GREMLIN Database
LEPW - Signal peptidase I W
UniProt: P54506 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (155)
Sequences: 1065 (849)
Seq/√Len: 68.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_L89_I8.2231.00
76_T86_T4.3501.00
88_R106_D3.9621.00
53_N56_S3.5501.00
104_K111_A3.2261.00
45_S54_T3.1761.00
142_Q145_G3.0041.00
56_S129_Q2.9911.00
90_V111_A2.7341.00
46_G107_N2.6581.00
46_G49_E2.6001.00
52_F74_V2.5611.00
49_E53_N2.5151.00
77_F103_T2.3291.00
47_S87_H2.0401.00
91_D102_K1.9451.00
66_V101_F1.8331.00
73_D124_Q1.7091.00
90_V104_K1.7011.00
49_E54_T1.6670.99
102_K115_P1.6650.99
101_F121_V1.6250.99
51_E74_V1.6040.99
77_F120_N1.5960.99
101_F116_V1.5920.99
56_S59_L1.5880.99
75_I116_V1.5760.99
60_V123_A1.5050.99
43_V58_I1.5000.99
63_I69_L1.4830.99
41_K60_V1.4690.99
148_V152_V1.4310.98
77_F101_F1.4010.98
105_G108_N1.3950.98
42_S134_G1.3850.98
87_H112_D1.3830.98
66_V121_V1.3750.98
75_I101_F1.3690.98
63_I66_V1.3630.98
59_L128_F1.3470.97
41_K76_T1.3220.97
150_L153_P1.2980.97
71_K92_I1.2750.96
47_S112_D1.2690.96
153_P165_I1.2630.96
137_L141_S1.2370.96
104_K107_N1.2300.96
46_G108_N1.2170.95
46_G54_T1.1690.94
65_D68_E1.1690.94
108_N112_D1.1470.94
147_A151_I1.1420.94
74_V125_Y1.1410.94
27_R30_G1.1310.93
74_V106_D1.1290.93
41_K84_A1.1130.93
39_T76_T1.1130.93
88_R108_N1.1050.92
58_I86_T1.0980.92
18_V22_V1.0820.92
45_S87_H1.0700.91
63_I124_Q1.0680.91
58_I125_Y1.0590.91
145_G153_P1.0510.90
88_R105_G1.0450.90
130_L133_A1.0340.90
84_A122_R1.0170.89
67_K97_D0.9970.88
29_S151_I0.9940.88
71_K91_D0.9810.87
153_P157_L0.9750.87
97_D114_A0.9550.86
93_T102_K0.9390.85
42_S137_L0.9380.85
106_D134_G0.9370.85
70_Q73_D0.9360.84
66_V69_L0.9310.84
56_S132_Y0.9300.84
145_G148_V0.9170.83
14_T17_I0.9120.83
57_L134_G0.9070.83
125_Y129_Q0.9050.82
92_I101_F0.9030.82
101_F118_D0.9020.82
132_Y135_Y0.8990.82
49_E107_N0.8950.82
69_L121_V0.8940.82
38_Y61_K0.8930.82
78_M120_N0.8850.81
157_L161_A0.8800.81
63_I118_D0.8740.80
124_Q127_G0.8710.80
44_L52_F0.8570.79
37_G86_T0.8500.78
50_P131_P0.8460.78
78_M82_N0.8440.78
145_G149_L0.8410.78
154_G157_L0.8350.77
161_A164_T0.8310.77
117_S121_V0.8290.76
47_S105_G0.8270.76
21_L68_E0.8240.76
131_P134_G0.8180.76
75_I103_T0.8130.75
155_V160_Y0.8090.75
13_F16_I0.8060.74
38_Y58_I0.8000.74
56_S84_A0.7990.74
54_T59_L0.7920.73
147_A152_V0.7910.73
27_R137_L0.7820.72
128_F150_L0.7770.72
154_G161_A0.7720.71
110_A113_S0.7720.71
106_D131_P0.7630.70
43_V103_T0.7490.69
41_K58_I0.7480.69
44_L54_T0.7430.68
164_T168_A0.7410.68
92_I102_K0.7330.67
50_P112_D0.7300.67
74_V134_G0.7230.66
90_V110_A0.7180.66
75_I121_V0.7150.65
