RSBRD - BACSU - GREMLIN Contacts

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RSBRD - RsbT co-antagonist protein RsbRD

UniProt:	P54504	Sequences: MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLKDQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEWIHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELSAPIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVAYQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIKEC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	278 (261)
Sequences:	883 (693)
Seq/√Len:	42.9

BACSU - RSBRD RSBRC RSBRA RSBRB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
96_R	131_D	5.609	1.00
11_H	14_D	5.314	1.00
6_Q	10_E	3.942	1.00
215_T	247_T	3.844	1.00
238_S	267_A	3.545	1.00
207_I	213_V	3.264	1.00
192_L	227_S	3.021	1.00
181_T	216_M	2.788	1.00
194_Q	197_A	2.742	1.00
93_N	134_I	2.720	1.00
179_I	184_A	2.610	1.00
17_Q	21_E	2.561	1.00
210_V	244_I	2.437	1.00
193_E	197_A	2.369	1.00
247_T	251_L	2.338	1.00
181_T	212_I	2.329	1.00
101_E	124_R	2.288	1.00
179_I	187_I	2.151	1.00
215_T	251_L	2.126	0.99
156_I	164_M	2.077	0.99
213_V	244_I	2.055	0.99
171_G	200_L	2.048	0.99
100_F	123_S	2.023	0.99
165_P	172_I	1.974	0.99
18_Q	101_E	1.950	0.99
12_K	48_E	1.808	0.98
215_T	218_A	1.770	0.98
103_I	168_D	1.767	0.98
218_A	247_T	1.760	0.98
219_Y	223_K	1.755	0.98
208_S	271_K	1.705	0.97
181_T	210_V	1.697	0.97
168_D	265_A	1.696	0.97
201_S	205_L	1.676	0.97
227_S	263_S	1.656	0.97
8_L	15_I	1.627	0.97
130_I	134_I	1.626	0.97
11_H	102_W	1.622	0.97
261_E	270_N	1.618	0.97
170_I	271_K	1.606	0.96
229_K	234_E	1.594	0.96
169_G	201_S	1.572	0.96
216_M	247_T	1.563	0.96
45_D	73_Q	1.553	0.96
14_D	17_Q	1.545	0.95
171_G	195_C	1.523	0.95
200_L	208_S	1.521	0.95
141_Y	144_V	1.512	0.95
181_T	185_R	1.500	0.95
150_N	154_E	1.466	0.94
188_L	227_S	1.445	0.93
152_Q	164_M	1.440	0.93
23_C	43_L	1.436	0.93
202_Y	236_I	1.430	0.93
42_K	46_Q	1.427	0.93
240_I	245_A	1.420	0.93
88_S	137_F	1.418	0.93
208_S	272_G	1.416	0.93
36_Q	141_Y	1.415	0.93
115_S	118_E	1.412	0.93
189_E	214_D	1.410	0.93
18_Q	102_W	1.409	0.93
136_V	140_E	1.403	0.92
225_I	237_I	1.382	0.92
19_W	152_Q	1.379	0.92
208_S	228_T	1.378	0.92
223_K	228_T	1.350	0.91
97_H	128_Q	1.339	0.91
39_L	54_V	1.328	0.90
43_L	46_Q	1.317	0.90
20_L	23_C	1.308	0.89
195_C	228_T	1.291	0.89
172_I	224_V	1.278	0.88
40_E	97_H	1.270	0.88
86_T	142_H	1.258	0.88
210_V	251_L	1.253	0.87
163_I	173_L	1.247	0.87
153_K	182_H	1.240	0.87
212_I	247_T	1.233	0.86
203_L	233_I	1.225	0.86
71_S	133_I	1.219	0.86
10_E	56_K	1.213	0.86
