GREMLIN Database
YQHB - UPF0053 protein YqhB
UniProt: P54505 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 442 (407)
Sequences: 7932 (5220)
Seq/√Len: 258.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
235_M338_L4.1931.00
407_N414_S3.6831.00
374_L438_V3.5961.00
415_A424_K3.4271.00
415_A422_S3.4201.00
417_E422_S3.4171.00
264_R269_N3.2741.00
305_V314_L3.2151.00
244_S247_N3.0381.00
403_F436_I3.0271.00
294_Q297_P2.9441.00
242_E247_N2.9431.00
373_L426_K2.9191.00
278_E300_Q2.9091.00
264_R296_E2.8681.00
237_S263_V2.8241.00
368_G371_H2.7061.00
262_V299_V2.6601.00
139_K142_S2.6251.00
152_I156_K2.5551.00
163_W167_H2.5451.00
225_A314_L2.5001.00
373_L435_F2.4711.00
402_W418_Y2.4191.00
309_I317_K2.3641.00
240_L264_R2.3551.00
122_Y168_S2.3481.00
327_I338_L2.3131.00
383_V387_L2.2871.00
235_M335_T2.2551.00
237_S267_K2.2191.00
43_I57_A2.2071.00
56_A152_I2.1711.00
25_T79_A2.1501.00
27_F150_P2.1111.00
56_A149_K2.0871.00
367_L371_H2.0861.00
240_L296_E2.0861.00
327_I335_T2.0781.00
240_L271_I2.0461.00
238_L248_L2.0381.00
171_L175_V2.0291.00
314_L339_V2.0231.00
426_K437_E2.0201.00
399_L436_I2.0001.00
42_K141_E1.9941.00
273_V302_V1.9831.00
228_I339_V1.9801.00
427_D435_F1.9541.00
371_H437_E1.9181.00
383_V438_V1.9121.00
66_E159_F1.9021.00
47_V58_K1.8841.00
238_L262_V1.8811.00
146_L150_P1.8331.00
378_L383_V1.8311.00
364_I378_L1.8231.00
228_I311_I1.8171.00
429_N434_L1.7941.00
46_L145_L1.7751.00
250_E254_Q1.7721.00
197_L214_M1.7631.00
263_V270_V1.7341.00
342_E346_E1.7331.00
242_E248_L1.7281.00
59_H152_I1.7271.00
258_T275_N1.7151.00
51_K145_L1.7091.00
427_D434_L1.6921.00
366_E372_Y1.6921.00
167_H171_L1.6451.00
378_L399_L1.6351.00
223_R227_E1.6321.00
236_V251_T1.6181.00
325_M338_L1.5941.00
424_K437_E1.5921.00
374_L399_L1.5911.00
31_V147_F1.5891.00
241_D264_R1.5851.00
213_Y217_I1.5811.00
383_V399_L1.5711.00
217_I348_I1.5691.00
307_E336_S1.5591.00
384_N389_T1.5581.00
403_F423_F1.5541.00
25_T75_I1.5481.00
239_S242_E1.5431.00
56_A148_A1.5331.00
142_S146_L1.5211.00
366_E369_K1.5171.00
266_D269_N1.5091.00
309_I314_L1.4851.00
373_L437_E1.4791.00
70_A154_F1.4781.00
367_L370_D1.4751.00
418_Y423_F1.4631.00
236_V257_Y1.4621.00
316_L319_Q1.4551.00
367_L373_L1.4391.00
233_N334_G1.4381.00
57_A148_A1.4361.00
24_L78_A1.4241.00
311_I344_I1.4161.00
404_L433_I1.4131.00
44_D48_A1.4131.00
16_L20_I1.4051.00
15_L19_A1.4031.00
354_D357_D1.3921.00
423_F436_I1.3891.00
406_Q418_Y1.3851.00
57_A144_T1.3781.00
374_L383_V1.3751.00
264_R271_I1.3751.00
91_Q95_R1.3721.00
367_L437_E1.3671.00
30_A143_I1.3611.00
232_R268_D1.3601.00
