GREMLIN Database
MNTR - Transcriptional regulator MntR
UniProt: P54512 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (121)
Sequences: 2658 (1743)
Seq/√Len: 158.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_K71_K3.0001.00
81_E95_Y2.8921.00
84_L101_I2.7331.00
97_D106_S2.6421.00
11_E77_H2.5531.00
93_K108_N2.4741.00
75_Y114_G2.3131.00
90_D93_K2.2961.00
6_M49_D2.2831.00
25_V39_V2.2801.00
5_S38_S2.2661.00
13_I52_L2.1531.00
53_I61_V2.1201.00
7_E103_H1.9301.00
112_R115_D1.8991.00
17_I67_K1.8861.00
43_V52_L1.8091.00
114_G119_Y1.7191.00
105_L110_I1.7161.00
51_Y65_K1.6701.00
41_K45_K1.6441.00
47_D54_Y1.6351.00
15_M74_V1.6111.00
64_S67_K1.6051.00
72_R107_W1.5971.00
34_V39_V1.5901.00
99_E103_H1.5731.00
82_Q85_R1.5541.00
19_E31_A1.5111.00
100_G104_H1.5011.00
83_F87_I1.5001.00
65_K68_K1.4921.00
12_Q31_A1.4591.00
11_E99_E1.4381.00
38_S42_M1.4341.00
13_I23_A1.4331.00
86_I116_L1.3961.00
27_D30_E1.3511.00
80_L105_L1.3481.00
54_Y57_Y1.3081.00
83_F116_L1.2921.00
17_I23_A1.2401.00
7_E102_E1.2381.00
99_E102_E1.2241.00
43_V60_L1.1861.00
12_Q28_I1.1101.00
115_D119_Y1.1021.00
11_E102_E1.0910.99
52_L60_L1.0890.99
28_I43_V1.0780.99
28_I60_L1.0690.99
83_F86_I1.0590.99
77_H95_Y1.0450.99
6_M42_M1.0410.99
12_Q32_L1.0240.99
72_R76_R1.0220.99
4_P8_D1.0190.99
36_P42_M1.0180.99
8_D103_H1.0150.99
15_M31_A1.0150.99
40_T54_Y1.0050.99
85_R91_E0.9890.99
97_D109_S0.9870.99
7_E73_L0.9750.99
8_D99_E0.9710.99
68_K72_R0.9680.99
90_D108_N0.9660.99
22_Y59_G0.9650.99
17_I21_G0.9650.99
9_Y38_S0.9530.99
117_V120_F0.9440.98
87_I112_R0.9420.98
14_Y74_V0.9360.98
89_V109_S0.9330.98
89_V97_D0.9270.98
77_H102_E0.9250.98
26_S36_P0.9220.98
80_L113_I0.9090.98
75_Y79_L0.8990.98
107_W111_D0.8930.98
18_E78_E0.8890.98
108_N112_R0.8780.98
44_Q47_D0.8780.98
16_L23_A0.8590.97
25_V36_P0.8580.97
8_D102_E0.8300.97
14_Y70_G0.8290.97
25_V43_V0.8290.97
77_H99_E0.8280.97
10_I14_Y0.8270.97
25_V40_T0.8270.97
14_Y18_E0.8250.96
35_H40_T0.8190.96
83_F117_V0.8150.96
10_I69_I0.8040.96
80_L109_S0.7980.96
44_Q48_K0.7770.95
50_E65_K0.7570.94
32_L42_M0.7520.94
53_I63_T0.7430.94
93_K97_D0.7430.94
88_G112_R0.7360.93
46_L51_Y0.7350.93
42_M45_K0.7350.93
24_R27_D0.7340.93
12_Q15_M0.7310.93
29_A34_V0.7240.93
7_E11_E0.7220.93
76_R107_W0.7200.93
76_R110_I0.7190.93
94_I99_E0.7160.92
6_M44_Q0.7130.92
8_D11_E0.7110.92
41_K44_Q0.6950.91
18_E67_K0.6910.91
28_I39_V0.6870.91
77_H103_H0.6830.91
64_S68_K0.6830.91
97_D104_H0.6810.90
69_I72_R0.6800.90
39_V43_V0.6760.90
32_L36_P0.6740.90
83_F113_I0.6700.90
98_V104_H0.6680.90
97_D105_L0.6630.89
34_V37_S0.6610.89
5_S8_D0.6600.89
25_V54_Y0.6520.88
17_I22_Y0.6470.88
13_I39_V0.6420.88
105_L109_S0.6340.87
14_Y71_K0.6340.87
49_D65_K0.6340.87
78_E81_E0.6310.87
47_D58_R0.6200.86
43_V54_Y0.6190.86
85_R95_Y0.6190.86
77_H81_E0.6160.86
5_S42_M0.6130.85
6_M11_E0.6020.84
97_D108_N0.6000.84
14_Y67_K0.5990.84
73_L76_R0.5980.84
34_V38_S0.5920.83
16_L27_D0.5900.83
65_K69_I0.5890.83
76_R106_S0.5800.82
97_D100_G0.5790.82
24_R59_G0.5780.82
8_D41_K0.5760.82
87_I116_L0.5710.81
82_Q113_I0.5700.81
6_M73_L0.5700.81
8_D104_H0.5590.80
55_E61_V0.5590.80
111_D114_G0.5570.79
15_M73_L0.5530.79
81_E91_E0.5510.79
79_L113_I0.5450.78
11_E15_M0.5410.77
91_E95_Y0.5410.77
22_Y61_V0.5370.77
79_L117_V0.5360.77
96_N100_G0.5360.77
28_I32_L0.5340.76
8_D77_H0.5320.76
34_V42_M0.5320.76
79_L86_I0.5300.76
4_P100_G0.5270.76
20_K57_Y0.5250.75
74_V78_E0.5250.75
82_Q120_F0.5230.75
99_E123_D0.5200.75
120_F124_D0.5190.74
27_D31_A0.5160.74
5_S41_K0.5130.74
9_Y39_V0.5130.74
55_E59_G0.5120.73
11_E103_H0.5070.73
56_K83_F0.5020.72
8_D12_Q0.5020.72
25_V59_G0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1on2A 2 0.9507 99.9 0.487 Contact Map
1fx7A 4 1 99.9 0.493 Contact Map
2qq9A 2 0.9437 99.9 0.497 Contact Map
4o5vA 2 0.9859 99.9 0.504 Contact Map
3hrsA 2 0.9859 99.9 0.506 Contact Map
2x4hA 3 0.9155 99.7 0.606 Contact Map
2h09A 2 0.831 99.7 0.61 Contact Map
2p8tA 1 0.8662 99.7 0.622 Contact Map
2fxaA 4 0.8873 99.1 0.73 Contact Map
2qvoA 2 0.5634 98.9 0.75 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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