GREMLIN Database
YQHQ - Uncharacterized protein YqhQ
UniProt: P54515 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (291)
Sequences: 735 (540)
Seq/√Len: 31.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
200_Q287_D7.2661.00
192_L202_Q6.2621.00
199_V290_V5.9841.00
200_Q290_V5.4531.00
224_V250_I4.9441.00
196_V287_D3.6721.00
192_L201_N3.3301.00
257_L261_V3.1251.00
118_F122_K3.1011.00
19_V296_S3.0541.00
30_A38_I2.8871.00
176_Q289_Q2.7401.00
111_A115_V2.5721.00
154_K240_R2.3580.99
254_V270_L2.3550.99
264_I267_L2.3010.99
223_F227_L2.2870.99
192_L198_N2.2670.99
59_F246_V2.1990.99
26_H42_K2.0340.98
183_K284_E2.0050.98
169_P172_K1.9730.97
215_L277_L1.9730.97
196_V290_V1.9710.97
41_F79_F1.9670.97
59_F63_I1.9560.97
216_F254_V1.9520.97
215_L219_I1.9340.97
199_V294_I1.9150.97
59_F250_I1.9100.97
255_L258_T1.8970.97
158_L218_I1.8610.96
205_L279_L1.8570.96
216_F270_L1.8430.96
187_C198_N1.8260.96
252_F256_Q1.8160.96
65_A252_F1.8000.95
47_H68_E1.7880.95
184_V294_I1.7700.95
272_Y276_W1.7180.94
187_C199_V1.7120.94
190_Q202_Q1.7050.94
204_R279_L1.6930.94
13_Q73_G1.6740.93
79_F83_R1.6720.93
186_N199_V1.6480.93
15_V29_T1.6390.92
295_E298_N1.6340.92
108_L112_V1.6300.92
286_K290_V1.6080.92
265_P269_L1.6070.92
193_P298_N1.6050.92
243_L246_V1.5930.91
127_L237_V1.5840.91
64_A68_E1.5550.90
52_N55_K1.5450.90
43_L75_K1.5360.90
163_Y167_M1.5330.90
119_L123_F1.5310.89
204_R284_E1.5190.89
214_I218_I1.5120.89
113_I117_S1.5100.89
130_V236_R1.5060.89
186_N207_Y1.4940.88
11_G14_A1.4570.87
238_I242_A1.4550.87
171_I174_V1.4500.87
54_V60_L1.4330.86
124_V268_K1.4290.86
186_N205_L1.4260.86
19_V28_V1.4180.85
261_V264_I1.4160.85
19_V30_A1.4040.85
196_V202_Q1.4010.85
159_L163_Y1.3970.85
59_F64_A1.3910.84
135_L139_I1.3880.84
102_S105_S1.3820.84
10_Y300_L1.3730.84
186_N203_S1.3580.83
195_T198_N1.3140.81
299_E302_R1.3080.80
287_D290_V1.3080.80
9_A256_Q1.2980.80
196_V199_V1.2940.80
258_T271_G1.2870.79
196_V200_Q1.2770.79
15_V31_I1.2760.79
261_V267_L1.2720.79
123_F127_L1.2680.78
92_E102_S1.2670.78
167_M172_K1.2550.78
123_F128_V1.2540.77
10_Y68_E1.2510.77
78_N114_G1.2480.77
10_Y297_F1.2370.77
151_S222_M1.2260.76
54_V57_I1.2160.75
154_K225_Y1.2160.75
19_V174_V1.1900.74
140_F149_I1.1860.73
224_V247_V1.1700.72
15_V78_N1.1600.72
136_T149_I1.1570.72
60_L143_N1.1500.71
149_I153_F1.1480.71
15_V19_V1.1410.70
146_Q218_I1.1240.69
269_L272_Y1.1180.69
228_V243_L1.1160.69
157_L247_V1.1160.69
159_L277_L1.1120.68
120_F124_V1.0910.67
38_I292_V1.0810.66
89_S102_S1.0700.65
64_A268_K1.0540.64
8_P23_G1.0480.64
28_V296_S1.0460.64
131_F135_L1.0460.64
29_T79_F1.0450.64
39_D83_R1.0400.63
220_V254_V1.0360.63
112_V116_L1.0350.63
268_K272_Y1.0340.63
184_V297_F1.0330.63
113_I116_L1.0330.63
172_K176_Q1.0180.61
132_L136_T1.0180.61
28_V299_E1.0170.61
227_L255_L1.0150.61
134_E137_R1.0120.61
146_Q230_T1.0070.61
165_L175_F1.0010.60
30_A40_F0.9940.60
188_Y207_Y0.9890.59
195_T294_I0.9880.59
212_S276_W0.9850.59
59_F249_G0.9810.59
296_S301_L0.9780.58
158_L217_T0.9740.58
147_I226_L0.9730.58
185_I204_R0.9720.58
226_L247_V0.9680.58
65_A215_L0.9640.57
29_T76_H0.9590.57
242_A295_E0.9590.57
