GREMLIN Database
YQHO - Uncharacterized protein YqhO
UniProt: P54513 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 291 (250)
Sequences: 9044 (6877)
Seq/√Len: 434.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_A160_S3.3741.00
23_V279_K3.2931.00
23_V283_E3.2301.00
128_D175_D3.2041.00
276_E280_R3.1601.00
45_A157_V3.0551.00
22_E279_K2.8951.00
23_V26_E2.7591.00
22_E57_H2.7091.00
26_E279_K2.5771.00
126_A137_L2.4561.00
171_K180_T2.4261.00
99_E155_R2.4011.00
103_A154_A2.3861.00
270_K273_A2.3061.00
52_T55_E2.3021.00
7_F17_L2.2771.00
44_A122_L2.2651.00
14_G39_A2.2641.00
128_D135_I2.2531.00
16_A281_R2.1851.00
134_M188_S2.1151.00
135_I181_V2.0871.00
35_A195_F2.0721.00
25_E53_S2.0331.00
23_V282_T2.0311.00
152_P155_R1.9871.00
22_E54_K1.9731.00
57_H61_E1.9221.00
34_V44_A1.9191.00
190_F205_G1.8981.00
61_E272_L1.8701.00
58_A62_E1.8361.00
23_V27_K1.8361.00
20_A206_V1.8161.00
272_L276_E1.8101.00
279_K283_E1.7431.00
27_K283_E1.7391.00
280_R284_L1.7221.00
39_A60_I1.6671.00
250_N254_L1.6511.00
9_G189_N1.6201.00
182_V186_V1.6101.00
188_S193_W1.5981.00
4_D195_F1.5841.00
155_R170_I1.5841.00
101_W105_L1.5511.00
21_Y47_I1.5391.00
277_L280_R1.5121.00
99_E158_R1.4911.00
128_D131_N1.4721.00
4_D33_R1.4531.00
117_L153_V1.4461.00
22_E26_E1.4271.00
164_P186_V1.4101.00
276_E279_K1.4011.00
281_R284_L1.3881.00
130_T175_D1.3821.00
95_G158_R1.3781.00
4_D200_K1.3651.00
233_T237_A1.3641.00
127_S187_L1.3561.00
138_P198_E1.3241.00
126_A181_V1.3231.00
37_T125_I1.3231.00
35_A123_R1.3181.00
134_M187_L1.3171.00
157_V160_S1.3121.00
171_K174_T1.3031.00
137_L156_A1.3001.00
242_H246_R1.2891.00
121_S138_P1.2821.00
207_T253_F1.2741.00
282_T286_L1.2741.00
259_V274_L1.2721.00
34_V48_A1.2721.00
3_I202_P1.2601.00
91_G168_E1.2521.00
55_E58_A1.2511.00
27_K286_L1.2501.00
194_L197_K1.2491.00
273_A277_L1.2451.00
123_R198_E1.2171.00
125_I134_M1.2111.00
26_E283_E1.2051.00
53_S56_I1.2011.00
193_W197_K1.1901.00
125_I136_V1.1901.00
41_A161_C1.1871.00
129_L182_V1.1851.00
8_S190_F1.1851.00
123_R136_V1.1851.00
20_A282_T1.1781.00
100_K104_D1.1731.00
51_Y55_E1.1661.00
45_A122_L1.1651.00
155_R172_L1.1531.00
84_V88_W1.1511.00
130_T180_T1.1511.00
241_R246_R1.1451.00
123_R138_P1.1401.00
241_R245_S1.1381.00
23_V286_L1.1251.00
48_A122_L1.1201.00
249_Q254_L1.1191.00
162_S170_I1.1041.00
172_L181_V1.1041.00
136_V194_L1.0851.00
234_M237_A1.0811.00
17_L43_I1.0711.00
42_I102_I1.0671.00
172_L175_D1.0561.00
159_M181_V1.0441.00
84_V87_Y1.0401.00
38_S183_D1.0401.00
248_E251_I1.0371.00
231_F235_K1.0331.00
110_G115_G1.0311.00
99_E103_A1.0291.00
271_K275_I1.0221.00
57_H275_I1.0181.00
280_R283_E1.0181.00
137_L172_L1.0151.00
123_R194_L1.0131.00
227_F230_L1.0051.00
194_L198_E1.0041.00
