GREMLIN Database
YQHH - Uncharacterized ATP-dependent helicase YqhH
UniProt: P54509 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 557 (454)
Sequences: 13327 (8720)
Seq/√Len: 409.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_G125_L4.0891.00
280_Q479_K3.8801.00
177_A201_L3.6901.00
388_L446_Y3.3481.00
185_T188_Y3.2781.00
419_R439_F3.2431.00
363_Q366_D3.2241.00
410_K413_W3.2121.00
373_D441_N3.1141.00
389_Q393_Q2.9761.00
67_V92_E2.8941.00
97_L109_I2.8521.00
369_K395_N2.8081.00
443_M462_I2.7971.00
120_Q436_N2.7891.00
273_H470_D2.7221.00
389_Q401_P2.6881.00
413_W417_L2.6761.00
125_L147_I2.6681.00
271_Q470_D2.6431.00
93_A173_I2.6261.00
412_D416_D2.6051.00
400_V417_L2.5841.00
93_A202_L2.5571.00
72_V99_E2.4751.00
386_I401_P2.4311.00
122_V126_Q2.4171.00
407_K410_K2.3881.00
389_Q399_S2.3101.00
445_N459_I2.2991.00
376_I462_I2.2931.00
379_T385_Q2.2701.00
123_K416_D2.2661.00
71_V96_I2.2141.00
68_A95_L2.1781.00
177_A217_L2.1701.00
261_R264_D2.1531.00
122_V149_V2.1191.00
101_M146_D2.1141.00
94_G129_F2.1111.00
192_R219_S2.0811.00
174_I180_L2.0551.00
188_Y192_R2.0431.00
281_F478_T2.0411.00
286_Q290_D2.0171.00
397_I424_V1.9451.00
391_F395_N1.9401.00
275_E472_H1.9301.00
60_P95_L1.9091.00
368_I375_V1.8961.00
153_D156_K1.8741.00
375_V444_I1.8731.00
93_A200_L1.8621.00
400_V414_M1.8581.00
459_I473_I1.8561.00
98_K129_F1.8431.00
152_I174_I1.8231.00
278_P479_K1.8161.00
155_A191_V1.8111.00
74_K79_A1.8091.00
456_E494_I1.8021.00
174_I191_V1.7761.00
118_V149_V1.7651.00
170_D197_K1.7481.00
393_Q399_S1.7301.00
360_K371_I1.7291.00
441_N469_R1.7171.00
311_L314_E1.7141.00
384_T446_Y1.6891.00
406_F414_M1.6801.00
56_P91_V1.6651.00
172_V194_L1.6631.00
109_I171_L1.6551.00
97_L173_I1.6461.00
365_V395_N1.6351.00
112_L150_S1.6311.00
168_P197_K1.6211.00
172_V196_K1.6211.00
58_F128_K1.6101.00
131_I134_V1.6051.00
272_R460_G1.5911.00
292_I315_C1.5881.00
112_L155_A1.5831.00
478_T481_T1.5811.00
168_P195_V1.5731.00
371_I442_H1.5671.00
442_H474_Y1.5661.00
148_V169_Y1.5621.00
307_S310_T1.5511.00
365_V369_K1.5391.00
417_L420_G1.5201.00
444_I476_M1.5201.00
253_V257_M1.5181.00
374_K439_F1.5151.00
290_D294_R1.5141.00
71_V79_A1.5031.00
367_L371_I1.5021.00
177_A203_T1.4961.00
79_A200_L1.4721.00
317_S384_T1.4661.00
488_K492_E1.4491.00
49_L52_P1.4361.00
367_L444_I1.4321.00
153_D179_K1.4271.00
123_K412_D1.4181.00
373_D442_H1.4181.00
210_R213_E1.4081.00
398_S423_Q1.3921.00
