GLK - BACSU - GREMLIN Contacts

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GLK - Glucokinase

UniProt:	P54495	Sequences: MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITVTIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETETGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGGEIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSARDVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVEKTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	321 (294)
Sequences:	12540 (9607)
Seq/√Len:	560.3

ECOLI - MLC NAGC MAK NAGK YPHH NANK ALSK
BACSU - GLK XYLR SCRK
HALSA - Q9HMA7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
94_A	97_N	3.346	1.00
110_E	153_H	3.193	1.00
30_K	301_D	3.059	1.00
22_N	26_E	3.049	1.00
47_A	102_E	2.800	1.00
240_K	278_T	2.617	1.00
183_I	245_V	2.573	1.00
129_A	257_K	2.521	1.00
257_K	294_S	2.506	1.00
21_I	308_A	2.454	1.00
19_A	304_V	2.441	1.00
126_G	132_V	2.412	1.00
156_N	254_N	2.394	1.00
177_C	182_C	2.350	1.00
134_L	261_G	2.296	1.00
76_D	79_A	2.274	1.00
117_A	144_G	2.260	1.00
96_K	100_E	2.251	1.00
236_D	274_K	2.199	1.00
133_I	249_L	2.179	1.00
116_A	134_L	2.176	1.00
31_W	52_S	2.123	1.00
66_Y	311_A	2.080	1.00
175_C	182_C	2.019	1.00
18_L	49_T	2.014	1.00
195_I	237_Y	2.000	1.00
7_A	50_I	1.965	1.00
117_A	146_I	1.963	1.00
165_I	248_N	1.962	1.00
110_E	114_N	1.918	1.00
123_K	309_W	1.884	1.00
131_D	256_S	1.870	1.00
51_D	102_E	1.862	1.00
147_A	152_V	1.848	1.00
18_L	53_K	1.844	1.00
98_H	101_T	1.825	1.00
29_H	56_E	1.817	1.00
97_N	101_T	1.814	1.00
155_I	256_S	1.812	1.00
110_E	115_I	1.805	1.00
278_T	281_K	1.790	1.00
243_G	278_T	1.775	1.00
44_V	102_E	1.760	1.00
246_L	258_I	1.740	1.00
279_F	293_I	1.729	1.00
272_R	276_E	1.704	1.00
93_Y	98_H	1.701	1.00
67_I	103_T	1.675	1.00
31_W	56_E	1.664	1.00
225_G	270_L	1.663	1.00
239_A	275_V	1.663	1.00
239_A	274_K	1.646	1.00
164_H	177_C	1.611	1.00
174_P	180_T	1.611	1.00
130_K	256_S	1.598	1.00
216_S	219_D	1.595	1.00
166_C	248_N	1.594	1.00
70_G	115_I	1.586	1.00
257_K	292_D	1.585	1.00
223_A	228_D	1.577	1.00
239_A	243_G	1.574	1.00
119_G	298_L	1.573	1.00
130_K	148_N	1.565	1.00
222_E	226_E	1.551	1.00
276_E	280_R	1.520	1.00
121_M	132_V	1.515	1.00
192_I	238_V	1.477	1.00
129_A	256_S	1.465	1.00
274_K	277_K	1.459	1.00
175_C	178_G	1.433	1.00
218_R	222_E	1.431	1.00
272_R	295_I	1.414	1.00
36_D	45_T	1.413	1.00
250_A	279_F	1.404	1.00
269_E	273_S	1.402	1.00
164_H	175_C	1.394	1.00
8_G	304_V	1.391	1.00
195_I	198_E	1.361	1.00
244_L	248_N	1.358	1.00
268_G	272_R	1.347	1.00
38_T	41_T	1.343	1.00
51_D	103_T	1.341	1.00
110_E	310_I	1.336	1.00
9_I	18_L	1.334	1.00
44_V	48_K	1.325	1.00
135_V	246_L	1.322	1.00
15_T	32_E	1.318	1.00
132_V	146_I	1.315	1.00
122_W	313_N	1.313	1.00
47_A	103_T	1.304	1.00
137_L	242_L	1.300	1.00
236_D	278_T	1.300	1.00
278_T	282_C	1.292	1.00
67_I	105_I	1.289	1.00
