GREMLIN Database
YQHT - Uncharacterized peptidase YqhT
UniProt: P54518 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 353 (335)
Sequences: 11018 (8025)
Seq/√Len: 438.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_E341_R5.3651.00
309_P337_E4.4211.00
255_I335_I3.3391.00
133_I334_V2.9811.00
236_Q324_T2.7041.00
242_Q246_D2.5831.00
138_E141_K2.5431.00
265_D269_R2.4281.00
24_T292_E2.4151.00
234_S237_L2.3961.00
250_L271_H2.3321.00
236_Q239_E2.3281.00
145_D174_Q2.3281.00
15_I91_G2.3241.00
149_H170_Y2.3231.00
189_L201_K2.3141.00
262_K304_S2.3041.00
260_T263_E2.2611.00
166_E169_F2.2571.00
169_F173_S2.2551.00
235_D239_E2.1971.00
136_L312_V2.1891.00
289_L332_D2.1711.00
127_I308_E2.1591.00
249_A253_A2.1491.00
270_D274_A2.1441.00
103_A106_S2.1351.00
159_S202_L2.1211.00
30_T39_A2.0811.00
89_R113_E2.0781.00
254_H267_L2.0521.00
137_E141_K2.0211.00
243_V275_K2.0071.00
135_I218_K1.9141.00
203_I230_V1.8971.00
251_G268_T1.8841.00
250_L253_A1.8651.00
49_I81_T1.8261.00
240_I325_G1.8141.00
204_E207_D1.8121.00
153_F166_E1.8001.00
240_I327_V1.7741.00
201_K207_D1.7561.00
161_I200_D1.7451.00
168_E172_R1.7431.00
244_V327_V1.7281.00
212_D223_D1.7211.00
266_A270_D1.6921.00
223_D330_E1.6871.00
336_T341_R1.6841.00
77_T80_D1.6771.00
208_L237_L1.6671.00
238_K242_Q1.6661.00
151_L228_V1.6401.00
229_A233_P1.6371.00
260_T306_I1.6351.00
315_V333_I1.6351.00
170_Y173_S1.6241.00
185_V209_V1.6201.00
170_Y174_Q1.5951.00
271_H275_K1.5811.00
212_D330_E1.5651.00
308_E311_M1.5501.00
314_T332_D1.5441.00
144_D346_S1.5401.00
65_F68_I1.5391.00
246_D250_L1.5331.00
159_S162_A1.5291.00
246_D275_K1.5211.00
165_N169_F1.5141.00
156_P205_S1.5071.00
180_S221_C1.4981.00
89_R115_V1.4881.00
252_V333_I1.4761.00
334_V343_I1.4721.00
272_I319_I1.4671.00
256_K259_M1.4571.00
148_R152_T1.4541.00
38_L41_I1.4431.00
126_L311_M1.4361.00
187_S201_K1.4261.00
149_H174_Q1.4121.00
208_L229_A1.3881.00
163_V203_I1.3781.00
246_D274_A1.3561.00
187_S203_I1.3541.00
41_I44_D1.3481.00
247_A271_H1.3441.00
130_S134_K1.3341.00
240_I321_I1.3321.00
257_P308_E1.3311.00
216_Y221_C1.3261.00
245_F249_A1.3251.00
322_P325_G1.3181.00
16_D88_K1.3141.00
27_R219_G1.3121.00
149_H152_T1.3101.00
134_K138_E1.3091.00
259_M263_E1.3011.00
166_E170_Y1.2881.00
257_P309_P1.2801.00
268_T285_T1.2661.00
235_D238_K1.2561.00
162_A173_S1.2511.00
147_F224_I1.2481.00
307_L313_V1.2481.00
248_Q331_D1.2451.00
29_M124_L1.2431.00
11_G43_G1.2321.00
51_D54_Y1.2281.00
57_Q61_Q1.2211.00
255_I264_A1.2181.00
142_I219_G1.2181.00
143_A224_I1.2031.00
239_E275_K1.2011.00
241_Y329_I1.1991.00
123_K308_E1.1981.00
15_I115_V1.1951.00
127_I311_M1.1841.00
263_E266_A1.1771.00
136_L140_A1.1671.00
252_V342_T1.1671.00
250_L267_L1.1641.00