187_N190_F1.3921.00
117_L434_G1.3881.00
94_G147_I1.3811.00
85_V204_A1.3791.00
196_K199_C1.3671.00
352_I355_V1.3461.00
494_I498_E1.3461.00
62_P65_L1.3431.00
180_L220_L1.3341.00
364_V444_I1.3321.00
186_K189_E1.3291.00
108_K170_D1.3271.00
233_Q238_K1.3251.00
245_A248_H1.3241.00
277_V474_Y1.3241.00
360_K367_L1.3181.00
373_D469_R1.3171.00
410_K414_M1.3031.00
400_V422_I1.2951.00
171_L200_L1.2901.00
489_L492_E1.2881.00
58_F91_V1.2871.00
273_H472_H1.2831.00
132_P146_D1.2811.00
186_K190_F1.2721.00
181_K213_E1.2671.00
495_H499_K1.2631.00
99_E102_I1.2621.00
56_P98_K1.2601.00
285_E359_S1.2521.00
98_K102_I1.2511.00
71_V200_L1.2501.00
123_K127_E1.2411.00
512_Q515_N1.2391.00
364_V377_I1.2361.00
487_L491_Y1.2331.00
391_F394_Q1.2331.00
413_W416_D1.2301.00
362_L395_N1.2281.00
97_L171_L1.2251.00
135_E139_S1.2181.00
317_S321_A1.2121.00
230_N233_Q1.2111.00
232_F235_E1.2091.00
199_C220_L1.2081.00
111_I147_I1.2071.00
279_I359_S1.2051.00
156_K187_N1.2041.00
61_L465_L1.2021.00
382_R405_G1.2001.00
287_A291_E1.1981.00
189_E193_N1.1981.00
232_F236_F1.1861.00
109_I170_D1.1791.00
50_R53_L1.1721.00
385_Q401_P1.1661.00
96_I171_L1.1641.00
392_L397_I1.1611.00
230_N234_E1.1611.00
171_L198_Y1.1581.00
431_G435_I1.1581.00
283_P287_A1.1551.00
179_K433_E1.1501.00
372_D423_Q1.1491.00
69_Q73_E1.1431.00
117_L435_I1.1411.00
115_A151_S1.1331.00
406_F411_K1.1321.00
99_E103_R1.1291.00
65_L69_Q1.1281.00
477_A487_L1.1271.00
178_H433_E1.1271.00
173_I202_L1.1261.00
290_D293_S1.1251.00
374_K420_G1.1161.00
165_L193_N1.1121.00
51_A54_Y1.1041.00
491_Y494_I1.0991.00
80_I221_L1.0981.00
462_I471_V1.0981.00
513_V517_E1.0951.00
442_H472_H1.0891.00
235_E248_H1.0891.00
281_F289_Y1.0851.00
360_K368_I1.0811.00
288_L315_C1.0811.00
417_L421_K1.0791.00
367_L474_Y1.0761.00
201_L217_L1.0751.00
390_W394_Q1.0741.00
280_Q286_Q1.0741.00
365_V391_F1.0731.00
515_N518_E1.0691.00
362_L391_F1.0591.00
282_S285_E1.0581.00
124_E127_E1.0571.00
154_T157_R1.0551.00
208_Q451_N1.0521.00
279_I478_T1.0511.00
229_Q233_Q1.0501.00
117_L120_Q1.0471.00
209_N493_K1.0471.00
68_A72_V1.0361.00
415_K419_R1.0361.00
307_S311_L1.0351.00
397_I423_Q1.0351.00
63_H265_T1.0301.00
120_Q124_E1.0281.00
364_V446_Y1.0261.00
119_S122_V1.0251.00
68_A99_E1.0241.00
212_E233_Q1.0241.00
101_M109_I1.0241.00
367_L370_K1.0201.00
71_V93_A1.0181.00
218_V221_L1.0161.00
80_I217_L1.0151.00
286_Q480_H1.0111.00
231_H235_E1.0101.00
364_V388_L1.0081.00