5_G31_F1.0011.00
58_A61_E0.9991.00
196_S203_V0.9931.00
241_R244_A0.9921.00
51_Y59_L0.9771.00
21_Y25_E0.9591.00
230_L235_K0.9561.00
6_V195_F0.9491.00
277_L281_R0.9481.00
64_D67_K0.9451.00
222_N226_L0.9431.00
22_E53_S0.9431.00
33_R123_R0.9411.00
25_E50_G0.9411.00
21_Y53_S0.9401.00
126_A156_A0.9281.00
18_A53_S0.9261.00
263_D270_K0.9261.00
158_R162_S0.9201.00
228_G232_E0.9181.00
229_A233_T0.9141.00
243_I246_R0.9111.00
202_P206_V0.9091.00
54_K58_A0.9091.00
25_E47_I0.9061.00
5_G34_V0.9061.00
137_L181_V0.9061.00
195_F200_K0.9021.00
3_I31_F0.8991.00
240_A244_A0.8931.00
278_G282_T0.8931.00
33_R195_F0.8921.00
175_D181_V0.8871.00
279_K282_T0.8861.00
108_A152_P0.8851.00
252_I281_R0.8811.00
24_L282_T0.8801.00
12_V65_G0.8761.00
159_M172_L0.8651.00
98_I161_C0.8641.00
233_T236_D0.8621.00
239_D242_H0.8581.00
7_F44_A0.8581.00
5_G21_Y0.8581.00
30_R50_G0.8491.00
56_I60_I0.8491.00
230_L234_M0.8481.00
102_I106_L0.8471.00
46_F56_I0.8441.00
96_D100_K0.8381.00
101_W104_D0.8381.00
169_P182_V0.8381.00
110_G116_D0.8361.00
232_E236_D0.8361.00
61_E275_I0.8361.00
31_F204_I0.8341.00
126_A159_M0.8341.00
175_D180_T0.8331.00
32_K121_S0.8331.00
234_M238_H0.8331.00
6_V192_I0.8301.00
192_I205_G0.8301.00
11_G163_I0.8281.00
17_L206_V0.8271.00
38_S163_I0.8241.00
248_E254_L0.8211.00
42_I161_C0.8171.00
164_P184_G0.8171.00
85_S88_W0.8161.00
154_A158_R0.8091.00
252_I255_P0.8091.00
33_R198_E0.8091.00
238_H242_H0.8021.00
44_A48_A0.7991.00
54_K57_H0.7981.00
41_A157_V0.7981.00
221_R226_L0.7961.00
35_A194_L0.7901.00
114_F117_L0.7871.00
230_L237_A0.7861.00
110_G114_F0.7841.00
242_H245_S0.7831.00
44_A124_L0.7821.00
39_A208_L0.7761.00
231_F237_A0.7741.00
261_A264_F0.7701.00
9_G185_G0.7691.00
229_A232_E0.7661.00
46_F106_L0.7641.00
8_S207_T0.7531.00
18_A43_I0.7521.00
128_D181_V0.7521.00
95_G99_E0.7501.00
235_K238_H0.7491.00
169_P180_T0.7481.00
14_G17_L0.7451.00
6_V35_A0.7451.00
232_E237_A0.7431.00
185_G189_N0.7401.00
4_D35_A0.7391.00
4_D203_V0.7381.00
100_K103_A0.7321.00
261_A265_H0.7281.00
17_L208_L0.7281.00
273_A276_E0.7271.00
33_R200_K0.7241.00
238_H246_R0.7201.00
103_A152_P0.7201.00
9_G37_T0.7181.00
3_I6_V0.7181.00
107_R110_G0.7121.00
53_S57_H0.7091.00
114_F153_V0.7061.00
157_V161_C0.7001.00
260_M263_D0.7001.00
45_A124_L0.6991.00
158_R170_I0.6961.00
59_L63_V0.6961.00
46_F105_L0.6951.00
102_I154_A0.6901.00
18_A57_H0.6871.00
129_L169_P0.6851.00
221_R225_E0.6801.00
258_D262_T0.6791.00
48_A119_K0.6771.00
16_A256_V0.6761.00
220_I229_A0.6741.00
247_Y250_N0.6701.00
49_S106_L0.6701.00
52_T56_I0.6691.00
34_V47_I0.6691.00
252_I282_T0.6681.00
63_V68_L0.6681.00
252_I256_V0.6671.00
13_K209_A0.6631.00
251_I255_P0.6621.00
99_E154_A0.6621.00
217_K221_R0.6591.00