190_R196_G1.1641.00
102_Y106_S1.1621.00
163_V209_V1.1581.00
10_F15_I1.1501.00
94_Q103_A1.1501.00
164_A168_E1.1421.00
55_T59_K1.1411.00
307_L335_I1.1411.00
149_H173_S1.1401.00
255_I315_V1.1341.00
246_D271_H1.1311.00
239_E243_V1.1311.00
142_I176_A1.1231.00
138_E217_Y1.1151.00
166_E173_S1.1141.00
251_G264_A1.1141.00
259_M267_L1.1131.00
73_S76_Q1.1131.00
141_K145_D1.1091.00
149_H166_E1.1051.00
208_L227_T1.1011.00
25_N93_E1.1001.00
134_K137_E1.0961.00
255_I333_I1.0891.00
186_A196_G1.0871.00
262_K266_A1.0851.00
239_E242_Q1.0851.00
64_G68_I1.0811.00
336_T339_G1.0761.00
264_A267_L1.0741.00
20_I29_M1.0721.00
58_A62_V1.0711.00
201_K204_E1.0691.00
251_G267_L1.0581.00
131_E135_I1.0571.00
188_G207_D1.0571.00
250_L254_H1.0551.00
265_D285_T1.0521.00
236_Q321_I1.0491.00
333_I342_T1.0461.00
64_G67_I1.0451.00
312_V334_V1.0451.00
140_A144_D1.0361.00
10_F17_G1.0351.00
168_E183_M1.0351.00
137_E334_V1.0321.00
16_D89_R1.0281.00
25_N122_E1.0231.00
99_Y102_Y1.0211.00
270_D273_A1.0201.00
254_H259_M1.0181.00
257_P336_T1.0171.00
262_K302_R1.0151.00
310_G334_V1.0141.00
79_A83_E1.0111.00
247_A272_I1.0101.00
313_V335_I0.9991.00
243_V272_I0.9991.00
99_Y103_A0.9981.00
191_S210_T0.9971.00
147_F228_V0.9951.00
158_I166_E0.9921.00
117_V120_S0.9911.00
321_I324_T0.9901.00
187_S207_D0.9871.00
289_L312_V0.9861.00
80_D84_S0.9861.00
161_I165_N0.9821.00
71_G74_L0.9741.00
255_I340_N0.9741.00
131_E134_K0.9741.00
91_G117_V0.9741.00
243_V246_D0.9741.00
154_M228_V0.9701.00
211_L228_V0.9671.00
29_M121_V0.9641.00
264_A307_L0.9641.00
140_A332_D0.9631.00
209_V230_V0.9631.00
288_G295_E0.9601.00
273_A278_G0.9581.00
168_E179_S0.9511.00
243_V271_H0.9491.00
144_D345_H0.9471.00
94_Q116_P0.9441.00
190_R201_K0.9271.00
123_K305_A0.9241.00
179_S183_M0.9191.00
81_T84_S0.9171.00
267_L270_D0.9171.00
20_I121_V0.9151.00
190_R193_L0.9141.00
176_A215_A0.9131.00
155_K158_I0.9081.00
146_A170_Y0.9071.00
73_S77_T0.9061.00
138_E142_I0.9051.00
167_L171_M0.9011.00
261_G307_L0.8931.00
138_E218_K0.8911.00
316_E330_E0.8901.00
267_L271_H0.8871.00
288_G297_P0.8861.00
130_S336_T0.8841.00
186_A191_S0.8831.00
163_V185_V0.8811.00
287_H330_E0.8811.00
212_D316_E0.8781.00
248_Q251_G0.8771.00
223_D287_H0.8761.00
154_M163_V0.8701.00
242_Q245_F0.8691.00
259_M264_A0.8671.00
247_A251_G0.8671.00
171_M215_A0.8651.00
271_H274_A0.8641.00
182_D197_V0.8631.00
241_Y245_F0.8611.00
252_V340_N0.8611.00
145_D148_R0.8611.00
305_A308_E0.8561.00
229_A237_L0.8561.00
18_M117_V0.8561.00
272_I277_Y0.8531.00
148_R346_S0.8511.00
318_G328_R0.8421.00
333_I340_N0.8401.00
245_F329_I0.8391.00
181_F214_G0.8361.00
226_R331_D0.8351.00
149_H153_F0.8311.00
143_A222_S0.8291.00
257_P337_E0.8281.00
58_A61_Q0.8241.00