352_I358_N1.0071.00
491_Y495_H1.0061.00
445_N458_R1.0051.00
276_T477_A1.0041.00
84_E463_H1.0011.00
360_K363_Q0.9981.00
427_A430_A0.9911.00
48_G51_A0.9891.00
56_P95_L0.9881.00
428_T458_R0.9861.00
377_I424_V0.9851.00
415_K435_I0.9841.00
277_V363_Q0.9831.00
455_L475_N0.9831.00
78_K221_L0.9821.00
360_K364_V0.9801.00
490_L493_K0.9781.00
62_P66_E0.9741.00
153_D157_R0.9711.00
267_L270_K0.9681.00
125_L149_V0.9641.00
125_L133_A0.9641.00
364_V368_I0.9621.00
487_L490_L0.9611.00
215_F219_S0.9601.00
313_R381_Y0.9531.00
188_Y191_V0.9531.00
250_K254_N0.9511.00
180_L191_V0.9491.00
310_T313_R0.9471.00
361_A388_L0.9461.00
47_E50_R0.9411.00
361_A446_Y0.9401.00
179_K187_N0.9381.00
366_D370_K0.9371.00
115_A153_D0.9331.00
228_S231_H0.9311.00
485_H488_K0.9301.00
243_L247_E0.9291.00
449_P455_L0.9251.00
150_S154_T0.9231.00
262_R460_G0.9211.00
107_K170_D0.9181.00
110_L169_Y0.9161.00
310_T381_Y0.9141.00
113_V118_V0.9131.00
363_Q371_I0.9131.00
212_E229_Q0.9131.00
184_K189_E0.9121.00
389_Q426_I0.9111.00
233_Q236_F0.9091.00
363_Q367_L0.9051.00
376_I443_M0.9051.00
318_S387_Y0.8981.00
187_N191_V0.8971.00
409_G413_W0.8961.00
427_A431_G0.8931.00
185_T190_F0.8931.00
310_T314_E0.8921.00
445_N475_N0.8911.00
68_A96_I0.8901.00
375_V442_H0.8901.00
233_Q237_A0.8881.00
231_H234_E0.8861.00
119_S412_D0.8841.00
90_T111_I0.8831.00
97_L125_L0.8821.00
207_I497_F0.8811.00
222_K225_H0.8791.00
204_A460_G0.8791.00
161_R193_N0.8751.00
174_I220_L0.8741.00
67_V81_L0.8741.00
110_L172_V0.8721.00
98_K101_M0.8711.00
83_D260_N0.8701.00
281_F481_T0.8641.00
134_V145_C0.8621.00
318_S321_A0.8621.00
345_I348_L0.8621.00
479_K484_E0.8601.00
71_V81_L0.8591.00
161_R190_F0.8591.00
402_F431_G0.8551.00
485_H489_L0.8541.00
119_S123_K0.8541.00
449_P454_R0.8511.00
296_K301_K0.8511.00
385_Q403_R0.8481.00
236_F240_K0.8441.00
386_I403_R0.8441.00
121_W124_E0.8431.00
398_S417_L0.8431.00
113_V151_S0.8411.00
105_L170_D0.8391.00
191_V194_L0.8391.00
258_I262_R0.8371.00
279_I285_E0.8361.00
66_E69_Q0.8351.00
51_A65_L0.8351.00
242_S245_A0.8351.00
156_K186_K0.8351.00
209_N213_E0.8331.00
419_R438_Q0.8331.00
219_S224_G0.8321.00
351_R354_Q0.8301.00
211_I496_L0.8291.00
367_L476_M0.8271.00
514_N518_E0.8261.00
309_M482_V0.8261.00
346_S349_I0.8251.00
363_Q370_K0.8241.00
190_F193_N0.8211.00
517_E520_L0.8181.00
214_I253_V0.8171.00
115_A408_R0.8141.00
161_R165_L0.8141.00
359_S362_L0.8131.00
457_Q461_R0.8131.00