80_L83_G1.3571.00
50_G54_A1.3531.00
403_F425_V1.3491.00
213_Y348_I1.3471.00
403_F416_I1.3421.00
114_V118_L1.3361.00
86_G120_V1.3291.00
159_F163_W1.3141.00
147_F150_P1.3121.00
396_V405_T1.3081.00
44_D58_K1.3051.00
268_D334_G1.3031.00
28_F74_G1.2891.00
259_R324_H1.2881.00
345_I349_V1.2831.00
110_L114_V1.2801.00
55_K59_H1.2801.00
273_V325_M1.2791.00
13_I17_A1.2721.00
53_G145_L1.2701.00
156_K159_F1.2661.00
247_N250_E1.2511.00
70_A162_I1.2481.00
293_H297_P1.2461.00
317_K321_E1.2461.00
58_K62_T1.2401.00
255_T260_Y1.2341.00
236_V260_Y1.2301.00
53_G149_K1.2281.00
426_K435_F1.2241.00
46_L51_K1.2221.00
47_V55_K1.2181.00
380_I384_N1.2121.00
17_A85_L1.2081.00
28_F154_F1.2041.00
236_V255_T1.1991.00
325_M340_T1.1911.00
149_K153_W1.1841.00
150_P153_W1.1831.00
306_I309_I1.1801.00
270_V327_I1.1731.00
302_V327_I1.1711.00
421_Y438_V1.1641.00
268_D335_T1.1601.00
131_A172_I1.1561.00
242_E251_T1.1561.00
225_A328_L1.1551.00
167_H170_R1.1491.00
51_K54_A1.1491.00
282_S298_F1.1451.00
18_V82_L1.1361.00
232_R334_G1.1321.00
75_I79_A1.1281.00
352_I357_D1.1111.00
33_F36_V1.0931.00
27_F147_F1.0821.00
225_A305_V1.0811.00
271_I299_V1.0791.00
246_S250_E1.0761.00
259_R342_E1.0751.00
274_I298_F1.0731.00
79_A124_N1.0711.00
342_E352_I1.0691.00
43_I58_K1.0611.00
135_F178_L1.0581.00
237_S335_T1.0571.00
20_I24_L1.0571.00
365_R373_L1.0561.00
188_Y196_L1.0561.00
387_L421_Y1.0551.00
384_N391_L1.0541.00
18_V120_V1.0461.00
95_R99_H1.0421.00
72_Q75_I1.0411.00
400_G404_L1.0341.00
305_V328_L1.0221.00
416_I423_F1.0221.00
364_I386_L1.0151.00
171_L174_G1.0091.00
239_S265_E1.0081.00
53_G57_A1.0071.00
305_V326_A1.0061.00
59_H63_H1.0041.00
201_Y211_L1.0021.00
128_G133_K1.0001.00
153_W156_K0.9971.00
52_K55_K0.9931.00
234_E432_H0.9931.00
32_E133_K0.9931.00
265_E269_N0.9911.00
364_I374_L0.9891.00
43_I61_I0.9871.00
226_K307_E0.9841.00
112_S116_A0.9751.00
417_E420_G0.9661.00
404_L408_I0.9641.00
25_T29_V0.9581.00
29_V33_F0.9571.00
70_A155_Y0.9531.00
54_A145_L0.9531.00
173_T178_L0.9521.00
94_L97_L0.9491.00
200_S204_G0.9491.00
402_W423_F0.9481.00
38_V140_A0.9461.00
30_A136_A0.9371.00
375_N435_F0.9341.00
60_V67_Y0.9341.00
250_E253_K0.9331.00
363_H375_N0.9321.00
80_L121_T0.9321.00
353_R360_E0.9311.00
384_N390_D0.9311.00
45_Q49_K0.9281.00
235_M267_K0.9271.00
303_I317_K0.9261.00
364_I372_Y0.9241.00
240_L299_V0.9211.00
309_I313_K0.9181.00
228_I344_I0.9181.00
249_Q253_K0.9151.00
47_V51_K0.9141.00
406_Q416_I0.9021.00
22_I123_L0.9011.00
376_A399_L0.8941.00
164_L167_H0.8921.00
423_F438_V0.8921.00
379_L382_D0.8911.00
342_E357_D0.8891.00
155_Y159_F0.8861.00