335_I340_N0.8221.00
248_Q252_V0.8221.00
28_Y124_L0.8211.00
334_V341_R0.8211.00
320_Y328_R0.8201.00
135_I138_E0.8191.00
100_G104_S0.8151.00
103_A107_A0.8131.00
236_Q240_I0.8121.00
81_T85_F0.8121.00
41_I46_A0.8101.00
80_D83_E0.8071.00
140_A344_T0.8071.00
156_P230_V0.8051.00
158_I162_A0.8051.00
268_T281_F0.8001.00
132_E220_Y0.8001.00
10_F18_M0.7971.00
30_T46_A0.7941.00
233_P238_K0.7941.00
299_L313_V0.7931.00
142_I217_Y0.7901.00
47_A66_E0.7901.00
92_F99_Y0.7891.00
146_A171_M0.7881.00
251_G254_H0.7861.00
251_G315_V0.7771.00
212_D287_H0.7751.00
144_D148_R0.7741.00
165_N172_R0.7721.00
120_S123_K0.7711.00
187_S230_V0.7701.00
194_P283_H0.7681.00
70_H74_L0.7671.00
11_G42_S0.7641.00
223_D316_E0.7641.00
240_I243_V0.7631.00
193_L196_G0.7621.00
160_E190_R0.7591.00
206_G230_V0.7581.00
17_G90_L0.7581.00
336_T340_N0.7561.00
249_A252_V0.7541.00
167_L211_L0.7531.00
153_F170_Y0.7511.00
98_T101_T0.7511.00
48_F58_A0.7471.00
221_C293_V0.7471.00
252_V315_V0.7461.00
247_A267_L0.7451.00
195_H294_H0.7441.00
60_V63_K0.7441.00
191_S208_L0.7431.00
27_R291_M0.7381.00
257_P335_I0.7361.00
140_A222_S0.7311.00
225_T330_E0.7281.00
269_R281_F0.7271.00
289_L314_T0.7261.00
167_L213_F0.7251.00
260_T304_S0.7241.00
150_I211_L0.7221.00
303_S306_I0.7211.00
126_L308_E0.7191.00
256_K340_N0.7171.00
162_A165_N0.7131.00
263_E267_L0.7021.00
42_S46_A0.7021.00
215_A222_S0.7011.00
135_I217_Y0.7001.00
14_G89_R0.7001.00
189_L323_E0.6991.00
133_I137_E0.6981.00
142_I174_Q0.6931.00
74_L82_V0.6921.00
179_S182_D0.6891.00
283_H294_H0.6861.00
240_I277_Y0.6851.00
305_A311_M0.6831.00
208_L233_P0.6811.00
87_I90_L0.6811.00
287_H316_E0.6801.00
140_A343_I0.6781.00
306_I309_P0.6781.00
169_F172_R0.6771.00
104_S107_A0.6771.00
74_L77_T0.6761.00
206_G232_Q0.6741.00
147_F213_F0.6721.00
47_A81_T0.6711.00
191_S326_G0.6681.00
88_K113_E0.6661.00
141_K144_D0.6651.00
150_I163_V0.6651.00
233_P237_L0.6621.00
23_N26_V0.6611.00
254_H257_P0.6601.00
128_K132_E0.6601.00
126_L305_A0.6601.00
45_K71_G0.6581.00
45_K66_E0.6561.00
257_P340_N0.6551.00
248_Q315_V0.6551.00
147_F150_I0.6470.99
298_G302_R0.6460.99
251_G285_T0.6460.99
142_I215_A0.6460.99
253_A264_A0.6450.99
243_V319_I0.6450.99
143_A146_A0.6440.99
312_V332_D0.6440.99
246_D249_A0.6430.99
255_I307_L0.6410.99
59_K62_V0.6410.99
152_T156_P0.6400.99
130_S310_G0.6380.99
205_S232_Q0.6380.99
207_D237_L0.6340.99
164_A198_A0.6340.99
134_K141_K0.6330.99
32_F57_Q0.6330.99
320_Y326_G0.6320.99
25_N121_V0.6320.99
159_S200_D0.6320.99
24_T291_M0.6320.99
318_G326_G0.6310.99
154_M230_V0.6300.99
71_G75_I0.6280.99
154_M209_V0.6240.99
229_A234_S0.6230.99
185_V211_L0.6230.99
212_D225_T0.6200.99
237_L324_T0.6200.99
191_S229_A0.6190.99
21_T24_T0.6160.99
