YQHO - BACSU - GREMLIN Contacts

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YQHO - Uncharacterized protein YqhO

UniProt:	P54513	Sequences: MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIAAFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWIADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMSCSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKKNIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIELGKRRTELFLKQWTY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	291 (250)
Sequences:	9044 (6877)
Seq/√Len:	434.9

ECOLI - YJJU RSSA
BACSU - YQHO YLBK COTR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
41_A	160_S	3.374	1.00
23_V	279_K	3.293	1.00
23_V	283_E	3.230	1.00
128_D	175_D	3.204	1.00
276_E	280_R	3.160	1.00
45_A	157_V	3.055	1.00
22_E	279_K	2.895	1.00
23_V	26_E	2.759	1.00
22_E	57_H	2.709	1.00
26_E	279_K	2.577	1.00
126_A	137_L	2.456	1.00
171_K	180_T	2.426	1.00
99_E	155_R	2.401	1.00
103_A	154_A	2.386	1.00
270_K	273_A	2.306	1.00
52_T	55_E	2.302	1.00
7_F	17_L	2.277	1.00
44_A	122_L	2.265	1.00
14_G	39_A	2.264	1.00
128_D	135_I	2.253	1.00
16_A	281_R	2.185	1.00
134_M	188_S	2.115	1.00
135_I	181_V	2.087	1.00
35_A	195_F	2.072	1.00
25_E	53_S	2.033	1.00
23_V	282_T	2.031	1.00
152_P	155_R	1.987	1.00
22_E	54_K	1.973	1.00
57_H	61_E	1.922	1.00
34_V	44_A	1.919	1.00
190_F	205_G	1.898	1.00
61_E	272_L	1.870	1.00
58_A	62_E	1.836	1.00
23_V	27_K	1.836	1.00
20_A	206_V	1.816	1.00
272_L	276_E	1.810	1.00
279_K	283_E	1.743	1.00
27_K	283_E	1.739	1.00
280_R	284_L	1.722	1.00
39_A	60_I	1.667	1.00
250_N	254_L	1.651	1.00
9_G	189_N	1.620	1.00
182_V	186_V	1.610	1.00
188_S	193_W	1.598	1.00
4_D	195_F	1.584	1.00
155_R	170_I	1.584	1.00
101_W	105_L	1.551	1.00
21_Y	47_I	1.539	1.00
277_L	280_R	1.512	1.00
99_E	158_R	1.491	1.00
128_D	131_N	1.472	1.00
4_D	33_R	1.453	1.00
117_L	153_V	1.446	1.00
22_E	26_E	1.427	1.00
164_P	186_V	1.410	1.00
276_E	279_K	1.401	1.00
281_R	284_L	1.388	1.00
130_T	175_D	1.382	1.00
95_G	158_R	1.378	1.00
4_D	200_K	1.365	1.00
233_T	237_A	1.364	1.00
127_S	187_L	1.356	1.00
138_P	198_E	1.324	1.00
126_A	181_V	1.323	1.00
37_T	125_I	1.323	1.00
35_A	123_R	1.318	1.00
134_M	187_L	1.317	1.00
157_V	160_S	1.312	1.00
171_K	174_T	1.303	1.00
137_L	156_A	1.300	1.00
242_H	246_R	1.289	1.00
121_S	138_P	1.282	1.00
207_T	253_F	1.274	1.00
282_T	286_L	1.274	1.00
259_V	274_L	1.272	1.00
34_V	48_A	1.272	1.00
3_I	202_P	1.260	1.00
91_G	168_E	1.252	1.00
