GREMLIN Database
NUSB - N utilization substance protein B homolog
UniProt: P54520 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 131 (125)
Sequences: 3375 (2406)
Seq/√Len: 215.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_G84_Y3.5681.00
56_D80_R3.5111.00
51_H54_Q2.8901.00
92_I97_S2.5091.00
93_P96_V2.4721.00
83_A124_I2.4121.00
63_L71_I2.3781.00
62_H127_D2.3601.00
43_Q89_A2.2861.00
82_A101_A2.1011.00
10_A44_L2.0851.00
8_E107_R2.0351.00
57_E61_K2.0091.00
51_H88_Y1.8741.00
42_E46_H1.7731.00
75_D109_G1.7541.00
73_N76_R1.7251.00
58_M87_A1.6991.00
15_F19_V1.6921.00
72_A75_D1.6731.00
18_D76_R1.6711.00
61_K127_D1.6701.00
12_Q108_F1.6581.00
55_L83_A1.6161.00
75_D113_A1.5941.00
78_I105_A1.5801.00
10_A45_V1.5041.00
58_M124_I1.4991.00
99_N106_K1.4881.00
60_S68_L1.4501.00
44_L84_Y1.4461.00
94_V125_K1.4301.00
57_E60_S1.4111.00
40_F44_L1.4051.00
86_M97_S1.3971.00
66_W70_R1.3921.00
99_N103_E1.3861.00
46_H50_E1.3461.00
105_A117_V1.3321.00
11_L81_L1.3291.00
40_F92_I1.3231.00
84_Y89_A1.3111.00
78_I101_A1.3021.00
59_I83_A1.2991.00
11_L77_A1.2721.00
54_Q57_E1.2251.00
55_L88_Y1.2151.00
98_M125_K1.1971.00
10_A48_V1.1941.00
14_L81_L1.1521.00
102_I114_T1.1271.00
63_L67_K1.1081.00
52_Q80_R1.1081.00
81_L104_L1.1081.00
103_E106_K1.1041.00
78_I117_V1.0961.00
48_V84_Y1.0901.00
86_M125_K1.0831.00
26_E29_E1.0581.00
122_S126_S1.0491.00
62_H124_I1.0471.00
8_E12_Q1.0281.00
123_N126_S0.9871.00
17_I49_L0.9851.00
79_L117_V0.9761.00
52_Q56_D0.9741.00
25_N46_H0.9691.00
54_Q88_Y0.9641.00
105_A114_T0.9370.99
109_G113_A0.9310.99
98_M122_S0.9200.99
13_A41_F0.9180.99
64_V123_N0.9180.99
75_D110_D0.9010.99
15_F73_N0.8960.99
62_H123_N0.8960.99
44_L48_V0.8850.99
8_E108_F0.8720.99
11_L15_F0.8720.99
44_L81_L0.8600.99
68_L76_R0.8580.99
119_G122_S0.8390.99
63_L120_V0.8380.99
60_S69_D0.8380.99
110_D114_T0.8330.99
43_Q84_Y0.8250.99
51_H87_A0.8130.99
54_Q87_A0.8120.99
98_M102_I0.8090.99
14_L77_A0.8070.98
65_N122_S0.8030.98
102_I117_V0.8010.98
8_E104_L0.8000.98
27_A31_A0.7980.98
110_D113_A0.7960.98
89_A92_I0.7960.98
6_A10_A0.7930.98
76_R80_R0.7910.98
29_E33_D0.7870.98
27_A30_H0.7860.98
21_D49_L0.7770.98
23_A26_E0.7770.98
39_P43_Q0.7740.98
18_D80_R0.7660.98
71_I75_D0.7660.98
48_V52_Q0.7650.98
15_F74_V0.7610.98
11_L74_V0.7610.98
96_V100_E0.7580.98
58_M61_K0.7580.98
95_N122_S0.7510.98
54_Q58_M0.7390.97
59_I63_L0.7390.97
53_D57_E0.7350.97
13_A45_V0.7350.97
102_I118_N0.7330.97
102_I106_K0.7250.97
38_D42_E0.7210.97
82_A85_E0.7020.96
62_H120_V0.6840.96
28_I42_E0.6790.96
5_T9_K0.6750.95
60_S67_K0.6740.95
4_R103_E0.6720.95
37_T41_F0.6710.95
58_M83_A0.6640.95
38_D41_F0.6640.95
65_N116_F0.6630.95
4_R107_R0.6610.95
48_V55_L0.6600.95
11_L78_I0.6600.95
90_E97_S0.6510.95
30_H33_D0.6490.94
11_L108_F0.6490.94
92_I96_V0.6470.94
44_L89_A0.6460.94
102_I105_A0.6440.94
6_A40_F0.6420.94
26_E30_H0.6390.94
16_Q20_S0.6380.94
49_L52_Q0.6340.94
9_K12_Q0.6340.94
56_D76_R0.6340.94
55_L59_I0.6270.93
68_L71_I0.6250.93
6_A41_F0.6250.93
43_Q50_E0.6220.93
40_F81_L0.6130.93
18_D114_T0.6090.92
17_I27_A0.6030.92
41_F44_L0.5990.92
89_A97_S0.5960.91
16_Q19_V0.5940.91
19_V73_N0.5910.91
32_L42_E0.5900.91
55_L84_Y0.5880.91
73_N77_A0.5840.91
82_A97_S0.5840.91
123_N127_D0.5810.90
109_G114_T0.5810.90
12_Q41_F0.5750.90
72_A122_S0.5720.90
63_L68_L0.5710.90
70_R110_D0.5700.90
35_E38_D0.5620.89
58_M62_H0.5570.89
18_D77_A0.5560.88
47_G50_E0.5550.88
4_R104_L0.5540.88
14_L48_V0.5530.88
72_A113_A0.5500.88
24_V49_L0.5480.88
58_M79_L0.5480.88
67_K71_I0.5410.87
17_I52_Q0.5380.87
48_V81_L0.5260.86
86_M94_V0.5230.85
67_K70_R0.5230.85
13_A31_A0.5220.85
70_R109_G0.5220.85
14_L18_D0.5150.84
59_I71_I0.5140.84
51_H55_L0.5110.84
24_V27_A0.5090.84
103_E107_R0.5040.83
10_A41_F0.5040.83
95_N102_I0.5000.83
52_Q55_L0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q8cA 1 0.9008 100 0.185 Contact Map
3r2dA 1 1 100 0.204 Contact Map
1tzvA 1 1 100 0.211 Contact Map
1eyvA 2 0.9542 100 0.225 Contact Map
3d3bA 1 0.9924 100 0.228 Contact Map
1sqgA 1 0.9618 100 0.364 Contact Map
2yxlA 1 0.9618 99.9 0.392 Contact Map
3ilwA 2 0.8397 16 0.932 Contact Map
2zc2A 1 0.5267 14.6 0.933 Contact Map
4am5A 6 0.9618 13.3 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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