GREMLIN Database
RSBRD - RsbT co-antagonist protein RsbRD
UniProt: P54504 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (261)
Sequences: 883 (693)
Seq/√Len: 42.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_R131_D5.6091.00
11_H14_D5.3141.00
6_Q10_E3.9421.00
215_T247_T3.8441.00
238_S267_A3.5451.00
207_I213_V3.2641.00
192_L227_S3.0211.00
181_T216_M2.7881.00
194_Q197_A2.7421.00
93_N134_I2.7201.00
179_I184_A2.6101.00
17_Q21_E2.5611.00
210_V244_I2.4371.00
193_E197_A2.3691.00
247_T251_L2.3381.00
181_T212_I2.3291.00
101_E124_R2.2881.00
179_I187_I2.1511.00
215_T251_L2.1260.99
156_I164_M2.0770.99
213_V244_I2.0550.99
171_G200_L2.0480.99
100_F123_S2.0230.99
165_P172_I1.9740.99
18_Q101_E1.9500.99
12_K48_E1.8080.98
215_T218_A1.7700.98
103_I168_D1.7670.98
218_A247_T1.7600.98
219_Y223_K1.7550.98
208_S271_K1.7050.97
181_T210_V1.6970.97
168_D265_A1.6960.97
201_S205_L1.6760.97
227_S263_S1.6560.97
8_L15_I1.6270.97
130_I134_I1.6260.97
11_H102_W1.6220.97
261_E270_N1.6180.97
170_I271_K1.6060.96
229_K234_E1.5940.96
169_G201_S1.5720.96
216_M247_T1.5630.96
45_D73_Q1.5530.96
14_D17_Q1.5450.95
171_G195_C1.5230.95
200_L208_S1.5210.95
141_Y144_V1.5120.95
181_T185_R1.5000.95
150_N154_E1.4660.94
188_L227_S1.4450.93
152_Q164_M1.4400.93
23_C43_L1.4360.93
202_Y236_I1.4300.93
42_K46_Q1.4270.93
240_I245_A1.4200.93
88_S137_F1.4180.93
208_S272_G1.4160.93
36_Q141_Y1.4150.93
115_S118_E1.4120.93
189_E214_D1.4100.93
18_Q102_W1.4090.93
136_V140_E1.4030.92
225_I237_I1.3820.92
19_W152_Q1.3790.92
208_S228_T1.3780.92
223_K228_T1.3500.91
97_H128_Q1.3390.91
39_L54_V1.3280.90
43_L46_Q1.3170.90
20_L23_C1.3080.89
195_C228_T1.2910.89
172_I224_V1.2780.88
40_E97_H1.2700.88
86_T142_H1.2580.88
210_V251_L1.2530.87
163_I173_L1.2470.87
153_K182_H1.2400.87
212_I247_T1.2330.86
203_L233_I1.2250.86
71_S133_I1.2190.86
10_E56_K1.2130.86
147_I151_A1.2080.85
81_H201_S1.2050.85
20_L43_L1.1920.85
191_V224_V1.1900.84
259_K262_Q1.1870.84
7_H106_F1.1840.84
205_L228_T1.1700.83
154_E182_H1.1560.83
93_N135_E1.1530.83
18_Q105_K1.1380.82
105_K121_E1.1280.81
18_Q22_V1.1280.81
214_D247_T1.1230.81
228_T233_I1.1230.81
247_T252_G1.1230.81
9_T14_D1.1170.80
234_E259_K1.1160.80
104_H117_Q1.1150.80
37_Q263_S1.1120.80
104_H121_E1.1090.80
6_Q9_T1.1070.80
207_I244_I1.1050.80
153_K226_D1.0930.79
70_W228_T1.0890.79
137_F155_M1.0820.78
51_V54_V1.0740.78
130_I147_I1.0700.77
208_S267_A1.0690.77
215_T219_Y1.0670.77
214_D244_I1.0640.77
238_S265_A1.0580.77
217_V252_G1.0510.76
158_E215_T1.0500.76
200_L271_K1.0390.75
174_P209_G1.0390.75
181_T217_V1.0350.75
168_D199_K1.0310.75
127_N131_D1.0310.75
191_V200_L1.0310.75
44_K48_E1.0260.74
154_E201_S1.0230.74
158_E222_F1.0220.74
237_I244_I1.0160.74
208_S224_V1.0130.73
184_A212_I1.0130.73
85_V139_E1.0120.73
208_S268_L1.0070.73
46_Q173_L1.0050.73
185_R217_V0.9990.72