147_I	151_A	1.208	0.85
81_H	201_S	1.205	0.85
20_L	43_L	1.192	0.85
191_V	224_V	1.190	0.84
259_K	262_Q	1.187	0.84
7_H	106_F	1.184	0.84
205_L	228_T	1.170	0.83
154_E	182_H	1.156	0.83
93_N	135_E	1.153	0.83
18_Q	105_K	1.138	0.82
105_K	121_E	1.128	0.81
18_Q	22_V	1.128	0.81
214_D	247_T	1.123	0.81
228_T	233_I	1.123	0.81
247_T	252_G	1.123	0.81
9_T	14_D	1.117	0.80
234_E	259_K	1.116	0.80
104_H	117_Q	1.115	0.80
37_Q	263_S	1.112	0.80
104_H	121_E	1.109	0.80
6_Q	9_T	1.107	0.80
207_I	244_I	1.105	0.80
153_K	226_D	1.093	0.79
70_W	228_T	1.089	0.79
137_F	155_M	1.082	0.78
51_V	54_V	1.074	0.78
130_I	147_I	1.070	0.77
208_S	267_A	1.069	0.77
215_T	219_Y	1.067	0.77
214_D	244_I	1.064	0.77
238_S	265_A	1.058	0.77
217_V	252_G	1.051	0.76
158_E	215_T	1.050	0.76
200_L	271_K	1.039	0.75
174_P	209_G	1.039	0.75
181_T	217_V	1.035	0.75
168_D	199_K	1.031	0.75
127_N	131_D	1.031	0.75
191_V	200_L	1.031	0.75
44_K	48_E	1.026	0.74
154_E	201_S	1.023	0.74
158_E	222_F	1.022	0.74
237_I	244_I	1.016	0.74
208_S	224_V	1.013	0.73
184_A	212_I	1.013	0.73
85_V	139_E	1.012	0.73
208_S	268_L	1.007	0.73
46_Q	173_L	1.005	0.73
185_R	217_V	0.999	0.72
89_V	134_I	0.999	0.72
181_T	215_T	0.991	0.72
216_M	250_K	0.985	0.71
215_T	242_P	0.985	0.71
211_P	255_F	0.983	0.71
46_Q	49_L	0.983	0.71
215_T	252_G	0.980	0.71
210_V	247_T	0.973	0.70
161_A	187_I	0.971	0.70
23_C	29_W	0.968	0.70
131_D	137_F	0.967	0.70
171_G	226_D	0.966	0.70
177_G	206_D	0.966	0.70
191_V	203_L	0.962	0.70
212_I	215_T	0.958	0.69
13_K	18_Q	0.958	0.69
45_D	49_L	0.956	0.69
85_V	141_Y	0.950	0.69
181_T	220_Q	0.949	0.68
46_Q	50_L	0.948	0.68
118_E	125_I	0.944	0.68
166_I	260_T	0.936	0.67
201_S	237_I	0.929	0.67
12_K	16_T	0.923	0.66
218_A	246_Q	0.918	0.66
248_V	271_K	0.915	0.66
155_M	187_I	0.914	0.66
11_H	105_K	0.914	0.66
7_H	54_V	0.910	0.65
138_T	142_H	0.908	0.65
17_Q	40_E	0.907	0.65
214_D	217_V	0.906	0.65
192_L	264_L	0.901	0.64
176_V	250_K	0.895	0.64
224_V	233_I	0.894	0.64
210_V	217_V	0.892	0.64
218_A	253_L	0.889	0.63
213_V	252_G	0.885	0.63
20_L	25_S	0.884	0.63
84_T	141_Y	0.882	0.63
11_H	25_S	0.882	0.63
220_Q	260_T	0.877	0.62
194_Q	208_S	0.872	0.62
167_T	238_S	0.868	0.62
52_T	56_K	0.866	0.61
214_D	245_A	0.855	0.60
43_L	47_H	0.854	0.60
184_A	214_D	0.850	0.60
248_V	255_F	0.848	0.60
208_S	233_I	0.848	0.60
133_I	223_K	0.848	0.60
22_V	97_H	0.845	0.59
86_T	138_T	0.845	0.59
204_F	267_A	0.844	0.59
13_K	54_V	0.841	0.59
4_L	97_H	0.840	0.59
189_E	264_L	0.839	0.59
40_E	47_H	0.838	0.59
41_Q	268_L	0.835	0.58
218_A	245_A	0.835	0.58
24_T	29_W	0.832	0.58
202_Y	227_S	0.831	0.58
