_R	0.621	0.84
383_K	462_L	0.621	0.84
90_L	96_L	0.620	0.84
280_K	284_Y	0.619	0.84
444_V	469_I	0.618	0.83
338_A	385_F	0.617	0.83
446_M	461_A	0.616	0.83
31_L	34_S	0.615	0.83
568_F	571_S	0.614	0.83
450_D	517_I	0.613	0.83
495_W	535_A	0.612	0.83
495_W	498_L	0.611	0.83
495_W	499_R	0.610	0.83
244_F	247_L	0.610	0.83
45_N	48_V	0.610	0.83
249_P	254_S	0.610	0.83
484_D	488_K	0.609	0.83
295_W	303_I	0.609	0.83
542_D	547_K	0.609	0.83
281_G	289_T	0.608	0.82
499_R	532_V	0.608	0.82
312_K	315_A	0.608	0.82
220_A	223_E	0.608	0.82
282_K	287_A	0.607	0.82
406_R	426_E	0.607	0.82
461_A	469_I	0.607	0.82
533_V	553_G	0.607	0.82
240_E	243_G	0.607	0.82
543_E	578_D	0.606	0.82
321_L	454_G	0.605	0.82
503_D	530_V	0.603	0.82
603_A	607_E	0.602	0.82
307_D	311_P	0.601	0.82
489_T	494_T	0.601	0.82
154_E	157_N	0.601	0.82
183_A	186_S	0.601	0.82
273_L	276_V	0.600	0.82
313_A	317_S	0.599	0.82
572_I	576_A	0.599	0.82
388_I	393_L	0.599	0.82
374_A	378_A	0.599	0.82
296_H	299_G	0.597	0.81
259_I	262_L	0.596	0.81
159_I	244_F	0.596	0.81
45_N	53_V	0.596	0.81
121_G	407_Q	0.596	0.81
559_I	610_L	0.596	0.81
298_T	303_I	0.595	0.81
23_L	26_E	0.595	0.81
522_E	617_N	0.593	0.81
378_A	384_P	0.592	0.81
283_G	287_A	0.592	0.81
142_I	152_A	0.592	0.81
338_A	349_L	0.591	0.81
315_A	477_N	0.590	0.81
404_I	468_P	0.590	0.81
258_L	266_K	0.586	0.80
90_L	98_G	0.586	0.80
423_A	601_V	0.586	0.80
38_S	92_Q	0.585	0.80
148_T	184_I	0.584	0.80
449_K	453_E	0.584	0.80
307_D	315_A	0.584	0.80
393_L	400_V	0.583	0.80
291_T	296_H	0.583	0.80
158_H	369_H	0.583	0.80
558_T	586_I	0.583	0.80
235_S	240_E	0.582	0.80
476_G	601_V	0.582	0.80
250_V	261_N	0.581	0.80
526_E	616_A	0.581	0.80
412_F	471_M	0.581	0.80
117_T	372_T	0.580	0.79
167_I	225_V	0.580	0.79
558_T	564_L	0.580	0.79
412_F	458_V	0.579	0.79
299_G	302_K	0.579	0.79
281_G	296_H	0.579	0.79
450_D	497_V	0.578	0.79
512_T	559_I	0.578	0.79
41_H	72_H	0.576	0.79
363_V	370_A	0.576	0.79
158_H	161_D	0.574	0.79
297_G	305_T	0.574	0.79
296_H	301_Y	0.573	0.79
75_Y	78_K	0.573	0.79
617_N	620_R	0.572	0.78
273_L	277_I	0.572	0.78
507_L	556_I	0.570	0.78
506_I	557_L	0.570	0.78
22_K	25_D	0.569	0.78
421_V	475_R	0.569	0.78
511_T	515_M	0.569	0.78
524_Q	530_V	0.568	0.78
228_S	234_V	0.568	0.78
496_E	499_R	0.568	0.78
434_I	472_R	0.568	0.78
558_T	567_G	0.567	0.78
335_R	383_K	0.566	0.78
572_I	580_G	0.565	0.78
145_G	176_S	0.560	0.77
336_I	385_F	0.560	0.77
577_H	580_G	0.559	0.77
218_L	234_V	0.559	0.77
323_S	327_Q	0.559	0.77
77_H	81_T	0.558	0.77
258_L	276_V	0.558	0.77
324_G	328_R	0.557	0.77
33_T	36_S	0.556	0.77
309_V	313_A	0.556	0.77
570_S	575_F	0.556	0.77
541_I	575_F	0.556	0.77
374_A	380_Q	0.555	0.76
412_F	464_Y	0.555	0.76
494_T	542_D	0.553	0.76
385_F	414_G	0.552	0.76
323_S	351_G	0.552	0.76
371_A	396_A	0.552	0.76
432_F	563_V	0.551	0.76
237_M	241_E	0.551	0.76
53_V	57_K	0.551	0.76
34_S	87_F	0.551	0.76
444_V	460_T	0.550	0.76