252_V260_Y0.8861.00
318_M326_A0.8841.00
31_V151_L0.8841.00
314_L344_I0.8841.00
38_V43_I0.8801.00
146_L149_K0.8781.00
129_E133_K0.8771.00
30_A34_S0.8771.00
170_R180_P0.8751.00
411_E427_D0.8721.00
220_F312_Y0.8701.00
391_L402_W0.8621.00
296_E299_V0.8611.00
174_G179_K0.8581.00
261_P270_V0.8571.00
220_F315_L0.8551.00
346_E351_E0.8530.99
330_D333_G0.8500.99
118_L122_Y0.8500.99
56_A59_H0.8480.99
238_L251_T0.8480.99
193_L200_S0.8480.99
245_I293_H0.8400.99
376_A400_G0.8380.99
400_G432_H0.8370.99
63_H66_E0.8360.99
220_F344_I0.8320.99
402_W406_Q0.8300.99
239_S263_V0.8290.99
330_D336_S0.8280.99
160_P164_L0.8270.99
60_V148_A0.8220.99
84_W117_F0.8210.99
13_I16_L0.8200.99
82_L120_V0.8180.99
27_F74_G0.8050.99
71_C151_L0.8040.99
26_G30_A0.8040.99
324_H345_I0.8020.99
380_I391_L0.8020.99
330_D334_G0.8010.99
253_K285_T0.8010.99
65_D170_R0.7960.99
342_E351_E0.7930.99
252_V279_V0.7920.99
234_E377_K0.7890.99
17_A20_I0.7890.99
42_K46_L0.7880.99
232_R330_D0.7870.99
303_I326_A0.7870.99
83_G86_G0.7850.99
33_F136_A0.7840.99
342_E355_E0.7830.99
76_T121_T0.7820.99
342_E347_E0.7770.99
170_R174_G0.7740.99
143_I147_F0.7690.99
21_L81_G0.7690.99
261_P327_I0.7670.99
73_L161_F0.7640.99
25_T124_N0.7620.99
306_I331_E0.7620.99
76_T133_K0.7600.99
278_E356_F0.7560.99
293_H298_F0.7540.99
80_L117_F0.7530.99
365_R435_F0.7530.99
342_E354_D0.7520.99
75_I129_E0.7490.99
65_D134_S0.7460.99
406_Q419_D0.7460.99
392_S396_V0.7450.99
245_I248_L0.7450.99
240_L248_L0.7420.99
40_R62_T0.7380.99
347_E351_E0.7360.99
380_I396_V0.7360.99
241_D296_E0.7350.98
258_T277_K0.7350.98
324_H342_E0.7340.98
149_K152_I0.7340.98
72_Q79_A0.7330.98
252_V276_M0.7310.98
22_I25_T0.7290.98
111_L115_I0.7280.98
75_I78_A0.7270.98
410_A414_S0.7250.98
75_I124_N0.7250.98
275_N278_E0.7220.98
211_L215_N0.7200.98
270_V335_T0.7190.98
193_L206_I0.7190.98
17_A21_L0.7180.98
331_E401_G0.7160.98
433_I436_I0.7160.98
283_M286_K0.7160.98
225_A339_V0.7150.98
225_A309_I0.7140.98
259_R355_E0.7140.98
389_T421_Y0.7140.98
224_M227_E0.7130.98
303_I321_E0.7130.98
53_G56_A0.7120.98
259_R275_N0.7110.98
408_I428_I0.7080.98
400_G433_I0.7080.98
315_L349_V0.7070.98
364_I383_V0.7060.98
68_L128_G0.7060.98
23_L26_G0.7050.98
352_I355_E0.7050.98
367_L427_D0.7050.98
375_N378_L0.7050.98
63_H155_Y0.7040.98
25_T78_A0.7040.98
190_E222_K0.7000.98
396_V402_W0.6990.98
383_V386_L0.6980.98
108_T112_S0.6970.98
346_E357_D0.6970.98
64_L67_Y0.6960.98
346_E354_D0.6960.98
386_L389_T0.6950.98
107_L110_L0.6930.98
38_V57_A0.6910.98
130_L165_L0.6910.98
341_V352_I0.6890.98
395_E405_T0.6880.98
144_T148_A0.6880.98