122_W	309_W	1.284	1.00
199_K	233_E	1.274	1.00
98_H	102_E	1.274	1.00
69_M	99_L	1.272	1.00
6_F	312_K	1.270	1.00
117_A	132_V	1.269	1.00
168_I	171_G	1.269	1.00
19_A	27_I	1.258	1.00
129_A	132_V	1.255	1.00
250_A	258_I	1.254	1.00
173_A	194_R	1.254	1.00
196_A	234_V	1.231	1.00
15_T	189_A	1.229	1.00
131_D	147_A	1.224	1.00
47_A	51_D	1.218	1.00
29_H	53_K	1.217	1.00
121_M	146_I	1.216	1.00
219_D	222_E	1.211	1.00
43_T	98_H	1.203	1.00
133_I	143_G	1.182	1.00
21_I	27_I	1.180	1.00
249_L	252_S	1.180	1.00
31_W	49_T	1.161	1.00
164_H	182_C	1.154	1.00
224_A	235_V	1.152	1.00
274_K	278_T	1.140	1.00
114_N	151_I	1.117	1.00
120_E	124_G	1.112	1.00
277_K	281_K	1.108	1.00
33_V	49_T	1.106	1.00
52_S	56_E	1.106	1.00
141_V	187_A	1.098	1.00
81_V	94_A	1.090	1.00
115_I	307_G	1.090	1.00
132_V	259_V	1.088	1.00
7_A	64_I	1.083	1.00
131_D	152_V	1.078	1.00
269_E	295_I	1.075	1.00
117_A	134_L	1.073	1.00
33_V	45_T	1.070	1.00
195_I	234_V	1.068	1.00
70_G	303_G	1.066	1.00
9_I	46_I	1.063	1.00
33_V	52_S	1.061	1.00
8_G	307_G	1.056	1.00
49_T	52_S	1.054	1.00
169_P	172_G	1.049	1.00
45_T	48_K	1.047	1.00
196_A	231_A	1.046	1.00
94_A	98_H	1.043	1.00
232_L	236_D	1.043	1.00
9_I	50_I	1.042	1.00
20_F	57_L	1.039	1.00
243_G	282_C	1.036	1.00
266_R	300_N	1.028	1.00
108_V	311_A	1.026	1.00
143_G	162_I	1.016	1.00
111_N	161_E	1.015	1.00
121_M	149_G	1.009	1.00
195_I	199_K	1.001	1.00
113_A	136_T	0.999	1.00
173_A	186_I	0.994	1.00
224_A	232_L	0.992	1.00
13_G	139_T	0.991	1.00
64_I	105_I	0.987	1.00
236_D	277_K	0.987	1.00
221_F	235_V	0.980	1.00
196_A	200_I	0.977	1.00
40_D	98_H	0.976	1.00
239_A	278_T	0.971	1.00
222_E	225_G	0.971	1.00
39_G	98_H	0.971	1.00
33_V	48_K	0.968	1.00
169_P	244_L	0.966	1.00
246_L	260_L	0.964	1.00
273_S	276_E	0.963	1.00
100_E	107_A	0.963	1.00
127_D	297_A	0.962	1.00
259_V	296_A	0.962	1.00
17_K	32_E	0.958	1.00
145_I	253_L	0.957	1.00
280_R	290_A	0.955	1.00
48_K	52_S	0.954	1.00
8_G	68_G	0.954	1.00
20_F	53_K	0.949	1.00
260_L	265_S	0.948	1.00
133_I	145_I	0.947	1.00
244_L	282_C	0.946	1.00
145_I	152_V	0.946	1.00
200_I	230_I	0.938	1.00
132_V	257_K	0.927	1.00
225_G	269_E	0.927	1.00
116_A	303_G	0.926	1.00
273_S	277_K	0.921	1.00
154_G	159_G	0.921	1.00
173_A	185_T	0.920	1.00
81_V	92_N	0.919	1.00
240_K	244_L	0.914	1.00
133_I	258_I	0.911	1.00
114_N	161_E	0.908	1.00
246_L	279_F	0.901	1.00
8_G	308_A	0.900	1.00
22_N	28_Q	0.900	1.00
99_L	107_A	0.899	1.00
259_V	294_S	0.896	1.00
123_K	305_I	0.890	1.00
182_C	185_T	0.888	1.00
173_A	198_E	0.886	1.00
76_D	83_Y	0.884	1.00
266_R	295_I	0.880	1.00
16_I	35_T	0.878	1.00
21_I	305_I	0.876	1.00
200_I	215_L	0.872	1.00
80_G	96_K	0.866	1.00
6_F	311_A	0.866	1.00
130_K	149_G	0.862	1.00
145_I	160_G	0.861	1.00
237_Y	241_H	0.859	1.00
42_I	90_W	0.858	1.00
173_A	195_I	0.858	1.00
124_G	127_D	0.852	1.00
71_A	75_V	0.852	1.00
27_I	30_K	0.834	1.00
154_G	254_N	0.833	1.00