52_F147_A0.7150.65
45_S134_G0.7110.65
39_T56_S0.7100.65
157_L165_I0.7090.65
30_G59_L0.7080.65
128_F155_V0.7070.64
119_E130_L0.7060.64
69_L158_L0.7050.64
52_F137_L0.7010.64
43_V123_A0.6970.63
81_A91_D0.6960.63
117_S120_N0.6920.63
20_T33_P0.6900.63
27_R56_S0.6880.62
33_P39_T0.6870.62
66_V118_D0.6870.62
34_A38_Y0.6870.62
21_L24_I0.6840.62
150_L161_A0.6760.61
147_A150_L0.6730.61
87_H105_G0.6730.61
133_A140_A0.6700.60
23_V103_T0.6680.60
57_L109_A0.6640.60
26_T30_G0.6620.59
76_T138_H0.6580.59
102_K111_A0.6540.58
55_G108_N0.6540.58
50_P77_F0.6480.58
33_P37_G0.6460.58
40_L85_V0.6450.57
34_A39_T0.6410.57
39_T45_S0.6390.57
92_I118_D0.6360.56
39_T85_V0.6320.56
95_Q124_Q0.6320.56
74_V104_K0.6290.56
41_K44_L0.6270.55
53_N129_Q0.6240.55
78_M110_A0.6240.55
87_H108_N0.6180.54
93_T97_D0.6170.54
43_V77_F0.6170.54
68_E118_D0.6160.54
92_I99_L0.6150.54
60_V76_T0.6140.54
94_K99_L0.6110.53
142_Q153_P0.6090.53
80_D133_A0.6060.53
27_R34_A0.6030.52
61_K127_G0.6020.52
54_T158_L0.6000.52
47_S108_N0.6000.52
52_F58_I0.5940.51
150_L165_I0.5910.51
17_I149_L0.5880.51
33_P44_L0.5830.50
58_I123_A0.5820.50
51_E95_Q0.5780.49
59_L83_T0.5680.48
35_V68_E0.5670.48
59_L99_L0.5650.48
20_T70_Q0.5650.48
60_V128_F0.5630.48
13_F20_T0.5630.48
25_S28_S0.5610.47
75_I145_G0.5610.47
115_P136_M0.5510.46
39_T86_T0.5510.46
159_V165_I0.5470.46
43_V153_P0.5450.46
103_T121_V0.5450.46
45_S112_D0.5410.45
25_S60_V0.5400.45
32_E160_Y0.5370.45
17_I113_S0.5350.44
146_T152_V0.5320.44
99_L159_V0.5300.44
81_A154_G0.5300.44
23_V32_E0.5300.44
58_I92_I0.5290.44
79_Q122_R0.5270.43
162_F165_I0.5270.43
135_Y158_L0.5260.43
95_Q130_L0.5260.43
102_K114_A0.5250.43
44_L76_T0.5250.43
109_A146_T0.5250.43
71_K89_I0.5240.43
16_I73_D0.5230.43
26_T158_L0.5220.43
15_L28_S0.5210.43
145_G157_L0.5190.42
152_V155_V0.5140.42
57_L137_L0.5140.42
58_I129_Q0.5130.42
50_P104_K0.5120.42
148_V155_V0.5120.42
154_G159_V0.5100.41
17_I21_L0.5070.41
83_T133_A0.5060.41
129_Q142_Q0.5050.41
18_V168_A0.5050.41
136_M139_F0.5040.41
161_A165_I0.5040.41
43_V84_A0.5030.41
20_T27_R0.5020.40
16_I56_S0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k8wA 2 0.4053 99.4 0.706 Contact Map
4n31A 5 0.5316 99.4 0.709 Contact Map
4nv4A 2 0.3368 99.3 0.721 Contact Map
4me8A 1 0.3263 99.2 0.729 Contact Map
1b12A 1 0.6158 99 0.756 Contact Map
1kcaA 6 0.5 98.3 0.804 Contact Map
1umuA 2 0.5158 98.3 0.804 Contact Map
2hnfA 1 0.6368 98 0.817 Contact Map
1jhfA 2 0.6421 97.9 0.823 Contact Map
3bdnA 2 0.6632 97.6 0.836 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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