55_E	58_A	1.251	1.00
27_K	286_L	1.250	1.00
194_L	197_K	1.249	1.00
273_A	277_L	1.245	1.00
123_R	198_E	1.217	1.00
125_I	134_M	1.211	1.00
26_E	283_E	1.205	1.00
53_S	56_I	1.201	1.00
193_W	197_K	1.190	1.00
125_I	136_V	1.190	1.00
41_A	161_C	1.187	1.00
129_L	182_V	1.185	1.00
8_S	190_F	1.185	1.00
123_R	136_V	1.185	1.00
20_A	282_T	1.178	1.00
100_K	104_D	1.173	1.00
51_Y	55_E	1.166	1.00
45_A	122_L	1.165	1.00
155_R	172_L	1.153	1.00
84_V	88_W	1.151	1.00
130_T	180_T	1.151	1.00
241_R	246_R	1.145	1.00
123_R	138_P	1.140	1.00
241_R	245_S	1.138	1.00
23_V	286_L	1.125	1.00
48_A	122_L	1.120	1.00
249_Q	254_L	1.119	1.00
162_S	170_I	1.104	1.00
172_L	181_V	1.104	1.00
136_V	194_L	1.085	1.00
234_M	237_A	1.081	1.00
17_L	43_I	1.071	1.00
42_I	102_I	1.067	1.00
172_L	175_D	1.056	1.00
159_M	181_V	1.044	1.00
84_V	87_Y	1.040	1.00
38_S	183_D	1.040	1.00
248_E	251_I	1.037	1.00
231_F	235_K	1.033	1.00
110_G	115_G	1.031	1.00
99_E	103_A	1.029	1.00
271_K	275_I	1.022	1.00
57_H	275_I	1.018	1.00
280_R	283_E	1.018	1.00
137_L	172_L	1.015	1.00
123_R	194_L	1.013	1.00
227_F	230_L	1.005	1.00
194_L	198_E	1.004	1.00
5_G	31_F	1.001	1.00
58_A	61_E	0.999	1.00
196_S	203_V	0.993	1.00
241_R	244_A	0.992	1.00
51_Y	59_L	0.977	1.00
21_Y	25_E	0.959	1.00
230_L	235_K	0.956	1.00
6_V	195_F	0.949	1.00
277_L	281_R	0.948	1.00
64_D	67_K	0.945	1.00
222_N	226_L	0.943	1.00
22_E	53_S	0.943	1.00
33_R	123_R	0.941	1.00
25_E	50_G	0.941	1.00
21_Y	53_S	0.940	1.00
126_A	156_A	0.928	1.00
18_A	53_S	0.926	1.00
263_D	270_K	0.926	1.00
158_R	162_S	0.920	1.00
228_G	232_E	0.918	1.00
229_A	233_T	0.914	1.00
243_I	246_R	0.911	1.00
202_P	206_V	0.909	1.00
54_K	58_A	0.909	1.00
25_E	47_I	0.906	1.00
5_G	34_V	0.906	1.00
137_L	181_V	0.906	1.00
195_F	200_K	0.902	1.00
3_I	31_F	0.899	1.00
240_A	244_A	0.893	1.00
278_G	282_T	0.893	1.00
33_R	195_F	0.892	1.00
175_D	181_V	0.887	1.00
279_K	282_T	0.886	1.00
108_A	152_P	0.885	1.00
252_I	281_R	0.881	1.00
24_L	282_T	0.880	1.00
12_V	65_G	0.876	1.00
159_M	172_L	0.865	1.00
98_I	161_C	0.864	1.00
233_T	236_D	0.862	1.00
239_D	242_H	0.858	1.00
7_F	44_A	0.858	1.00
5_G	21_Y	0.858	1.00
30_R	50_G	0.849	1.00
56_I	60_I	0.849	1.00
230_L	234_M	0.848	1.00
102_I	106_L	0.847	1.00
46_F	56_I	0.844	1.00
96_D	100_K	0.838	1.00
101_W	104_D	0.838	1.00
169_P	182_V	0.838	1.00
110_G	116_D	0.836	1.00
232_E	236_D	0.836	1.00
61_E	275_I	0.836	1.00
31_F	204_I	0.834	1.00
126_A	159_M	0.834	1.00
175_D	180_T	0.833	1.00
