GREMLIN Database
EX7L - Exodeoxyribonuclease 7 large subunit
UniProt: P54521 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 448 (385)
Sequences: 2548 (1911)
Seq/√Len: 97.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_N227_S5.3191.00
224_I244_S4.6561.00
123_E222_R4.6101.00
130_Y225_F4.5751.00
221_A243_I4.2171.00
174_L183_S4.0931.00
232_I262_A3.5431.00
158_T256_T3.4291.00
192_N229_I3.4061.00
332_L336_K3.2221.00
140_T167_K3.2191.00
192_N228_N3.1781.00
180_A214_A3.0861.00
143_V155_V2.9471.00
118_K122_G2.8951.00
35_L38_V2.8231.00
181_S217_E2.8061.00
125_L222_R2.7991.00
73_P101_M2.7501.00
287_H291_K2.7111.00
185_V220_V2.6151.00
217_E220_V2.5541.00
188_I200_L2.5241.00
173_A184_I2.5181.00
189_E226_A2.5031.00
377_Q381_L2.4571.00
114_E118_K2.4221.00
224_I231_I2.4151.00
185_V219_I2.3661.00
142_G197_C2.3481.00
74_E77_M2.3481.00
155_V203_G2.3371.00
48_F98_A2.3221.00
58_Q93_N2.3031.00
142_G200_L2.2731.00
241_F246_F2.2451.00
16_I87_V2.1981.00
191_A200_L2.1761.00
221_A247_V2.1671.00
59_S98_A2.1341.00
155_V201_I2.0781.00
46_I66_S2.0771.00
134_I250_I2.0201.00
184_I220_V2.0151.00
38_V46_I1.9881.00
119_K218_E1.9871.00
188_I202_V1.9371.00
142_G191_A1.9271.00
203_G234_A1.9201.00
250_I261_I1.9051.00
199_V262_A1.8951.00
173_A187_R1.8601.00
159_L168_V1.8491.00
253_A257_G1.8201.00
156_I168_V1.8061.00
201_I262_A1.8041.00
316_Q319_D1.7531.00
15_Y23_D1.7481.00
14_K89_E1.7191.00
336_K339_Q1.7011.00
60_V95_Q1.6911.00
151_A239_T1.6821.00
161_R260_E1.6741.00
173_A183_S1.6581.00
49_T56_R1.6471.00
40_I72_K1.6461.00
143_V168_V1.6391.00
220_V223_A1.6221.00
358_Q361_T1.6121.00
13_T94_Y1.6071.00
111_L115_E1.5861.00
81_V101_M1.5851.00
86_S97_Y1.5831.00
83_G96_L1.5261.00
182_R219_I1.5171.00
140_T169_I1.5051.00
108_A112_A1.4841.00
30_W82_R1.4801.00
163_Y264_P1.4771.00
171_L194_K1.4551.00
225_F247_V1.4431.00
355_Q359_A1.4421.00
181_S219_I1.4301.00
185_V217_E1.4291.00
203_G235_V1.4020.99
35_L79_V1.3990.99
121_A127_D1.3900.99
151_A203_G1.3880.99
218_E222_R1.3860.99
32_K78_K1.3840.99
188_I231_I1.3730.99
138_P141_I1.3610.99
149_G152_V1.3550.99
265_H268_D1.3490.99
200_L227_S1.3410.99
84_G99_K1.3310.99
37_N75_N1.3240.99
238_E251_R1.3220.99
189_E193_E1.3210.99
15_Y26_L1.3130.99
169_I197_C1.3110.99
171_L197_C1.3090.99
174_L179_N1.3060.99
185_V188_I1.3000.99
140_T197_C1.3000.99
171_L191_A1.2990.99
87_V94_Y1.2990.99
179_N182_R1.2990.99
31_I96_L1.2830.99
82_R100_E1.2820.99
7_V12_L1.2740.99
