LEPW - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

LEPW - Signal peptidase I W

UniProt:	P54506	Sequences: MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVLSGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFKTKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVYAFVTISSAIREIERKTKALETDTKDSTMST	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	190 (155)
Sequences:	1065 (849)
Seq/√Len:	68.2

BACSU - LEPW

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
69_L	89_I	8.223	1.00
76_T	86_T	4.350	1.00
88_R	106_D	3.962	1.00
53_N	56_S	3.550	1.00
104_K	111_A	3.226	1.00
45_S	54_T	3.176	1.00
142_Q	145_G	3.004	1.00
56_S	129_Q	2.991	1.00
90_V	111_A	2.734	1.00
46_G	107_N	2.658	1.00
46_G	49_E	2.600	1.00
52_F	74_V	2.561	1.00
49_E	53_N	2.515	1.00
77_F	103_T	2.329	1.00
47_S	87_H	2.040	1.00
91_D	102_K	1.945	1.00
66_V	101_F	1.833	1.00
73_D	124_Q	1.709	1.00
90_V	104_K	1.701	1.00
49_E	54_T	1.667	0.99
102_K	115_P	1.665	0.99
101_F	121_V	1.625	0.99
51_E	74_V	1.604	0.99
77_F	120_N	1.596	0.99
101_F	116_V	1.592	0.99
56_S	59_L	1.588	0.99
75_I	116_V	1.576	0.99
60_V	123_A	1.505	0.99
43_V	58_I	1.500	0.99
63_I	69_L	1.483	0.99
41_K	60_V	1.469	0.99
148_V	152_V	1.431	0.98
77_F	101_F	1.401	0.98
105_G	108_N	1.395	0.98
42_S	134_G	1.385	0.98
87_H	112_D	1.383	0.98
66_V	121_V	1.375	0.98
75_I	101_F	1.369	0.98
63_I	66_V	1.363	0.98
59_L	128_F	1.347	0.97
41_K	76_T	1.322	0.97
150_L	153_P	1.298	0.97
71_K	92_I	1.275	0.96
47_S	112_D	1.269	0.96
153_P	165_I	1.263	0.96
137_L	141_S	1.237	0.96
104_K	107_N	1.230	0.96
46_G	108_N	1.217	0.95
46_G	54_T	1.169	0.94
65_D	68_E	1.169	0.94
108_N	112_D	1.147	0.94
147_A	151_I	1.142	0.94
74_V	125_Y	1.141	0.94
27_R	30_G	1.131	0.93
74_V	106_D	1.129	0.93
41_K	84_A	1.113	0.93
39_T	76_T	1.113	0.93
88_R	108_N	1.105	0.92
58_I	86_T	1.098	0.92
18_V	22_V	1.082	0.92
45_S	87_H	1.070	0.91
63_I	124_Q	1.068	0.91
58_I	125_Y	1.059	0.91
145_G	153_P	1.051	0.90
88_R	105_G	1.045	0.90
130_L	133_A	1.034	0.90
84_A	122_R	1.017	0.89
67_K	97_D	0.997	0.88
29_S	151_I	0.994	0.88
71_K	91_D	0.981	0.87
153_P	157_L	0.975	0.87
97_D	114_A	0.955	0.86
93_T	102_K	0.939	0.85
42_S	137_L	0.938	0.85
106_D	134_G	0.937	0.85
70_Q	73_D	0.936	0.84
66_V	69_L	0.931	0.84
56_S	132_Y	0.930	0.84
145_G	148_V	0.917	0.83
14_T	17_I	0.912	0.83
57_L	134_G	0.907	0.83
125_Y	129_Q	0.905	0.82
92_I	101_F	0.903	0.82
101_F	118_D	0.902	0.82
132_Y	135_Y	0.899	0.82
49_E	107_N	0.895	0.82
69_L	121_V	0.894	0.82
38_Y	61_K	0.893	0.82
78_M	120_N	0.885	0.81
157_L	161_A	0.880	0.81
63_I	118_D	0.874	0.80
124_Q	127_G	0.871	0.80
44_L	52_F	0.857	0.79
37_G	86_T	0.850	0.78
50_P	131_P	0.846	0.78
78_M	82_N	0.844	0.78
145_G	149_L	0.841	0.78
154_G	157_L	0.835	0.77
161_A	164_T	0.831	0.77
117_S	121_V	0.829	0.76
47_S	105_G	0.827	0.76
21_L	68_E	0.824	0.76
131_P	134_G	0.818	0.76
75_I	103_T	0.813	0.75
155_V	160_Y	0.809	0.75
13_F	16_I	0.806	0.74
38_Y	58_I	0.800	0.74
56_S	84_A	0.799	0.74
54_T	59_L	0.792	0.73
147_A	152_V	0.791	0.73
27_R	137_L	0.782	0.72
128_F	150_L	0.777	0.72
154_G	161_A	0.772	0.71
110_A	113_S	0.772	0.71
106_D	131_P	0.763	0.70
