GREMLIN Database
LIPM - Octanoyltransferase LipM
UniProt: P54511 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (236)
Sequences: 2516 (1731)
Seq/√Len: 112.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_H267_T4.0651.00
187_D220_N3.8771.00
217_V222_L3.3881.00
24_E28_Y2.8981.00
66_V73_F2.8361.00
115_E119_Q2.7311.00
65_A69_Y2.6581.00
122_R127_D2.5941.00
69_Y196_L2.5521.00
228_T231_E2.4091.00
123_N242_T2.3401.00
64_E68_K2.2991.00
254_S257_E2.2171.00
123_N239_G2.1351.00
24_E268_K2.1281.00
42_Y92_S2.1191.00
260_F263_H2.1061.00
265_A270_A2.0221.00
119_Q242_T2.0081.00
91_Y182_G1.9961.00
264_L269_Y1.9861.00
159_L166_V1.8901.00
189_D192_K1.8591.00
85_H90_T1.8441.00
262_H266_E1.8331.00
127_D162_E1.8011.00
74_V275_N1.7661.00
217_V221_E1.7491.00
78_T172_T1.7311.00
65_A68_K1.7211.00
119_Q122_R1.7091.00
69_Y195_D1.6991.00
89_L229_M1.6881.00
28_Y260_F1.6791.00
264_L268_K1.6671.00
15_S18_F1.6571.00
204_V208_M1.6541.00
124_L235_A1.6391.00
49_L66_V1.6241.00
119_Q239_G1.6241.00
28_Y174_Q1.6231.00
51_V57_I1.5971.00
24_E269_Y1.5951.00
46_P72_G1.5851.00
18_F258_L1.5841.00
10_D233_R1.5681.00
85_H88_E1.5661.00
29_W260_F1.5501.00
257_E260_F1.5211.00
65_A196_L1.5181.00
97_E176_G1.5041.00
23_D181_H1.4971.00
63_F67_H1.4931.00
63_F73_F1.4861.00
225_K231_E1.4841.00
167_A183_S1.4791.00
201_S205_R1.4651.00
157_Y203_R1.4601.00
120_G239_G1.4541.00
208_M211_N1.4351.00
256_E259_D1.4341.00
50_S85_H1.4311.00
234_K238_E1.4291.00
164_R217_V1.4191.00
161_V166_V1.4151.00
39_I240_F1.4031.00
266_E270_A1.3901.00
166_V219_I1.3891.00
25_A29_W1.3871.00
89_L232_A1.3721.00
170_A181_H1.3471.00
26_L38_V1.3441.00
204_V209_Q1.3371.00
69_Y192_K1.3351.00
19_N45_N1.3301.00
37_P96_S1.3291.00
20_M23_D1.3000.99
45_N85_H1.2990.99
186_L232_A1.2890.99
251_Y257_E1.2870.99
164_R221_E1.2770.99
111_R115_E1.2710.99
82_G197_F1.2380.99
18_F22_L1.2220.99
157_Y215_K1.2100.99
253_L261_V1.2080.99
88_E183_S1.1960.99
161_V222_L1.1940.99
20_M50_S1.1900.99
123_N235_A1.1850.99
62_N198_L1.1840.99
195_D198_L1.1830.99
19_N85_H1.1710.99
230_D234_K1.1680.99
128_A161_V1.1670.99
16_P74_V1.1310.99
42_Y180_Q1.1170.98
118_L128_A1.1140.98
167_A182_G1.1090.98
203_R215_K1.0990.98
55_Q60_E1.0990.98
272_D275_N1.0970.98
237_K241_E1.0960.98
89_L233_R1.0960.98
50_S83_V1.0950.98
65_A71_L1.0820.98
123_N238_E1.0740.98
193_L216_A1.0670.98
263_H266_E1.0650.98
57_I276_Y1.0590.98
8_F237_K1.0520.98
192_K195_D1.0480.98
160_V163_G1.0460.98
42_Y50_S1.0440.98
169_S180_Q1.0400.97
169_S182_G1.0380.97
77_P268_K1.0380.97
71_L196_L1.0330.97
120_G236_F1.0320.97