32_K	121_S	0.833	1.00
234_M	238_H	0.833	1.00
6_V	192_I	0.830	1.00
192_I	205_G	0.830	1.00
11_G	163_I	0.828	1.00
17_L	206_V	0.827	1.00
38_S	163_I	0.824	1.00
248_E	254_L	0.821	1.00
42_I	161_C	0.817	1.00
164_P	184_G	0.817	1.00
85_S	88_W	0.816	1.00
154_A	158_R	0.809	1.00
252_I	255_P	0.809	1.00
33_R	198_E	0.809	1.00
238_H	242_H	0.802	1.00
44_A	48_A	0.799	1.00
54_K	57_H	0.798	1.00
41_A	157_V	0.798	1.00
221_R	226_L	0.796	1.00
35_A	194_L	0.790	1.00
114_F	117_L	0.787	1.00
230_L	237_A	0.786	1.00
110_G	114_F	0.784	1.00
242_H	245_S	0.783	1.00
44_A	124_L	0.782	1.00
39_A	208_L	0.776	1.00
231_F	237_A	0.774	1.00
261_A	264_F	0.770	1.00
9_G	185_G	0.769	1.00
229_A	232_E	0.766	1.00
46_F	106_L	0.764	1.00
8_S	207_T	0.753	1.00
18_A	43_I	0.752	1.00
128_D	181_V	0.752	1.00
95_G	99_E	0.750	1.00
235_K	238_H	0.749	1.00
169_P	180_T	0.748	1.00
14_G	17_L	0.745	1.00
6_V	35_A	0.745	1.00
232_E	237_A	0.743	1.00
185_G	189_N	0.740	1.00
4_D	35_A	0.739	1.00
4_D	203_V	0.738	1.00
100_K	103_A	0.732	1.00
261_A	265_H	0.728	1.00
17_L	208_L	0.728	1.00
273_A	276_E	0.727	1.00
33_R	200_K	0.724	1.00
238_H	246_R	0.720	1.00
103_A	152_P	0.720	1.00
9_G	37_T	0.718	1.00
3_I	6_V	0.718	1.00
107_R	110_G	0.712	1.00
53_S	57_H	0.709	1.00
114_F	153_V	0.706	1.00
157_V	161_C	0.700	1.00
260_M	263_D	0.700	1.00
45_A	124_L	0.699	1.00
158_R	170_I	0.696	1.00
59_L	63_V	0.696	1.00
46_F	105_L	0.695	1.00
102_I	154_A	0.690	1.00
18_A	57_H	0.687	1.00
129_L	169_P	0.685	1.00
221_R	225_E	0.680	1.00
258_D	262_T	0.679	1.00
48_A	119_K	0.677	1.00
16_A	256_V	0.676	1.00
220_I	229_A	0.674	1.00
247_Y	250_N	0.670	1.00
49_S	106_L	0.670	1.00
52_T	56_I	0.669	1.00
34_V	47_I	0.669	1.00
252_I	282_T	0.668	1.00
63_V	68_L	0.668	1.00
252_I	256_V	0.667	1.00
13_K	209_A	0.663	1.00
251_I	255_P	0.662	1.00
99_E	154_A	0.662	1.00
217_K	221_R	0.659	1.00
232_E	235_K	0.659	1.00
208_L	211_R	0.658	1.00
45_A	160_S	0.658	1.00
220_I	226_L	0.653	0.99
226_L	230_L	0.653	0.99
48_A	117_L	0.653	0.99
249_Q	252_I	0.652	0.99
163_I	166_F	0.650	0.99
60_I	63_V	0.649	0.99
222_N	225_E	0.647	0.99
281_R	285_F	0.647	0.99
265_H	270_K	0.646	0.99
13_K	261_A	0.645	0.99
97_T	100_K	0.645	0.99
244_A	247_Y	0.644	0.99
225_E	228_G	0.642	0.99
259_V	263_D	0.640	0.99
216_P	219_N	0.639	0.99
282_T	285_F	0.638	0.99
254_L	281_R	0.636	0.99
195_F	203_V	0.631	0.99
7_F	34_V	0.630	0.99
15_I	39_A	0.629	0.99
125_I	194_L	0.626	0.99
195_F	198_E	0.624	0.99
8_S	208_L	0.624	0.99
228_G	237_A	0.623	0.99