503_D	531_R	0.550	0.76
422_G	429_Q	0.550	0.76
596_I	599_G	0.550	0.76
420_L	429_Q	0.549	0.76
213_A	221_T	0.549	0.76
392_F	428_H	0.548	0.75
460_T	463_S	0.548	0.75
219_A	222_A	0.547	0.75
241_E	246_Y	0.547	0.75
127_A	158_H	0.546	0.75
404_I	411_V	0.545	0.75
259_I	265_A	0.543	0.75
118_S	152_A	0.543	0.75
312_K	317_S	0.543	0.75
318_W	478_G	0.543	0.75
572_I	579_Q	0.542	0.75
252_G	256_H	0.541	0.75
312_K	316_P	0.541	0.75
589_M	615_V	0.540	0.74
519_A	619_I	0.538	0.74
202_D	205_E	0.538	0.74
281_G	286_P	0.538	0.74
507_L	533_V	0.537	0.74
460_T	469_I	0.537	0.74
311_P	315_A	0.536	0.74
135_D	165_D	0.535	0.74
460_T	464_Y	0.535	0.74
520_A	524_Q	0.534	0.74
444_V	537_F	0.534	0.74
595_F	599_G	0.533	0.73
568_F	573_L	0.533	0.73
308_F	314_A	0.532	0.73
226_K	229_L	0.532	0.73
165_D	229_L	0.532	0.73
252_G	278_T	0.531	0.73
395_R	398_D	0.531	0.73
609_G	614_Q	0.530	0.73
280_K	286_P	0.530	0.73
571_S	580_G	0.530	0.73
79_L	87_F	0.529	0.73
330_A	360_M	0.529	0.73
67_L	118_S	0.528	0.73
318_W	321_L	0.527	0.73
287_A	290_D	0.526	0.73
33_T	37_A	0.526	0.73
278_T	283_G	0.526	0.73
193_T	198_Q	0.525	0.72
327_Q	351_G	0.525	0.72
123_M	197_Y	0.525	0.72
429_Q	604_L	0.524	0.72
231_Y	241_E	0.523	0.72
84_G	96_L	0.521	0.72
201_K	237_M	0.521	0.72
425_G	428_H	0.521	0.72
284_Y	291_T	0.521	0.72
96_L	101_K	0.521	0.72
523_L	620_R	0.520	0.72
74_S	100_P	0.520	0.72
492_I	496_E	0.519	0.72
523_L	527_G	0.518	0.71
55_L	141_I	0.517	0.71
290_D	294_T	0.516	0.71
414_G	473_F	0.516	0.71
221_T	225_V	0.515	0.71
210_K	240_E	0.515	0.71
271_P	275_H	0.514	0.71
279_K	284_Y	0.514	0.71
98_G	102_R	0.514	0.71
463_S	489_T	0.513	0.71
115_S	368_Q	0.512	0.71
308_F	316_P	0.511	0.70
280_K	290_D	0.511	0.70
489_T	497_V	0.511	0.70
200_V	204_L	0.511	0.70
575_F	580_G	0.510	0.70
410_N	466_E	0.510	0.70
192_R	197_Y	0.510	0.70
63_K	66_F	0.509	0.70
413_I	443_M	0.509	0.70
593_D	596_I	0.509	0.70
51_L	55_L	0.509	0.70
48_V	51_L	0.509	0.70
204_L	209_K	0.508	0.70
494_T	497_V	0.508	0.70
612_K	615_V	0.507	0.70
97_C	100_P	0.507	0.70
338_A	360_M	0.505	0.69
172_D	177_I	0.503	0.69
399_Q	403_D	0.503	0.69
327_Q	360_M	0.503	0.69
247_L	272_V	0.503	0.69
530_V	619_I	0.502	0.69
576_A	579_Q	0.502	0.69
326_V	347_S	0.502	0.69
239_F	246_Y	0.501	0.69
295_W	300_P	0.501	0.69
573_L	578_D	0.501	0.69
186_S	189_G	0.500	0.69
591_I	596_I	0.500	0.69
563_V	593_D	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2o1xA	2	0.9068	100	0.236	Contact Map
2o1sA	2	0.8389	100	0.246	Contact Map
1r9jA	2	0.9321	100	0.291	Contact Map
3rimA	2	0.9447	100	0.292	Contact Map
4kxvA	2	0.9336	100	0.296	Contact Map
1itzA	2	0.9258	100	0.297	Contact Map
2qtcA	2	0.9542	100	0.299	Contact Map
3uk1A	2	0.9258	100	0.301	Contact Map
1gpuA	2	0.9336	100	0.306	Contact Map
2r8oA	2	0.9321	100	0.312	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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