GREMLIN Database
MGSR - Regulatory protein MgsR
UniProt: P54503 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 126 (111)
Sequences: 2569 (1821)
Seq/√Len: 172.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_K30_F3.2511.00
42_R84_E2.6781.00
49_L83_L2.6201.00
36_F91_K2.3221.00
9_S32_E2.3191.00
7_F20_K2.2731.00
98_L113_L2.2351.00
100_D103_K2.1781.00
42_R46_K2.0831.00
11_P34_H1.9871.00
46_K83_L1.8461.00
34_H37_R1.7541.00
66_T89_K1.6481.00
22_W108_Y1.6481.00
41_T44_E1.5781.00
65_Q69_N1.5631.00
47_Y51_L1.5161.00
66_T70_L1.4721.00
78_T81_E1.4311.00
109_N112_E1.4261.00
22_W26_H1.3971.00
50_S79_V1.3751.00
64_S91_K1.3601.00
57_D62_T1.3531.00
49_L59_I1.3501.00
7_F16_C1.3231.00
54_E59_I1.3161.00
99_V104_L1.3101.00
65_Q68_K1.3051.00
58_E63_R1.2961.00
45_L87_I1.2951.00
33_R39_T1.2931.00
8_Y33_R1.2891.00
44_E99_V1.2791.00
20_K32_E1.2771.00
16_C35_L1.2751.00
6_T31_N1.2691.00
105_V116_L1.2401.00
20_K24_K1.2401.00
11_P37_R1.2321.00
76_E81_E1.2141.00
33_R44_E1.2081.00
111_G114_L1.2081.00
60_L86_L1.2031.00
12_S17_R1.1901.00
63_R109_N1.1701.00
44_E47_Y1.1581.00
58_E106_I1.1461.00
42_R83_L1.1321.00
51_L104_L1.1221.00
44_E48_I1.1221.00
9_S20_K1.1081.00
66_T69_N1.1011.00
86_L92_L1.0851.00
54_E106_I1.0811.00
11_P20_K1.0781.00
112_E115_K1.0601.00
16_C20_K1.0531.00
56_I82_V1.0430.99
6_T33_R1.0380.99
74_I77_M1.0310.99
22_W114_L1.0180.99
79_V83_L1.0150.99
10_Y16_C0.9960.99
5_L28_I0.9700.99
86_L93_L0.9670.99
48_I97_I0.9630.99
31_N38_E0.9560.99
39_T93_L0.9510.99
49_L56_I0.9480.99
46_K50_S0.9470.99
49_L55_G0.9430.99
45_L83_L0.9410.99
55_G82_V0.9320.99
21_H25_A0.9250.99
105_V117_S0.9180.99
112_E116_L0.9050.99
67_F92_L0.9050.99
7_F98_L0.8940.98
54_E58_E0.8930.98
42_R80_N0.8900.98
105_V113_L0.8870.98
55_G58_E0.8850.98
110_P114_L0.8790.98
26_H114_L0.8730.98
74_I82_V0.8690.98
54_E104_L0.8650.98
103_K116_L0.8610.98
46_K79_V0.8610.98
73_N81_E0.8580.98
67_F77_M0.8530.98
17_R21_H0.8520.98
111_G115_K0.8340.97
48_I104_L0.8300.97
16_C92_L0.8270.97
49_L79_V0.8260.97
97_I106_I0.8180.97
33_R38_E0.8050.97
19_T23_L0.7910.97
59_I106_I0.7900.96
77_M81_E0.7720.96
37_R64_S0.7720.96
84_E88_E0.7650.96
47_Y99_V0.7610.96
70_L85_L0.7570.96
98_L105_V0.7430.95
46_K80_N0.7400.95
79_V82_V0.7310.95
72_L75_E0.7290.95
113_L117_S0.7260.94
35_L93_L0.7240.94
35_L97_I0.7230.94
7_F23_L0.7110.94
43_E46_K0.7110.94
77_M82_V0.7080.94
24_K29_E0.7040.93
64_S69_N0.6740.92
73_N77_M0.6710.92
14_T21_H0.6670.91
10_Y91_K0.6670.91
33_R40_P0.6650.91
21_H24_K0.6570.91
73_N76_E0.6520.91
36_F66_T0.6480.90
11_P16_C0.6450.90
42_R87_I0.6420.90
9_S34_H0.6410.90
20_K30_F0.6390.90
5_L100_D0.6350.89
57_D82_V0.6330.89
60_L90_P0.6320.89
5_L117_S0.6310.89
67_F73_N0.6310.89
69_N89_K0.6310.89
7_F32_E0.6300.89
60_L82_V0.6270.89
99_V102_K0.6250.89
73_N88_E0.6180.88
40_P87_I0.6140.88
98_L117_S0.6080.87
77_M85_L0.6060.87
51_L103_K0.6040.87
12_S34_H0.5950.86
40_P44_E0.5870.85
14_T17_R0.5860.85
8_Y44_E0.5820.85
81_E84_E0.5790.85
17_R20_K0.5790.85
66_T91_K0.5760.84
56_I79_V0.5750.84
105_V112_E0.5730.84
8_Y39_T0.5720.84
19_T108_Y0.5670.83
54_E97_I0.5660.83
71_N75_E0.5540.82
15_S64_S0.5510.82
13_C95_R0.5400.80
59_I97_I0.5390.80
19_T113_L0.5370.80
24_K27_Q0.5260.79
35_L40_P0.5190.78
61_A68_K0.5120.77
67_F74_I0.5090.76
105_V109_N0.5080.76
36_F64_S0.5020.75
45_L93_L0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z3eA 1 0.9444 100 0.285 Contact Map
3l78A 1 0.9286 100 0.29 Contact Map
1s3cA 2 0.9762 100 0.296 Contact Map
3fz4A 1 0.9206 100 0.299 Contact Map
3gkxA 2 0.9286 100 0.305 Contact Map
2mu0A 1 0.9286 100 0.307 Contact Map
3f0iA 1 0.9127 100 0.316 Contact Map
3rdwA 1 0.9048 100 0.317 Contact Map
2kokA 1 0.9206 100 0.323 Contact Map
2m46A 1 0.9127 100 0.326 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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