11_L	71_A	0.831	1.00
100_E	106_P	0.826	1.00
148_N	152_V	0.819	1.00
131_D	148_N	0.818	1.00
250_A	291_A	0.818	1.00
39_G	93_Y	0.810	1.00
29_H	57_L	0.810	1.00
133_I	255_P	0.809	1.00
223_A	231_A	0.809	1.00
268_G	273_S	0.809	1.00
192_I	264_V	0.807	1.00
230_I	233_E	0.803	1.00
272_R	275_V	0.803	1.00
219_D	223_A	0.798	1.00
196_A	220_V	0.798	1.00
168_I	244_L	0.796	1.00
224_A	270_L	0.792	1.00
129_A	292_D	0.791	1.00
197_K	213_E	0.788	1.00
228_D	231_A	0.785	1.00
40_D	44_V	0.784	1.00
268_G	295_I	0.783	1.00
11_L	46_I	0.783	1.00
18_L	31_W	0.782	1.00
47_A	98_H	0.780	1.00
183_I	238_V	0.780	1.00
247_G	282_C	0.779	1.00
223_A	226_E	0.779	1.00
221_F	225_G	0.778	1.00
240_K	282_C	0.777	1.00
233_E	237_Y	0.769	1.00
41_T	44_V	0.766	1.00
71_A	82_V	0.766	1.00
80_G	100_E	0.766	1.00
195_I	238_V	0.765	1.00
154_G	160_G	0.764	1.00
51_D	55_D	0.763	1.00
196_A	201_A	0.761	1.00
136_T	303_G	0.757	1.00
193_V	197_K	0.755	1.00
113_A	144_G	0.755	1.00
260_L	293_I	0.746	1.00
294_S	297_A	0.745	1.00
140_G	161_E	0.744	1.00
19_A	30_K	0.743	1.00
17_K	30_K	0.739	1.00
140_G	184_E	0.739	1.00
115_I	310_I	0.736	1.00
186_I	241_H	0.735	1.00
131_D	155_I	0.735	1.00
68_G	311_A	0.733	1.00
243_G	279_F	0.731	1.00
51_D	54_L	0.729	1.00
167_S	241_H	0.728	1.00
124_G	128_G	0.724	1.00
299_G	302_A	0.723	1.00
215_L	219_D	0.717	1.00
54_L	105_I	0.715	1.00
240_K	281_K	0.714	1.00
199_K	230_I	0.711	1.00
221_F	267_A	0.708	1.00
118_L	121_M	0.708	1.00
100_E	104_G	0.707	1.00
68_G	115_I	0.704	1.00
49_T	53_K	0.702	1.00
66_Y	106_P	0.700	1.00
111_N	140_G	0.699	1.00
72_P	87_N	0.698	1.00
224_A	231_A	0.696	1.00
48_K	51_D	0.695	1.00
167_S	245_V	0.690	1.00
298_L	305_I	0.688	1.00
134_L	259_V	0.686	1.00
199_K	234_V	0.686	1.00
125_A	297_A	0.685	1.00
138_G	263_G	0.684	1.00
123_K	298_L	0.682	1.00
36_D	41_T	0.680	1.00
125_A	259_V	0.679	1.00
192_I	234_V	0.676	1.00
166_C	244_L	0.676	1.00
125_A	294_S	0.675	1.00
18_L	33_V	0.675	1.00
229_E	233_E	0.672	1.00
9_I	67_I	0.671	1.00
7_A	54_L	0.668	1.00
112_D	142_G	0.668	1.00
168_I	186_I	0.668	1.00
234_V	238_V	0.665	1.00
45_T	49_T	0.665	1.00
12_G	139_T	0.664	1.00
242_L	275_V	0.662	1.00
126_G	259_V	0.657	1.00
84_E	91_K	0.656	1.00
12_G	263_G	0.656	1.00
232_L	270_L	0.655	1.00
165_I	245_V	0.653	1.00
169_P	240_K	0.652	1.00
247_G	251_S	0.652	1.00
11_L	16_I	0.651	1.00
74_P	85_T	0.650	1.00
191_G	194_R	0.647	1.00
97_N	100_E	0.646	1.00
229_E	232_L	0.641	1.00
120_E	296_A	0.640	1.00
187_A	238_V	0.637	1.00
271_L	274_K	0.633	1.00
179_K	282_C	0.632	1.00
96_K	109_I	0.632	1.00
120_E	298_L	0.628	1.00
16_I	33_V	0.628	1.00
43_T	102_E	0.628	1.00
239_A	271_L	0.627	1.00
276_E	292_D	0.627	1.00
270_L	274_K	0.625	1.00
175_C	179_K	0.622	1.00
190_T	194_R	0.620	1.00
108_V	310_I	0.620	1.00
159_G	254_N	0.619	1.00
238_V	271_L	0.619	1.00
87_N	176_N	0.618	1.00
247_G	279_F	0.617	1.00
243_G	247_G	0.617	1.00