238_L260_Y0.6870.98
76_T124_N0.6850.98
230_V353_R0.6850.98
75_I130_L0.6840.98
93_L96_P0.6840.98
253_K281_F0.6840.98
246_S292_K0.6830.98
19_A23_L0.6830.98
226_K336_S0.6820.98
238_L252_V0.6810.98
190_E194_R0.6800.98
317_K320_K0.6780.97
43_I54_A0.6770.97
402_W416_I0.6760.97
53_G148_A0.6760.97
238_L295_I0.6740.97
190_E218_F0.6740.97
232_R332_Y0.6710.97
251_T254_Q0.6710.97
29_V124_N0.6700.97
107_L111_L0.6700.97
38_V141_E0.6680.97
22_I128_G0.6680.97
42_K45_Q0.6670.97
22_I82_L0.6660.97
80_L116_A0.6640.97
248_L295_I0.6640.97
127_I172_I0.6630.97
376_A433_I0.6630.97
263_V266_D0.6620.97
34_S144_T0.6590.97
82_L124_N0.6590.97
366_E370_D0.6580.97
329_I335_T0.6570.97
66_E155_Y0.6560.97
366_E371_H0.6560.97
271_I296_E0.6560.97
91_Q109_H0.6560.97
304_H329_I0.6560.97
72_Q76_T0.6550.97
46_L49_K0.6520.97
98_F111_L0.6510.97
236_V254_Q0.6510.97
80_L84_W0.6480.97
363_H378_L0.6470.97
81_G113_L0.6450.97
57_A61_I0.6450.97
29_V129_E0.6410.96
302_V325_M0.6400.96
216_N348_I0.6390.96
198_A215_N0.6370.96
261_P273_V0.6350.96
154_F158_M0.6340.96
238_L242_E0.6340.96
92_T95_R0.6330.96
390_D419_D0.6320.96
94_L98_F0.6310.96
247_N251_T0.6300.96
248_L294_Q0.6300.96
316_L320_K0.6300.96
273_V299_V0.6290.96
248_L252_V0.6270.96
223_R347_E0.6260.96
194_R219_T0.6230.96
84_W113_L0.6220.96
194_R215_N0.6210.96
214_M218_F0.6210.96
434_L437_E0.6200.96
213_Y220_F0.6200.96
411_E428_I0.6170.96
219_T222_K0.6170.96
25_T76_T0.6170.96
99_H108_T0.6150.96
29_V75_I0.6130.95
282_S286_K0.6130.95
283_M287_D0.6130.95
24_L28_F0.6120.95
97_L100_K0.6110.95
113_L117_F0.6110.95
83_G121_T0.6110.95
78_A121_T0.6090.95
138_Q178_L0.6080.95
314_L318_M0.6070.95
387_L438_V0.6060.95
259_R325_M0.6060.95
179_K183_E0.6050.95
72_Q83_G0.6050.95
221_D312_Y0.6050.95
140_A143_I0.6020.95
142_S145_L0.6010.95
94_L112_S0.6000.95
161_F165_L0.5980.95
258_T355_E0.5970.95
78_A82_L0.5960.95
72_Q124_N0.5960.95
275_N300_Q0.5940.95
40_R58_K0.5930.95
173_T177_G0.5930.95
32_E129_E0.5920.94
73_L121_T0.5880.94
157_I160_P0.5880.94
315_L344_I0.5880.94
190_E221_D0.5880.94
407_N410_A0.5880.94
428_I431_H0.5870.94
53_G146_L0.5850.94
14_N18_V0.5850.94
32_E76_T0.5830.94
380_I383_V0.5820.94
305_V309_I0.5810.94
228_I347_E0.5800.94
55_K58_K0.5790.94
47_V50_G0.5790.94
76_T117_F0.5790.94
76_T80_L0.5780.94
37_K137_I0.5770.94
225_A310_P0.5770.94
259_R273_V0.5760.94
263_V267_K0.5750.94
46_L50_G0.5750.94
232_R331_E0.5730.93
262_V272_G0.5720.93
232_R333_G0.5700.93
261_P397_D0.5670.93
73_L80_L0.5670.93
68_L72_Q0.5660.93
353_R359_D0.5660.93
315_L341_V0.5650.93
422_S426_K0.5650.93
295_I299_V0.5630.93