133_I312_V0.6140.99
257_P339_G0.6140.99
309_P336_T0.6140.99
92_F114_L0.6120.99
73_S81_T0.6090.99
58_A63_K0.6090.99
140_A224_I0.6090.99
26_V37_G0.6030.99
77_T81_T0.6020.99
280_Y322_P0.6010.99
264_A285_T0.6010.99
261_G299_L0.6010.99
110_S114_L0.6010.99
45_K64_G0.6000.99
150_I166_E0.5990.99
97_M102_Y0.5970.99
147_F151_L0.5960.99
143_A213_F0.5960.99
256_K338_N0.5960.99
19_L90_L0.5960.99
232_Q238_K0.5940.99
146_A167_L0.5940.99
16_D42_S0.5930.99
13_L16_D0.5930.99
321_I325_G0.5920.99
247_A268_T0.5900.99
224_I332_D0.5890.99
139_A143_A0.5840.99
158_I163_V0.5790.99
243_V247_A0.5790.99
191_S194_P0.5770.99
266_A301_V0.5750.99
253_A267_L0.5750.99
237_L325_G0.5720.99
150_I153_F0.5700.99
342_T345_H0.5700.99
250_L268_T0.5660.99
130_S309_P0.5650.99
26_V30_T0.5640.99
281_F285_T0.5640.99
10_F13_L0.5630.99
284_S287_H0.5620.99
163_V211_L0.5610.98
189_L192_S0.5590.98
128_K220_Y0.5590.98
19_L40_V0.5590.98
122_E296_S0.5550.98
71_G82_V0.5550.98
25_N28_Y0.5540.98
52_F282_G0.5540.98
262_K303_S0.5520.98
258_G306_I0.5520.98
17_G42_S0.5520.98
183_M213_F0.5520.98
247_A250_L0.5520.98
332_D344_T0.5510.98
146_A215_A0.5490.98
259_M335_I0.5480.98
162_A202_L0.5450.98
151_L346_S0.5420.98
143_A214_G0.5420.98
90_L112_A0.5420.98
316_E328_R0.5400.98
144_D344_T0.5390.98
205_S231_G0.5390.98
59_K63_K0.5360.98
123_K126_L0.5350.98
236_Q325_G0.5340.98
127_I309_P0.5340.98
261_G303_S0.5330.98
254_H264_A0.5330.98
50_T55_T0.5320.98
98_T102_Y0.5320.98
76_Q79_A0.5310.98
265_D281_F0.5300.98
258_G308_E0.5290.98
54_Y57_Q0.5280.98
24_T125_R0.5270.98
243_V277_Y0.5260.98
140_A143_A0.5250.98
234_S324_T0.5250.98
186_A209_V0.5250.98
27_R33_T0.5240.98
248_Q329_I0.5230.98
272_I278_G0.5230.98
47_A73_S0.5220.98
20_I26_V0.5220.98
294_H328_R0.5220.98
221_C291_M0.5190.98
294_H318_G0.5140.97
26_V39_A0.5140.97
265_D284_S0.5140.97
47_A85_F0.5130.97
266_A273_A0.5110.97
283_H320_Y0.5110.97
161_I177_D0.5090.97
171_M176_A0.5070.97
240_I319_I0.5060.97
264_A299_L0.5060.97
284_S298_G0.5060.97
341_R345_H0.5060.97
190_R200_D0.5050.97
92_F102_Y0.5050.97
39_A46_A0.5040.97
195_H283_H0.5020.97
283_H328_R0.5020.97
268_T271_H0.5020.97
138_E219_G0.5010.97
17_G40_V0.5000.97
223_D294_H0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3q6dA 1 0.9972 100 0.124 Contact Map
2zsgA 2 0.9972 100 0.125 Contact Map
4fkcA 2 0.9972 100 0.126 Contact Map
1wn1A 2 0.9858 100 0.144 Contact Map
4r60A 2 0.9943 100 0.149 Contact Map
1wy2A 2 0.9717 100 0.159 Contact Map
4egeA 2 0.9887 100 0.163 Contact Map
1kp0A 2 0.8895 100 0.186 Contact Map
3ig4A 4 0.9915 100 0.186 Contact Map
1chmA 2 0.9915 100 0.19 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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