167_S	186_I	0.615	1.00
150_E	313_N	0.611	1.00
298_L	302_A	0.610	1.00
85_T	88_L	0.608	1.00
175_C	181_G	0.608	1.00
277_K	280_R	0.608	1.00
193_V	217_A	0.608	1.00
96_K	107_A	0.607	1.00
166_C	179_K	0.604	1.00
41_T	45_T	0.603	1.00
47_A	99_L	0.603	1.00
152_V	253_L	0.600	1.00
43_T	93_Y	0.599	1.00
193_V	220_V	0.596	1.00
14_T	139_T	0.595	1.00
195_I	241_H	0.592	1.00
53_K	57_L	0.592	1.00
11_L	42_I	0.592	1.00
37_K	41_T	0.592	1.00
16_I	46_I	0.588	1.00
251_S	284_F	0.587	1.00
52_S	55_D	0.586	1.00
31_W	53_K	0.586	1.00
135_V	143_G	0.583	1.00
246_L	275_V	0.581	1.00
46_I	99_L	0.580	1.00
179_K	182_C	0.578	1.00
155_I	254_N	0.577	1.00
189_A	193_V	0.576	0.99
104_G	107_A	0.576	0.99
305_I	308_A	0.576	0.99
135_V	162_I	0.572	0.99
197_K	214_Q	0.571	0.99
122_W	312_K	0.571	0.99
267_A	270_L	0.570	0.99
175_C	185_T	0.570	0.99
189_A	264_V	0.570	0.99
270_L	273_S	0.569	0.99
44_V	47_A	0.568	0.99
275_V	279_F	0.568	0.99
135_V	249_L	0.567	0.99
17_K	304_V	0.566	0.99
194_R	198_E	0.566	0.99
20_F	64_I	0.565	0.99
184_E	188_S	0.565	0.99
177_C	181_G	0.565	0.99
212_T	215_L	0.564	0.99
232_L	274_K	0.563	0.99
39_G	90_W	0.562	0.99
224_A	227_N	0.562	0.99
119_G	309_W	0.562	0.99
99_L	103_T	0.561	0.99
309_W	313_N	0.561	0.99
155_I	255_P	0.557	0.99
116_A	261_G	0.555	0.99
261_G	296_A	0.550	0.99
111_N	114_N	0.548	0.99
177_C	185_T	0.548	0.99
162_I	252_S	0.546	0.99
6_F	23_Q	0.546	0.99
144_G	151_I	0.544	0.99
10_D	13_G	0.543	0.99
224_A	239_A	0.542	0.99
54_L	64_I	0.539	0.99
178_G	182_C	0.539	0.99
101_T	104_G	0.538	0.99
77_M	153_H	0.538	0.99
111_N	142_G	0.536	0.99
142_G	161_E	0.534	0.99
268_G	274_K	0.533	0.99
255_P	258_I	0.533	0.99
134_L	138_G	0.532	0.99
147_A	255_P	0.532	0.99
90_W	93_Y	0.532	0.99
116_A	136_T	0.532	0.99
124_G	294_S	0.530	0.99
66_Y	108_V	0.530	0.99
220_V	224_A	0.529	0.99
165_I	249_L	0.528	0.99
234_V	237_Y	0.526	0.99
68_G	310_I	0.526	0.99
247_G	283_A	0.525	0.99
228_D	232_L	0.521	0.99
301_D	305_I	0.520	0.99
120_E	297_A	0.520	0.99
167_S	183_I	0.518	0.99
168_I	241_H	0.516	0.99
141_V	183_I	0.513	0.99
155_I	290_A	0.510	0.99
191_G	195_I	0.509	0.99
118_L	310_I	0.508	0.99
6_F	21_I	0.506	0.99
54_L	103_T	0.505	0.99
67_I	99_L	0.503	0.99
124_G	298_L	0.503	0.99
291_A	295_I	0.502	0.99
166_C	169_P	0.502	0.99
201_A	212_T	0.501	0.99
137_L	264_V	0.501	0.99
240_K	274_K	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1z05A	2	0.9907	100	0.173	Contact Map
1z6rA	3	0.9875	100	0.183	Contact Map
2qm1A	2	0.9844	100	0.202	Contact Map
3vglA	3	0.9502	100	0.207	Contact Map
2yhwA	2	0.9439	100	0.209	Contact Map
3vovA	3	0.919	100	0.221	Contact Map
2hoeA	2	0.9128	100	0.235	Contact Map
2ap1A	2	0.9128	100	0.241	Contact Map
4htlA	4	0.9003	100	0.247	Contact Map
3r8eA	2	0.9221	100	0.249	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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