100_Y170_D0.8101.00
188_Y216_N0.8091.00
368_I371_I0.8081.00
116_S430_A0.8061.00
345_I349_I0.8041.00
236_F239_K0.8041.00
311_L318_S0.8031.00
183_S229_Q0.8031.00
237_A241_S0.8021.00
91_V128_K0.7991.00
441_N472_H0.7991.00
374_K441_N0.7981.00
328_K331_D0.7961.00
124_E436_N0.7961.00
47_E53_L0.7951.00
189_E192_R0.7941.00
133_A149_V0.7931.00
448_L490_L0.7931.00
150_S155_A0.7931.00
429_E454_R0.7921.00
251_D254_N0.7891.00
379_T447_D0.7881.00
402_F430_A0.7861.00
173_I200_L0.7831.00
364_V367_L0.7801.00
371_I444_I0.7781.00
329_M332_Q0.7721.00
83_D87_L0.7711.00
382_R386_I0.7691.00
388_L392_L0.7691.00
145_C148_V0.7681.00
281_F285_E0.7641.00
100_Y171_L0.7601.00
484_E488_K0.7601.00
184_K187_N0.7591.00
481_T484_E0.7591.00
110_L150_S0.7581.00
236_F252_L0.7571.00
276_T487_L0.7571.00
309_M312_Q0.7541.00
501_V504_L0.7541.00
142_W145_C0.7511.00
67_V83_D0.7501.00
386_I390_W0.7471.00
82_A206_P0.7451.00
306_F310_T0.7431.00
361_A391_F0.7431.00
130_L133_A0.7411.00
289_Y481_T0.7401.00
461_R464_R0.7391.00
306_F311_L0.7391.00
360_K365_V0.7371.00
402_F405_G0.7361.00
111_I121_W0.7351.00
489_L493_K0.7351.00
516_F520_L0.7341.00
118_V122_V0.7341.00
190_F194_L0.7331.00
269_W272_R0.7311.00
93_A97_L0.7301.00
488_K491_Y0.7281.00
212_E237_A0.7251.00
493_K497_F0.7241.00
392_L423_Q0.7241.00
373_D472_H0.7231.00
497_F500_V0.7231.00
236_F248_H0.7231.00
153_D187_N0.7221.00
460_G463_H0.7171.00
70_K74_K0.7151.00
97_L111_I0.7151.00
178_H208_Q0.7151.00
369_K397_I0.7141.00
130_L134_V0.7131.00
516_F519_H0.7121.00
361_A365_V0.7111.00
122_V133_A0.7101.00
324_M327_K0.7081.00
347_V350_D0.7081.00
456_E459_I0.7071.00
125_L129_F0.7071.00
406_F410_K0.7041.00
362_L366_D0.7041.00
284_S287_A0.7031.00
257_M260_N0.7021.00
346_S350_D0.7011.00
305_M309_M0.6991.00
259_R262_R0.6981.00
154_T158_S0.6981.00
492_E495_H0.6971.00
414_M417_L0.6971.00
348_L351_R0.6961.00
349_I355_V0.6961.00
279_I363_Q0.6941.00
314_E321_A0.6931.00
185_T189_E0.6921.00
291_E295_L0.6911.00
326_L329_M0.6891.00
315_C322_V0.6891.00
375_V424_V0.6891.00
303_A307_S0.6881.00
385_Q426_I0.6871.00
52_P68_A0.6871.00
274_V277_V0.6851.00
276_T475_N0.6851.00
275_E278_P0.6831.00
507_I511_I0.6831.00
215_F232_F0.6811.00
142_W148_V0.6801.00
347_V351_R0.6791.00
312_Q316_C0.6791.00
304_S308_I0.6760.99
508_L511_I0.6760.99
443_M473_I0.6760.99
234_E238_K0.6740.99
285_E288_L0.6680.99
448_L487_L0.6670.99
274_V459_I0.6660.99
351_R355_V0.6650.99
150_S158_S0.6650.99