173_L	248_V	0.829	0.58
207_I	238_S	0.824	0.57
217_V	251_L	0.823	0.57
166_I	253_L	0.822	0.57
221_I	255_F	0.821	0.57
19_W	164_M	0.818	0.57
8_L	41_Q	0.814	0.57
215_T	222_F	0.814	0.57
191_V	233_I	0.812	0.56
163_I	214_D	0.807	0.56
4_L	12_K	0.807	0.56
268_L	272_G	0.806	0.56
6_Q	21_E	0.804	0.56
8_L	100_F	0.801	0.55
167_T	172_I	0.797	0.55
215_T	253_L	0.797	0.55
200_L	207_I	0.796	0.55
75_A	89_V	0.793	0.55
40_E	44_K	0.793	0.55
8_L	270_N	0.791	0.54
108_E	117_Q	0.790	0.54
73_Q	121_E	0.786	0.54
15_I	44_K	0.783	0.54
10_E	21_E	0.782	0.54
48_E	56_K	0.782	0.54
16_T	29_W	0.780	0.53
204_F	264_L	0.769	0.52
50_L	74_C	0.760	0.51
22_V	37_Q	0.757	0.51
22_V	98_I	0.753	0.51
232_G	239_G	0.751	0.51
158_E	181_T	0.750	0.51
152_Q	161_A	0.747	0.50
130_I	262_Q	0.746	0.50
17_Q	120_Y	0.746	0.50
163_I	186_T	0.746	0.50
107_S	116_I	0.744	0.50
159_L	180_D	0.742	0.50
203_L	224_V	0.741	0.50
181_T	247_T	0.737	0.49
102_W	106_F	0.737	0.49
190_S	238_S	0.736	0.49
173_L	233_I	0.725	0.48
7_H	25_S	0.724	0.48
222_F	244_I	0.723	0.48
26_N	201_S	0.722	0.48
13_K	17_Q	0.721	0.48
163_I	252_G	0.720	0.48
179_I	246_Q	0.720	0.48
222_F	272_G	0.720	0.48
165_P	187_I	0.717	0.47
92_F	133_I	0.716	0.47
248_V	253_L	0.714	0.47
8_L	50_L	0.714	0.47
268_L	273_F	0.710	0.47
120_Y	123_S	0.708	0.47
148_Q	156_I	0.706	0.46
39_L	42_K	0.704	0.46
175_L	272_G	0.703	0.46
138_T	263_S	0.703	0.46
180_D	242_P	0.703	0.46
231_L	237_I	0.698	0.46
14_D	24_T	0.697	0.45
82_E	249_V	0.696	0.45
231_L	267_A	0.690	0.45
186_T	241_R	0.689	0.45
51_V	69_R	0.688	0.45
168_D	268_L	0.687	0.45
196_S	213_V	0.683	0.44
48_E	57_S	0.682	0.44
152_Q	271_K	0.682	0.44
195_C	200_L	0.679	0.44
9_T	51_V	0.678	0.44
20_L	33_A	0.677	0.44
203_L	208_S	0.676	0.44
217_V	245_A	0.674	0.43
216_M	241_R	0.670	0.43
85_V	134_I	0.669	0.43
29_W	33_A	0.668	0.43
152_Q	158_E	0.667	0.43
18_Q	32_S	0.666	0.43
20_L	24_T	0.665	0.42
182_H	253_L	0.663	0.42
184_A	251_L	0.663	0.42
13_K	44_K	0.662	0.42
23_C	36_Q	0.662	0.42
207_I	248_V	0.662	0.42
184_A	187_I	0.661	0.42
9_T	55_A	0.660	0.42
233_I	271_K	0.660	0.42
149_L	185_R	0.659	0.42
44_K	72_L	0.657	0.42
9_T	27_G	0.656	0.42
16_T	43_L	0.648	0.41
194_Q	198_L	0.647	0.41
82_E	188_L	0.646	0.41
171_G	271_K	0.644	0.41
195_C	233_I	0.643	0.40
11_H	17_Q	0.643	0.40
227_S	264_L	0.641	0.40
223_K	249_V	0.640	0.40
202_Y	271_K	0.639	0.40
72_L	263_S	0.635	0.40
191_V	195_C	0.635	0.40
241_R	252_G	0.635	0.40
211_P	245_A	0.635	0.40
165_P	266_K	0.633	0.40
117_Q	121_E	0.633	0.40
33_A	54_V	0.632	0.39
219_Y	252_G	0.628	0.39
21_E	55_A	0.627	0.39