132_K228_N1.2740.99
81_V98_A1.2640.99
209_I213_W1.2580.99
166_V263_V1.2570.99
115_E119_K1.2560.99
250_I253_A1.2540.99
180_A184_I1.2440.99
141_I199_V1.2380.99
30_W80_L1.2330.99
46_I69_L1.2310.99
13_T16_I1.2270.99
359_A362_R1.2240.99
381_L384_Q1.2220.99
184_I202_V1.2220.99
35_L101_M1.2180.99
119_K123_E1.2110.98
60_V97_Y1.2070.98
71_F101_M1.1910.98
391_K394_A1.1780.98
12_L85_I1.1710.98
163_Y166_V1.1670.98
39_K75_N1.1640.98
135_P199_V1.1620.98
102_Q108_A1.1620.98
324_Q328_Q1.1610.98
17_K89_E1.1600.98
266_T270_I1.1570.98
147_P152_V1.1520.98
142_G171_L1.1440.98
188_I220_V1.1400.98
365_E369_Q1.1350.98
272_R276_A1.1340.98
188_I227_S1.1320.98
117_K246_F1.1290.98
186_T189_E1.1240.98
243_I247_V1.1230.98
7_V15_Y1.1150.97
138_P264_P1.1120.97
123_E218_E1.1090.97
113_Y246_F1.1080.97
144_V202_V1.1020.97
372_K376_I1.0940.97
114_E117_K1.0940.97
115_E118_K1.0920.97
153_R156_I1.0820.97
113_Y243_I1.0810.97
12_L57_M1.0790.97
202_V233_S1.0720.97
141_I159_L1.0640.97
306_F309_R1.0640.97
129_R225_F1.0640.97
71_F103_P1.0600.96
61_M101_M1.0550.96
346_R350_L1.0530.96
291_K294_R1.0510.96
369_Q373_N1.0490.96
118_K121_A1.0490.96
73_P77_M1.0440.96
134_I232_I1.0400.96
61_M66_S1.0400.96
57_M96_L1.0350.96
282_R286_Q1.0270.96
181_S214_A1.0250.96
376_I379_K1.0210.96
63_A67_E1.0190.96
38_V73_P1.0180.96
16_I94_Y1.0050.95
144_V173_A1.0050.95
338_R342_R0.9990.95
387_T390_G0.9990.95
195_E229_I0.9910.95
103_P111_L0.9870.95
41_H148_T0.9840.95
61_M71_F0.9820.95
320_L327_A0.9790.94
17_K23_D0.9790.94
222_R226_A0.9780.94
65_Q99_K0.9750.94
385_F389_L0.9740.94
59_S96_L0.9720.94
188_I224_I0.9690.94
310_L314_K0.9640.94
331_A335_R0.9610.94
109_L213_W0.9610.94
184_I188_I0.9600.94
79_V101_M0.9570.94
317_Q321_A0.9520.94
331_A334_D0.9500.94
162_R260_E0.9500.94
125_L218_E0.9490.94
362_R366_Q0.9480.93
112_A115_E0.9480.93
112_A116_L0.9440.93
8_T11_A0.9390.93
57_M83_G0.9390.93
293_E296_Q0.9350.93
213_W217_E0.9350.93
161_R257_G0.9330.93
200_L229_I0.9290.93
134_I199_V0.9280.93
157_T161_R0.9270.93
278_V282_R0.9230.93
181_S185_V0.9230.93
35_L59_S0.9220.93
10_S54_N0.9200.92
10_S55_A0.9190.92
227_S231_I0.9180.92
189_E223_A0.9130.92
40_I46_I0.9110.92
61_M69_L0.9080.92
309_R312_A0.9070.92
85_I94_Y0.9020.92
329_L332_L0.9000.92
343_E346_R0.8980.92
157_T253_A0.8970.91
144_V187_R0.8960.91
327_A331_A0.8910.91
57_M94_Y0.8880.91
217_E223_A0.8870.91
323_Q327_A0.8870.91
144_V191_A0.8860.91
42_T148_T0.8860.91
106_V110_Y0.8860.91
16_I57_M0.8850.91