131_A160_V1.0290.97
258_L262_H1.0240.97
121_F232_A1.0210.97
20_M85_H1.0200.97
45_N88_E1.0170.97
85_H181_H1.0160.97
43_G229_M1.0140.97
128_A131_A1.0120.97
61_I66_V1.0120.97
155_S158_E1.0080.97
64_E67_H1.0060.97
22_L261_V1.0030.97
220_N226_R1.0020.97
30_H96_S0.9970.97
204_V207_R0.9950.97
206_E210_R0.9930.97
51_V82_G0.9840.96
81_R167_A0.9790.96
256_E260_F0.9780.96
209_Q212_F0.9770.96
199_Y203_R0.9750.96
50_S88_E0.9650.96
78_T181_H0.9630.96
66_V71_L0.9630.96
23_D40_R0.9580.96
26_L30_H0.9480.96
20_M88_E0.9460.96
171_Q180_Q0.9440.96
86_D192_K0.9360.95
25_A261_V0.9290.95
191_D213_K0.9180.95
111_R130_F0.9040.94
77_P269_Y0.9040.94
203_R207_R0.9020.94
208_M212_F0.9000.94
77_P172_T0.8990.94
65_A195_D0.8980.94
239_G242_T0.8870.94
190_E218_A0.8850.94
120_G235_A0.8840.94
62_N65_A0.8720.93
259_D263_H0.8670.93
113_I116_G0.8650.93
43_G233_R0.8600.93
118_L159_L0.8550.93
83_V90_T0.8540.92
114_S169_S0.8520.92
84_L196_L0.8510.92
15_S72_G0.8480.92
50_S180_Q0.8440.92
262_H265_A0.8400.92
97_E173_R0.8360.92
50_S90_T0.8350.92
20_M90_T0.8320.91
41_F233_R0.8320.91
57_I63_F0.8300.91
259_D262_H0.8290.91
239_G243_G0.8270.91
265_A271_S0.8260.91
92_S180_Q0.8250.91
97_E178_I0.8240.91
273_E276_Y0.8220.91
128_A159_L0.8210.91
10_D237_K0.8200.91
190_E194_F0.8200.91
59_K206_E0.8200.91
189_D218_A0.8180.91
185_L188_L0.8140.91
35_I38_V0.8110.90
251_Y254_S0.8090.90
121_F166_V0.7980.90
186_L229_M0.7820.89
190_E193_L0.7800.89
131_A155_S0.7800.89
241_E248_L0.7790.89
49_L197_F0.7760.88
48_T72_G0.7750.88
92_S181_H0.7750.88
227_V235_A0.7740.88
47_A192_K0.7690.88
61_I73_F0.7680.88
30_H36_P0.7650.88
95_V178_I0.7610.87
50_S183_S0.7610.87
26_L37_P0.7500.87
235_A238_E0.7480.86
83_V183_S0.7440.86
166_V217_V0.7440.86
15_S270_A0.7420.86
119_Q243_G0.7400.86
110_Y171_Q0.7370.86
60_E211_N0.7340.85
255_Q259_D0.7330.85
191_D194_F0.7320.85
92_S170_A0.7310.85
87_Q187_D0.7310.85
232_A236_F0.7300.85
206_E211_N0.7240.85
155_S215_K0.7230.85
83_V88_E0.7220.85
87_Q218_A0.7190.84
157_Y207_R0.7190.84
204_V211_N0.7120.84
162_E222_L0.7070.83
186_L227_V0.7050.83
79_G168_G0.7040.83
92_S179_L0.7010.83
110_Y113_I0.7000.83
81_R158_E0.6940.82
60_E185_L0.6930.82
22_L253_L0.6910.82
65_A192_K0.6870.81
59_K210_R0.6870.81
192_K196_L0.6860.81
261_V264_L0.6850.81
253_L258_L0.6810.81
114_S159_L0.6810.81
155_S203_R0.6750.80
18_F265_A0.6710.80
37_P95_V0.6700.80
211_N214_N0.6690.80
185_L218_A0.6640.79
27_L174_Q0.6620.79
19_N182_G0.6570.79
117_I236_F0.6550.78
38_V257_E0.6510.78
8_F248_L0.6440.77
81_R183_S0.6430.77
229_M233_R0.6410.77
45_N90_T0.6400.77
68_K259_D0.6400.77