33_R83_R0.9430.56
140_F145_A0.9380.55
51_L55_K0.9350.55
33_R37_S0.9300.54
166_S175_F0.9270.54
23_G301_L0.9220.54
48_N52_N0.9200.54
140_F153_F0.9200.54
218_I251_S0.9140.53
57_I223_F0.9100.53
212_S271_G0.9000.52
145_A295_E0.8990.52
259_N271_G0.8980.52
127_L131_F0.8970.52
102_S108_L0.8950.52
65_A69_A0.8920.51
16_V216_F0.8760.50
17_E173_R0.8760.50
157_L160_G0.8740.50
158_L162_I0.8700.50
220_V224_V0.8690.50
298_N302_R0.8690.50
154_K239_D0.8660.49
19_V277_L0.8650.49
144_T147_I0.8640.49
142_L145_A0.8540.48
196_V288_E0.8540.48
221_G225_Y0.8530.48
120_F157_L0.8530.48
295_E299_E0.8530.48
187_C204_R0.8520.48
36_G277_L0.8500.48
212_S236_R0.8410.47
42_K299_E0.8350.47
81_S103_G0.8330.47
79_F201_N0.8330.47
120_F126_T0.8320.46
132_L148_A0.8320.46
139_I288_E0.8310.46
115_V172_K0.8300.46
49_P55_K0.8290.46
91_D105_S0.8260.46
135_L223_F0.8260.46
239_D242_A0.8260.46
23_G188_Y0.8240.46
81_S170_L0.8230.46
39_D79_F0.8230.46
74_T78_N0.8200.46
147_I215_L0.8150.45
34_T247_V0.8120.45
70_S105_S0.8000.44
205_L289_Q0.7950.44
31_I88_P0.7930.43
184_V202_Q0.7920.43
92_E103_G0.7910.43
217_T221_G0.7880.43
237_V280_L0.7860.43
105_S108_L0.7860.43
60_L153_F0.7850.43
49_P56_K0.7850.43
22_G256_Q0.7810.42
113_I172_K0.7800.42
160_G164_F0.7780.42
128_V291_E0.7780.42
162_I218_I0.7770.42
52_N112_V0.7760.42
78_N82_E0.7690.41
257_L267_L0.7670.41
293_A296_S0.7660.41
283_K286_K0.7660.41
255_L259_N0.7640.41
122_K153_F0.7620.41
219_I223_F0.7610.41
193_P226_L0.7590.41
225_Y243_L0.7550.40
199_V287_D0.7540.40
160_G234_W0.7530.40
115_V295_E0.7530.40
29_T43_L0.7480.40
248_L300_L0.7450.40
117_S294_I0.7420.39
114_G118_F0.7400.39
136_T204_R0.7390.39
82_E106_M0.7370.39
160_G163_Y0.7340.39
70_S215_L0.7320.39
51_L57_I0.7310.38
204_R248_L0.7300.38
15_V255_L0.7280.38
46_K50_K0.7270.38
31_I84_Y0.7260.38
32_R38_I0.7260.38
146_Q150_E0.7260.38
39_D42_K0.7250.38
259_N300_L0.7240.38
228_V231_D0.7230.38
68_E72_N0.7230.38
252_F296_S0.7170.37
63_I248_L0.7150.37
298_N303_L0.7140.37
118_F121_S0.7120.37
216_F224_V0.7090.37
8_P188_Y0.7080.37
133_A146_Q0.7060.37
235_L247_V0.7040.36
166_S198_N0.7030.36
31_I86_L0.6990.36
53_I156_I0.6940.36
40_F220_V0.6890.35
107_Y110_L0.6880.35
91_D108_L0.6850.35
43_L241_V0.6850.35
122_K127_L0.6820.35
26_H302_R0.6810.35
8_P24_K0.6780.34
25_H90_E0.6770.34
188_Y202_Q0.6760.34
148_A152_L0.6750.34
66_I271_G0.6740.34
54_V280_L0.6730.34
150_E240_R0.6720.34
63_I246_V0.6690.34
64_A148_A0.6660.34
197_E287_D0.6660.34
272_Y275_L0.6650.34
167_M175_F0.6630.33
92_E234_W0.6630.33
107_Y111_A0.6620.33
130_V230_T0.6600.33
34_T136_T0.6580.33
154_K245_P0.6550.33
207_Y297_F0.6530.33
230_T236_R0.6530.33
227_L266_G0.6510.33
12_G18_G0.6510.33
11_G18_G0.6510.33
205_L218_I0.6500.32
204_R228_V0.6490.32
33_R39_D0.6480.32
80_S215_L0.6480.32
217_T247_V0.6470.32
220_V266_G0.6460.32
12_G15_V0.6460.32
11_G15_V0.6460.32
221_G224_V0.6450.32
59_F72_N0.6450.32
216_F255_L0.6450.32
258_T267_L0.6440.32
59_F90_E0.6440.32
64_A190_Q0.6440.32
186_N300_L0.6430.32
187_C263_D0.6430.32
74_T248_L0.6430.32
184_V188_Y0.6420.32
119_L124_V0.6400.32
257_L304_E0.6400.32
239_D252_F0.6370.32