194_R214_M0.5620.93
275_N324_H0.5620.93
378_L382_D0.5620.93
384_N392_S0.5610.93
60_V155_Y0.5600.93
21_L78_A0.5590.93
25_T72_Q0.5590.93
200_S205_E0.5580.93
392_S406_Q0.5580.93
83_G117_F0.5570.93
303_I323_T0.5560.92
75_I128_G0.5560.92
38_V67_Y0.5560.92
341_V349_V0.5550.92
59_H156_K0.5550.92
166_N170_R0.5540.92
309_I328_L0.5510.92
51_K55_K0.5500.92
79_A130_L0.5500.92
35_I144_T0.5500.92
367_L434_L0.5490.92
342_E356_F0.5480.92
324_H352_I0.5480.92
374_L386_L0.5440.92
153_W157_I0.5440.92
212_K216_N0.5440.92
259_R354_D0.5440.92
38_V46_L0.5440.92
134_S137_I0.5440.92
96_P99_H0.5430.92
226_K397_D0.5420.91
44_D47_V0.5410.91
29_V79_A0.5410.91
220_F310_P0.5400.91
52_K149_K0.5400.91
252_V280_L0.5390.91
380_I399_L0.5390.91
36_V137_I0.5380.91
342_E349_V0.5380.91
304_H327_I0.5380.91
404_L414_S0.5370.91
91_Q112_S0.5370.91
372_Y386_L0.5360.91
300_Q323_T0.5360.91
346_E352_I0.5360.91
29_V76_T0.5360.91
313_K316_L0.5360.91
227_E397_D0.5340.91
197_L206_I0.5340.91
267_K335_T0.5310.91
33_F73_L0.5310.91
403_F433_I0.5310.91
91_Q116_A0.5290.91
301_P304_H0.5290.91
374_L387_L0.5290.91
72_Q130_L0.5290.91
95_R114_V0.5280.90
197_L201_Y0.5270.90
81_G85_L0.5270.90
306_I329_I0.5260.90
189_T192_E0.5250.90
297_P301_P0.5250.90
331_E334_G0.5240.90
21_L26_G0.5240.90
79_A82_L0.5240.90
240_L244_S0.5240.90
258_T354_D0.5230.90
92_T96_P0.5230.90
231_P234_E0.5230.90
160_P163_W0.5220.90
29_V71_C0.5210.90
239_S269_N0.5210.90
381_S385_S0.5200.90
324_H341_V0.5190.90
96_P112_S0.5190.90
225_A229_M0.5170.90
197_L215_N0.5170.90
37_K125_V0.5170.90
33_F72_Q0.5170.90
345_I352_I0.5160.89
384_N393_E0.5160.89
364_I368_G0.5160.89
76_T137_I0.5150.89
46_L54_A0.5140.89
299_V302_V0.5130.89
307_E333_G0.5130.89
270_V304_H0.5120.89
166_N169_A0.5120.89
172_I176_F0.5110.89
71_C117_F0.5100.89
403_F409_D0.5100.89
64_L117_F0.5090.89
374_L436_I0.5080.89
38_V145_L0.5070.89
94_L119_V0.5060.88
61_I64_L0.5050.88
227_E404_L0.5050.88
95_R112_S0.5030.88
165_L169_A0.5030.88
84_W91_Q0.5020.88
232_R336_S0.5010.88
382_D386_L0.5010.88
47_V141_E0.5000.88
78_A128_G0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hg0A 2 0.5204 100 0.518 Contact Map
3lhhA 1 0.2828 100 0.766 Contact Map
3ocoA 2 0.3054 99.9 0.782 Contact Map
3oi8A 2 0.3529 99.9 0.783 Contact Map
2v8qE 1 0.5204 99.9 0.785 Contact Map
3ocmA 5 0.3371 99.9 0.788 Contact Map
3kxrA 3 0.3643 99.9 0.795 Contact Map
3lv9A 2 0.2941 99.9 0.798 Contact Map
4iysA 2 0.3213 99.9 0.805 Contact Map
3t4nC 1 0.5317 99.9 0.805 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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