89_V134_I0.9990.72
181_T215_T0.9910.72
216_M250_K0.9850.71
215_T242_P0.9850.71
211_P255_F0.9830.71
46_Q49_L0.9830.71
215_T252_G0.9800.71
210_V247_T0.9730.70
161_A187_I0.9710.70
23_C29_W0.9680.70
131_D137_F0.9670.70
171_G226_D0.9660.70
177_G206_D0.9660.70
191_V203_L0.9620.70
212_I215_T0.9580.69
13_K18_Q0.9580.69
45_D49_L0.9560.69
85_V141_Y0.9500.69
181_T220_Q0.9490.68
46_Q50_L0.9480.68
118_E125_I0.9440.68
166_I260_T0.9360.67
201_S237_I0.9290.67
12_K16_T0.9230.66
218_A246_Q0.9180.66
248_V271_K0.9150.66
155_M187_I0.9140.66
11_H105_K0.9140.66
7_H54_V0.9100.65
138_T142_H0.9080.65
17_Q40_E0.9070.65
214_D217_V0.9060.65
192_L264_L0.9010.64
176_V250_K0.8950.64
224_V233_I0.8940.64
210_V217_V0.8920.64
218_A253_L0.8890.63
213_V252_G0.8850.63
20_L25_S0.8840.63
84_T141_Y0.8820.63
11_H25_S0.8820.63
220_Q260_T0.8770.62
194_Q208_S0.8720.62
167_T238_S0.8680.62
52_T56_K0.8660.61
214_D245_A0.8550.60
43_L47_H0.8540.60
184_A214_D0.8500.60
248_V255_F0.8480.60
208_S233_I0.8480.60
133_I223_K0.8480.60
22_V97_H0.8450.59
86_T138_T0.8450.59
204_F267_A0.8440.59
13_K54_V0.8410.59
4_L97_H0.8400.59
189_E264_L0.8390.59
40_E47_H0.8380.59
41_Q268_L0.8350.58
218_A245_A0.8350.58
24_T29_W0.8320.58
202_Y227_S0.8310.58
173_L248_V0.8290.58
207_I238_S0.8240.57
217_V251_L0.8230.57
166_I253_L0.8220.57
221_I255_F0.8210.57
19_W164_M0.8180.57
8_L41_Q0.8140.57
215_T222_F0.8140.57
191_V233_I0.8120.56
163_I214_D0.8070.56
4_L12_K0.8070.56
268_L272_G0.8060.56
6_Q21_E0.8040.56
8_L100_F0.8010.55
167_T172_I0.7970.55
215_T253_L0.7970.55
200_L207_I0.7960.55
75_A89_V0.7930.55
40_E44_K0.7930.55
8_L270_N0.7910.54
108_E117_Q0.7900.54
73_Q121_E0.7860.54
15_I44_K0.7830.54
10_E21_E0.7820.54
48_E56_K0.7820.54
16_T29_W0.7800.53
204_F264_L0.7690.52
50_L74_C0.7600.51
22_V37_Q0.7570.51
22_V98_I0.7530.51
232_G239_G0.7510.51
158_E181_T0.7500.51
152_Q161_A0.7470.50
130_I262_Q0.7460.50
17_Q120_Y0.7460.50
163_I186_T0.7460.50
107_S116_I0.7440.50
159_L180_D0.7420.50
203_L224_V0.7410.50
181_T247_T0.7370.49
102_W106_F0.7370.49
190_S238_S0.7360.49
173_L233_I0.7250.48
7_H25_S0.7240.48
222_F244_I0.7230.48
26_N201_S0.7220.48
13_K17_Q0.7210.48
163_I252_G0.7200.48
179_I246_Q0.7200.48
222_F272_G0.7200.48
165_P187_I0.7170.47
92_F133_I0.7160.47
248_V253_L0.7140.47
8_L50_L0.7140.47
268_L273_F0.7100.47
120_Y123_S0.7080.47
148_Q156_I0.7060.46
39_L42_K0.7040.46
175_L272_G0.7030.46
138_T263_S0.7030.46
180_D242_P0.7030.46
231_L237_I0.6980.46
14_D24_T0.6970.45
82_E249_V0.6960.45
231_L267_A0.6900.45
186_T241_R0.6890.45
51_V69_R0.6880.45
168_D268_L0.6870.45
196_S213_V0.6830.44
48_E57_S0.6820.44
152_Q271_K0.6820.44
195_C200_L0.6790.44
9_T51_V0.6780.44
20_L33_A0.6770.44
203_L208_S0.6760.44
217_V245_A0.6740.43
216_M241_R0.6700.43
85_V134_I0.6690.43
29_W33_A0.6680.43
152_Q158_E0.6670.43
18_Q32_S0.6660.43
20_L24_T0.6650.42
