GREMLIN Database
GLK - Glucokinase
UniProt: P54495 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (294)
Sequences: 12540 (9607)
Seq/√Len: 560.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_A97_N3.3461.00
110_E153_H3.1931.00
30_K301_D3.0591.00
22_N26_E3.0491.00
47_A102_E2.8001.00
240_K278_T2.6171.00
183_I245_V2.5731.00
129_A257_K2.5211.00
257_K294_S2.5061.00
21_I308_A2.4541.00
19_A304_V2.4411.00
126_G132_V2.4121.00
156_N254_N2.3941.00
177_C182_C2.3501.00
134_L261_G2.2961.00
76_D79_A2.2741.00
117_A144_G2.2601.00
96_K100_E2.2511.00
236_D274_K2.1991.00
133_I249_L2.1791.00
116_A134_L2.1761.00
31_W52_S2.1231.00
66_Y311_A2.0801.00
175_C182_C2.0191.00
18_L49_T2.0141.00
195_I237_Y2.0001.00
7_A50_I1.9651.00
117_A146_I1.9631.00
165_I248_N1.9621.00
110_E114_N1.9181.00
123_K309_W1.8841.00
131_D256_S1.8701.00
51_D102_E1.8621.00
147_A152_V1.8481.00
18_L53_K1.8441.00
98_H101_T1.8251.00
29_H56_E1.8171.00
97_N101_T1.8141.00
155_I256_S1.8121.00
110_E115_I1.8051.00
278_T281_K1.7901.00
243_G278_T1.7751.00
44_V102_E1.7601.00
246_L258_I1.7401.00
279_F293_I1.7291.00
272_R276_E1.7041.00
93_Y98_H1.7011.00
67_I103_T1.6751.00
31_W56_E1.6641.00
225_G270_L1.6631.00
239_A275_V1.6631.00
239_A274_K1.6461.00
164_H177_C1.6111.00
174_P180_T1.6111.00
130_K256_S1.5981.00
216_S219_D1.5951.00
166_C248_N1.5941.00
70_G115_I1.5861.00
257_K292_D1.5851.00
223_A228_D1.5771.00
239_A243_G1.5741.00
119_G298_L1.5731.00
130_K148_N1.5651.00
222_E226_E1.5511.00
276_E280_R1.5201.00
121_M132_V1.5151.00
192_I238_V1.4771.00
129_A256_S1.4651.00
274_K277_K1.4591.00
175_C178_G1.4331.00
218_R222_E1.4311.00
272_R295_I1.4141.00
36_D45_T1.4131.00
250_A279_F1.4041.00
269_E273_S1.4021.00
164_H175_C1.3941.00
8_G304_V1.3911.00
195_I198_E1.3611.00
244_L248_N1.3581.00
268_G272_R1.3471.00
38_T41_T1.3431.00
51_D103_T1.3411.00
110_E310_I1.3361.00
9_I18_L1.3341.00
44_V48_K1.3251.00
135_V246_L1.3221.00
15_T32_E1.3181.00
132_V146_I1.3151.00
122_W313_N1.3131.00
47_A103_T1.3041.00
137_L242_L1.3001.00
236_D278_T1.3001.00
278_T282_C1.2921.00
67_I105_I1.2891.00
122_W309_W1.2841.00
199_K233_E1.2741.00
98_H102_E1.2741.00
69_M99_L1.2721.00
6_F312_K1.2701.00
117_A132_V1.2691.00
168_I171_G1.2691.00
19_A27_I1.2581.00
129_A132_V1.2551.00
250_A258_I1.2541.00
173_A194_R1.2541.00
196_A234_V1.2311.00
15_T189_A1.2291.00
131_D147_A1.2241.00
47_A51_D1.2181.00
29_H53_K1.2171.00
121_M146_I1.2161.00
219_D222_E1.2111.00
43_T98_H1.2031.00
133_I143_G1.1821.00
21_I27_I1.1801.00
249_L252_S1.1801.00
31_W49_T1.1611.00
164_H182_C1.1541.00
224_A235_V1.1521.00
274_K278_T1.1401.00
114_N151_I1.1171.00
120_E124_G1.1121.00
277_K281_K1.1081.00
33_V49_T1.1061.00
52_S56_E1.1061.00
141_V187_A1.0981.00
81_V94_A1.0901.00
115_I307_G1.0901.00
132_V259_V1.0881.00
7_A64_I1.0831.00
131_D152_V1.0781.00
269_E295_I1.0751.00
117_A134_L1.0731.00
33_V45_T1.0701.00
195_I234_V1.0681.00
70_G303_G1.0661.00
9_I46_I1.0631.00
33_V52_S1.0611.00
8_G307_G1.0561.00
49_T52_S1.0541.00
169_P172_G1.0491.00
45_T48_K1.0471.00
196_A231_A1.0461.00
94_A98_H1.0431.00
232_L236_D1.0431.00
9_I50_I1.0421.00
20_F57_L1.0391.00
243_G282_C1.0361.00
266_R300_N1.0281.00