103_P115_E0.8850.91
151_A156_I0.8840.91
223_A227_S0.8840.91
202_V234_A0.8800.91
233_S244_S0.8770.91
139_A167_K0.8770.91
185_V189_E0.8750.90
188_I192_N0.8720.90
279_R283_A0.8720.90
171_L190_E0.8720.90
61_M98_A0.8660.90
159_L263_V0.8600.90
23_D26_L0.8600.90
110_Y114_E0.8590.90
308_K312_A0.8580.90
371_R375_N0.8560.89
13_T87_V0.8510.89
32_K104_D0.8470.89
185_V223_A0.8470.89
374_M378_M0.8460.89
12_L31_I0.8400.89
141_I166_V0.8360.88
149_G234_A0.8330.88
163_Y269_L0.8300.88
38_V66_S0.8280.88
153_R239_T0.8270.88
354_E357_K0.8270.88
77_M103_P0.8230.88
360_R364_Q0.8220.87
199_V232_I0.8120.87
194_K197_C0.8120.87
147_P172_P0.8110.87
164_P264_P0.8090.87
125_L225_F0.8090.87
142_G169_I0.8050.86
147_P153_R0.8030.86
366_Q369_Q0.8010.86
354_E358_Q0.7950.86
36_S51_K0.7950.86
314_K317_Q0.7950.86
20_F87_V0.7890.85
334_D338_R0.7850.85
173_A191_A0.7790.85
43_R63_A0.7780.84
151_A155_V0.7780.84
156_I170_V0.7770.84
88_Y91_S0.7760.84
39_K42_T0.7760.84
380_Q383_S0.7760.84
359_A363_Y0.7760.84
57_M85_I0.7740.84
140_T196_I0.7700.84
153_R157_T0.7650.83
41_H97_Y0.7630.83
362_R365_E0.7600.83
367_T371_R0.7600.83
330_T334_D0.7580.83
190_E194_K0.7580.83
159_L259_A0.7570.83
35_L73_P0.7570.83
81_V96_L0.7550.83
28_N82_R0.7530.82
213_W216_N0.7520.82
108_A111_L0.7520.82
69_L101_M0.7480.82
383_S387_T0.7460.82
132_K227_S0.7450.82
202_V220_V0.7440.82
187_R191_A0.7440.82
292_K337_S0.7430.82
361_T365_E0.7420.82
197_C200_L0.7390.81
82_R99_K0.7380.81
253_A256_T0.7380.81
56_R91_S0.7360.81
64_R67_E0.7350.81
191_A197_C0.7350.81
233_S245_D0.7330.81
37_N49_T0.7320.81
161_R261_I0.7310.81
6_Y80_L0.7290.80
316_Q320_L0.7280.80
109_L209_I0.7270.80
152_V156_I0.7250.80
368_N372_K0.7240.80
150_A239_T0.7210.80
48_F59_S0.7200.80
151_A170_V0.7180.79
13_T92_G0.7160.79
284_M291_K0.7150.79
173_A220_V0.7120.79
113_Y117_K0.7100.79
309_R313_Q0.7080.78
7_V11_A0.7070.78
276_A280_M0.7050.78
83_G94_Y0.7020.78
390_G394_A0.7010.78
120_L221_A0.6970.77
195_E228_N0.6930.77
56_R93_N0.6930.77
337_S341_E0.6930.77
30_W100_E0.6920.77
44_G63_A0.6910.77
165_L266_T0.6880.76
16_I20_F0.6880.76
384_Q388_V0.6880.76
15_Y19_K0.6870.76
305_R310_L0.6850.76
284_M288_L0.6840.76
56_R211_E0.6810.76
43_R95_Q0.6810.76
55_A89_E0.6800.76
117_K221_A0.6780.75
293_E297_T0.6780.75
39_K66_S0.6780.75
280_M325_F0.6740.75
320_L323_Q0.6740.75
381_L385_F0.6720.75
156_I159_L0.6710.75
48_F61_M0.6710.75
389_L392_L0.6700.75
169_I196_I0.6700.75
36_S49_T0.6670.74
