GREMLIN Database
YQGX - Probable metallo-hydrolase YqgX
UniProt: P54501 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 211 (179)
Sequences: 17739 (12507)
Seq/√Len: 934.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_T136_S4.0211.00
23_Q48_L3.8521.00
52_L63_L3.4351.00
114_E121_H2.7781.00
49_A75_Y2.6861.00
116_N121_H2.6071.00
111_G176_K2.5521.00
182_E200_Q2.4741.00
51_L137_Y2.4741.00
114_E123_E2.4361.00
123_E140_K2.4231.00
122_L139_V2.4051.00
78_Q110_E2.3221.00
124_T135_V2.2881.00
25_L49_A2.2011.00
37_N69_K2.1941.00
75_Y107_H2.1451.00
80_E133_G2.1331.00
73_P107_H2.0031.00
144_L187_L1.9961.00
49_A73_P1.8931.00
16_Y187_L1.8841.00
124_T137_Y1.8711.00
165_N168_T1.8561.00
139_V142_A1.8111.00
24_C45_L1.7581.00
77_H126_F1.7501.00
143_D183_H1.7451.00
67_R106_D1.7441.00
75_Y109_I1.7041.00
23_Q46_T1.6991.00
27_F146_I1.6971.00
27_F53_T1.6921.00
39_Y43_K1.6271.00
110_E113_G1.6101.00
182_E197_L1.5221.00
37_N41_K1.5191.00
19_I45_L1.4921.00
39_Y42_E1.4771.00
63_L74_V1.4741.00
19_I24_C1.4661.00
171_T175_E1.4591.00
25_L51_L1.4511.00
65_E69_K1.4171.00
47_P72_I1.3831.00
136_S145_V1.3741.00
123_E138_Y1.3561.00
37_N70_W1.3561.00
77_H135_V1.3351.00
16_Y146_I1.3311.00
138_Y145_V1.3201.00
120_F139_V1.3161.00
107_H113_G1.3161.00
40_I47_P1.2981.00
38_Q42_E1.2891.00
34_H38_Q1.2411.00
125_L176_K1.2381.00
78_Q108_L1.2331.00
81_K85_A1.2311.00
64_D68_E1.2311.00
168_T171_T1.2231.00
29_P50_I1.2091.00
125_L138_Y1.2051.00
33_G65_E1.1921.00
47_P70_W1.1901.00
127_T172_S1.1851.00
129_G172_S1.1741.00
33_G62_A1.1731.00
136_S177_L1.1641.00
24_C47_P1.1531.00
41_K69_K1.1461.00
109_I135_V1.1201.00
64_D67_R1.1011.00
79_N126_F1.1001.00
176_K179_T1.0941.00
186_V194_T1.0831.00
111_G126_F1.0751.00
81_K108_L1.0731.00
145_V180_L1.0711.00
131_S134_S1.0681.00
116_N119_P1.0611.00
175_E179_T1.0591.00
38_Q41_K1.0531.00
67_R74_V1.0531.00
134_S148_G1.0481.00
26_I47_P1.0411.00
33_G37_N1.0361.00
20_S23_Q1.0181.00
20_S119_P1.0151.00
112_D123_E1.0101.00
127_T150_V1.0081.00
175_E178_L0.9971.00
138_Y184_T0.9831.00
53_T148_G0.9661.00
136_S150_V0.9651.00
150_V177_L0.9631.00
132_P168_T0.9571.00
65_E68_E0.9521.00
166_Q169_L0.9431.00
167_E171_T0.9421.00
150_V169_L0.9411.00
166_Q170_L0.9411.00
196_V199_E0.9351.00
17_F39_Y0.9331.00
120_F142_A0.9261.00
20_S118_G0.9191.00
147_S186_V0.9161.00
17_F24_C0.8981.00
73_P106_D0.8951.00
186_V196_V0.8951.00
51_L122_L0.8911.00
23_Q49_A0.8801.00
145_V186_V0.8711.00
76_L80_E0.8711.00
26_I29_P0.8601.00
25_L117_I0.8591.00
79_N82_N0.8561.00
187_L193_E0.8501.00
140_K143_D0.8441.00
50_I72_I0.8401.00
127_T134_S0.8291.00
55_A76_L0.8271.00
52_L74_V0.8261.00
194_T199_E0.8251.00
57_F61_G0.8241.00
138_Y180_L0.8221.00
117_I120_F0.8181.00
15_A36_I0.8101.00
18_L27_F0.8071.00
154_G198_T0.8071.00
76_L84_L0.8031.00
138_Y143_D0.7981.00
13_A30_G0.7961.00
122_L137_Y0.7941.00
32_E35_K0.7891.00
55_A80_E0.7881.00
158_R161_L0.7871.00
78_Q81_K0.7851.00
25_L122_L0.7851.00
195_D198_T0.7811.00
178_L200_Q0.7811.00