108_V311_A1.0261.00
143_G162_I1.0161.00
111_N161_E1.0151.00
121_M149_G1.0091.00
195_I199_K1.0011.00
113_A136_T0.9991.00
173_A186_I0.9941.00
224_A232_L0.9921.00
13_G139_T0.9911.00
64_I105_I0.9871.00
236_D277_K0.9871.00
221_F235_V0.9801.00
196_A200_I0.9771.00
40_D98_H0.9761.00
239_A278_T0.9711.00
222_E225_G0.9711.00
39_G98_H0.9711.00
33_V48_K0.9681.00
169_P244_L0.9661.00
246_L260_L0.9641.00
273_S276_E0.9631.00
100_E107_A0.9631.00
127_D297_A0.9621.00
259_V296_A0.9621.00
17_K32_E0.9581.00
145_I253_L0.9571.00
280_R290_A0.9551.00
48_K52_S0.9541.00
8_G68_G0.9541.00
20_F53_K0.9491.00
260_L265_S0.9481.00
133_I145_I0.9471.00
244_L282_C0.9461.00
145_I152_V0.9461.00
200_I230_I0.9381.00
132_V257_K0.9271.00
225_G269_E0.9271.00
116_A303_G0.9261.00
273_S277_K0.9211.00
154_G159_G0.9211.00
173_A185_T0.9201.00
81_V92_N0.9191.00
240_K244_L0.9141.00
133_I258_I0.9111.00
114_N161_E0.9081.00
246_L279_F0.9011.00
8_G308_A0.9001.00
22_N28_Q0.9001.00
99_L107_A0.8991.00
259_V294_S0.8961.00
123_K305_I0.8901.00
182_C185_T0.8881.00
173_A198_E0.8861.00
76_D83_Y0.8841.00
266_R295_I0.8801.00
16_I35_T0.8781.00
21_I305_I0.8761.00
200_I215_L0.8721.00
80_G96_K0.8661.00
6_F311_A0.8661.00
130_K149_G0.8621.00
145_I160_G0.8611.00
237_Y241_H0.8591.00
42_I90_W0.8581.00
173_A195_I0.8581.00
124_G127_D0.8521.00
71_A75_V0.8521.00
27_I30_K0.8341.00
154_G254_N0.8331.00
11_L71_A0.8311.00
100_E106_P0.8261.00
148_N152_V0.8191.00
131_D148_N0.8181.00
250_A291_A0.8181.00
39_G93_Y0.8101.00
29_H57_L0.8101.00
133_I255_P0.8091.00
223_A231_A0.8091.00
268_G273_S0.8091.00
192_I264_V0.8071.00
230_I233_E0.8031.00
272_R275_V0.8031.00
219_D223_A0.7981.00
196_A220_V0.7981.00
168_I244_L0.7961.00
224_A270_L0.7921.00
129_A292_D0.7911.00
197_K213_E0.7881.00
228_D231_A0.7851.00
40_D44_V0.7841.00
268_G295_I0.7831.00
11_L46_I0.7831.00
18_L31_W0.7821.00
47_A98_H0.7801.00
183_I238_V0.7801.00
247_G282_C0.7791.00
223_A226_E0.7791.00
221_F225_G0.7781.00
240_K282_C0.7771.00
233_E237_Y0.7691.00
41_T44_V0.7661.00
71_A82_V0.7661.00
80_G100_E0.7661.00
195_I238_V0.7651.00
154_G160_G0.7641.00
51_D55_D0.7631.00
196_A201_A0.7611.00
136_T303_G0.7571.00
193_V197_K0.7551.00
113_A144_G0.7551.00
260_L293_I0.7461.00
294_S297_A0.7451.00
140_G161_E0.7441.00
19_A30_K0.7431.00
17_K30_K0.7391.00
140_G184_E0.7391.00
115_I310_I0.7361.00
186_I241_H0.7351.00
131_D155_I0.7351.00
68_G311_A0.7331.00
243_G279_F0.7311.00
51_D54_L0.7291.00
167_S241_H0.7281.00
124_G128_G0.7241.00
299_G302_A0.7231.00
215_L219_D0.7171.00
54_L105_I0.7151.00
240_K281_K0.7141.00
199_K230_I0.7111.00
221_F267_A0.7081.00
118_L121_M0.7081.00
100_E104_G0.7071.00
68_G115_I0.7041.00
49_T53_K0.7021.00
66_Y106_P0.7001.00
111_N140_G0.6991.00
72_P87_N0.6981.00
224_A231_A0.6961.00
48_K51_D0.6951.00
167_S245_V0.6901.00
298_L305_I0.6881.00
134_L259_V0.6861.00
199_K234_V0.6861.00
125_A297_A0.6851.00
138_G263_G0.6841.00
123_K298_L0.6821.00
36_D41_T0.6801.00
125_A259_V0.6791.00
192_I234_V0.6761.00
166_C244_L0.6761.00
125_A294_S0.6751.00
18_L33_V0.6751.00
229_E233_E0.6721.00
9_I67_I0.6711.00
7_A54_L0.6681.00
112_D142_G0.6681.00
168_I186_I0.6681.00
234_V238_V0.6651.00
45_T49_T0.6651.00