182_H253_L0.6630.42
184_A251_L0.6630.42
13_K44_K0.6620.42
23_C36_Q0.6620.42
207_I248_V0.6620.42
184_A187_I0.6610.42
9_T55_A0.6600.42
233_I271_K0.6600.42
149_L185_R0.6590.42
44_K72_L0.6570.42
9_T27_G0.6560.42
16_T43_L0.6480.41
194_Q198_L0.6470.41
82_E188_L0.6460.41
171_G271_K0.6440.41
195_C233_I0.6430.40
11_H17_Q0.6430.40
227_S264_L0.6410.40
223_K249_V0.6400.40
202_Y271_K0.6390.40
72_L263_S0.6350.40
191_V195_C0.6350.40
241_R252_G0.6350.40
211_P245_A0.6350.40
165_P266_K0.6330.40
117_Q121_E0.6330.40
33_A54_V0.6320.39
219_Y252_G0.6280.39
21_E55_A0.6270.39
132_E176_V0.6260.39
249_V252_G0.6260.39
160_S215_T0.6250.39
18_Q65_D0.6250.39
175_L203_L0.6230.39
5_D51_V0.6230.39
217_V220_Q0.6220.39
100_F126_L0.6170.38
15_I27_G0.6170.38
159_L241_R0.6150.38
203_L216_M0.6100.37
8_L66_E0.6090.37
83_V89_V0.6040.37
227_S233_I0.5990.37
131_D187_I0.5990.37
213_V217_V0.5960.36
254_D257_N0.5960.36
27_G164_M0.5920.36
79_A148_Q0.5910.36
10_E57_S0.5910.36
152_Q217_V0.5860.35
188_L252_G0.5850.35
18_Q25_S0.5850.35
244_I267_A0.5840.35
104_H124_R0.5830.35
164_M241_R0.5820.35
181_T188_L0.5820.35
228_T271_K0.5810.35
236_I270_N0.5810.35
48_E66_E0.5790.35
102_W143_Q0.5780.35
201_S243_E0.5770.35
32_S106_F0.5750.34
15_I102_W0.5750.34
218_A224_V0.5710.34
116_I119_F0.5700.34
7_H123_S0.5700.34
195_C204_F0.5700.34
17_Q22_V0.5700.34
163_I234_E0.5670.34
175_L228_T0.5660.34
87_Q190_S0.5650.34
18_Q97_H0.5630.33
150_N153_K0.5630.33
155_M181_T0.5620.33
200_L258_V0.5600.33
52_T66_E0.5580.33
183_R245_A0.5580.33
105_K168_D0.5560.33
14_D121_E0.5510.32
181_T250_K0.5490.32
180_D261_E0.5470.32
236_I250_K0.5430.32
180_D183_R0.5400.31
158_E245_A0.5400.31
137_F149_L0.5390.31
244_I251_L0.5390.31
23_C91_Q0.5390.31
104_H120_Y0.5380.31
125_I132_E0.5360.31
43_L53_I0.5350.31
149_L152_Q0.5340.31
173_L179_I0.5340.31
206_D232_G0.5280.31
67_L130_I0.5270.30
177_G232_G0.5250.30
8_L79_A0.5230.30
191_V207_I0.5220.30
174_P230_L0.5200.30
46_Q140_E0.5170.30
226_D268_L0.5160.30
14_D105_K0.5160.30
4_L21_E0.5160.30
204_F224_V0.5130.29
69_R108_E0.5130.29
70_W86_T0.5120.29
78_R131_D0.5120.29
142_H156_I0.5110.29
206_D239_G0.5110.29
177_G239_G0.5090.29
33_A43_L0.5030.29
270_N273_F0.5030.29
43_L55_A0.5030.29
103_I257_N0.5020.28
24_T33_A0.5020.28
92_F134_I0.5010.28
97_H124_R0.5000.28
18_Q108_E0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zxnA 1 0.4245 99.6 0.768 Contact Map
4dgfA 1 0.4424 99.2 0.815 Contact Map
3ny7A 1 0.4173 99.2 0.817 Contact Map
4dghA 4 0.4532 99.1 0.825 Contact Map
1th8B 1 0.4101 99.1 0.828 Contact Map
2ka5A 1 0.4496 99.1 0.829 Contact Map
1h4xA 1 0.3993 99.1 0.829 Contact Map
3t6oA 5 0.3993 99 0.831 Contact Map
3lloA 1 0.4604 99 0.833 Contact Map
2klnA 1 0.4317 99 0.833 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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