GREMLIN Database
AROQ - 3-dehydroquinate dehydratase
UniProt: P54517 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (140)
Sequences: 3215 (2039)
Seq/√Len: 172.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_G139_L2.6621.00
49_F60_A2.6351.00
38_F137_R2.4831.00
8_N32_E2.2401.00
31_I129_A2.1351.00
81_Y115_V2.1241.00
53_H59_D2.0521.00
130_E141_S2.0481.00
42_L140_L2.0431.00
86_R119_V1.9991.00
44_I140_L1.9261.00
101_L129_A1.9051.00
3_H45_Q1.8631.00
32_E48_F1.8571.00
38_F133_K1.8221.00
34_D133_K1.7681.00
86_R90_S1.7331.00
19_E90_S1.7131.00
122_G127_L1.7001.00
130_E133_K1.6901.00
57_L85_I1.6811.00
39_A46_L1.6701.00
90_S119_V1.6591.00
127_L134_L1.6511.00
17_S65_E1.6381.00
26_Q129_A1.5821.00
22_V102_S1.5771.00
29_T32_E1.5591.00
26_Q34_D1.5551.00
49_F56_D1.4751.00
53_H56_D1.4521.00
75_P116_I1.4461.00
14_R91_S1.4411.00
4_F136_V1.4331.00
86_R118_P1.4281.00
60_A63_E1.4061.00
83_Y115_V1.4041.00
14_R65_E1.4001.00
5_L68_Y1.3831.00
56_D59_D1.3821.00
105_Y125_V1.3651.00
133_K137_R1.3581.00
6_I48_F1.3581.00
121_K142_Q1.3381.00
89_V96_V1.3351.00
7_L57_L1.3131.00
127_L131_G1.3111.00
51_S78_L1.2811.00
77_A83_Y1.2791.00
117_A123_Q1.2631.00
96_V120_A1.2541.00
32_E36_F1.2481.00
26_Q30_D1.2421.00
61_I92_I1.2381.00
35_L46_L1.2101.00
27_T30_D1.2081.00
96_V116_I1.2021.00
72_V135_A1.2001.00
61_I71_I1.1801.00
72_V99_V1.1771.00
6_I35_L1.1711.00
127_L138_Y1.1691.00
38_F41_A1.1631.00
78_L84_A1.1621.00
35_L136_V1.1491.00
130_E134_L1.1381.00
57_L78_L1.1211.00
13_N52_N1.1031.00
97_V138_Y1.0931.00
28_L32_E1.0801.00
13_N62_H1.0661.00
56_D60_A1.0561.00
105_Y123_Q1.0500.99
62_H88_A1.0380.99
104_L123_Q1.0330.99
34_D38_F1.0180.99
8_N48_F1.0140.99
33_T37_Q1.0090.99
28_L31_I1.0070.99
77_A84_A1.0060.99
106_A121_K1.0020.99
52_N59_D0.9930.99
39_A136_V0.9810.99
5_L64_A0.9800.99
78_L85_I0.9710.99
61_I85_I0.9700.99
42_L137_R0.9540.99
3_H47_T0.9530.99
134_L138_Y0.9470.99
14_R62_H0.9450.99
103_N122_G0.9420.99
38_F42_L0.9310.99
30_D33_T0.9280.99
90_S118_P0.9210.99
17_S66_E0.9190.99
47_T60_A0.8940.98
79_S104_L0.8860.98
109_E112_H0.8850.98
14_R66_E0.8760.98
3_H69_S0.8750.98
51_S57_L0.8630.98
103_N127_L0.8620.98
124_I127_L0.8600.98
4_F44_I0.8590.98
28_L48_F0.8550.98
122_G138_Y0.8540.98
65_E93_S0.8490.98
58_I84_A0.8480.98
79_S114_S0.8470.98
14_R17_S0.8470.98
137_R141_S0.8470.98
29_T33_T0.8450.98
83_Y110_F0.8410.98
42_L136_V0.8360.97
104_L125_V0.8320.97
73_L89_V0.8310.97
31_I101_L0.8290.97
63_E67_Q0.8280.97
7_L73_L0.8240.97
58_I77_A0.8240.97
58_I62_H0.8070.97
36_F40_E0.7960.97
122_G134_L0.7920.96
55_G78_L0.7890.96
12_V101_L0.7780.96
71_I96_V0.7760.96
92_I96_V0.7760.96
7_L49_F0.7730.96
6_I32_E0.7680.96
71_I92_I0.7650.96
97_V127_L0.7560.95
130_E138_Y0.7540.95
37_Q41_A0.7520.95
80_H111_R0.7480.95
72_V136_V0.7450.95
89_V116_I0.7420.95
97_V139_L0.7390.95
4_F139_L0.7360.95
3_H68_Y0.7310.95
109_E113_Q0.7230.94
41_A137_R0.7220.94
10_P58_I0.7190.94
115_V120_A0.7180.94
34_D129_A0.7110.94
35_L133_K0.7040.93
33_T36_F0.7030.93
5_L60_A0.7000.93
89_V120_A0.6960.93
116_I120_A0.6910.93
37_Q40_E0.6880.93
138_Y142_Q0.6820.92
44_I69_S0.6760.92
130_E137_R0.6740.92
91_S96_V0.6540.91
61_I89_V0.6530.91
19_E91_S0.6520.90
78_L81_Y0.6510.90
64_A94_L0.6510.90
124_I134_L0.6450.90
15_L101_L0.6360.89
103_N134_L0.6300.89
10_P78_L0.6300.89
47_T67_Q0.6280.89
110_F115_V0.6090.87
46_L136_V0.6020.87
35_L72_V0.6020.87
21_E25_R0.6010.87
59_D62_H0.5990.86
66_E94_L0.5940.86
133_K141_S0.5900.86
20_P25_R0.5840.85
64_A71_I0.5830.85
124_I131_G0.5810.85
60_A64_A0.5800.85
12_V28_L0.5790.84
36_F48_F0.5780.84
77_A81_Y0.5770.84
131_G135_A0.5770.84
92_I121_K0.5730.84
34_D37_Q0.5720.84
47_T68_Y0.5670.83
19_E22_V0.5650.83
96_V121_K0.5650.83
113_Q117_A0.5620.83
49_F63_E0.5620.83
55_G76_G0.5590.82
75_P131_G0.5590.82
130_E142_Q0.5570.82
6_I46_L0.5540.82
108_E111_R0.5430.81
97_V142_Q0.5430.81
60_A68_Y0.5340.79
10_P84_A0.5320.79
89_V119_V0.5290.79
58_I78_L0.5290.79
68_Y94_L0.5250.78
117_A125_V0.5250.78
76_G83_Y0.5230.78
36_F39_A0.5220.78
105_Y117_A0.5220.78
40_E45_Q0.5220.78
39_A48_F0.5190.78
70_G95_P0.5170.77
7_L51_S0.5170.77
72_V139_L0.5140.77
134_L137_R0.5100.76
12_V15_L0.5090.76
71_I89_V0.5090.76
101_L131_G0.5060.76
124_I138_Y0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uqrA 4 1 100 0.036 Contact Map
1gtzA 4 0.973 100 0.042 Contact Map
3lwzA 4 0.9865 100 0.042 Contact Map
3u80A 2 0.8514 100 0.044 Contact Map
3n8kA 4 0.9527 100 0.046 Contact Map
4kiwA 6 0.9459 100 0.048 Contact Map
4rc9A 4 1 100 0.05 Contact Map
4l8lA 4 0.9189 100 0.051 Contact Map
1h05A 4 0.9324 100 0.051 Contact Map
3kipA 6 0.9459 100 0.053 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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