132_E	176_V	0.626	0.39
249_V	252_G	0.626	0.39
160_S	215_T	0.625	0.39
18_Q	65_D	0.625	0.39
175_L	203_L	0.623	0.39
5_D	51_V	0.623	0.39
217_V	220_Q	0.622	0.39
100_F	126_L	0.617	0.38
15_I	27_G	0.617	0.38
159_L	241_R	0.615	0.38
203_L	216_M	0.610	0.37
8_L	66_E	0.609	0.37
83_V	89_V	0.604	0.37
227_S	233_I	0.599	0.37
131_D	187_I	0.599	0.37
213_V	217_V	0.596	0.36
254_D	257_N	0.596	0.36
27_G	164_M	0.592	0.36
79_A	148_Q	0.591	0.36
10_E	57_S	0.591	0.36
152_Q	217_V	0.586	0.35
188_L	252_G	0.585	0.35
18_Q	25_S	0.585	0.35
244_I	267_A	0.584	0.35
104_H	124_R	0.583	0.35
164_M	241_R	0.582	0.35
181_T	188_L	0.582	0.35
228_T	271_K	0.581	0.35
236_I	270_N	0.581	0.35
48_E	66_E	0.579	0.35
102_W	143_Q	0.578	0.35
201_S	243_E	0.577	0.35
32_S	106_F	0.575	0.34
15_I	102_W	0.575	0.34
218_A	224_V	0.571	0.34
116_I	119_F	0.570	0.34
7_H	123_S	0.570	0.34
195_C	204_F	0.570	0.34
17_Q	22_V	0.570	0.34
163_I	234_E	0.567	0.34
175_L	228_T	0.566	0.34
87_Q	190_S	0.565	0.34
18_Q	97_H	0.563	0.33
150_N	153_K	0.563	0.33
155_M	181_T	0.562	0.33
200_L	258_V	0.560	0.33
52_T	66_E	0.558	0.33
183_R	245_A	0.558	0.33
105_K	168_D	0.556	0.33
14_D	121_E	0.551	0.32
181_T	250_K	0.549	0.32
180_D	261_E	0.547	0.32
236_I	250_K	0.543	0.32
180_D	183_R	0.540	0.31
158_E	245_A	0.540	0.31
137_F	149_L	0.539	0.31
244_I	251_L	0.539	0.31
23_C	91_Q	0.539	0.31
104_H	120_Y	0.538	0.31
125_I	132_E	0.536	0.31
43_L	53_I	0.535	0.31
149_L	152_Q	0.534	0.31
173_L	179_I	0.534	0.31
206_D	232_G	0.528	0.31
67_L	130_I	0.527	0.30
177_G	232_G	0.525	0.30
8_L	79_A	0.523	0.30
191_V	207_I	0.522	0.30
174_P	230_L	0.520	0.30
46_Q	140_E	0.517	0.30
226_D	268_L	0.516	0.30
14_D	105_K	0.516	0.30
4_L	21_E	0.516	0.30
204_F	224_V	0.513	0.29
69_R	108_E	0.513	0.29
70_W	86_T	0.512	0.29
78_R	131_D	0.512	0.29
142_H	156_I	0.511	0.29
206_D	239_G	0.511	0.29
177_G	239_G	0.509	0.29
33_A	43_L	0.503	0.29
270_N	273_F	0.503	0.29
43_L	55_A	0.503	0.29
103_I	257_N	0.502	0.28
24_T	33_A	0.502	0.28
92_F	134_I	0.501	0.28
97_H	124_R	0.500	0.28
18_Q	108_E	0.500	0.28

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zxnA	1	0.4245	99.6	0.768	Contact Map
4dgfA	1	0.4424	99.2	0.815	Contact Map
3ny7A	1	0.4173	99.2	0.817	Contact Map
4dghA	4	0.4532	99.1	0.825	Contact Map
1th8B	1	0.4101	99.1	0.828	Contact Map
2ka5A	1	0.4496	99.1	0.829	Contact Map
1h4xA	1	0.3993	99.1	0.829	Contact Map
3t6oA	5	0.3993	99	0.831	Contact Map
3lloA	1	0.4604	99	0.833	Contact Map
2klnA	1	0.4317	99	0.833	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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