224_V241_V0.6310.31
134_E233_L0.6300.31
280_L283_K0.6290.31
188_Y306_L0.6280.31
60_L265_P0.6270.31
23_G229_P0.6260.31
7_P268_K0.6260.31
103_G135_L0.6240.31
23_G150_E0.6240.31
136_T140_F0.6230.31
33_R84_Y0.6230.31
133_A234_W0.6220.30
162_I277_L0.6220.30
304_E307_S0.6200.30
49_P52_N0.6190.30
119_L122_K0.6160.30
7_P114_G0.6160.30
126_T254_V0.6150.30
24_K243_L0.6140.30
82_E196_V0.6120.30
15_V24_K0.6120.30
170_L211_S0.6100.30
27_Y45_R0.6090.30
109_S112_V0.6080.30
86_L159_L0.6080.30
67_I139_I0.6080.30
35_D280_L0.6060.29
135_L242_A0.6050.29
14_A18_G0.6030.29
184_V301_L0.6020.29
130_V150_E0.6010.29
69_A274_G0.5980.29
29_T299_E0.5980.29
38_I248_L0.5970.29
224_V243_L0.5960.29
134_E162_I0.5950.29
33_R184_V0.5930.28
86_L152_L0.5920.28
82_E85_G0.5910.28
76_H79_F0.5890.28
23_G302_R0.5860.28
71_A261_V0.5860.28
239_D275_L0.5850.28
39_D85_G0.5840.28
116_L145_A0.5840.28
22_G151_S0.5830.28
44_P136_T0.5830.28
10_Y204_R0.5820.28
121_S240_R0.5810.28
192_L196_V0.5810.28
222_M241_V0.5790.28
34_T39_D0.5790.28
188_Y301_L0.5790.28
84_Y106_M0.5780.28
138_P141_S0.5760.27
53_I57_I0.5760.27
166_S301_L0.5750.27
44_P184_V0.5750.27
47_H50_K0.5710.27
161_Y185_I0.5710.27
153_F170_L0.5710.27
51_L169_P0.5700.27
187_C264_I0.5650.27
47_H293_A0.5630.27
127_L241_V0.5630.27
31_I83_R0.5610.26
298_N306_L0.5610.26
212_S258_T0.5570.26
42_K79_F0.5570.26
167_M257_L0.5570.26
174_V215_L0.5560.26
28_V300_L0.5550.26
214_I217_T0.5550.26
24_K224_V0.5540.26
186_N190_Q0.5540.26
297_F304_E0.5520.26
155_L174_V0.5510.26
60_L279_L0.5510.26
9_A23_G0.5500.26
23_G184_V0.5500.26
197_E201_N0.5450.25
195_T232_P0.5440.25
71_A82_E0.5420.25
223_F299_E0.5410.25
31_I246_V0.5410.25
200_Q284_E0.5390.25
118_F214_I0.5380.25
217_T251_S0.5380.25
26_H54_V0.5380.25
225_Y242_A0.5380.25
48_N51_L0.5360.25
35_D90_E0.5360.25
154_K221_G0.5340.25
174_V214_I0.5340.25
59_F128_V0.5330.25
266_G269_L0.5320.25
187_C202_Q0.5310.25
90_E102_S0.5300.24
205_L275_L0.5290.24
29_T85_G0.5260.24
233_L241_V0.5250.24
132_L224_V0.5240.24
17_E20_M0.5240.24
115_V167_M0.5240.24
167_M192_L0.5210.24
227_L254_V0.5200.24
276_W279_L0.5200.24
160_G172_K0.5200.24
186_N204_R0.5190.24
43_L120_F0.5190.24
245_P249_G0.5190.24
38_I294_I0.5180.24
28_V40_F0.5170.24
38_I176_Q0.5160.24
220_V247_V0.5160.24
231_D296_S0.5150.24
77_L80_S0.5150.24
23_G146_Q0.5140.24
111_A241_V0.5110.23
106_M109_S0.5100.23
66_I187_C0.5100.23
148_A287_D0.5090.23
73_G273_P0.5090.23
19_V153_F0.5060.23
220_V251_S0.5050.23
46_K67_I0.5030.23
79_F280_L0.5030.23
204_R229_P0.5030.23
116_L135_L0.5020.23
150_E229_P0.5010.23
163_Y175_F0.5010.23
130_V233_L0.5000.23
265_P275_L0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q9hA 1 0.6164 7 0.982 Contact Map
4x01A 4 0.1447 6.6 0.983 Contact Map
1y9lA 1 0.1447 4.9 0.984 Contact Map
3zdqA 2 0.6415 4.6 0.984 Contact Map
3wmgA 1 0.6352 4.4 0.984 Contact Map
4mnoA 1 0.283 4.3 0.984 Contact Map
4aybP 1 0.1352 4.1 0.984 Contact Map
3e5dA 2 0.1352 4 0.984 Contact Map
4f4cA 1 0.7704 3.5 0.985 Contact Map
4q4hA 1 0.6289 3.4 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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