352_I356_T0.6650.99
462_I473_I0.6640.99
306_F313_R0.6630.99
282_S359_S0.6630.99
232_F239_K0.6620.99
350_D353_N0.6600.99
345_I358_N0.6600.99
247_E250_K0.6600.99
371_I375_V0.6600.99
208_Q213_E0.6590.99
349_I353_N0.6590.99
245_A249_L0.6580.99
390_W393_Q0.6560.99
377_I423_Q0.6560.99
386_I389_Q0.6560.99
377_I444_I0.6560.99
111_I125_L0.6540.99
248_H251_D0.6530.99
59_T65_L0.6530.99
313_R317_S0.6510.99
65_L68_A0.6480.99
403_R406_F0.6470.99
382_R427_A0.6450.99
235_E239_K0.6440.99
60_P68_A0.6440.99
96_I100_Y0.6430.99
393_Q398_S0.6430.99
229_Q232_F0.6420.99
226_L229_Q0.6420.99
228_S236_F0.6410.99
278_P484_E0.6410.99
411_K430_A0.6400.99
345_I352_I0.6380.99
208_Q452_P0.6380.99
226_L235_E0.6370.99
235_E240_K0.6370.99
515_N520_L0.6360.99
497_F501_V0.6350.99
72_V96_I0.6340.99
385_Q389_Q0.6340.99
203_T217_L0.6340.99
366_D369_K0.6340.99
429_E449_P0.6320.99
322_V325_T0.6320.99
308_I315_C0.6310.99
81_L200_L0.6310.99
116_S402_F0.6300.99
358_N371_I0.6290.99
257_M501_V0.6290.99
246_H250_K0.6270.99
51_A68_A0.6250.99
275_E474_Y0.6250.99
87_L92_E0.6240.99
511_I515_N0.6230.99
70_K258_I0.6220.99
362_L365_V0.6220.99
307_S314_E0.6210.99
83_D258_I0.6200.99
233_Q239_K0.6200.99
178_H203_T0.6200.99
49_L68_A0.6190.99
292_I295_L0.6180.99
132_P145_C0.6180.99
348_L355_V0.6170.99
415_K439_F0.6170.99
302_P305_M0.6160.99
317_S326_L0.6160.99
357_Q363_Q0.6150.99
316_C483_E0.6150.99
498_E502_G0.6140.99
288_L292_I0.6140.99
495_H498_E0.6130.99
311_L321_A0.6120.99
247_E251_D0.6110.99
311_L315_C0.6100.99
218_V256_V0.6090.99
47_E52_P0.6090.99
365_V368_I0.6070.99
70_K79_A0.6070.99
155_A164_V0.6040.99
54_Y57_S0.6030.99
244_E248_H0.6020.99
73_E77_G0.6010.99
108_K169_Y0.6000.99
292_I322_V0.5980.99
490_L497_F0.5970.99
323_Y327_K0.5970.99
50_R54_Y0.5970.99
85_V460_G0.5960.99
482_V486_I0.5950.99
135_E141_V0.5950.99
456_E460_G0.5950.99
404_G411_K0.5940.99
327_K330_L0.5930.99
316_C321_A0.5920.99
114_P121_W0.5920.99
274_V475_N0.5910.99
512_Q520_L0.5900.99
376_I440_C0.5870.99
505_D508_L0.5870.99
325_T328_K0.5860.99
312_Q315_C0.5860.99
91_V95_L0.5840.99
141_V144_Q0.5830.99
86_G89_K0.5810.98
309_M313_R0.5790.98
236_F249_L0.5760.98
486_I489_L0.5750.98
368_I377_I0.5740.98
78_K199_C0.5730.98
380_E449_P0.5720.98
46_F49_L0.5720.98
67_V71_V0.5700.98
308_I311_L0.5690.98
113_V149_V0.5690.98
381_Y384_T0.5690.98
497_F502_G0.5680.98
384_T387_Y0.5670.98
345_I350_D0.5630.98
97_L131_I0.5600.98
