GREMLIN Database
YQHL - Uncharacterized protein YqhL
UniProt: P54510 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 126 (97)
Sequences: 7877 (5764)
Seq/√Len: 585.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
82_P109_Y3.0151.00
51_P55_E2.9561.00
32_T35_E2.4221.00
35_E39_G2.3661.00
31_L35_E2.2851.00
44_Q81_K2.2601.00
54_F58_H2.1851.00
117_K121_K2.1141.00
33_E121_K2.0121.00
51_P64_N2.0101.00
33_E117_K1.9611.00
57_G119_G1.9471.00
85_L100_L1.7531.00
53_E92_R1.7191.00
36_F84_Y1.7111.00
73_R76_E1.6681.00
82_P107_E1.6001.00
39_G42_K1.5711.00
78_R81_K1.5341.00
36_F111_L1.5221.00
113_G117_K1.4441.00
86_Y115_F1.4231.00
36_F45_L1.4191.00
79_T105_C1.3851.00
31_L36_F1.3111.00
33_E37_R1.3041.00
39_G43_A1.3011.00
93_S110_N1.2971.00
97_A108_I1.2941.00
115_F119_G1.2871.00
48_V96_A1.2821.00
71_K74_K1.2561.00
30_T112_K1.2321.00
97_A110_N1.2201.00
45_L86_Y1.2201.00
46_I77_I1.2181.00
39_G82_P1.2061.00
33_E111_L1.1941.00
32_T112_K1.1511.00
59_I86_Y1.1181.00
83_V100_L1.0751.00
30_T110_N1.0721.00
44_Q63_R1.0711.00
87_C93_S1.0661.00
50_E53_E1.0631.00
71_K99_T1.0551.00
31_L109_Y1.0541.00
58_H86_Y1.0471.00
77_I83_V1.0411.00
99_T103_N1.0341.00
43_A84_Y1.0211.00
111_L117_K1.0151.00
89_N116_K1.0001.00
48_V85_L0.9961.00
116_K119_G0.9851.00
37_R41_R0.9811.00
26_R29_K0.9761.00
49_R88_Q0.9621.00
72_Q76_E0.9511.00
39_G84_Y0.9481.00
88_Q116_K0.9431.00
62_A86_Y0.9261.00
101_R106_T0.9121.00
116_K120_G0.9041.00
31_L84_Y0.8931.00
54_F64_N0.8831.00
85_L108_I0.8781.00
53_E88_Q0.8771.00
44_Q78_R0.8631.00
49_R115_F0.8581.00
100_L108_I0.8491.00
36_F43_A0.8471.00
69_Q73_R0.8461.00
70_L74_K0.8301.00
59_I62_A0.8291.00
111_L118_W0.8281.00
111_L114_G0.8211.00
60_L118_W0.8161.00
94_G110_N0.8101.00
34_E38_A0.8061.00
87_C90_S0.8051.00
57_G115_F0.8031.00
101_R108_I0.7991.00
97_A101_R0.7861.00
88_Q91_V0.7821.00
29_K101_R0.7811.00
36_F39_G0.7751.00
43_A82_P0.7701.00
54_F62_A0.7641.00
85_L97_A0.7641.00
45_L59_I0.7581.00
85_L96_A0.7431.00
29_K109_Y0.7421.00
45_L62_A0.7361.00
34_E121_K0.7351.00
35_E38_A0.7331.00
88_Q92_R0.7291.00
72_Q75_N0.7211.00
37_R40_Y0.7161.00
67_L95_R0.7121.00
83_V105_C0.7031.00
46_I85_L0.7011.00
98_Q102_K0.6991.00
119_G122_I0.6831.00
53_E56_G0.6821.00
52_N56_G0.6821.00
52_N55_E0.6771.00
95_R98_Q0.6761.00
59_I118_W0.6611.00
71_K76_E0.6611.00
38_A42_K0.6551.00
67_L92_R0.6521.00
105_C108_I0.6471.00
49_R64_N0.6431.00
58_H64_N0.6401.00
100_L105_C0.6371.00
84_Y111_L0.6321.00
36_F40_Y0.6281.00
46_I63_R0.6201.00
53_E89_N0.6011.00
44_Q77_I0.5931.00
46_I96_A0.5861.00
101_R107_E0.5600.99
94_G98_Q0.5500.99
50_E92_R0.5490.99
70_L73_R0.5490.99
65_I70_L0.5450.99
44_Q83_V0.5420.99
70_L75_N0.5400.99
78_R82_P0.5360.99
49_R89_N0.5350.99
29_K97_A0.5350.99
37_R121_K0.5300.99
104_G107_E0.5290.99
50_E66_P0.5280.99
89_N92_R0.5270.99
50_E68_S0.5260.99
45_L84_Y0.5260.99
68_S74_K0.5250.99
117_K120_G0.5180.99
28_M97_A0.5120.99
85_L114_G0.5100.99
40_Y43_A0.5040.99
84_Y109_Y0.5030.99
33_E40_Y0.5030.99
93_S114_G0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fojA 1 0.7698 99.9 0.315 Contact Map
3ilmA 2 0.7619 99.9 0.317 Contact Map
3gk5A 1 0.7778 99.9 0.319 Contact Map
3d1pA 1 0.8016 99.9 0.324 Contact Map
3tp9A 2 0.9921 99.9 0.324 Contact Map
1urhA 1 0.7937 99.9 0.327 Contact Map
3iwhA 1 0.7778 99.9 0.328 Contact Map
1uarA 1 0.8254 99.9 0.329 Contact Map
1qxnA 2 0.9365 99.9 0.33 Contact Map
1yt8A 1 1 99.9 0.33 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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