43_V	103_T	0.749	0.69
41_K	58_I	0.748	0.69
44_L	54_T	0.743	0.68
164_T	168_A	0.741	0.68
92_I	102_K	0.733	0.67
50_P	112_D	0.730	0.67
74_V	134_G	0.723	0.66
90_V	110_A	0.718	0.66
75_I	121_V	0.715	0.65
52_F	147_A	0.715	0.65
45_S	134_G	0.711	0.65
39_T	56_S	0.710	0.65
157_L	165_I	0.709	0.65
30_G	59_L	0.708	0.65
128_F	155_V	0.707	0.64
119_E	130_L	0.706	0.64
69_L	158_L	0.705	0.64
52_F	137_L	0.701	0.64
43_V	123_A	0.697	0.63
81_A	91_D	0.696	0.63
117_S	120_N	0.692	0.63
20_T	33_P	0.690	0.63
27_R	56_S	0.688	0.62
33_P	39_T	0.687	0.62
66_V	118_D	0.687	0.62
34_A	38_Y	0.687	0.62
21_L	24_I	0.684	0.62
150_L	161_A	0.676	0.61
147_A	150_L	0.673	0.61
87_H	105_G	0.673	0.61
133_A	140_A	0.670	0.60
23_V	103_T	0.668	0.60
57_L	109_A	0.664	0.60
26_T	30_G	0.662	0.59
76_T	138_H	0.658	0.59
102_K	111_A	0.654	0.58
55_G	108_N	0.654	0.58
50_P	77_F	0.648	0.58
33_P	37_G	0.646	0.58
40_L	85_V	0.645	0.57
34_A	39_T	0.641	0.57
39_T	45_S	0.639	0.57
92_I	118_D	0.636	0.56
39_T	85_V	0.632	0.56
95_Q	124_Q	0.632	0.56
74_V	104_K	0.629	0.56
41_K	44_L	0.627	0.55
53_N	129_Q	0.624	0.55
78_M	110_A	0.624	0.55
87_H	108_N	0.618	0.54
93_T	97_D	0.617	0.54
43_V	77_F	0.617	0.54
68_E	118_D	0.616	0.54
92_I	99_L	0.615	0.54
60_V	76_T	0.614	0.54
94_K	99_L	0.611	0.53
142_Q	153_P	0.609	0.53
80_D	133_A	0.606	0.53
27_R	34_A	0.603	0.52
61_K	127_G	0.602	0.52
54_T	158_L	0.600	0.52
47_S	108_N	0.600	0.52
52_F	58_I	0.594	0.51
150_L	165_I	0.591	0.51
17_I	149_L	0.588	0.51
33_P	44_L	0.583	0.50
58_I	123_A	0.582	0.50
51_E	95_Q	0.578	0.49
59_L	83_T	0.568	0.48
35_V	68_E	0.567	0.48
59_L	99_L	0.565	0.48
20_T	70_Q	0.565	0.48
60_V	128_F	0.563	0.48
13_F	20_T	0.563	0.48
25_S	28_S	0.561	0.47
75_I	145_G	0.561	0.47
115_P	136_M	0.551	0.46
39_T	86_T	0.551	0.46
159_V	165_I	0.547	0.46
43_V	153_P	0.545	0.46
103_T	121_V	0.545	0.46
45_S	112_D	0.541	0.45
25_S	60_V	0.540	0.45
32_E	160_Y	0.537	0.45
17_I	113_S	0.535	0.44
146_T	152_V	0.532	0.44
99_L	159_V	0.530	0.44
81_A	154_G	0.530	0.44
23_V	32_E	0.530	0.44
58_I	92_I	0.529	0.44
79_Q	122_R	0.527	0.43
162_F	165_I	0.527	0.43
135_Y	158_L	0.526	0.43
95_Q	130_L	0.526	0.43
102_K	114_A	0.525	0.43
44_L	76_T	0.525	0.43
109_A	146_T	0.525	0.43
71_K	89_I	0.524	0.43
16_I	73_D	0.523	0.43
26_T	158_L	0.522	0.43
15_L	28_S	0.521	0.43
145_G	157_L	0.519	0.42
152_V	155_V	0.514	0.42
57_L	137_L	0.514	0.42
58_I	129_Q	0.513	0.42
50_P	104_K	0.512	0.42
148_V	155_V	0.512	0.42
154_G	159_V	0.510	0.41
17_I	21_L	0.507	0.41
83_T	133_A	0.506	0.41
129_Q	142_Q	0.505	0.41
18_V	168_A	0.505	0.41
136_M	139_F	0.504	0.41
161_A	165_I	0.504	0.41
43_V	84_A	0.503	0.41
20_T	27_R	0.502	0.40
16_I	56_S	0.500	0.40

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4k8wA	2	0.4053	99.4	0.706	Contact Map
4n31A	5	0.5316	99.4	0.709	Contact Map
4nv4A	2	0.3368	99.3	0.721	Contact Map
4me8A	1	0.3263	99.2	0.729	Contact Map
1b12A	1	0.6158	99	0.756	Contact Map
1kcaA	6	0.5	98.3	0.804	Contact Map
1umuA	2	0.5158	98.3	0.804	Contact Map
2hnfA	1	0.6368	98	0.817	Contact Map
1jhfA	2	0.6421	97.9	0.823	Contact Map
3bdnA	2	0.6632	97.6	0.836	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.