GREMLIN Database
EX7S - Exodeoxyribonuclease 7 small subunit
UniProt: P54522 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 84 (72)
Sequences: 856 (569)
Seq/√Len: 67.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_G42_E6.6271.00
32_P36_A3.8941.00
37_I44_M2.8541.00
41_Q45_A2.3361.00
34_E53_K2.2051.00
52_E56_K2.2041.00
41_Q60_Q2.2021.00
25_K39_Y2.1171.00
14_E17_K2.0801.00
15_A49_M1.9101.00
25_K35_Q1.9051.00
15_A50_C1.8661.00
37_I57_V1.8201.00
38_N41_Q1.6220.99
31_V39_Y1.5590.99
17_K21_S1.3820.98
21_S25_K1.3320.97
40_F65_L1.2900.97
51_H55_Q1.2720.96
22_I39_Y1.2480.96
9_N72_A1.2150.95
48_K52_E1.2000.95
11_T14_E1.1420.93
61_M64_I1.1240.93
44_M51_H1.1020.92
41_Q61_M1.0930.92
41_Q59_K1.0810.91
18_G21_S1.0780.91
32_P35_Q1.0770.91
21_S72_A1.0560.90
66_K71_L1.0330.89
63_F74_F1.0290.89
31_V64_I1.0230.89
10_M18_G1.0210.89
12_F16_M1.0070.88
44_M47_S1.0050.88
39_Y50_C0.9760.86
41_Q64_I0.9670.86
65_L72_A0.9560.85
23_V60_Q0.8760.80
16_M57_V0.8720.79
10_M15_A0.8630.79
22_I66_K0.8530.78
34_E47_S0.8220.75
16_M58_E0.8040.74
48_K67_E0.7920.73
61_M76_V0.7910.72
62_D73_P0.7850.72
36_A57_V0.7820.72
51_H61_M0.7780.71
22_I47_S0.7720.71
35_Q38_N0.7640.70
10_M52_E0.7160.65
69_G72_A0.7090.64
60_Q64_I0.7070.64
65_L74_F0.7070.64
40_F63_F0.7010.63
37_I47_S0.7000.63
63_F71_L0.6880.62
45_A49_M0.6830.61
20_E50_C0.6790.61
37_I64_I0.6720.60
40_F76_V0.6700.60
60_Q63_F0.6680.59
41_Q57_V0.6680.59
17_K44_M0.6640.59
26_L62_D0.6630.59
55_Q59_K0.6530.58
22_I28_E0.6470.57
22_I63_F0.6400.56
11_T16_M0.6400.56
37_I41_Q0.6360.56
17_K77_Q0.6320.55
23_V32_P0.6300.55
66_K69_G0.6140.53
24_S55_Q0.6110.53
55_Q73_P0.6040.52
39_Y61_M0.6020.52
43_G73_P0.5990.51
11_T53_K0.5960.51
23_V40_F0.5950.51
37_I48_K0.5850.50
34_E45_A0.5840.50
48_K59_K0.5780.49
14_E18_G0.5780.49
28_E35_Q0.5770.49
58_E65_L0.5730.48
51_H57_V0.5700.48
15_A51_H0.5580.46
21_S24_S0.5580.46
41_Q47_S0.5550.46
37_I53_K0.5400.44
20_E77_Q0.5390.44
61_M74_F0.5340.44
43_G65_L0.5290.43
63_F76_V0.5260.43
35_Q48_K0.5250.43
26_L78_E0.5240.42
30_D45_A0.5210.42
36_A53_K0.5210.42
40_F47_S0.5210.42
38_N75_S0.5160.42
16_M55_Q0.5120.41
34_E77_Q0.5080.41
47_S58_E0.5050.40
66_K70_E0.5040.40
10_M49_M0.5010.40
53_K60_Q0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vp7A 2 0.9286 99.8 0.318 Contact Map
4tptA 2 0.5952 23.8 0.895 Contact Map
4cqeA 1 0.2976 15.1 0.904 Contact Map
2ozoA 1 0.4643 14.6 0.905 Contact Map
2psqA 2 0.3333 14.1 0.905 Contact Map
2w1iA 1 0.3333 13.9 0.905 Contact Map
3lxpA 1 0.3333 13.2 0.906 Contact Map
3ugcA 1 0.2976 11.7 0.909 Contact Map
4qqtA 1 0.3095 10.4 0.911 Contact Map
3socA 1 0.3095 10.3 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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