55_E	62_E	0.623	0.99
22_E	275_I	0.619	0.99
188_S	194_L	0.619	0.99
200_K	203_V	0.619	0.99
163_I	261_A	0.619	0.99
25_E	30_R	0.617	0.99
230_L	233_T	0.617	0.99
262_T	265_H	0.617	0.99
49_S	109_K	0.616	0.99
115_G	140_D	0.613	0.99
51_Y	56_I	0.612	0.99
240_A	245_S	0.610	0.99
275_I	279_K	0.609	0.99
12_V	264_F	0.609	0.99
41_A	124_L	0.607	0.99
199_R	203_V	0.606	0.99
126_A	135_I	0.605	0.99
62_E	104_D	0.605	0.99
163_I	182_V	0.605	0.99
95_G	168_E	0.602	0.99
226_L	229_A	0.601	0.99
62_E	66_E	0.592	0.99
259_V	262_T	0.592	0.99
65_G	68_L	0.591	0.99
249_Q	255_P	0.588	0.99
34_V	119_K	0.586	0.99
30_R	119_K	0.585	0.99
93_Y	166_F	0.582	0.99
19_G	278_G	0.582	0.99
8_S	189_N	0.578	0.99
251_I	254_L	0.577	0.99
121_S	198_E	0.577	0.99
4_D	199_R	0.576	0.99
217_K	220_I	0.572	0.99
57_H	272_L	0.571	0.99
234_M	240_A	0.570	0.99
19_G	279_K	0.567	0.99
253_F	256_V	0.567	0.99
15_I	271_K	0.566	0.99
248_E	253_F	0.566	0.99
123_R	195_F	0.563	0.98
32_K	200_K	0.562	0.98
6_V	190_F	0.561	0.98
46_F	51_Y	0.561	0.98
24_L	31_F	0.561	0.98
21_Y	24_L	0.561	0.98
86_I	89_R	0.560	0.98
15_I	60_I	0.558	0.98
259_V	273_A	0.557	0.98
37_T	188_S	0.555	0.98
38_S	164_P	0.554	0.98
205_G	248_E	0.551	0.98
250_N	255_P	0.548	0.98
36_G	40_G	0.547	0.98
103_A	108_A	0.543	0.98
224_F	228_G	0.542	0.98
51_Y	54_K	0.541	0.98
159_M	162_S	0.538	0.98
33_R	121_S	0.536	0.98
19_G	23_V	0.535	0.98
231_F	234_M	0.532	0.98
133_T	175_D	0.531	0.98
15_I	19_G	0.531	0.98
227_F	231_F	0.530	0.98
135_I	139_D	0.528	0.98
202_P	205_G	0.524	0.98
12_V	42_I	0.524	0.98
258_D	277_L	0.523	0.98
228_G	231_F	0.522	0.98
223_A	230_L	0.521	0.97
114_F	118_Q	0.518	0.97
193_W	242_H	0.518	0.97
272_L	275_I	0.516	0.97
37_T	191_P	0.513	0.97
43_I	56_I	0.513	0.97
7_F	21_Y	0.509	0.97
7_F	43_I	0.508	0.97
54_K	61_E	0.507	0.97
251_I	256_V	0.504	0.97
115_G	119_K	0.504	0.97
216_P	222_N	0.501	0.97
49_S	117_L	0.501	0.97
99_E	170_I	0.501	0.97
238_H	241_R	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qmkA	2	0.7216	100	0.268	Contact Map
3tu3B	1	0.7938	100	0.277	Contact Map
4akfA	2	0.9519	100	0.278	Contact Map
4pk9A	2	0.9347	100	0.327	Contact Map
1cjyA	1	0.8007	99.1	0.793	Contact Map
4c23A	1	0.2543	67.9	0.932	Contact Map
4rr5A	1	0.6667	60.8	0.935	Contact Map
3im8A	1	0.811	59.1	0.936	Contact Map
2uytA	1	0.2955	51.7	0.939	Contact Map
3hz6A	1	0.3127	49.4	0.94	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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