364_Q371_R0.6670.74
50_L81_V0.6660.74
143_V152_V0.6660.74
43_R315_E0.6640.74
158_T239_T0.6640.74
137_F269_L0.6630.74
39_K148_T0.6610.74
169_I194_K0.6600.73
49_T58_Q0.6590.73
114_E121_A0.6580.73
296_Q299_Q0.6550.73
268_D271_E0.6540.73
286_Q289_G0.6520.73
365_E368_N0.6520.73
233_S248_A0.6520.73
183_S187_R0.6510.72
387_T391_K0.6510.72
8_T94_Y0.6510.72
13_T55_A0.6500.72
70_P112_A0.6490.72
292_K296_Q0.6480.72
234_A244_S0.6450.72
171_L200_L0.6430.72
113_Y216_N0.6420.71
187_R190_E0.6390.71
41_H56_R0.6360.71
19_K23_D0.6350.71
155_V259_A0.6350.71
202_V244_S0.6350.71
335_R338_R0.6350.71
58_Q91_S0.6340.70
182_R186_T0.6340.70
320_L324_Q0.6330.70
132_K247_V0.6320.70
82_R102_Q0.6320.70
382_H386_Q0.6310.70
33_G59_S0.6290.70
266_T269_L0.6250.69
141_I262_A0.6250.69
117_K126_F0.6230.69
147_P170_V0.6230.69
209_I239_T0.6230.69
360_R368_N0.6210.69
175_V215_F0.6210.69
389_L393_N0.6210.69
297_T300_S0.6210.69
137_F163_Y0.6210.69
351_H354_E0.6200.69
202_V231_I0.6200.69
144_V188_I0.6180.68
158_T253_A0.6180.68
46_I73_P0.6170.68
116_L119_K0.6150.68
132_K225_F0.6140.68
363_Y366_Q0.6130.68
157_T256_T0.6120.68
358_Q362_R0.6120.68
379_K386_Q0.6120.68
29_I83_G0.6120.68
285_Q289_G0.6100.68
366_Q374_M0.6090.67
355_Q382_H0.6080.67
17_K86_S0.6070.67
163_Y263_V0.6070.67
275_T278_V0.6040.67
294_R298_L0.6030.67
90_P97_Y0.6030.67
61_M97_Y0.6020.66
264_P269_L0.6010.66
153_R170_V0.6010.66
80_L102_Q0.6010.66
109_L113_Y0.6000.66
50_L79_V0.6000.66
364_Q368_N0.5990.66
290_Q294_R0.5990.66
23_D97_Y0.5980.66
148_T152_V0.5980.66
166_V262_A0.5960.66
103_P110_Y0.5950.66
11_A15_Y0.5950.66
349_A354_E0.5940.65
197_C229_I0.5940.65
315_E319_D0.5930.65
151_A234_A0.5910.65
34_E107_G0.5910.65
315_E337_S0.5890.65
201_I232_I0.5890.65
286_Q290_Q0.5880.65
375_N383_S0.5850.64
178_E182_R0.5850.64
65_Q68_R0.5850.64
386_Q389_L0.5850.64
20_F85_I0.5840.64
291_K336_K0.5820.64
90_P94_Y0.5810.64
271_E275_T0.5800.64
342_R345_Y0.5800.64
192_N223_A0.5800.64
174_L182_R0.5790.63
15_Y25_H0.5790.63
86_S96_L0.5780.63
252_A261_I0.5780.63
360_R375_N0.5780.63
144_V200_L0.5770.63
315_E318_F0.5760.63
136_A272_R0.5750.63
28_N83_G0.5740.63
39_K60_V0.5740.63
147_P156_I0.5730.63
274_K277_E0.5730.63
131_K249_D0.5710.62
224_I243_I0.5710.62
182_R185_V0.5700.62
378_M386_Q0.5700.62
19_K24_P0.5700.62
142_G202_V0.5690.62
362_R376_I0.5690.62
192_N231_I0.5690.62
112_A119_K0.5650.62
171_L196_I0.5640.61
322_Y326_Q0.5630.61
142_G155_V0.5630.61
137_F165_L0.5610.61