232_E235_K0.6591.00
208_L211_R0.6581.00
45_A160_S0.6581.00
220_I226_L0.6530.99
226_L230_L0.6530.99
48_A117_L0.6530.99
249_Q252_I0.6520.99
163_I166_F0.6500.99
60_I63_V0.6490.99
222_N225_E0.6470.99
281_R285_F0.6470.99
265_H270_K0.6460.99
13_K261_A0.6450.99
97_T100_K0.6450.99
244_A247_Y0.6440.99
225_E228_G0.6420.99
259_V263_D0.6400.99
216_P219_N0.6390.99
282_T285_F0.6380.99
254_L281_R0.6360.99
195_F203_V0.6310.99
7_F34_V0.6300.99
15_I39_A0.6290.99
125_I194_L0.6260.99
195_F198_E0.6240.99
8_S208_L0.6240.99
228_G237_A0.6230.99
55_E62_E0.6230.99
22_E275_I0.6190.99
188_S194_L0.6190.99
200_K203_V0.6190.99
163_I261_A0.6190.99
25_E30_R0.6170.99
230_L233_T0.6170.99
262_T265_H0.6170.99
49_S109_K0.6160.99
115_G140_D0.6130.99
51_Y56_I0.6120.99
240_A245_S0.6100.99
275_I279_K0.6090.99
12_V264_F0.6090.99
41_A124_L0.6070.99
199_R203_V0.6060.99
126_A135_I0.6050.99
62_E104_D0.6050.99
163_I182_V0.6050.99
95_G168_E0.6020.99
226_L229_A0.6010.99
62_E66_E0.5920.99
259_V262_T0.5920.99
65_G68_L0.5910.99
249_Q255_P0.5880.99
34_V119_K0.5860.99
30_R119_K0.5850.99
93_Y166_F0.5820.99
19_G278_G0.5820.99
8_S189_N0.5780.99
251_I254_L0.5770.99
121_S198_E0.5770.99
4_D199_R0.5760.99
217_K220_I0.5720.99
57_H272_L0.5710.99
234_M240_A0.5700.99
19_G279_K0.5670.99
253_F256_V0.5670.99
15_I271_K0.5660.99
248_E253_F0.5660.99
123_R195_F0.5630.98
32_K200_K0.5620.98
6_V190_F0.5610.98
46_F51_Y0.5610.98
24_L31_F0.5610.98
21_Y24_L0.5610.98
86_I89_R0.5600.98
15_I60_I0.5580.98
259_V273_A0.5570.98
37_T188_S0.5550.98
38_S164_P0.5540.98
205_G248_E0.5510.98
250_N255_P0.5480.98
36_G40_G0.5470.98
103_A108_A0.5430.98
224_F228_G0.5420.98
51_Y54_K0.5410.98
159_M162_S0.5380.98
33_R121_S0.5360.98
19_G23_V0.5350.98
231_F234_M0.5320.98
133_T175_D0.5310.98
15_I19_G0.5310.98
227_F231_F0.5300.98
135_I139_D0.5280.98
202_P205_G0.5240.98
12_V42_I0.5240.98
258_D277_L0.5230.98
228_G231_F0.5220.98
223_A230_L0.5210.97
114_F118_Q0.5180.97
193_W242_H0.5180.97
272_L275_I0.5160.97
37_T191_P0.5130.97
43_I56_I0.5130.97
7_F21_Y0.5090.97
7_F43_I0.5080.97
54_K61_E0.5070.97
251_I256_V0.5040.97
115_G119_K0.5040.97
216_P222_N0.5010.97
49_S117_L0.5010.97
99_E170_I0.5010.97
238_H241_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qmkA 2 0.7216 100 0.268 Contact Map
3tu3B 1 0.7938 100 0.277 Contact Map
4akfA 2 0.9519 100 0.278 Contact Map
4pk9A 2 0.9347 100 0.327 Contact Map
1cjyA 1 0.8007 99.1 0.793 Contact Map
4c23A 1 0.2543 67.9 0.932 Contact Map
4rr5A 1 0.6667 60.8 0.935 Contact Map
3im8A 1 0.811 59.1 0.936 Contact Map
2uytA 1 0.2955 51.7 0.939 Contact Map
3hz6A 1 0.3127 49.4 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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