360_K369_K0.5590.98
114_P117_L0.5590.98
72_V100_Y0.5570.98
285_E289_Y0.5560.98
229_Q235_E0.5550.98
419_R436_N0.5550.98
359_S363_Q0.5550.98
317_S325_T0.5540.98
514_N517_E0.5520.98
310_T316_C0.5520.98
365_V371_I0.5510.98
490_L494_I0.5500.98
515_N519_H0.5490.98
97_L147_I0.5480.98
313_R316_C0.5470.98
60_P91_V0.5470.98
490_L496_L0.5470.98
109_I173_I0.5460.98
285_E315_C0.5460.98
379_T388_L0.5410.98
311_L317_S0.5410.98
354_Q357_Q0.5410.98
459_I475_N0.5370.97
314_E317_S0.5370.97
382_R385_Q0.5370.97
383_A386_I0.5360.97
368_I392_L0.5360.97
242_S250_K0.5360.97
374_K418_F0.5360.97
212_E215_F0.5360.97
116_S435_I0.5350.97
349_I352_I0.5330.97
428_T449_P0.5310.97
183_S188_Y0.5310.97
260_N264_D0.5310.97
96_I99_E0.5310.97
345_I351_R0.5300.97
201_L221_L0.5300.97
190_F195_V0.5300.97
388_L426_I0.5300.97
242_S249_L0.5290.97
172_V220_L0.5280.97
253_V256_V0.5280.97
304_S309_M0.5280.97
53_L102_I0.5250.97
408_R412_D0.5250.97
185_T191_V0.5250.97
48_G54_Y0.5240.97
81_L258_I0.5240.97
226_L232_F0.5240.97
360_K370_K0.5230.97
244_E249_L0.5230.97
368_I397_I0.5230.97
289_Y293_S0.5220.97
457_Q464_R0.5210.97
91_V94_G0.5210.97
306_F314_E0.5210.97
398_S422_I0.5200.97
272_R463_H0.5190.97
380_E429_E0.5170.97
228_S235_E0.5160.97
307_S315_C0.5160.97
378_F458_R0.5160.97
238_K241_S0.5150.97
49_L53_L0.5150.97
313_R321_A0.5150.97
48_G53_L0.5140.97
378_F443_M0.5130.97
262_R463_H0.5130.97
258_I265_T0.5130.97
314_E319_R0.5130.97
259_R265_T0.5130.97
376_I435_I0.5120.97
248_H252_L0.5120.97
211_I237_A0.5120.97
191_V195_V0.5120.97
156_K185_T0.5110.97
287_A294_R0.5100.97
357_Q360_K0.5090.97
348_L353_N0.5090.97
85_V458_R0.5080.96
271_Q274_V0.5080.96
183_S212_E0.5080.96
355_V358_N0.5080.96
417_L422_I0.5070.96
63_H92_E0.5060.96
113_V117_L0.5040.96
100_Y198_Y0.5040.96
120_Q128_K0.5030.96
84_E262_R0.5030.96
432_G454_R0.5020.96
81_L92_E0.5010.96
418_F440_C0.5000.96
429_E458_R0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mwyW 2 0.9282 100 0.308 Contact Map
1z3iX 4 0.9785 100 0.323 Contact Map
1z63A 1 0.7971 100 0.328 Contact Map
3dmqA 1 0.939 100 0.425 Contact Map
4a2qA 1 0.7756 100 0.467 Contact Map
2ykgA 1 0.8259 100 0.474 Contact Map
4a2wA 1 0.7666 100 0.478 Contact Map
1wp9A 1 0.7648 100 0.487 Contact Map
4a2pA 1 0.7271 100 0.501 Contact Map
2fwrA 1 0.7522 100 0.511 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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