92_S171_Q0.6400.77
209_Q215_K0.6390.77
59_K204_V0.6390.77
169_S172_T0.6360.76
26_L94_I0.6360.76
16_P275_N0.6340.76
259_D266_E0.6310.76
157_Y199_Y0.6310.76
234_K249_E0.6300.76
169_S181_H0.6290.75
167_A185_L0.6280.75
81_R216_A0.6270.75
109_A173_R0.6260.75
57_I275_N0.6240.75
58_K272_D0.6240.75
20_M269_Y0.6210.75
48_T85_H0.6210.75
158_E216_A0.6170.74
241_E247_H0.6160.74
207_R210_R0.6090.73
159_L167_A0.6090.73
110_Y156_W0.6080.73
218_A222_L0.6040.73
173_R178_I0.6030.72
94_I179_L0.6020.72
36_P96_S0.6010.72
186_L220_N0.5980.72
208_M215_K0.5970.72
67_H272_D0.5940.71
261_V265_A0.5930.71
85_H188_L0.5910.71
91_Y155_S0.5900.71
156_W197_F0.5890.71
255_Q260_F0.5890.71
91_Y180_Q0.5860.70
11_S253_L0.5850.70
171_Q178_I0.5850.70
42_Y88_E0.5840.70
159_L178_I0.5840.70
251_Y261_V0.5820.70
30_H35_I0.5800.69
128_A166_V0.5800.69
260_F266_E0.5800.69
85_H182_G0.5780.69
98_E259_D0.5780.69
28_Y32_E0.5760.69
158_E203_R0.5760.69
42_Y186_L0.5750.69
81_R157_Y0.5740.69
63_F276_Y0.5720.68
158_E167_A0.5690.68
49_L244_L0.5680.68
52_G158_E0.5650.67
123_N231_E0.5640.67
122_R128_A0.5630.67
93_V113_I0.5590.67
11_S22_L0.5560.66
90_T169_S0.5540.66
204_V210_R0.5520.66
62_N68_K0.5510.66
231_E234_K0.5490.65
77_P82_G0.5490.65
84_L192_K0.5470.65
60_E197_F0.5460.65
42_Y90_T0.5450.65
16_P20_M0.5450.65
96_S177_V0.5440.65
219_I232_A0.5430.64
190_E221_E0.5430.64
272_D276_Y0.5420.64
42_Y169_S0.5410.64
253_L257_E0.5400.64
87_Q188_L0.5380.64
129_Y163_G0.5370.64
269_Y275_N0.5360.63
77_P179_L0.5330.63
67_H250_P0.5290.62
27_L172_T0.5280.62
217_V220_N0.5280.62
183_S216_A0.5280.62
50_S78_T0.5280.62
40_R113_I0.5280.62
93_V160_V0.5240.62
75_R81_R0.5220.61
11_S40_R0.5200.61
82_G121_F0.5180.61
24_E172_T0.5180.61
41_F92_S0.5180.61
18_F262_H0.5180.61
255_Q258_L0.5180.61
27_L179_L0.5180.61
10_D43_G0.5150.60
27_L31_S0.5140.60
256_E267_T0.5130.60
260_F264_L0.5120.60
127_D222_L0.5120.60
57_I90_T0.5120.60
81_R84_L0.5110.60
41_F120_G0.5100.60
63_F66_V0.5080.59
51_V73_F0.5070.59
22_L40_R0.5020.58
98_E176_G0.5010.58
17_A275_N0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a7rA 1 0.8633 100 0.252 Contact Map
2c8mA 1 0.8705 100 0.273 Contact Map
2e5aA 1 0.8561 100 0.283 Contact Map
1vqzA 1 0.8705 100 0.314 Contact Map
2p0lA 1 0.8921 100 0.37 Contact Map
2p5iA 1 0.8885 100 0.385 Contact Map
2qhsA 1 0.7446 100 0.466 Contact Map
1w66A 1 0.7374 100 0.498 Contact Map
2dxuA 2 0.6619 97.9 0.885 Contact Map
2eayA 2 0.6259 97.6 0.893 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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