63_L67_R0.7791.00
177_L196_V0.7721.00
35_K38_Q0.7711.00
80_E131_S0.7681.00
35_K39_Y0.7631.00
16_Y189_G0.7621.00
134_S150_V0.7591.00
170_L175_E0.7551.00
121_H140_K0.7471.00
150_V172_S0.7461.00
125_L136_S0.7441.00
19_I39_Y0.7351.00
138_Y182_E0.7331.00
139_V143_D0.7291.00
153_Q192_P0.7261.00
114_E140_K0.7251.00
29_P63_L0.7241.00
80_E83_W0.7211.00
24_C48_L0.7201.00
132_P163_G0.7151.00
146_I187_L0.7101.00
109_I124_T0.7081.00
147_S188_S0.7041.00
184_T195_D0.7031.00
103_K106_D0.7031.00
161_L166_Q0.7031.00
27_F51_L0.6971.00
85_A104_P0.6971.00
109_I113_G0.6961.00
121_H141_D0.6941.00
19_I43_K0.6921.00
109_I137_Y0.6881.00
123_E180_L0.6881.00
50_I63_L0.6871.00
19_I22_D0.6841.00
14_N189_G0.6821.00
50_I74_V0.6751.00
173_I178_L0.6751.00
68_E101_T0.6721.00
55_A133_G0.6721.00
56_H59_H0.6701.00
126_F135_V0.6641.00
49_A107_H0.6571.00
13_A189_G0.6481.00
14_N191_G0.6471.00
26_I66_V0.6431.00
82_N85_A0.6391.00
51_L135_V0.6391.00
32_E36_I0.6371.00
52_L60_I0.6371.00
34_H65_E0.6321.00
169_L173_I0.6311.00
152_F157_G0.6291.00
48_L73_P0.6281.00
181_P184_T0.6281.00
152_F156_I0.6261.00
158_R162_I0.6251.00
109_I115_L0.6251.00
67_R71_D0.6241.00
171_T176_K0.6231.00
128_P172_S0.6221.00
20_S120_F0.6191.00
8_V13_A0.6181.00
17_F26_I0.6181.00
14_N192_P0.6161.00
76_L105_A0.6091.00
34_H37_N0.6061.00
152_F155_G0.6061.00
50_I66_V0.6041.00
143_D181_P0.6021.00
15_A29_P0.6021.00
139_V144_L0.5981.00
159_T166_Q0.5971.00
53_T137_Y0.5951.00
77_H80_E0.5941.00
126_F176_K0.5891.00
170_L178_L0.5841.00
82_N86_D0.5841.00
27_F137_Y0.5831.00
11_I57_F0.5791.00
24_C40_I0.5781.00
17_F40_I0.5771.00
56_H189_G0.5741.00
83_W132_P0.5581.00
9_G13_A0.5551.00
151_L186_V0.5541.00
99_E103_K0.5541.00
163_G169_L0.5531.00
36_I39_Y0.5531.00
182_E186_V0.5521.00
110_E126_F0.5521.00
18_L139_V0.5521.00
23_Q118_G0.5511.00
21_D119_P0.5491.00
125_L180_L0.5481.00
62_A65_E0.5471.00
66_V70_W0.5461.00
36_I40_I0.5441.00
149_D190_H0.5411.00
75_Y113_G0.5401.00
54_H149_D0.5381.00
105_A108_L0.5341.00
188_S191_G0.5331.00
31_G36_I0.5321.00
20_S117_I0.5291.00
22_D44_G0.5291.00
79_N110_E0.5281.00
15_A30_G0.5241.00
112_D176_K0.5211.00
41_K44_G0.5201.00
75_Y106_D0.5191.00
138_Y181_P0.5181.00
120_F141_D0.5151.00
22_D45_L0.5141.00
144_L184_T0.5141.00
76_L81_K0.5131.00
43_K46_T0.5121.00
8_V15_A0.5121.00
113_G124_T0.5121.00
155_G158_R0.5111.00
60_I63_L0.5071.00
81_K84_L0.5071.00
26_I40_I0.5061.00
188_S192_P0.5061.00
118_G121_H0.5031.00
18_L25_L0.5011.00
29_P52_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tp9A 2 0.9384 100 0.231 Contact Map
3r2uA 4 0.9336 100 0.233 Contact Map
2xf4A 2 0.981 100 0.234 Contact Map
4efzA 2 0.9905 100 0.243 Contact Map
4yslA 2 0.9905 100 0.244 Contact Map
2zwrA 1 0.9716 100 0.26 Contact Map
1qh5A 1 0.8768 100 0.265 Contact Map
1xm8A 1 0.8863 100 0.268 Contact Map
2p18A 1 0.8863 100 0.272 Contact Map
4chlA 2 0.9005 100 0.283 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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