378_M382_H0.5600.61
45_H62_F0.5600.61
110_Y256_T0.5590.61
110_Y113_Y0.5590.61
162_R258_A0.5580.61
318_F321_A0.5570.61
149_G203_G0.5570.61
13_T19_K0.5560.60
203_G233_S0.5560.60
291_K298_L0.5550.60
338_R341_E0.5550.60
110_Y209_I0.5540.60
368_N371_R0.5530.60
116_L218_E0.5520.60
175_V180_A0.5510.60
110_Y158_T0.5490.59
151_A191_A0.5490.59
329_L333_L0.5490.59
308_K313_Q0.5490.59
158_T257_G0.5490.59
252_A258_A0.5470.59
386_Q390_G0.5470.59
149_G172_P0.5450.59
383_S386_Q0.5450.59
211_E238_E0.5440.59
16_I85_I0.5430.59
132_K231_I0.5400.58
378_M387_T0.5400.58
361_T364_Q0.5390.58
175_V184_I0.5390.58
30_W102_Q0.5390.58
340_L343_E0.5380.58
36_S75_N0.5360.58
313_Q316_Q0.5350.57
34_E51_K0.5340.57
348_E368_N0.5340.57
363_Y367_T0.5330.57
51_K210_E0.5330.57
87_V95_Q0.5330.57
120_L222_R0.5330.57
46_I61_M0.5320.57
277_E281_T0.5310.57
272_R275_T0.5300.57
257_G260_E0.5290.57
358_Q384_Q0.5290.57
70_P102_Q0.5290.57
5_A11_A0.5280.57
7_V320_L0.5270.56
138_P163_Y0.5270.56
194_K229_I0.5270.56
297_T301_S0.5260.56
41_H44_G0.5260.56
203_G239_T0.5260.56
69_L73_P0.5260.56
356_L360_R0.5250.56
355_Q369_Q0.5230.56
336_K340_L0.5200.55
239_T242_T0.5200.55
41_H84_G0.5190.55
152_V170_V0.5180.55
376_I391_K0.5160.55
146_S151_A0.5150.55
91_S211_E0.5140.55
388_V391_K0.5130.54
356_L359_A0.5130.54
31_I57_M0.5120.54
253_A261_I0.5120.54
357_K365_E0.5120.54
138_P199_V0.5120.54
27_E30_W0.5110.54
40_I66_S0.5110.54
282_R346_R0.5110.54
315_E322_Y0.5110.54
121_A128_D0.5090.54
158_T201_I0.5090.54
38_V75_N0.5080.54
357_K389_L0.5080.54
209_I242_T0.5060.53
379_K383_S0.5060.53
31_I81_V0.5040.53
244_S248_A0.5040.53
271_E278_V0.5040.53
191_A229_I0.5040.53
43_R60_V0.5040.53
155_V257_G0.5030.53
113_Y213_W0.5030.53
6_Y11_A0.5030.53
149_G163_Y0.5020.53
71_F115_E0.5020.53
11_A19_K0.5020.53
214_A217_E0.5020.53
273_T276_A0.5010.53
265_H271_E0.5010.53
199_V229_I0.5010.53
357_K371_R0.5000.53
162_R252_A0.5000.53
170_V203_G0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gnxB 1 0.25 99.5 0.887 Contact Map
4joiA 1 0.2768 98.6 0.922 Contact Map
3kdfD 2 0.25 97.7 0.94 Contact Map
3dm3A 4 0.1897 96.6 0.949 Contact Map
3e0eA 1 0.1853 96.4 0.95 Contact Map
3au7A 1 0.2969 96.4 0.95 Contact Map
3kf6A 1 0.2812 96.3 0.951 Contact Map
2hpiA 2 0.317 95.9 0.953 Contact Map
1o7iA 1 0.2299 95.7 0.953 Contact Map
2pi2A 1 0.2679 94.4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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