12_G139_T0.6641.00
242_L275_V0.6621.00
126_G259_V0.6571.00
84_E91_K0.6561.00
12_G263_G0.6561.00
232_L270_L0.6551.00
165_I245_V0.6531.00
169_P240_K0.6521.00
247_G251_S0.6521.00
11_L16_I0.6511.00
74_P85_T0.6501.00
191_G194_R0.6471.00
97_N100_E0.6461.00
229_E232_L0.6411.00
120_E296_A0.6401.00
187_A238_V0.6371.00
271_L274_K0.6331.00
179_K282_C0.6321.00
96_K109_I0.6321.00
120_E298_L0.6281.00
16_I33_V0.6281.00
43_T102_E0.6281.00
239_A271_L0.6271.00
276_E292_D0.6271.00
270_L274_K0.6251.00
175_C179_K0.6221.00
190_T194_R0.6201.00
108_V310_I0.6201.00
159_G254_N0.6191.00
238_V271_L0.6191.00
87_N176_N0.6181.00
247_G279_F0.6171.00
243_G247_G0.6171.00
167_S186_I0.6151.00
150_E313_N0.6111.00
298_L302_A0.6101.00
85_T88_L0.6081.00
175_C181_G0.6081.00
277_K280_R0.6081.00
193_V217_A0.6081.00
96_K107_A0.6071.00
166_C179_K0.6041.00
41_T45_T0.6031.00
47_A99_L0.6031.00
152_V253_L0.6001.00
43_T93_Y0.5991.00
193_V220_V0.5961.00
14_T139_T0.5951.00
195_I241_H0.5921.00
53_K57_L0.5921.00
11_L42_I0.5921.00
37_K41_T0.5921.00
16_I46_I0.5881.00
251_S284_F0.5871.00
52_S55_D0.5861.00
31_W53_K0.5861.00
135_V143_G0.5831.00
246_L275_V0.5811.00
46_I99_L0.5801.00
179_K182_C0.5781.00
155_I254_N0.5771.00
189_A193_V0.5760.99
104_G107_A0.5760.99
305_I308_A0.5760.99
135_V162_I0.5720.99
197_K214_Q0.5710.99
122_W312_K0.5710.99
267_A270_L0.5700.99
175_C185_T0.5700.99
189_A264_V0.5700.99
270_L273_S0.5690.99
44_V47_A0.5680.99
275_V279_F0.5680.99
135_V249_L0.5670.99
17_K304_V0.5660.99
194_R198_E0.5660.99
20_F64_I0.5650.99
184_E188_S0.5650.99
177_C181_G0.5650.99
212_T215_L0.5640.99
232_L274_K0.5630.99
39_G90_W0.5620.99
224_A227_N0.5620.99
119_G309_W0.5620.99
99_L103_T0.5610.99
309_W313_N0.5610.99
155_I255_P0.5570.99
116_A261_G0.5550.99
261_G296_A0.5500.99
111_N114_N0.5480.99
177_C185_T0.5480.99
162_I252_S0.5460.99
6_F23_Q0.5460.99
144_G151_I0.5440.99
10_D13_G0.5430.99
224_A239_A0.5420.99
54_L64_I0.5390.99
178_G182_C0.5390.99
101_T104_G0.5380.99
77_M153_H0.5380.99
111_N142_G0.5360.99
142_G161_E0.5340.99
268_G274_K0.5330.99
255_P258_I0.5330.99
134_L138_G0.5320.99
147_A255_P0.5320.99
90_W93_Y0.5320.99
116_A136_T0.5320.99
124_G294_S0.5300.99
66_Y108_V0.5300.99
220_V224_A0.5290.99
165_I249_L0.5280.99
234_V237_Y0.5260.99
68_G310_I0.5260.99
247_G283_A0.5250.99
228_D232_L0.5210.99
301_D305_I0.5200.99
120_E297_A0.5200.99
167_S183_I0.5180.99
168_I241_H0.5160.99
141_V183_I0.5130.99
155_I290_A0.5100.99
191_G195_I0.5090.99
118_L310_I0.5080.99
6_F21_I0.5060.99
54_L103_T0.5050.99
67_I99_L0.5030.99
124_G298_L0.5030.99
291_A295_I0.5020.99
166_C169_P0.5020.99
201_A212_T0.5010.99
137_L264_V0.5010.99
240_K274_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z05A 2 0.9907 100 0.173 Contact Map
1z6rA 3 0.9875 100 0.183 Contact Map
2qm1A 2 0.9844 100 0.202 Contact Map
3vglA 3 0.9502 100 0.207 Contact Map
2yhwA 2 0.9439 100 0.209 Contact Map
3vovA 3 0.919 100 0.221 Contact Map
2hoeA 2 0.9128 100 0.235 Contact Map
2ap1A 2 0.9128 100 0.241 Contact Map
4htlA 4 0.9003 100 0.247 Contact Map
3r8eA 2 0.9221 100 0.249 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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